LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
calcium/calmodulin-dependent protein kinase, putative
Species:
Leishmania major
UniProt:
E9ACW7_LEIMA
TriTrypDb:
LmjF.27.2470 , LMJLV39_270032500 * , LMJSD75_270032400 *
Length:
561

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 6
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 21
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 15
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 40
NetGPI no yes: 0, no: 40
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 4
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 5
GO:0031974 membrane-enclosed lumen 2 2
GO:0031981 nuclear lumen 5 2
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 2
GO:0043233 organelle lumen 3 2
GO:0070013 intracellular organelle lumen 4 2
GO:0097014 ciliary plasm 5 2
GO:0099568 cytoplasmic region 3 2
GO:0005930 axoneme 2 1
GO:0005952 cAMP-dependent protein kinase complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0061695 transferase complex, transferring phosphorus-containing groups 4 1
GO:0140535 intracellular protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1902554 serine/threonine protein kinase complex 6 1
GO:1902911 protein kinase complex 5 1
GO:1990234 transferase complex 3 1
GO:0016020 membrane 2 1

Expansion

Sequence features

E9ACW7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACW7

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 41
GO:0006793 phosphorus metabolic process 3 41
GO:0006796 phosphate-containing compound metabolic process 4 41
GO:0006807 nitrogen compound metabolic process 2 41
GO:0007165 signal transduction 2 4
GO:0008152 metabolic process 1 41
GO:0009987 cellular process 1 41
GO:0016310 phosphorylation 5 41
GO:0018105 peptidyl-serine phosphorylation 6 4
GO:0018193 peptidyl-amino acid modification 5 4
GO:0018209 peptidyl-serine modification 6 4
GO:0019538 protein metabolic process 3 41
GO:0035556 intracellular signal transduction 3 3
GO:0036211 protein modification process 4 41
GO:0043170 macromolecule metabolic process 3 41
GO:0043412 macromolecule modification 4 41
GO:0044237 cellular metabolic process 2 41
GO:0044238 primary metabolic process 2 41
GO:0046777 protein autophosphorylation 6 2
GO:0050789 regulation of biological process 2 4
GO:0050794 regulation of cellular process 3 4
GO:0065007 biological regulation 1 4
GO:0071704 organic substance metabolic process 2 41
GO:1901564 organonitrogen compound metabolic process 3 41
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0022402 cell cycle process 2 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:1903047 mitotic cell cycle process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 41
GO:0003824 catalytic activity 1 41
GO:0004672 protein kinase activity 3 41
GO:0004674 protein serine/threonine kinase activity 4 34
GO:0004683 calmodulin-dependent protein kinase activity 5 2
GO:0005488 binding 1 41
GO:0005515 protein binding 2 2
GO:0005516 calmodulin binding 3 2
GO:0005524 ATP binding 5 41
GO:0009931 calcium-dependent protein serine/threonine kinase activity 5 2
GO:0010857 calcium-dependent protein kinase activity 4 2
GO:0016301 kinase activity 4 41
GO:0016740 transferase activity 2 41
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 41
