Protein kinase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calcium/calmodulin-dependent protein kinase, putative

Species:

Leishmania major

UniProt:

E9ACW7_LEIMA

TriTrypDb:

LmjF.27.2470 , LMJLV39_270032500 , LMJSD75_270032400

Length:

561

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 21

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 10

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 15

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 40
NetGPI	no	yes: 0, no: 40

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	4
GO:0005930	axoneme	2	1
GO:0005952	cAMP-dependent protein kinase complex	3	1
GO:0016020	membrane	2	1
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	2

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Expansion

Sequence features

E9ACW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACW7

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0000281	mitotic cytokinesis	4	1
GO:0000910	cytokinesis	3	1
GO:0006468	protein phosphorylation	5	41
GO:0006793	phosphorus metabolic process	3	41
GO:0006796	phosphate-containing compound metabolic process	4	41
GO:0006807	nitrogen compound metabolic process	2	41
GO:0007165	signal transduction	2	4
GO:0008152	metabolic process	1	41
GO:0009987	cellular process	1	41
GO:0016310	phosphorylation	5	41

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	41
GO:0003824	catalytic activity	1	41
GO:0004672	protein kinase activity	3	41
GO:0004674	protein serine/threonine kinase activity	4	34
GO:0004683	calmodulin-dependent protein kinase activity	5	2
GO:0004690	cyclic nucleotide-dependent protein kinase activity	5	1
GO:0004691	cAMP-dependent protein kinase activity	6	1
GO:0005488	binding	1	41
GO:0005515	protein binding	2	2
GO:0005516	calmodulin binding	3	2

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	430	434	PF00656	0.343
CLV_NRD_NRD_1	202	204	PF00675	0.324
CLV_NRD_NRD_1	436	438	PF00675	0.332
CLV_NRD_NRD_1	52	54	PF00675	0.419
CLV_NRD_NRD_1	90	92	PF00675	0.317
CLV_PCSK_KEX2_1	404	406	PF00082	0.417
CLV_PCSK_KEX2_1	438	440	PF00082	0.317
CLV_PCSK_KEX2_1	52	54	PF00082	0.498
CLV_PCSK_KEX2_1	546	548	PF00082	0.513
CLV_PCSK_KEX2_1	90	92	PF00082	0.317

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Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE80	Leptomonas seymouri	73%	100%
A0A0S4J7K4	Bodo saltans	58%	100%
A0A1X0NJV4	Trypanosomatidae	57%	100%
A0A1X0P1A2	Trypanosomatidae	60%	100%
A0A3Q8IC87	Leishmania donovani	31%	100%
A0A3Q8IDK8	Leishmania donovani	92%	100%
A0A3Q8IFK8	Leishmania donovani	28%	100%
A0A3Q8INQ4	Leishmania donovani	30%	100%
A0A3Q8IVR8	Leishmania donovani	25%	100%
A0A3S5H5G0	Leishmania donovani	28%	100%

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