DNA-directed RNA polymerase III subunit RPC3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACX1_LEIMA

TriTrypDb:

LmjF.27.2600 , LMJLV39_270033000 , LMJSD75_270032900

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	10
GO:0005666	RNA polymerase III complex	4	10
GO:0030880	RNA polymerase complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	10
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	10
GO:0140513	nuclear protein-containing complex	2	10
GO:0140535	intracellular protein-containing complex	2	10
GO:1902494	catalytic complex	2	10
GO:1990234	transferase complex	3	10

Expansion

Sequence features

E9ACX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACX1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003697	single-stranded DNA binding	5	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.552
CLV_NRD_NRD_1	302	304	PF00675	0.480
CLV_NRD_NRD_1	331	333	PF00675	0.647
CLV_PCSK_KEX2_1	301	303	PF00082	0.461
CLV_PCSK_KEX2_1	331	333	PF00082	0.644
CLV_PCSK_PC7_1	298	304	PF00082	0.526
CLV_PCSK_SKI1_1	155	159	PF00082	0.362
CLV_PCSK_SKI1_1	174	178	PF00082	0.263
CLV_PCSK_SKI1_1	23	27	PF00082	0.486
CLV_PCSK_SKI1_1	291	295	PF00082	0.520
CLV_PCSK_SKI1_1	392	396	PF00082	0.574
CLV_PCSK_SKI1_1	435	439	PF00082	0.365
CLV_PCSK_SKI1_1	463	467	PF00082	0.381
CLV_PCSK_SKI1_1	489	493	PF00082	0.548
CLV_PCSK_SKI1_1	513	517	PF00082	0.432
CLV_PCSK_SKI1_1	582	586	PF00082	0.534
CLV_PCSK_SKI1_1	596	600	PF00082	0.477
CLV_Separin_Metazoa	479	483	PF03568	0.565
DEG_APCC_DBOX_1	290	298	PF00400	0.560
DEG_APCC_DBOX_1	462	470	PF00400	0.379
DEG_SCF_FBW7_1	196	203	PF00400	0.580
DEG_SPOP_SBC_1	345	349	PF00917	0.571
DOC_CYCLIN_RxL_1	593	602	PF00134	0.506
DOC_CYCLIN_yCln2_LP_2	360	366	PF00134	0.553
DOC_MAPK_gen_1	489	497	PF00069	0.424
DOC_MAPK_gen_1	511	520	PF00069	0.459
DOC_MAPK_MEF2A_6	147	156	PF00069	0.425
DOC_MAPK_MEF2A_6	189	196	PF00069	0.527
DOC_MAPK_MEF2A_6	428	436	PF00069	0.392
DOC_MAPK_MEF2A_6	596	603	PF00069	0.483
DOC_PP1_RVXF_1	153	159	PF00149	0.475
DOC_PP2B_LxvP_1	224	227	PF13499	0.463
DOC_USP7_MATH_1	313	317	PF00917	0.591
DOC_USP7_MATH_1	346	350	PF00917	0.644
DOC_USP7_MATH_1	374	378	PF00917	0.691
DOC_USP7_MATH_1	452	456	PF00917	0.494
DOC_USP7_MATH_1	481	485	PF00917	0.532
DOC_USP7_MATH_1	491	495	PF00917	0.369
DOC_USP7_MATH_1	547	551	PF00917	0.710
DOC_WW_Pin1_4	196	201	PF00397	0.563
DOC_WW_Pin1_4	258	263	PF00397	0.465
DOC_WW_Pin1_4	379	384	PF00397	0.719
DOC_WW_Pin1_4	542	547	PF00397	0.687
