Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACW5_LEIMA

TriTrypDb:

LmjF.27.2450 , LMJLV39_270032300 , LMJSD75_270032200

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ACW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACW5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.579
CLV_NRD_NRD_1	11	13	PF00675	0.491
CLV_NRD_NRD_1	115	117	PF00675	0.595
CLV_NRD_NRD_1	131	133	PF00675	0.325
CLV_NRD_NRD_1	192	194	PF00675	0.758
CLV_NRD_NRD_1	260	262	PF00675	0.568
CLV_NRD_NRD_1	318	320	PF00675	0.517
CLV_NRD_NRD_1	323	325	PF00675	0.532
CLV_NRD_NRD_1	378	380	PF00675	0.571
CLV_PCSK_FUR_1	321	325	PF00082	0.365
CLV_PCSK_KEX2_1	11	13	PF00082	0.491
CLV_PCSK_KEX2_1	115	117	PF00082	0.500
CLV_PCSK_KEX2_1	192	194	PF00082	0.618
CLV_PCSK_KEX2_1	260	262	PF00082	0.519
CLV_PCSK_KEX2_1	318	320	PF00082	0.549
CLV_PCSK_KEX2_1	323	325	PF00082	0.557
CLV_PCSK_KEX2_1	378	380	PF00082	0.578
CLV_PCSK_PC7_1	314	320	PF00082	0.450
CLV_PCSK_SKI1_1	292	296	PF00082	0.487
CLV_PCSK_SKI1_1	72	76	PF00082	0.408
DEG_APCC_DBOX_1	343	351	PF00400	0.524
DEG_Nend_UBRbox_3	1	3	PF02207	0.617
DEG_SPOP_SBC_1	243	247	PF00917	0.547
DEG_SPOP_SBC_1	388	392	PF00917	0.497
DOC_MAPK_gen_1	11	17	PF00069	0.480
DOC_MAPK_gen_1	367	376	PF00069	0.614
DOC_MAPK_HePTP_8	364	376	PF00069	0.439
DOC_MAPK_MEF2A_6	202	209	PF00069	0.633
DOC_MAPK_MEF2A_6	367	376	PF00069	0.618
DOC_PP2B_LxvP_1	232	235	PF13499	0.580
DOC_PP4_FxxP_1	228	231	PF00568	0.532
DOC_USP7_MATH_1	183	187	PF00917	0.638
DOC_USP7_MATH_1	242	246	PF00917	0.759
DOC_USP7_MATH_1	249	253	PF00917	0.717
DOC_USP7_MATH_1	356	360	PF00917	0.572
DOC_USP7_MATH_1	388	392	PF00917	0.673
DOC_USP7_MATH_1	420	424	PF00917	0.690
DOC_USP7_UBL2_3	113	117	PF12436	0.453
DOC_WW_Pin1_4	227	232	PF00397	0.574
DOC_WW_Pin1_4	238	243	PF00397	0.642
DOC_WW_Pin1_4	352	357	PF00397	0.599
DOC_WW_Pin1_4	393	398	PF00397	0.725
DOC_WW_Pin1_4	405	410	PF00397	0.719
LIG_14-3-3_CanoR_1	115	123	PF00244	0.618
LIG_14-3-3_CanoR_1	260	270	PF00244	0.633
LIG_14-3-3_CanoR_1	341	351	PF00244	0.501
LIG_14-3-3_CanoR_1	367	376	PF00244	0.539
LIG_14-3-3_CanoR_1	410	419	PF00244	0.621
LIG_14-3-3_CanoR_1	85	91	PF00244	0.487
LIG_BRCT_BRCA1_1	220	224	PF00533	0.464
LIG_BRCT_BRCA1_1	275	279	PF00533	0.645
LIG_deltaCOP1_diTrp_1	439	443	PF00928	0.611
LIG_FHA_1	325	331	PF00498	0.536
LIG_FHA_1	359	365	PF00498	0.622
LIG_FHA_1	39	45	PF00498	0.394
LIG_FHA_1	390	396	PF00498	0.632
