TBPIP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACW2_LEIMA

TriTrypDb:

LmjF.27.2420 , LMJLV39_270032000 , LMJSD75_270031900

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000228	nuclear chromosome	6	2
GO:0000793	condensed chromosome	6	2
GO:0000794	condensed nuclear chromosome	7	2
GO:0005694	chromosome	5	2
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	4
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12
GO:0120231	DNA recombinase auxiliary factor complex	3	2
GO:0150005	enzyme activator complex	2	2
GO:0005634	nucleus	5	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0000502	proteasome complex	3	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1905368	peptidase complex	3	2
GO:1905369	endopeptidase complex	4	2

Expansion

Sequence features

E9ACW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACW2

Function

Biological processes
Term	Name	Level	Count
GO:0000708	meiotic strand invasion	4	2
GO:0000709	meiotic joint molecule formation	3	2
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006996	organelle organization	4	2
GO:0007129	homologous chromosome pairing at meiosis	4	2
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0010774	meiotic strand invasion involved in reciprocal meiotic recombination	5	2
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	12
GO:0022414	reproductive process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0042148	strand invasion	5	2
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0051276	chromosome organization	5	2
GO:0061982	meiosis I cell cycle process	3	2
GO:0070192	chromosome organization involved in meiotic cell cycle	3	2
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1903046	meiotic cell cycle process	2	12
GO:0006310	DNA recombination	5	10
GO:0007131	reciprocal meiotic recombination	3	10
GO:0035825	homologous recombination	6	10
GO:0140527	reciprocal homologous recombination	7	10