LIG_14-3-3_CanoR_1	291	297	PF00244	0.554
LIG_14-3-3_CanoR_1	513	519	PF00244	0.426
LIG_Actin_WH2_2	323	341	PF00022	0.636
LIG_Actin_WH2_2	44	62	PF00022	0.523
LIG_AP2alpha_1	470	474	PF02296	0.519
LIG_BRCT_BRCA1_1	381	385	PF00533	0.742
LIG_Clathr_ClatBox_1	598	602	PF01394	0.474
LIG_EH1_1	208	216	PF00400	0.448
LIG_eIF4E_1	148	154	PF01652	0.499
LIG_FHA_1	125	131	PF00498	0.441
LIG_FHA_1	197	203	PF00498	0.520
LIG_FHA_1	309	315	PF00498	0.620
LIG_FHA_1	325	331	PF00498	0.406
LIG_FHA_1	340	346	PF00498	0.569
LIG_FHA_1	35	41	PF00498	0.546
LIG_FHA_1	389	395	PF00498	0.622
LIG_FHA_1	481	487	PF00498	0.614
LIG_FHA_1	515	521	PF00498	0.435
LIG_FHA_1	88	94	PF00498	0.659
LIG_FHA_2	448	454	PF00498	0.507
LIG_GBD_Chelix_1	292	300	PF00786	0.481
LIG_GBD_Chelix_1	43	51	PF00786	0.378
LIG_LIR_Apic_2	216	222	PF02991	0.517
LIG_LIR_Gen_1	208	215	PF02991	0.526
LIG_LIR_Gen_1	316	325	PF02991	0.563
LIG_LIR_Gen_1	382	393	PF02991	0.699
LIG_LIR_Gen_1	458	466	PF02991	0.452
LIG_LIR_Gen_1	519	528	PF02991	0.511
LIG_LIR_LC3C_4	127	131	PF02991	0.550
LIG_LIR_Nem_3	208	212	PF02991	0.528
LIG_LIR_Nem_3	316	320	PF02991	0.494
LIG_LIR_Nem_3	402	407	PF02991	0.527
LIG_LIR_Nem_3	427	432	PF02991	0.466
LIG_LIR_Nem_3	458	462	PF02991	0.466
LIG_LIR_Nem_3	519	525	PF02991	0.471
LIG_NRBOX	593	599	PF00104	0.479
LIG_PCNA_yPIPBox_3	582	595	PF02747	0.537
LIG_PDZ_Class_3	599	604	PF00595	0.491
LIG_Pex14_2	470	474	PF04695	0.519
LIG_RPA_C_Fungi	327	339	PF08784	0.467
LIG_SH2_CRK	209	213	PF00017	0.530
LIG_SH2_CRK	429	433	PF00017	0.483
LIG_SH2_PTP2	459	462	PF00017	0.460
LIG_SH2_SRC	287	290	PF00017	0.600
LIG_SH2_STAP1	144	148	PF00017	0.441
LIG_SH2_STAP1	310	314	PF00017	0.646
LIG_SH2_STAP1	367	371	PF00017	0.570
LIG_SH2_STAT5	273	276	PF00017	0.510
LIG_SH2_STAT5	310	313	PF00017	0.662
LIG_SH2_STAT5	459	462	PF00017	0.505
LIG_SH2_STAT5	496	499	PF00017	0.506
LIG_SH3_3	153	159	PF00018	0.475
LIG_SH3_3	182	188	PF00018	0.526
LIG_SH3_3	244	250	PF00018	0.642
LIG_SH3_4	397	404	PF00018	0.545
LIG_Sin3_3	158	165	PF02671	0.508
LIG_SUMO_SIM_par_1	596	602	PF11976	0.369
LIG_TRAF2_1	316	319	PF00917	0.567
LIG_TYR_ITIM	207	212	PF00017	0.524
LIG_WRC_WIRS_1	314	319	PF05994	0.585
LIG_WW_3	186	190	PF00397	0.535
MOD_CK1_1	308	314	PF00069	0.630
MOD_CK1_1	34	40	PF00069	0.481
MOD_CK1_1	384	390	PF00069	0.691
MOD_CK1_1	455	461	PF00069	0.527
MOD_CK1_1	551	557	PF00069	0.644
MOD_CK2_1	313	319	PF00069	0.527
MOD_CK2_1	345	351	PF00069	0.586
MOD_CK2_1	447	453	PF00069	0.470
MOD_GlcNHglycan	149	152	PF01048	0.449