LIG_FHA_1	406	412	PF00498	0.560
LIG_FHA_2	168	174	PF00498	0.614
LIG_FHA_2	368	374	PF00498	0.543
LIG_FHA_2	434	440	PF00498	0.573
LIG_LIR_Apic_2	227	231	PF02991	0.535
LIG_LIR_Gen_1	223	233	PF02991	0.470
LIG_LIR_Gen_1	276	285	PF02991	0.605
LIG_LIR_Gen_1	355	365	PF02991	0.521
LIG_LIR_Gen_1	415	426	PF02991	0.616
LIG_LIR_Gen_1	438	447	PF02991	0.561
LIG_LIR_Nem_3	223	228	PF02991	0.501
LIG_LIR_Nem_3	239	243	PF02991	0.547
LIG_LIR_Nem_3	276	282	PF02991	0.628
LIG_LIR_Nem_3	415	421	PF02991	0.616
LIG_NRBOX	346	352	PF00104	0.564
LIG_PCNA_PIPBox_1	340	349	PF02747	0.455
LIG_PCNA_yPIPBox_3	29	38	PF02747	0.494
LIG_Pex14_2	224	228	PF04695	0.457
LIG_SH2_PTP2	281	284	PF00017	0.459
LIG_SH2_PTP2	418	421	PF00017	0.614
LIG_SH2_SRC	281	284	PF00017	0.459
LIG_SH2_SRC	91	94	PF00017	0.414
LIG_SH2_STAP1	137	141	PF00017	0.434
LIG_SH2_STAP1	225	229	PF00017	0.474
LIG_SH2_STAP1	38	42	PF00017	0.454
LIG_SH2_STAT3	160	163	PF00017	0.703
LIG_SH2_STAT5	143	146	PF00017	0.374
LIG_SH2_STAT5	281	284	PF00017	0.459
LIG_SH2_STAT5	418	421	PF00017	0.678
LIG_SH3_3	202	208	PF00018	0.498
LIG_SH3_3	391	397	PF00018	0.517
LIG_SH3_3	416	422	PF00018	0.568
LIG_SUMO_SIM_anti_2	172	179	PF11976	0.474
LIG_SUMO_SIM_anti_2	54	59	PF11976	0.572
LIG_TRAF2_1	170	173	PF00917	0.616
LIG_TRAF2_1	284	287	PF00917	0.565
LIG_TRAF2_1	90	93	PF00917	0.320
LIG_TYR_ITIM	416	421	PF00017	0.570
LIG_UBA3_1	66	75	PF00899	0.463
LIG_WRC_WIRS_1	225	230	PF05994	0.471
MOD_CDK_SPK_2	405	410	PF00069	0.523
MOD_CK1_1	159	165	PF00069	0.522
MOD_CK1_1	227	233	PF00069	0.713
MOD_CK1_1	252	258	PF00069	0.603
MOD_CK1_1	329	335	PF00069	0.490
MOD_CK1_1	414	420	PF00069	0.586
MOD_CK1_1	424	430	PF00069	0.544
MOD_CK1_1	73	79	PF00069	0.458
MOD_CK2_1	167	173	PF00069	0.432
MOD_CK2_1	213	219	PF00069	0.605
MOD_CK2_1	356	362	PF00069	0.548
MOD_CK2_1	367	373	PF00069	0.487
MOD_CK2_1	433	439	PF00069	0.576
MOD_GlcNHglycan	109	112	PF01048	0.367
MOD_GlcNHglycan	185	188	PF01048	0.568
MOD_GlcNHglycan	211	216	PF01048	0.602
MOD_GlcNHglycan	253	257	PF01048	0.695
MOD_GlcNHglycan	270	273	PF01048	0.445
MOD_GlcNHglycan	309	312	PF01048	0.472
MOD_GlcNHglycan	423	426	PF01048	0.610
MOD_GlcNHglycan	431	434	PF01048	0.551
MOD_GSK3_1	183	190	PF00069	0.656
MOD_GSK3_1	220	227	PF00069	0.668
MOD_GSK3_1	238	245	PF00069	0.477
MOD_GSK3_1	248	255	PF00069	0.671
MOD_GSK3_1	296	303	PF00069	0.589
MOD_GSK3_1	352	359	PF00069	0.522