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 41
GO:0017076 purine nucleotide binding 4 41
GO:0030554 adenyl nucleotide binding 5 41
GO:0032553 ribonucleotide binding 3 41
GO:0032555 purine ribonucleotide binding 4 41
GO:0032559 adenyl ribonucleotide binding 5 41
GO:0035639 purine ribonucleoside triphosphate binding 4 41
GO:0036094 small molecule binding 2 41
GO:0043167 ion binding 2 41
GO:0043168 anion binding 3 41
GO:0097159 organic cyclic compound binding 2 41
GO:0097367 carbohydrate derivative binding 2 41
GO:0140096 catalytic activity, acting on a protein 2 41
GO:1901265 nucleoside phosphate binding 3 41
GO:1901363 heterocyclic compound binding 2 41
GO:0008270 zinc ion binding 6 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1
GO:0046914 transition metal ion binding 5 1
GO:0004690 cyclic nucleotide-dependent protein kinase activity 5 1
GO:0004691 cAMP-dependent protein kinase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 430 434 PF00656 0.343
CLV_NRD_NRD_1 202 204 PF00675 0.324
CLV_NRD_NRD_1 436 438 PF00675 0.332
CLV_NRD_NRD_1 52 54 PF00675 0.419
CLV_NRD_NRD_1 90 92 PF00675 0.317
CLV_PCSK_KEX2_1 404 406 PF00082 0.417
CLV_PCSK_KEX2_1 438 440 PF00082 0.317
CLV_PCSK_KEX2_1 52 54 PF00082 0.498
CLV_PCSK_KEX2_1 546 548 PF00082 0.513
CLV_PCSK_KEX2_1 90 92 PF00082 0.317
CLV_PCSK_PC1ET2_1 404 406 PF00082 0.432
CLV_PCSK_PC1ET2_1 438 440 PF00082 0.317
CLV_PCSK_PC1ET2_1 52 54 PF00082 0.334
CLV_PCSK_PC1ET2_1 546 548 PF00082 0.513
CLV_PCSK_SKI1_1 124 128 PF00082 0.235
CLV_PCSK_SKI1_1 141 145 PF00082 0.328
CLV_PCSK_SKI1_1 305 309 PF00082 0.412
CLV_PCSK_SKI1_1 486 490 PF00082 0.494
CLV_PCSK_SKI1_1 546 550 PF00082 0.518
DEG_APCC_DBOX_1 123 131 PF00400 0.263
DEG_APCC_DBOX_1 436 444 PF00400 0.314
DEG_SCF_FBW7_1 533 538 PF00400 0.520
DEG_SPOP_SBC_1 178 182 PF00917 0.319
DEG_SPOP_SBC_1 528 532 PF00917 0.521
DEG_SPOP_SBC_1 541 545 PF00917 0.486
DOC_CYCLIN_yCln2_LP_2 283 289 PF00134 0.213
DOC_MAPK_gen_1 141 150 PF00069 0.319
DOC_MAPK_gen_1 309 318 PF00069 0.485
DOC_MAPK_gen_1 39 49 PF00069 0.220
DOC_MAPK_gen_1 90 98 PF00069 0.401
DOC_MAPK_JIP1_4 144 150 PF00069 0.283
DOC_MAPK_JIP1_4 276 282 PF00069 0.196
DOC_MAPK_MEF2A_6 90 98 PF00069 0.337
DOC_MAPK_NFAT4_5 91 99 PF00069 0.283
DOC_SPAK_OSR1_1 91 95 PF12202 0.186
DOC_USP7_MATH_1 154 158 PF00917 0.309
DOC_USP7_MATH_1 206 210 PF00917 0.262
DOC_USP7_MATH_1 528 532 PF00917 0.624
DOC_USP7_MATH_1 535 539 PF00917 0.688
DOC_USP7_UBL2_3 309 313 PF12436 0.396
DOC_USP7_UBL2_3 48 52 PF12436 0.333
DOC_USP7_UBL2_3 536 540 PF12436 0.528
DOC_USP7_UBL2_3 54 58 PF12436 0.332
DOC_WW_Pin1_4 152 157 PF00397 0.347
DOC_WW_Pin1_4 183 188 PF00397 0.321
DOC_WW_Pin1_4 255 260 PF00397 0.252
DOC_WW_Pin1_4 329 334 PF00397 0.415
DOC_WW_Pin1_4 512 517 PF00397 0.612
DOC_WW_Pin1_4 529 534 PF00397 0.628
DOC_WW_Pin1_4 553 558 PF00397 0.753
LIG_14-3-3_CanoR_1 16 22 PF00244 0.296
LIG_14-3-3_CanoR_1 246 254 PF00244 0.406
LIG_14-3-3_CanoR_1 340 348 PF00244 0.487
LIG_14-3-3_CanoR_1 475 479 PF00244 0.609
LIG_14-3-3_CanoR_1 529 533 PF00244 0.510
LIG_14-3-3_CanoR_1 547 552 PF00244 0.494
LIG_14-3-3_CterR_2 559 561 PF00244 0.502
LIG_APCC_ABBA_1 409 414 PF00400 0.450
LIG_APCC_ABBAyCdc20_2 136 142 PF00400 0.235
LIG_BRCT_BRCA1_1 341 345 PF00533 0.299
LIG_deltaCOP1_diTrp_1 330 338 PF00928 0.475
