Aldo-keto reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldo-keto reductase-like protein

Species:

Leishmania major

UniProt:

E9ACW1_LEIMA

TriTrypDb:

LmjF.27.2410 , LMJLV39_270031900 , LMJSD75_270031800

Length:

372

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACW1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	7	4
GO:0004033	aldo-keto reductase (NADP) activity	5	4
GO:0008106	alcohol dehydrogenase (NADP+) activity	6	4
GO:0016491	oxidoreductase activity	2	12
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	4
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.475
CLV_NRD_NRD_1	86	88	PF00675	0.298
CLV_PCSK_KEX2_1	86	88	PF00082	0.254
CLV_PCSK_SKI1_1	273	277	PF00082	0.247
CLV_PCSK_SKI1_1	304	308	PF00082	0.269
CLV_PCSK_SKI1_1	312	316	PF00082	0.352
DEG_APCC_DBOX_1	110	118	PF00400	0.464
DEG_SCF_FBW7_1	133	140	PF00400	0.558
DOC_CDC14_PxL_1	203	211	PF14671	0.539
DOC_CYCLIN_RxL_1	270	279	PF00134	0.492
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.604
DOC_MAPK_DCC_7	25	35	PF00069	0.509
DOC_MAPK_gen_1	83	92	PF00069	0.457
DOC_MAPK_HePTP_8	6	18	PF00069	0.517
DOC_MAPK_MEF2A_6	9	18	PF00069	0.489
DOC_PP2B_LxvP_1	240	243	PF13499	0.453
DOC_PP2B_PxIxI_1	13	19	PF00149	0.533
DOC_USP7_MATH_1	243	247	PF00917	0.391
DOC_USP7_MATH_1	355	359	PF00917	0.530
DOC_WW_Pin1_4	133	138	PF00397	0.494
DOC_WW_Pin1_4	150	155	PF00397	0.421
DOC_WW_Pin1_4	244	249	PF00397	0.475
DOC_WW_Pin1_4	267	272	PF00397	0.514
DOC_WW_Pin1_4	336	341	PF00397	0.504
DOC_WW_Pin1_4	366	371	PF00397	0.736
LIG_14-3-3_CanoR_1	111	115	PF00244	0.539
LIG_14-3-3_CanoR_1	261	269	PF00244	0.562
LIG_14-3-3_CanoR_1	360	370	PF00244	0.655
LIG_14-3-3_CanoR_1	39	49	PF00244	0.524
LIG_BIR_II_1	1	5	PF00653	0.659
LIG_eIF4E_1	121	127	PF01652	0.453
LIG_FHA_1	151	157	PF00498	0.543
LIG_FHA_1	17	23	PF00498	0.486
LIG_FHA_1	186	192	PF00498	0.558
LIG_FHA_1	309	315	PF00498	0.597
LIG_FHA_1	35	41	PF00498	0.534
LIG_FHA_1	44	50	PF00498	0.501
LIG_FHA_1	91	97	PF00498	0.464
LIG_FHA_2	138	144	PF00498	0.456
LIG_FHA_2	159	165	PF00498	0.504
LIG_FHA_2	83	89	PF00498	0.543
LIG_LIR_Apic_2	37	41	PF02991	0.558
LIG_LIR_Gen_1	120	127	PF02991	0.464
LIG_LIR_Gen_1	164	173	PF02991	0.558
LIG_LIR_Gen_1	316	325	PF02991	0.417
LIG_LIR_Nem_3	120	124	PF02991	0.464
LIG_LIR_Nem_3	264	269	PF02991	0.512
LIG_LIR_Nem_3	316	321	PF02991	0.400
LIG_LIR_Nem_3	54	60	PF02991	0.497
LIG_SH2_CRK	237	241	PF00017	0.457
LIG_SH2_CRK	318	322	PF00017	0.523
LIG_SH2_CRK	38	42	PF00017	0.564
LIG_SH2_CRK	8	12	PF00017	0.610
LIG_SH2_SRC	125	128	PF00017	0.478
LIG_SH2_STAT5	121	124	PF00017	0.453
LIG_SH2_STAT5	125	128	PF00017	0.453
LIG_SH2_STAT5	237	240	PF00017	0.514
LIG_SH3_3	324	330	PF00018	0.452
LIG_SH3_3	364	370	PF00018	0.753
LIG_SUMO_SIM_anti_2	157	165	PF11976	0.540
LIG_SUMO_SIM_par_1	14	19	PF11976	0.528
LIG_SUMO_SIM_par_1	284	290	PF11976	0.452
LIG_TYR_ITIM	119	124	PF00017	0.305
LIG_TYR_ITIM	6	11	PF00017	0.633
MOD_CDC14_SPxK_1	270	273	PF00782	0.390
MOD_CDK_SPK_2	366	371	PF00069	0.676
MOD_CDK_SPxK_1	267	273	PF00069	0.390
MOD_CK1_1	264	270	PF00069	0.322
MOD_CK1_1	358	364	PF00069	0.611
MOD_CK1_1	43	49	PF00069	0.452
MOD_CK2_1	137	143	PF00069	0.428
MOD_CK2_1	82	88	PF00069	0.432
MOD_GlcNHglycan	1	4	PF01048	0.661
MOD_GlcNHglycan	263	266	PF01048	0.346
MOD_GlcNHglycan	289	292	PF01048	0.375
MOD_GSK3_1	133	140	PF00069	0.428
MOD_GSK3_1	158	165	PF00069	0.390
MOD_GSK3_1	356	363	PF00069	0.630
MOD_N-GLC_1	184	189	PF02516	0.362
MOD_N-GLC_1	276	281	PF02516	0.392
MOD_NEK2_1	162	167	PF00069	0.311
MOD_NEK2_1	177	182	PF00069	0.321