MOD_GlcNHglycan	307	310	PF01048	0.624
MOD_GlcNHglycan	333	337	PF01048	0.616
MOD_GlcNHglycan	376	379	PF01048	0.642
MOD_GlcNHglycan	483	486	PF01048	0.530
MOD_GlcNHglycan	488	492	PF01048	0.503
MOD_GlcNHglycan	502	505	PF01048	0.239
MOD_GlcNHglycan	53	56	PF01048	0.574
MOD_GlcNHglycan	532	535	PF01048	0.570
MOD_GlcNHglycan	554	557	PF01048	0.598
MOD_GlcNHglycan	83	86	PF01048	0.613
MOD_GSK3_1	194	201	PF00069	0.545
MOD_GSK3_1	245	252	PF00069	0.649
MOD_GSK3_1	257	264	PF00069	0.538
MOD_GSK3_1	379	386	PF00069	0.681
MOD_GSK3_1	47	54	PF00069	0.470
MOD_GSK3_1	487	494	PF00069	0.519
MOD_GSK3_1	498	505	PF00069	0.488
MOD_GSK3_1	547	554	PF00069	0.699
MOD_GSK3_1	582	589	PF00069	0.487
MOD_GSK3_1	83	90	PF00069	0.652
MOD_N-GLC_1	257	262	PF02516	0.480
MOD_N-GLC_1	552	557	PF02516	0.680
MOD_NEK2_1	292	297	PF00069	0.472
MOD_NEK2_1	31	36	PF00069	0.395
MOD_NEK2_1	500	505	PF00069	0.463
MOD_NEK2_1	51	56	PF00069	0.237
MOD_NEK2_1	514	519	PF00069	0.321
MOD_NEK2_2	491	496	PF00069	0.417
MOD_OFUCOSY	5	12	PF10250	0.567
MOD_PIKK_1	397	403	PF00454	0.626
MOD_PK_1	198	204	PF00069	0.538
MOD_PKA_2	481	487	PF00069	0.640
MOD_PKA_2	81	87	PF00069	0.637
MOD_Plk_1	447	453	PF00069	0.507
MOD_Plk_2-3	109	115	PF00069	0.609
MOD_Plk_2-3	447	453	PF00069	0.507
MOD_Plk_4	292	298	PF00069	0.494
MOD_Plk_4	455	461	PF00069	0.553
MOD_Plk_4	491	497	PF00069	0.410
MOD_Plk_4	502	508	PF00069	0.395
MOD_Plk_4	590	596	PF00069	0.430
MOD_ProDKin_1	196	202	PF00069	0.554
MOD_ProDKin_1	258	264	PF00069	0.477
MOD_ProDKin_1	379	385	PF00069	0.717
MOD_ProDKin_1	542	548	PF00069	0.690
TRG_DiLeu_BaEn_1	216	221	PF01217	0.473
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.470
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.433
TRG_DiLeu_BaLyEn_6	593	598	PF01217	0.481
TRG_ENDOCYTIC_2	209	212	PF00928	0.525
TRG_ENDOCYTIC_2	429	432	PF00928	0.451
TRG_ENDOCYTIC_2	459	462	PF00928	0.460
TRG_ER_diArg_1	300	303	PF00400	0.456
TRG_ER_diArg_1	330	332	PF00400	0.623
TRG_NES_CRM1_1	464	479	PF08389	0.536
TRG_Pf-PMV_PEXEL_1	449	453	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	572	576	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS15	Leptomonas seymouri	65%	100%
A0A1X0NK92	Trypanosomatidae	31%	100%
A0A3R7KAG0	Trypanosoma rangeli	32%	100%
A0A3S7X119	Leishmania donovani	98%	100%
A4HG31	Leishmania braziliensis	84%	100%
C9ZJ53	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AZG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BEQ8	Trypanosoma cruzi	32%	100%