LIG_EH1_1 92 100 PF00400 0.209
LIG_eIF4E_1 93 99 PF01652 0.220
LIG_FHA_1 218 224 PF00498 0.282
LIG_FHA_1 236 242 PF00498 0.220
LIG_FHA_1 320 326 PF00498 0.439
LIG_FHA_1 39 45 PF00498 0.334
LIG_FHA_1 62 68 PF00498 0.246
LIG_FHA_2 200 206 PF00498 0.229
LIG_FHA_2 258 264 PF00498 0.283
LIG_FHA_2 276 282 PF00498 0.239
LIG_LIR_Apic_2 186 192 PF02991 0.328
LIG_LIR_Apic_2 330 334 PF02991 0.488
LIG_LIR_Apic_2 489 495 PF02991 0.468
LIG_LIR_Gen_1 220 229 PF02991 0.231
LIG_LIR_Gen_1 237 243 PF02991 0.281
LIG_LIR_Gen_1 251 261 PF02991 0.204
LIG_LIR_Gen_1 332 339 PF02991 0.428
LIG_LIR_Gen_1 342 349 PF02991 0.351
LIG_LIR_Gen_1 398 407 PF02991 0.361
LIG_LIR_LC3C_4 238 243 PF02991 0.176
LIG_LIR_Nem_3 220 224 PF02991 0.274
LIG_LIR_Nem_3 237 242 PF02991 0.334
LIG_LIR_Nem_3 251 257 PF02991 0.249
LIG_LIR_Nem_3 270 274 PF02991 0.376
LIG_LIR_Nem_3 332 338 PF02991 0.362
LIG_LIR_Nem_3 342 348 PF02991 0.321
LIG_LIR_Nem_3 398 402 PF02991 0.318
LIG_LIR_Nem_3 408 413 PF02991 0.338
LIG_LIR_Nem_3 477 482 PF02991 0.634
LIG_LIR_Nem_3 89 95 PF02991 0.361
LIG_LYPXL_S_1 409 413 PF13949 0.334
LIG_LYPXL_yS_3 410 413 PF13949 0.329
LIG_Pex14_1 331 335 PF04695 0.478
LIG_Pex14_2 235 239 PF04695 0.319
LIG_SH2_CRK 30 34 PF00017 0.267
LIG_SH2_NCK_1 271 275 PF00017 0.191
LIG_SH2_NCK_1 30 34 PF00017 0.212
LIG_SH2_PTP2 189 192 PF00017 0.253
LIG_SH2_PTP2 221 224 PF00017 0.293
LIG_SH2_PTP2 93 96 PF00017 0.406
LIG_SH2_SRC 177 180 PF00017 0.374
LIG_SH2_SRC 271 274 PF00017 0.191
LIG_SH2_STAP1 30 34 PF00017 0.220
LIG_SH2_STAP1 45 49 PF00017 0.319
LIG_SH2_STAT5 177 180 PF00017 0.280
LIG_SH2_STAT5 189 192 PF00017 0.307
LIG_SH2_STAT5 221 224 PF00017 0.295
LIG_SH2_STAT5 399 402 PF00017 0.322
LIG_SH2_STAT5 445 448 PF00017 0.265
LIG_SH2_STAT5 85 88 PF00017 0.312
LIG_SH2_STAT5 93 96 PF00017 0.312
LIG_SH3_3 271 277 PF00018 0.403
LIG_SUMO_SIM_anti_2 278 284 PF11976 0.196
LIG_SUMO_SIM_anti_2 66 71 PF11976 0.241
LIG_TYR_ITIM 219 224 PF00017 0.343
LIG_TYR_ITIM 269 274 PF00017 0.191
MOD_CDK_SPK_2 531 536 PF00069 0.519
MOD_CDK_SPxK_1 553 559 PF00069 0.494
MOD_CDK_SPxxK_3 255 262 PF00069 0.246
MOD_CDK_SPxxK_3 529 536 PF00069 0.707
MOD_CK1_1 117 123 PF00069 0.236
MOD_CK1_1 155 161 PF00069 0.229
MOD_CK1_1 162 168 PF00069 0.210
MOD_CK1_1 248 254 PF00069 0.402
MOD_CK1_1 300 306 PF00069 0.444
MOD_CK1_1 474 480 PF00069 0.560
MOD_CK1_1 515 521 PF00069 0.510
MOD_CK1_1 531 537 PF00069 0.537
MOD_CK1_1 539 545 PF00069 0.581
MOD_CK2_1 199 205 PF00069 0.229
MOD_CK2_1 231 237 PF00069 0.291
MOD_CK2_1 275 281 PF00069 0.251
MOD_Cter_Amidation 402 405 PF01082 0.392
MOD_DYRK1A_RPxSP_1 529 533 PF00069 0.517
MOD_GlcNHglycan 127 130 PF01048 0.297
MOD_GlcNHglycan 224 227 PF01048 0.233
MOD_GSK3_1 152 159 PF00069 0.265
MOD_GSK3_1 179 186 PF00069 0.346
MOD_GSK3_1 231 238 PF00069 0.255
MOD_GSK3_1 253 260 PF00069 0.262
MOD_GSK3_1 303 310 PF00069 0.527
MOD_GSK3_1 339 346 PF00069 0.424
MOD_GSK3_1 482 489 PF00069 0.553
MOD_GSK3_1 515 522 PF00069 0.499
MOD_GSK3_1 527 534 PF00069 0.742
MOD_GSK3_1 535 542 PF00069 0.635
MOD_N-GLC_1 117 122 PF02516 0.191
MOD_N-GLC_1 162 167 PF02516 0.386
MOD_NEK2_1 307 312 PF00069 0.455
MOD_NEK2_1 319 324 PF00069 0.389
MOD_NEK2_1 471 476 PF00069 0.514
MOD_NEK2_1 482 487 PF00069 0.528
MOD_PIKK_1 319 325 PF00454 0.579
MOD_PIKK_1 350 356 PF00454 0.368
MOD_PKA_2 235 241 PF00069 0.418
