Putative TPR-repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR-repeat protein, putative

Species:

Leishmania major

UniProt:

E9ACV9_LEIMA

TriTrypDb:

LmjF.27.2390 , LMJLV39_270031700 , LMJSD75_270031600

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	2
GO:0101031	protein folding chaperone complex	3	2
GO:0140535	intracellular protein-containing complex	2	2

Expansion

Sequence features

E9ACV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.664
CLV_NRD_NRD_1	167	169	PF00675	0.280
CLV_NRD_NRD_1	171	173	PF00675	0.280
CLV_NRD_NRD_1	272	274	PF00675	0.561
CLV_NRD_NRD_1	277	279	PF00675	0.543
CLV_NRD_NRD_1	301	303	PF00675	0.629
CLV_NRD_NRD_1	381	383	PF00675	0.347
CLV_NRD_NRD_1	39	41	PF00675	0.569
CLV_NRD_NRD_1	483	485	PF00675	0.501
CLV_PCSK_FUR_1	299	303	PF00082	0.589
CLV_PCSK_KEX2_1	167	169	PF00082	0.280
CLV_PCSK_KEX2_1	212	214	PF00082	0.509
CLV_PCSK_KEX2_1	229	231	PF00082	0.438
CLV_PCSK_KEX2_1	272	274	PF00082	0.567
CLV_PCSK_KEX2_1	298	300	PF00082	0.600
CLV_PCSK_KEX2_1	301	303	PF00082	0.579
CLV_PCSK_KEX2_1	381	383	PF00082	0.347
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.509
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.438
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.588
CLV_PCSK_SKI1_1	149	153	PF00082	0.466
CLV_PCSK_SKI1_1	484	488	PF00082	0.448
DEG_APCC_DBOX_1	16	24	PF00400	0.593
DEG_APCC_DBOX_1	171	179	PF00400	0.287
DEG_APCC_DBOX_1	181	189	PF00400	0.268
DEG_Nend_UBRbox_2	1	3	PF02207	0.566
DEG_SCF_FBW7_1	333	340	PF00400	0.537
DEG_SPOP_SBC_1	326	330	PF00917	0.633
DEG_SPOP_SBC_1	338	342	PF00917	0.725
DEG_SPOP_SBC_1	344	348	PF00917	0.770
DOC_CKS1_1	472	477	PF01111	0.469
DOC_CYCLIN_yCln2_LP_2	399	405	PF00134	0.404
DOC_MAPK_gen_1	227	233	PF00069	0.618
DOC_MAPK_gen_1	298	308	PF00069	0.545
DOC_MAPK_gen_1	95	102	PF00069	0.493
DOC_MAPK_MEF2A_6	445	453	PF00069	0.471
DOC_PP2B_LxvP_1	370	373	PF13499	0.396
DOC_USP7_MATH_1	214	218	PF00917	0.596
DOC_USP7_MATH_1	248	252	PF00917	0.691
DOC_USP7_MATH_1	326	330	PF00917	0.653
DOC_USP7_MATH_1	345	349	PF00917	0.701
DOC_USP7_MATH_1	366	370	PF00917	0.671
DOC_USP7_UBL2_3	173	177	PF12436	0.374
DOC_USP7_UBL2_3	37	41	PF12436	0.571
DOC_WW_Pin1_4	312	317	PF00397	0.710
DOC_WW_Pin1_4	322	327	PF00397	0.636
DOC_WW_Pin1_4	333	338	PF00397	0.601
DOC_WW_Pin1_4	340	345	PF00397	0.650
DOC_WW_Pin1_4	346	351	PF00397	0.747
DOC_WW_Pin1_4	411	416	PF00397	0.455
DOC_WW_Pin1_4	471	476	PF00397	0.516
LIG_APCC_ABBA_1	449	454	PF00400	0.430
LIG_FHA_1	113	119	PF00498	0.459
LIG_FHA_1	124	130	PF00498	0.473
LIG_FHA_1	150	156	PF00498	0.463
LIG_FHA_1	204	210	PF00498	0.402
LIG_FHA_1	334	340	PF00498	0.708
LIG_FHA_1	429	435	PF00498	0.529
LIG_FHA_2	143	149	PF00498	0.438
LIG_FHA_2	255	261	PF00498	0.664
LIG_FHA_2	76	82	PF00498	0.490
LIG_LIR_Gen_1	375	383	PF02991	0.445
LIG_LIR_Gen_1	394	403	PF02991	0.428
LIG_LIR_Nem_3	375	379	PF02991	0.445
LIG_LIR_Nem_3	380	386	PF02991	0.443
LIG_LIR_Nem_3	394	399	PF02991	0.428
LIG_PCNA_PIPBox_1	389	398	PF02747	0.495
LIG_Pex14_2	379	383	PF04695	0.455
LIG_SH2_GRB2like	131	134	PF00017	0.417
LIG_SH2_NCK_1	161	165	PF00017	0.406
LIG_SH2_PTP2	396	399	PF00017	0.430
LIG_SH2_STAP1	131	135	PF00017	0.418
LIG_SH2_STAP1	161	165	PF00017	0.406
LIG_SH2_STAT5	114	117	PF00017	0.462
LIG_SH2_STAT5	138	141	PF00017	0.384
LIG_SH2_STAT5	396	399	PF00017	0.486
LIG_SH3_1	469	475	PF00018	0.496
LIG_SH3_2	472	477	PF14604	0.516
LIG_SH3_3	384	390	PF00018	0.565
LIG_SH3_3	39	45	PF00018	0.621