MOD_NEK2_1	24	29	PF00069	0.436
MOD_NEK2_1	51	56	PF00069	0.402
MOD_NEK2_1	90	95	PF00069	0.325
MOD_OFUCOSY	238	245	PF10250	0.180
MOD_PKA_2	110	116	PF00069	0.305
MOD_PKA_2	24	30	PF00069	0.518
MOD_PKA_2	356	362	PF00069	0.565
MOD_PKA_2	82	88	PF00069	0.456
MOD_Plk_1	156	162	PF00069	0.362
MOD_Plk_1	276	282	PF00069	0.360
MOD_Plk_1	308	314	PF00069	0.544
MOD_Plk_4	158	164	PF00069	0.426
MOD_Plk_4	250	256	PF00069	0.438
MOD_ProDKin_1	133	139	PF00069	0.362
MOD_ProDKin_1	150	156	PF00069	0.261
MOD_ProDKin_1	244	250	PF00069	0.336
MOD_ProDKin_1	267	273	PF00069	0.390
MOD_ProDKin_1	336	342	PF00069	0.497
MOD_ProDKin_1	366	372	PF00069	0.739
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.341
TRG_ENDOCYTIC_2	121	124	PF00928	0.305
TRG_ENDOCYTIC_2	237	240	PF00928	0.311
TRG_ENDOCYTIC_2	318	321	PF00928	0.515
TRG_ENDOCYTIC_2	57	60	PF00928	0.397
TRG_ENDOCYTIC_2	8	11	PF00928	0.597
TRG_ER_diArg_1	147	150	PF00400	0.419
TRG_ER_diArg_1	310	313	PF00400	0.541
TRG_ER_diArg_1	80	83	PF00400	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4R8	Leptomonas seymouri	27%	98%
A0A0N0P8F4	Leptomonas seymouri	69%	100%
A0A0N1I3R2	Leptomonas seymouri	25%	100%
A0A0N1I9Z1	Leptomonas seymouri	29%	100%
A0A0N1PCR7	Leptomonas seymouri	31%	100%
A0A0S4J2H7	Bodo saltans	24%	100%
A0A0S4J7K9	Bodo saltans	53%	100%
A0A1D5XGW0	Triticum aestivum	34%	100%
A0A1X0NFW0	Trypanosomatidae	54%	100%
A0A1X0NIH1	Trypanosomatidae	30%	100%
A0A1X0NNX8	Trypanosomatidae	32%	100%
A0A1X0P7C2	Trypanosomatidae	29%	100%
A0A1X9QHJ0	Triticum aestivum	34%	100%
A0A2P1GIY9	Catharanthus roseus	29%	100%
A0A3Q8IFG1	Leishmania donovani	31%	100%
A0A3Q8IJ05	Leishmania donovani	29%	100%
A0A3R7NJY8	Trypanosoma rangeli	56%	100%
A0A3S7X124	Leishmania donovani	97%	100%
A0A3S7X518	Leishmania donovani	27%	100%
A0A422N1G0	Trypanosoma rangeli	30%	100%
A0A422N9R4	Trypanosoma rangeli	31%	100%
A0A422NBS6	Trypanosoma rangeli	31%	100%
A0PQ11	Mycobacterium ulcerans (strain Agy99)	33%	100%
A0QJ99	Mycobacterium avium (strain 104)	33%	100%
A0QL30	Mycobacterium avium (strain 104)	32%	100%
A0QV09	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	33%	100%
A0QV10	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	34%	100%
A1CRI1	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	30%	100%
A1D4E3	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	29%	100%
A1KMW6	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	36%	100%
A1T726	Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 / PYR-1)	34%	100%
A1UEC5	Mycobacterium sp. (strain KMS)	33%	100%
A1UEC6	Mycobacterium sp. (strain KMS)	32%	100%
A2Q8B5	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	29%	100%
A3PXS9	Mycobacterium sp. (strain JLS)	33%	100%
A3PXT0	Mycobacterium sp. (strain JLS)	32%	100%
A4HEX6	Leishmania braziliensis	25%	89%
A4HG21	Leishmania braziliensis	87%	100%
A4HJJ7	Leishmania braziliensis	29%	100%
A4HJS6	Leishmania braziliensis	27%	100%
A4HK26	Leishmania braziliensis	31%	100%
A4I342	Leishmania infantum	96%	100%
A4I6Z4	Leishmania infantum	31%	100%
A4I792	Leishmania infantum	27%	100%
A4I7L0	Leishmania infantum	29%	100%
A4TE41	Mycolicibacterium gilvum (strain PYR-GCK)	33%	100%
A5U6Y1	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	35%	100%
B0XNR0	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	29%	100%
B2HIJ9	Mycobacterium marinum (strain ATCC BAA-535 / M)	33%	100%
B4F9A4	Zea mays	34%	100%
B8N195	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	30%	100%
B8ZS00	Mycobacterium leprae (strain Br4923)	33%	100%