MOD_PKA_2 245 251 PF00069 0.394
MOD_PKA_2 275 281 PF00069 0.276
MOD_PKA_2 339 345 PF00069 0.493
MOD_PKA_2 38 44 PF00069 0.251
MOD_PKA_2 425 431 PF00069 0.368
MOD_PKA_2 474 480 PF00069 0.632
MOD_PKA_2 528 534 PF00069 0.504
MOD_Plk_1 117 123 PF00069 0.305
MOD_Plk_4 117 123 PF00069 0.217
MOD_Plk_4 185 191 PF00069 0.271
MOD_Plk_4 217 223 PF00069 0.327
MOD_Plk_4 321 327 PF00069 0.410
MOD_Plk_4 344 350 PF00069 0.303
MOD_Plk_4 474 480 PF00069 0.584
MOD_ProDKin_1 152 158 PF00069 0.347
MOD_ProDKin_1 183 189 PF00069 0.321
MOD_ProDKin_1 255 261 PF00069 0.252
MOD_ProDKin_1 329 335 PF00069 0.408
MOD_ProDKin_1 512 518 PF00069 0.616
MOD_ProDKin_1 529 535 PF00069 0.624
MOD_ProDKin_1 553 559 PF00069 0.753
MOD_SUMO_for_1 143 146 PF00179 0.310
TRG_DiLeu_BaEn_1 237 242 PF01217 0.191
TRG_DiLeu_BaEn_2 407 413 PF01217 0.452
TRG_ENDOCYTIC_2 221 224 PF00928 0.327
TRG_ENDOCYTIC_2 271 274 PF00928 0.191
TRG_ENDOCYTIC_2 30 33 PF00928 0.275
TRG_ENDOCYTIC_2 399 402 PF00928 0.319
TRG_ENDOCYTIC_2 410 413 PF00928 0.329
TRG_ENDOCYTIC_2 93 96 PF00928 0.345
TRG_ER_diArg_1 200 203 PF00400 0.368
TRG_ER_diArg_1 437 440 PF00400 0.321
TRG_ER_diArg_1 90 92 PF00400 0.480
TRG_Pf-PMV_PEXEL_1 141 146 PF00026 0.305

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE80 Leptomonas seymouri 73% 100%
A0A0S4J7K4 Bodo saltans 58% 100%
A0A1X0NJV4 Trypanosomatidae 57% 100%
A0A1X0P1A2 Trypanosomatidae 60% 100%
A0A3Q8IC87 Leishmania donovani 31% 100%
A0A3Q8IDK8 Leishmania donovani 92% 100%
A0A3Q8IFK8 Leishmania donovani 28% 100%
A0A3Q8INQ4 Leishmania donovani 30% 100%
A0A3Q8IVR8 Leishmania donovani 25% 100%
A0A3S5H5G0 Leishmania donovani 28% 100%
A0A3S5H5U5 Leishmania donovani 23% 100%
A0A3S7WTN9 Leishmania donovani 25% 100%
A0A3S7X9R4 Leishmania donovani 29% 100%
A4H459 Leishmania braziliensis 29% 100%
A4H4S9 Leishmania braziliensis 24% 100%
A4H8C4 Leishmania braziliensis 26% 100%
A4HAS1 Leishmania braziliensis 26% 100%
A4HCD7 Leishmania braziliensis 32% 100%
A4HED7 Leishmania braziliensis 30% 100%
A4HG27 Leishmania braziliensis 81% 100%
A4HJT5 Leishmania braziliensis 28% 100%
A4HN71 Leishmania braziliensis 29% 100%
A4HNT2 Leishmania braziliensis 24% 100%
A4HSE2 Leishmania infantum 28% 100%
A4HWP5 Leishmania infantum 25% 100%
A4HZV1 Leishmania infantum 31% 100%
A4I1T4 Leishmania infantum 30% 100%
A4I349 Leishmania infantum 92% 99%
A4I7A1 Leishmania infantum 28% 100%
A4IBT4 Leishmania infantum 29% 100%
A4IBT9 Leishmania infantum 29% 100%
A4ICR2 Leishmania infantum 25% 100%
C9ZK98 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
C9ZN29 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9AG71 Leishmania infantum 23% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AQF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9ASJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AUS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AZF6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
Q4Q204 Leishmania major 25% 100%
Q4Q5W2 Leishmania major 28% 100%
Q4Q9K2 Leishmania major 31% 100%
Q4QBR6 Leishmania major 31% 100%
Q4QF23 Leishmania major 25% 100%
Q4QIV8 Leishmania major 25% 100%
Q4QJJ0 Leishmania major 28% 100%
Q6C7U0 Yarrowia lipolytica (strain CLIB 122 / E 150) 26% 79%
Q9GNR4 Leishmania major 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS