Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACW3_LEIMA

TriTrypDb:

LmjF.27.2430 , LMJLV39_270032100 , LMJSD75_270032000

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	7	11	PF00656	0.531
CLV_NRD_NRD_1	147	149	PF00675	0.546
CLV_NRD_NRD_1	186	188	PF00675	0.589
CLV_NRD_NRD_1	206	208	PF00675	0.598
CLV_NRD_NRD_1	343	345	PF00675	0.604
CLV_NRD_NRD_1	403	405	PF00675	0.676
CLV_NRD_NRD_1	545	547	PF00675	0.702
CLV_NRD_NRD_1	60	62	PF00675	0.557
CLV_PCSK_KEX2_1	146	148	PF00082	0.552
CLV_PCSK_KEX2_1	186	188	PF00082	0.589
CLV_PCSK_KEX2_1	206	208	PF00082	0.598
CLV_PCSK_KEX2_1	335	337	PF00082	0.691
CLV_PCSK_KEX2_1	343	345	PF00082	0.619
CLV_PCSK_KEX2_1	379	381	PF00082	0.694
CLV_PCSK_KEX2_1	545	547	PF00082	0.702
CLV_PCSK_KEX2_1	60	62	PF00082	0.557
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.691
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.663
CLV_PCSK_SKI1_1	157	161	PF00082	0.419
CLV_PCSK_SKI1_1	355	359	PF00082	0.661
CLV_PCSK_SKI1_1	95	99	PF00082	0.541
DEG_SCF_FBW7_1	421	428	PF00400	0.579
DEG_SIAH_1	318	326	PF03145	0.649
DEG_SPOP_SBC_1	109	113	PF00917	0.558
DEG_SPOP_SBC_1	550	554	PF00917	0.699
DOC_CKS1_1	192	197	PF01111	0.485
DOC_CKS1_1	422	427	PF01111	0.600
DOC_CKS1_1	453	458	PF01111	0.624
DOC_CYCLIN_RxL_1	154	163	PF00134	0.417
DOC_CYCLIN_yClb3_PxF_3	497	503	PF00134	0.596
DOC_CYCLIN_yClb5_NLxxxL_5	355	361	PF00134	0.559
DOC_PP2B_LxvP_1	250	253	PF13499	0.642
DOC_PP2B_LxvP_1	496	499	PF13499	0.600
DOC_PP4_FxxP_1	525	528	PF00568	0.580
DOC_USP7_MATH_1	109	113	PF00917	0.622
DOC_USP7_MATH_1	257	261	PF00917	0.669
DOC_USP7_MATH_1	281	285	PF00917	0.670
DOC_USP7_MATH_1	313	317	PF00917	0.646
DOC_USP7_MATH_1	326	330	PF00917	0.579
DOC_USP7_MATH_1	385	389	PF00917	0.768
DOC_USP7_MATH_1	425	429	PF00917	0.719
DOC_USP7_MATH_1	487	491	PF00917	0.671
DOC_USP7_MATH_1	5	9	PF00917	0.552
DOC_USP7_MATH_1	531	535	PF00917	0.583
DOC_USP7_MATH_1	72	76	PF00917	0.510
DOC_WW_Pin1_4	123	128	PF00397	0.612
DOC_WW_Pin1_4	178	183	PF00397	0.597
DOC_WW_Pin1_4	191	196	PF00397	0.414
DOC_WW_Pin1_4	219	224	PF00397	0.678
DOC_WW_Pin1_4	248	253	PF00397	0.591
DOC_WW_Pin1_4	315	320	PF00397	0.686
DOC_WW_Pin1_4	321	326	PF00397	0.637
DOC_WW_Pin1_4	327	332	PF00397	0.578
DOC_WW_Pin1_4	381	386	PF00397	0.672
DOC_WW_Pin1_4	407	412	PF00397	0.813
DOC_WW_Pin1_4	417	422	PF00397	0.686
DOC_WW_Pin1_4	438	443	PF00397	0.703
DOC_WW_Pin1_4	446	451	PF00397	0.548
DOC_WW_Pin1_4	452	457	PF00397	0.544
DOC_WW_Pin1_4	469	474	PF00397	0.504
DOC_WW_Pin1_4	529	534	PF00397	0.637
LIG_14-3-3_CanoR_1	104	109	PF00244	0.468
LIG_14-3-3_CanoR_1	25	29	PF00244	0.503
LIG_14-3-3_CanoR_1	280	286	PF00244	0.635
LIG_14-3-3_CanoR_1	343	349	PF00244	0.700
LIG_14-3-3_CanoR_1	366	371	PF00244	0.629
LIG_14-3-3_CanoR_1	54	62	PF00244	0.534
LIG_14-3-3_CanoR_1	68	76	PF00244	0.657
LIG_EVH1_1	496	500	PF00568	0.600
LIG_EVH1_2	499	503	PF00568	0.645
LIG_FHA_1	267	273	PF00498	0.656
LIG_FHA_1	47	53	PF00498	0.589
LIG_FHA_1	96	102	PF00498	0.540
LIG_FHA_2	137	143	PF00498	0.653
LIG_FHA_2	32	38	PF00498	0.539
LIG_FHA_2	384	390	PF00498	0.652
LIG_FHA_2	5	11	PF00498	0.531
LIG_FHA_2	551	557	PF00498	0.689
LIG_LIR_Gen_1	151	160	PF02991	0.522
LIG_LIR_Gen_1	19	28	PF02991	0.528
LIG_LIR_Nem_3	19	24	PF02991	0.521
LIG_PROFILIN_1	456	462	PF00235	0.613
LIG_PROFILIN_1	478	484	PF00235	0.587
LIG_PTAP_UEV_1	242	247	PF05743	0.607
LIG_PTAP_UEV_1	488	493	PF05743	0.548
LIG_RPA_C_Fungi	369	381	PF08784	0.585
LIG_SH2_CRK	471	475	PF00017	0.634
LIG_SH2_NCK_1	471	475	PF00017	0.634
LIG_SH2_STAP1	199	203	PF00017	0.532
LIG_SH2_STAT5	152	155	PF00017	0.520
LIG_SH2_STAT5	471	474	PF00017	0.546
LIG_SH3_2	243	248	PF14604	0.604
LIG_SH3_2	541	546	PF14604	0.695
LIG_SH3_3	162	168	PF00018	0.613
LIG_SH3_3	240	246	PF00018	0.654
LIG_SH3_3	258	264	PF00018	0.531
LIG_SH3_3	269	275	PF00018	0.594
LIG_SH3_3	282	288	PF00018	0.560
LIG_SH3_3	403	409	PF00018	0.754
LIG_SH3_3	419	425	PF00018	0.611
LIG_SH3_3	439	445	PF00018	0.576
LIG_SH3_3	447	453	PF00018	0.586
LIG_SH3_3	454	460	PF00018	0.575
LIG_SH3_3	475	481	PF00018	0.625
LIG_SH3_3	483	489	PF00018	0.558
LIG_SH3_3	492	498	PF00018	0.528
LIG_SH3_3	538	544	PF00018	0.592
LIG_TRAF2_1	112	115	PF00917	0.613
LIG_WW_3	420	424	PF00397	0.684
LIG_WW_3	542	546	PF00397	0.628
MOD_CDC14_SPxK_1	126	129	PF00782	0.582
MOD_CDC14_SPxK_1	420	423	PF00782	0.661
MOD_CDK_SPxK_1	123	129	PF00069	0.583
MOD_CDK_SPxK_1	417	423	PF00069	0.688
MOD_CDK_SPxxK_3	321	328	PF00069	0.655
MOD_CK1_1	121	127	PF00069	0.657
MOD_CK1_1	134	140	PF00069	0.516
MOD_CK1_1	222	228	PF00069	0.589
MOD_CK1_1	251	257	PF00069	0.721
MOD_CK1_1	3	9	PF00069	0.620
MOD_CK1_1	307	313	PF00069	0.698
MOD_CK1_1	315	321	PF00069	0.606
MOD_CK1_1	360	366	PF00069	0.695
MOD_CK1_1	369	375	PF00069	0.608
MOD_CK1_1	384	390	PF00069	0.645
MOD_CK1_1	393	399	PF00069	0.680
MOD_CK1_1	407	413	PF00069	0.586
MOD_CK1_1	426	432	PF00069	0.663
MOD_CK1_1	435	441	PF00069	0.636
MOD_CK1_1	444	450	PF00069	0.534
MOD_CK1_1	534	540	PF00069	0.579
MOD_CK1_1	55	61	PF00069	0.533
MOD_CK1_1	552	558	PF00069	0.683
MOD_CK2_1	108	114	PF00069	0.758
MOD_CK2_1	136	142	PF00069	0.573
MOD_CK2_1	31	37	PF00069	0.548
MOD_GlcNHglycan	212	215	PF01048	0.518
MOD_GlcNHglycan	243	246	PF01048	0.705
MOD_GlcNHglycan	253	256	PF01048	0.720
MOD_GlcNHglycan	311	314	PF01048	0.630
MOD_GlcNHglycan	315	318	PF01048	0.644
MOD_GlcNHglycan	319	322	PF01048	0.607
MOD_GlcNHglycan	34	37	PF01048	0.461
MOD_GlcNHglycan	346	349	PF01048	0.779
MOD_GlcNHglycan	371	374	PF01048	0.695
MOD_GlcNHglycan	425	428	PF01048	0.694
MOD_GlcNHglycan	435	438	PF01048	0.643
MOD_GlcNHglycan	464	467	PF01048	0.650
MOD_GlcNHglycan	474	477	PF01048	0.544
MOD_GlcNHglycan	489	492	PF01048	0.637
MOD_GlcNHglycan	508	511	PF01048	0.512
MOD_GlcNHglycan	525	528	PF01048	0.550
MOD_GlcNHglycan	529	532	PF01048	0.640
MOD_GlcNHglycan	54	57	PF01048	0.406
MOD_GSK3_1	104	111	PF00069	0.636
MOD_GSK3_1	117	124	PF00069	0.666
MOD_GSK3_1	130	137	PF00069	0.668
MOD_GSK3_1	237	244	PF00069	0.642
MOD_GSK3_1	304	311	PF00069	0.694
MOD_GSK3_1	313	320	PF00069	0.617
MOD_GSK3_1	327	334	PF00069	0.592
MOD_GSK3_1	357	364	PF00069	0.694
MOD_GSK3_1	381	388	PF00069	0.763
MOD_GSK3_1	389	396	PF00069	0.743
MOD_GSK3_1	417	424	PF00069	0.642
MOD_GSK3_1	425	432	PF00069	0.694
MOD_GSK3_1	523	530	PF00069	0.651
MOD_GSK3_1	63	70	PF00069	0.529
MOD_NEK2_1	131	136	PF00069	0.733
MOD_NEK2_1	24	29	PF00069	0.562
MOD_NEK2_1	305	310	PF00069	0.707
MOD_NEK2_1	357	362	PF00069	0.694
MOD_NEK2_1	414	419	PF00069	0.682
MOD_NEK2_1	504	509	PF00069	0.681
MOD_PIKK_1	222	228	PF00454	0.589
MOD_PIKK_1	429	435	PF00454	0.654
MOD_PIKK_1	63	69	PF00454	0.531
MOD_PIKK_1	84	90	PF00454	0.502
MOD_PK_1	366	372	PF00069	0.629
MOD_PKA_1	404	410	PF00069	0.571
MOD_PKA_2	24	30	PF00069	0.568
MOD_PKA_2	67	73	PF00069	0.663
MOD_Plk_4	281	287	PF00069	0.627
MOD_ProDKin_1	123	129	PF00069	0.616
MOD_ProDKin_1	178	184	PF00069	0.596
MOD_ProDKin_1	191	197	PF00069	0.404
MOD_ProDKin_1	219	225	PF00069	0.678
MOD_ProDKin_1	248	254	PF00069	0.596
MOD_ProDKin_1	315	321	PF00069	0.688
MOD_ProDKin_1	327	333	PF00069	0.577
MOD_ProDKin_1	381	387	PF00069	0.673
MOD_ProDKin_1	407	413	PF00069	0.813
MOD_ProDKin_1	417	423	PF00069	0.689
MOD_ProDKin_1	438	444	PF00069	0.702
MOD_ProDKin_1	446	452	PF00069	0.542
MOD_ProDKin_1	469	475	PF00069	0.617
MOD_ProDKin_1	529	535	PF00069	0.640
MOD_SUMO_for_1	297	300	PF00179	0.636
TRG_DiLeu_BaEn_4	12	18	PF01217	0.569
TRG_ENDOCYTIC_2	152	155	PF00928	0.476
TRG_ER_diArg_1	145	148	PF00400	0.554
TRG_ER_diArg_1	186	188	PF00400	0.589
TRG_ER_diArg_1	343	345	PF00400	0.575
TRG_ER_diArg_1	544	546	PF00400	0.696
TRG_ER_diArg_1	60	62	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X110	Leishmania donovani	91%	98%
A4HG23	Leishmania braziliensis	64%	100%
A4I344	Leishmania infantum	90%	98%
E9AZF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%