Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACV7_LEIMA

TriTrypDb:

LmjF.27.2370 , LMJLV39_270031500 , LMJSD75_270031400

Length:

153

Annotations

LeishMANIAdb annotations

Unique but conserved family

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9ACV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACV7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.574
CLV_NRD_NRD_1	24	26	PF00675	0.465
CLV_NRD_NRD_1	47	49	PF00675	0.372
CLV_NRD_NRD_1	65	67	PF00675	0.355
CLV_NRD_NRD_1	68	70	PF00675	0.346
CLV_PCSK_KEX2_1	118	120	PF00082	0.578
CLV_PCSK_KEX2_1	2	4	PF00082	0.473
CLV_PCSK_KEX2_1	24	26	PF00082	0.465
CLV_PCSK_KEX2_1	47	49	PF00082	0.372
CLV_PCSK_KEX2_1	65	67	PF00082	0.363
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.692
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.473
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.363
CLV_PCSK_SKI1_1	120	124	PF00082	0.563
CLV_PCSK_SKI1_1	131	135	PF00082	0.543
CLV_PCSK_SKI1_1	147	151	PF00082	0.563
DEG_Nend_UBRbox_1	1	4	PF02207	0.673
DOC_MAPK_gen_1	118	126	PF00069	0.357
DOC_MAPK_gen_1	65	77	PF00069	0.477
DOC_MAPK_MEF2A_6	70	79	PF00069	0.413
DOC_PP1_RVXF_1	67	74	PF00149	0.488
DOC_WW_Pin1_4	33	38	PF00397	0.684
LIG_14-3-3_CanoR_1	69	74	PF00244	0.477
LIG_14-3-3_CanoR_1	99	105	PF00244	0.398
LIG_FHA_1	79	85	PF00498	0.475
LIG_FHA_2	139	145	PF00498	0.443
LIG_LIR_Gen_1	23	30	PF02991	0.687
LIG_LIR_Nem_3	23	29	PF02991	0.668
LIG_MYND_1	50	54	PF01753	0.565
LIG_NRP_CendR_1	150	153	PF00754	0.676
LIG_Pex14_1	76	80	PF04695	0.344
LIG_SH2_CRK	97	101	PF00017	0.393
LIG_SH2_STAP1	101	105	PF00017	0.353
LIG_SH2_STAP1	22	26	PF00017	0.744
LIG_SH2_STAT5	104	107	PF00017	0.397
LIG_SH2_STAT5	55	58	PF00017	0.567
LIG_SH3_1	3	9	PF00018	0.690
LIG_SH3_3	3	9	PF00018	0.690
LIG_TYR_ITIM	95	100	PF00017	0.350
MOD_CDK_SPxxK_3	33	40	PF00069	0.681
MOD_NEK2_1	100	105	PF00069	0.427
MOD_NEK2_1	20	25	PF00069	0.683
MOD_NEK2_1	80	85	PF00069	0.415
MOD_PKA_1	69	75	PF00069	0.476
MOD_PKA_2	138	144	PF00069	0.458
MOD_Plk_4	100	106	PF00069	0.413
MOD_Plk_4	69	75	PF00069	0.552
MOD_ProDKin_1	33	39	PF00069	0.681
MOD_SUMO_for_1	111	114	PF00179	0.360
MOD_SUMO_rev_2	144	149	PF00179	0.430
TRG_ENDOCYTIC_2	97	100	PF00928	0.351
TRG_ER_diArg_1	24	26	PF00400	0.681
TRG_NES_CRM1_1	51	63	PF08389	0.562
TRG_NLS_Bipartite_1	47	69	PF00514	0.563
TRG_NLS_MonoCore_2	117	122	PF00514	0.474
TRG_NLS_MonoExtC_3	64	69	PF00514	0.571
TRG_NLS_MonoExtN_4	65	70	PF00514	0.585
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE08	Leptomonas seymouri	85%	100%
A0A0S4J669	Bodo saltans	63%	100%
A0A1X0NFB4	Trypanosomatidae	70%	100%
A0A3Q8ICW4	Leishmania donovani	97%	100%
A0A422NE01	Trypanosoma rangeli	74%	100%
A4HG17	Leishmania braziliensis	95%	100%
A4I339	Leishmania infantum	97%	100%
C9ZJL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AZE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5B6L7	Trypanosoma cruzi	76%	100%