B9VRJ2	Papaver somniferum	32%	100%
C5FFQ7	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	33%	100%
C9JRZ8	Homo sapiens	35%	100%
C9ZJL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D0A6W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A735	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D3ZF77	Rattus norvegicus	34%	100%
E7C196	Erythroxylum coca	32%	100%
E9AYA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	90%
E9AZF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B215	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B287	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B2G7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
G4MZI3	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	30%	100%
G4N708	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	30%	100%
H9JTG9	Bombyx mori	30%	100%
O08782	Cricetulus griseus	36%	100%
O13283	Candida tropicalis	33%	100%
O13848	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
O14088	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
O23016	Arabidopsis thaliana	23%	100%
O32210	Bacillus subtilis (strain 168)	32%	100%
O34678	Bacillus subtilis (strain 168)	34%	100%
O42888	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
O49133	Fragaria ananassa	31%	100%
O60218	Homo sapiens	36%	100%
O69462	Mycobacterium leprae (strain TN)	33%	100%
O70473	Cricetulus griseus	38%	100%
O74237	Candida tenuis	34%	100%
O80944	Arabidopsis thaliana	33%	100%
O94735	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	34%	100%
P02532	Rana temporaria	33%	100%
P05980	Bos taurus	37%	100%
P06632	Corynebacterium sp. (strain ATCC 31090)	32%	100%
P07943	Rattus norvegicus	37%	100%
P14065	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P14550	Homo sapiens	37%	100%
P15121	Homo sapiens	37%	100%
P15122	Oryctolagus cuniculus	37%	100%
P15339	Corynebacterium sp. (strain SHS752001)	30%	100%
P16116	Bos taurus	38%	100%
P17264	Lithobates catesbeianus	34%	100%
P17516	Homo sapiens	34%	100%
P21300	Mus musculus	34%	100%
P22045	Leishmania major	31%	96%
P23457	Rattus norvegicus	33%	100%
P23901	Hordeum vulgare	32%	100%
P26690	Glycine max	31%	100%
P27800	Sporidiobolus salmonicolor	36%	100%
P28475	Malus domestica	36%	100%
P30863	Escherichia coli (strain K12)	29%	100%
P31210	Rattus norvegicus	33%	100%
P31867	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	33%	100%
P38115	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P38715	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P42330	Homo sapiens	34%	100%
P45376	Mus musculus	37%	100%
P45377	Mus musculus	36%	100%
P47137	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P49378	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	29%	100%
P50578	Sus scrofa	36%	100%
P51635	Rattus norvegicus	37%	100%
P51652	Rattus norvegicus	35%	100%
P51857	Homo sapiens	35%	100%
P52895	Homo sapiens	35%	100%
P52897	Bos taurus	37%	100%
P52898	Bos taurus	38%	100%
P58744	Salmonella typhi	35%	100%
P70694	Mus musculus	36%	100%
P74308	Synechocystis sp. (strain PCC 6803 / Kazusa)	37%	100%
P76234	Escherichia coli (strain K12)	26%	100%
P78736	Pachysolen tannophilus	33%	100%
P80276	Sus scrofa	39%	100%
P80508	Oryctolagus cuniculus	35%	100%
P82125	Sus scrofa	37%	100%
P82809	Mesocricetus auratus	33%	100%
P87039	Candida tropicalis	34%	100%
P9WQA4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	35%	100%
P9WQA5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	35%	100%
Q01213	Mucor mucedo	29%	100%
Q02198	Pseudomonas putida	29%	100%
Q04828	Homo sapiens	35%	100%