LIG_SH3_3	469	475	PF00018	0.534
LIG_SUMO_SIM_anti_2	304	311	PF11976	0.635
LIG_SUMO_SIM_anti_2	463	470	PF11976	0.469
LIG_TRAF2_1	198	201	PF00917	0.536
LIG_TRAF2_1	256	259	PF00917	0.662
LIG_TRAF2_1	280	283	PF00917	0.640
LIG_UBA3_1	417	426	PF00899	0.444
LIG_WRC_WIRS_1	425	430	PF05994	0.547
MOD_CDK_SPxK_1	471	477	PF00069	0.520
MOD_CDK_SPxxK_3	312	319	PF00069	0.512
MOD_CK1_1	124	130	PF00069	0.473
MOD_CK1_1	217	223	PF00069	0.692
MOD_CK1_1	253	259	PF00069	0.668
MOD_CK1_1	325	331	PF00069	0.666
MOD_CK1_1	340	346	PF00069	0.643
MOD_CK1_1	348	354	PF00069	0.650
MOD_CK1_1	411	417	PF00069	0.504
MOD_CK1_1	79	85	PF00069	0.612
MOD_CK2_1	1	7	PF00069	0.635
MOD_CK2_1	142	148	PF00069	0.453
MOD_CK2_1	253	259	PF00069	0.581
MOD_CK2_1	312	318	PF00069	0.745
MOD_CK2_1	372	378	PF00069	0.445
MOD_CK2_1	441	447	PF00069	0.462
MOD_CK2_1	58	64	PF00069	0.536
MOD_CK2_1	79	85	PF00069	0.491
MOD_GlcNHglycan	103	106	PF01048	0.540
MOD_GlcNHglycan	123	126	PF01048	0.367
MOD_GlcNHglycan	195	199	PF01048	0.412
MOD_GlcNHglycan	250	253	PF01048	0.719
MOD_GlcNHglycan	353	356	PF01048	0.713
MOD_GlcNHglycan	469	472	PF01048	0.520
MOD_GlcNHglycan	78	81	PF01048	0.619
MOD_GSK3_1	1	8	PF00069	0.535
MOD_GSK3_1	214	221	PF00069	0.655
MOD_GSK3_1	250	257	PF00069	0.586
MOD_GSK3_1	322	329	PF00069	0.645
MOD_GSK3_1	333	340	PF00069	0.595
MOD_GSK3_1	344	351	PF00069	0.697
MOD_GSK3_1	368	375	PF00069	0.487
MOD_GSK3_1	424	431	PF00069	0.515
MOD_GSK3_1	467	474	PF00069	0.388
MOD_GSK3_1	75	82	PF00069	0.593
MOD_N-GLC_1	411	416	PF02516	0.255
MOD_N-GLC_1	428	433	PF02516	0.255
MOD_NEK2_1	1	6	PF00069	0.639
MOD_NEK2_1	101	106	PF00069	0.483
MOD_NEK2_1	339	344	PF00069	0.570
MOD_NEK2_1	408	413	PF00069	0.511
MOD_NEK2_1	428	433	PF00069	0.415
MOD_NEK2_1	467	472	PF00069	0.434
MOD_PIKK_1	214	220	PF00454	0.580
MOD_PKA_2	55	61	PF00069	0.547
MOD_PKA_2	73	79	PF00069	0.658
MOD_Plk_1	1	7	PF00069	0.635
MOD_Plk_2-3	235	241	PF00069	0.723
MOD_ProDKin_1	312	318	PF00069	0.712
MOD_ProDKin_1	322	328	PF00069	0.639
MOD_ProDKin_1	333	339	PF00069	0.605
MOD_ProDKin_1	340	346	PF00069	0.653
MOD_ProDKin_1	348	354	PF00069	0.738
MOD_ProDKin_1	411	417	PF00069	0.455
MOD_ProDKin_1	471	477	PF00069	0.520
MOD_SUMO_rev_2	13	23	PF00179	0.475
MOD_SUMO_rev_2	313	322	PF00179	0.705
MOD_SUMO_rev_2	478	486	PF00179	0.551
TRG_DiLeu_BaLyEn_6	395	400	PF01217	0.445
TRG_ENDOCYTIC_2	138	141	PF00928	0.410
TRG_ENDOCYTIC_2	396	399	PF00928	0.426
TRG_ER_diArg_1	166	168	PF00400	0.280
TRG_ER_diArg_1	271	273	PF00400	0.643
TRG_ER_diArg_1	299	302	PF00400	0.569
TRG_ER_diArg_1	359	362	PF00400	0.725
TRG_ER_diArg_1	381	383	PF00400	0.547
TRG_ER_diLys_1	485	489	PF00400	0.559
TRG_NLS_Bipartite_1	212	232	PF00514	0.651
TRG_NLS_MonoCore_2	226	231	PF00514	0.616
TRG_NLS_MonoExtC_3	297	302	PF00514	0.508
TRG_NLS_MonoExtN_4	227	232	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.245

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF88	Leptomonas seymouri	60%	99%
A0A0S4J9Z5	Bodo saltans	40%	100%
A0A1X0NH58	Trypanosomatidae	40%	100%
A0A3Q8IHU4	Leishmania donovani	93%	100%
A0A3R7KY85	Trypanosoma rangeli	40%	100%
A4HG19	Leishmania braziliensis	82%	100%
A4I340	Leishmania infantum	94%	100%
C9ZJL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AZE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	98%
Q28IV3	Xenopus tropicalis	25%	74%
Q68FQ7	Rattus norvegicus	26%	74%
Q6NU95	Xenopus laevis	25%	74%
Q9D706	Mus musculus	25%	74%
V5AR46	Trypanosoma cruzi	39%	100%