MOD_GSK3_1	363	370	PF00069	0.498
MOD_GSK3_1	384	391	PF00069	0.597
MOD_GSK3_1	410	417	PF00069	0.560
MOD_GSK3_1	420	427	PF00069	0.457
MOD_GSK3_1	429	436	PF00069	0.524
MOD_N-GLC_1	249	254	PF02516	0.564
MOD_N-GLC_1	30	35	PF02516	0.493
MOD_N-GLC_1	411	416	PF02516	0.484
MOD_NEK2_1	224	229	PF00069	0.456
MOD_NEK2_1	270	275	PF00069	0.652
MOD_NEK2_1	30	35	PF00069	0.510
MOD_NEK2_1	350	355	PF00069	0.559
MOD_NEK2_1	389	394	PF00069	0.594
MOD_NEK2_1	411	416	PF00069	0.507
MOD_NEK2_1	70	75	PF00069	0.432
MOD_PIKK_1	149	155	PF00454	0.464
MOD_PIKK_1	159	165	PF00454	0.471
MOD_PIKK_1	270	276	PF00454	0.582
MOD_PIKK_1	350	356	PF00454	0.478
MOD_PIKK_1	398	404	PF00454	0.601
MOD_PIKK_1	93	99	PF00454	0.498
MOD_PKA_1	115	121	PF00069	0.442
MOD_PKA_2	115	121	PF00069	0.533
MOD_PKA_2	191	197	PF00069	0.713
MOD_PKA_2	268	274	PF00069	0.486
MOD_PKA_2	317	323	PF00069	0.585
MOD_PKA_2	84	90	PF00069	0.509
MOD_Plk_1	149	155	PF00069	0.583
MOD_Plk_1	18	24	PF00069	0.528
MOD_Plk_1	30	36	PF00069	0.507
MOD_Plk_1	411	417	PF00069	0.708
MOD_Plk_4	18	24	PF00069	0.528
MOD_Plk_4	224	230	PF00069	0.667
MOD_Plk_4	300	306	PF00069	0.591
MOD_Plk_4	390	396	PF00069	0.555
MOD_Plk_4	414	420	PF00069	0.769
MOD_Plk_4	51	57	PF00069	0.493
MOD_Plk_4	62	68	PF00069	0.347
MOD_ProDKin_1	227	233	PF00069	0.573
MOD_ProDKin_1	238	244	PF00069	0.643
MOD_ProDKin_1	352	358	PF00069	0.599
MOD_ProDKin_1	393	399	PF00069	0.726
MOD_ProDKin_1	405	411	PF00069	0.717
TRG_DiLeu_BaEn_1	286	291	PF01217	0.565
TRG_DiLeu_BaEn_1	52	57	PF01217	0.583
TRG_DiLeu_BaEn_4	286	292	PF01217	0.569
TRG_ENDOCYTIC_2	109	112	PF00928	0.433
TRG_ENDOCYTIC_2	225	228	PF00928	0.475
TRG_ENDOCYTIC_2	418	421	PF00928	0.614
TRG_ER_diArg_1	11	14	PF00400	0.511
TRG_ER_diArg_1	192	195	PF00400	0.711
TRG_ER_diArg_1	260	262	PF00400	0.636
TRG_ER_diArg_1	318	321	PF00400	0.550
TRG_ER_diArg_1	322	324	PF00400	0.572
TRG_ER_diArg_1	378	380	PF00400	0.514
TRG_NES_CRM1_1	362	375	PF08389	0.466
TRG_Pf-PMV_PEXEL_1	124	129	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB83	Leptomonas seymouri	48%	100%
A0A1X0NF90	Trypanosomatidae	28%	100%
A0A3R7KL96	Trypanosoma rangeli	29%	100%
A0A3S7X122	Leishmania donovani	92%	100%
A4HG25	Leishmania braziliensis	72%	100%
A4I346	Leishmania infantum	92%	100%
C9ZJL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AZF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BB13	Trypanosoma cruzi	28%	100%