Q07551	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q09632	Caenorhabditis elegans	28%	100%
Q0CUL0	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	31%	100%
Q0GYU4	Hypocrea jecorina	35%	100%
Q0GYU5	Hypocrea jecorina	34%	100%
Q0PCF4	Hordeum vulgare	34%	100%
Q0PGJ6	Arabidopsis thaliana	35%	100%
Q10494	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q10PE7	Oryza sativa subsp. japonica	34%	100%
Q12458	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
Q1BAN7	Mycobacterium sp. (strain MCS)	33%	100%
Q1XAA8	Equus caballus	36%	100%
Q28FD1	Xenopus tropicalis	37%	100%
Q2UKD0	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	30%	100%
Q3ZCJ2	Bos taurus	37%	100%
Q3ZFI7	Hypocrea jecorina	32%	100%
Q40648	Oryza sativa subsp. japonica	23%	100%
Q46857	Escherichia coli (strain K12)	34%	100%
Q4DJ07	Trypanosoma cruzi (strain CL Brener)	29%	100%
Q4Q5N9	Leishmania major	29%	93%
Q4Q5X1	Leishmania major	27%	100%
Q4Q973	Leishmania major	27%	90%
Q4R802	Macaca fascicularis	35%	100%
Q4WJT9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	29%	100%
Q54NZ7	Dictyostelium discoideum	36%	100%
Q55FL3	Dictyostelium discoideum	33%	100%
Q568L5	Danio rerio	37%	100%
Q5BGA7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	30%	100%
Q5R5D5	Pongo abelii	37%	100%
Q5R7C9	Pongo abelii	35%	100%
Q5REQ0	Pongo abelii	35%	100%
Q5RJP0	Rattus norvegicus	36%	100%
Q5U1Y4	Rattus norvegicus	38%	100%
Q5ZK84	Gallus gallus	39%	100%
Q6AYQ2	Rattus norvegicus	35%	100%
Q6AZW2	Danio rerio	40%	100%
Q6GMC7	Xenopus laevis	37%	100%
Q6IMN8	Dictyostelium discoideum	33%	100%
Q6W8P9	Equus caballus	35%	100%
Q6Y0Z3	Candida parapsilosis	34%	100%
Q73SC5	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	32%	100%
Q73VK6	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	33%	100%
Q76L36	Candida parapsilosis	27%	100%
Q76L37	Candida parapsilosis	26%	100%
Q7G764	Oryza sativa subsp. japonica	31%	100%
Q7G765	Oryza sativa subsp. japonica	30%	100%
Q7TXI6	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	36%	100%
Q84TF0	Arabidopsis thaliana	33%	100%
Q876L8	Hypocrea jecorina	33%	100%
Q8K023	Mus musculus	34%	100%
Q8SSK6	Encephalitozoon cuniculi (strain GB-M1)	32%	100%
Q8VC28	Mus musculus	36%	100%
Q8VCX1	Mus musculus	33%	100%
Q8X195	Candida boidinii	31%	100%
Q8X7Z7	Escherichia coli O157:H7	29%	100%
Q8XBT6	Escherichia coli O157:H7	34%	100%
Q8Z988	Salmonella typhi	28%	100%
Q8ZH36	Yersinia pestis	27%	100%
Q8ZI40	Yersinia pestis	31%	100%
Q8ZM06	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	35%	100%
Q8ZRM7	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	28%	100%
Q91WR5	Mus musculus	34%	100%
Q95JH4	Macaca fuscata fuscata	36%	100%
Q95JH5	Macaca fascicularis	36%	100%
Q95JH6	Macaca fuscata fuscata	35%	100%
Q95JH7	Macaca fascicularis	35%	100%
Q96JD6	Homo sapiens	36%	100%
Q9C1X5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q9DCT1	Mus musculus	39%	100%
Q9GV41	Trypanosoma brucei brucei	29%	100%
Q9JII6	Mus musculus	37%	100%
Q9M338	Arabidopsis thaliana	32%	100%
Q9P430	Scheffersomyces shehatae	32%	100%
Q9P8R5	Aspergillus niger	29%	100%
Q9SQ64	Papaver somniferum	34%	100%
Q9SQ67	Papaver somniferum	33%	100%
Q9SQ68	Papaver somniferum	33%	100%
Q9SQ69	Papaver somniferum	32%	100%
Q9SQ70	Papaver somniferum	31%	100%
Q9TV64	Oryctolagus cuniculus	35%	100%
Q9USV2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
V5B6J8	Trypanosoma cruzi	52%	100%
V5BBS9	Trypanosoma cruzi	30%	100%
V5BR74	Trypanosoma cruzi	31%	100%
W5DYE3	Triticum aestivum	35%	100%