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003690	double-stranded DNA binding	5	2
GO:0005488	binding	1	2
GO:0008047	enzyme activator activity	3	2
GO:0030234	enzyme regulator activity	2	2
GO:0097159	organic cyclic compound binding	2	2
GO:0098772	molecular function regulator activity	1	2
GO:0120230	recombinase activator activity	4	2
GO:0140677	molecular function activator activity	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.612
CLV_C14_Caspase3-7	36	40	PF00656	0.281
CLV_C14_Caspase3-7	82	86	PF00656	0.468
CLV_NRD_NRD_1	207	209	PF00675	0.439
CLV_NRD_NRD_1	214	216	PF00675	0.364
CLV_NRD_NRD_1	217	219	PF00675	0.333
CLV_NRD_NRD_1	222	224	PF00675	0.319
CLV_NRD_NRD_1	27	29	PF00675	0.200
CLV_NRD_NRD_1	76	78	PF00675	0.380
CLV_PCSK_FUR_1	205	209	PF00082	0.476
CLV_PCSK_FUR_1	212	216	PF00082	0.448
CLV_PCSK_KEX2_1	207	209	PF00082	0.471
CLV_PCSK_KEX2_1	214	216	PF00082	0.418
CLV_PCSK_KEX2_1	217	219	PF00082	0.406
CLV_PCSK_KEX2_1	27	29	PF00082	0.202
CLV_PCSK_KEX2_1	76	78	PF00082	0.449
CLV_PCSK_PC7_1	72	78	PF00082	0.314
CLV_PCSK_SKI1_1	30	34	PF00082	0.408
CLV_PCSK_SKI1_1	44	48	PF00082	0.360
CLV_PCSK_SKI1_1	66	70	PF00082	0.257
CLV_PCSK_SKI1_1	76	80	PF00082	0.441
DEG_APCC_DBOX_1	178	186	PF00400	0.544
DEG_Nend_UBRbox_1	1	4	PF02207	0.525
DOC_CKS1_1	31	36	PF01111	0.411
DOC_CYCLIN_RxL_1	270	278	PF00134	0.416
DOC_CYCLIN_RxL_1	72	85	PF00134	0.487
DOC_MAPK_gen_1	223	230	PF00069	0.483
DOC_PP1_RVXF_1	67	74	PF00149	0.312
DOC_PP2B_LxvP_1	267	270	PF13499	0.535
DOC_USP7_MATH_1	190	194	PF00917	0.689
DOC_USP7_MATH_1	256	260	PF00917	0.419
DOC_USP7_MATH_1	40	44	PF00917	0.266
DOC_USP7_UBL2_3	62	66	PF12436	0.284
DOC_WW_Pin1_4	123	128	PF00397	0.497
DOC_WW_Pin1_4	237	242	PF00397	0.456
DOC_WW_Pin1_4	30	35	PF00397	0.411
LIG_14-3-3_CanoR_1	179	183	PF00244	0.471
LIG_14-3-3_CanoR_1	44	50	PF00244	0.273
LIG_Actin_WH2_2	136	153	PF00022	0.489
LIG_BIR_III_4	39	43	PF00653	0.266
LIG_BIR_III_4	83	87	PF00653	0.566
LIG_CaM_IQ_9	140	156	PF13499	0.445
LIG_FHA_1	16	22	PF00498	0.299
LIG_FHA_1	201	207	PF00498	0.468
LIG_FHA_2	101	107	PF00498	0.560
LIG_FHA_2	120	126	PF00498	0.392
LIG_FHA_2	232	238	PF00498	0.538
LIG_FHA_2	250	256	PF00498	0.529
LIG_LIR_Gen_1	166	175	PF02991	0.315
LIG_LIR_Nem_3	166	171	PF02991	0.319
LIG_SH2_CRK	75	79	PF00017	0.350
LIG_SH2_STAP1	168	172	PF00017	0.402
LIG_SH3_1	28	34	PF00018	0.200
LIG_SH3_3	108	114	PF00018	0.553
LIG_SH3_3	262	268	PF00018	0.564
LIG_SH3_3	28	34	PF00018	0.411
LIG_SUMO_SIM_anti_2	18	23	PF11976	0.200
LIG_SUMO_SIM_par_1	15	23	PF11976	0.255
LIG_UBA3_1	53	62	PF00899	0.331
MOD_CK1_1	146	152	PF00069	0.416
MOD_CK1_1	15	21	PF00069	0.433
MOD_CK1_1	201	207	PF00069	0.505
MOD_CK2_1	100	106	PF00069	0.802
MOD_CK2_1	119	125	PF00069	0.427
MOD_CK2_1	157	163	PF00069	0.525
MOD_CK2_1	249	255	PF00069	0.433
MOD_CK2_1	91	97	PF00069	0.723
MOD_CMANNOS	155	158	PF00535	0.564
MOD_GlcNHglycan	140	143	PF01048	0.525
MOD_GlcNHglycan	192	195	PF01048	0.561
MOD_GSK3_1	119	126	PF00069	0.652
MOD_GSK3_1	146	153	PF00069	0.419
MOD_GSK3_1	256	263	PF00069	0.397
MOD_GSK3_1	87	94	PF00069	0.729
MOD_N-GLC_1	275	280	PF02516	0.369
MOD_NEK2_1	150	155	PF00069	0.480
MOD_NEK2_1	231	236	PF00069	0.477
MOD_NEK2_1	260	265	PF00069	0.400
MOD_NEK2_1	275	280	PF00069	0.456
MOD_OFUCOSY	117	123	PF10250	0.532
MOD_PKA_2	150	156	PF00069	0.517
MOD_PKA_2	178	184	PF00069	0.495
MOD_Plk_1	146	152	PF00069	0.453
MOD_Plk_1	15	21	PF00069	0.411
MOD_Plk_1	260	266	PF00069	0.422
MOD_Plk_4	15	21	PF00069	0.262
MOD_Plk_4	45	51	PF00069	0.205
MOD_ProDKin_1	123	129	PF00069	0.489
MOD_ProDKin_1	237	243	PF00069	0.457
MOD_ProDKin_1	30	36	PF00069	0.411
MOD_SUMO_rev_2	55	63	PF00179	0.360
TRG_DiLeu_BaEn_1	16	21	PF01217	0.411
TRG_ENDOCYTIC_2	168	171	PF00928	0.605
TRG_ENDOCYTIC_2	75	78	PF00928	0.469
TRG_ER_diArg_1	205	208	PF00400	0.431
TRG_ER_diArg_1	213	215	PF00400	0.362
TRG_ER_diArg_1	75	77	PF00400	0.326
TRG_NLS_MonoExtN_4	66	73	PF00514	0.266

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9H7	Leptomonas seymouri	49%	100%
A0A0S4J6Z3	Bodo saltans	31%	100%
A0A1X0NFH4	Trypanosomatidae	35%	100%
A0A3R7MDB5	Trypanosoma rangeli	32%	100%
A0A3S7X109	Leishmania donovani	93%	100%
A4HG22	Leishmania braziliensis	75%	84%
A4I343	Leishmania infantum	93%	100%
C9ZJL5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AZF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5D720	Trypanosoma cruzi	30%	100%