CPL domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACV6_LEIMA

TriTrypDb:

LmjF.27.2360 , LMJLV39_270031400 , LMJSD75_270031300

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACV6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.503
CLV_NRD_NRD_1	305	307	PF00675	0.477
CLV_NRD_NRD_1	329	331	PF00675	0.593
CLV_PCSK_KEX2_1	329	331	PF00082	0.613
CLV_PCSK_KEX2_1	337	339	PF00082	0.548
CLV_PCSK_KEX2_1	381	383	PF00082	0.563
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.419
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.561
CLV_PCSK_SKI1_1	107	111	PF00082	0.531
CLV_PCSK_SKI1_1	139	143	PF00082	0.431
CLV_PCSK_SKI1_1	158	162	PF00082	0.381
CLV_PCSK_SKI1_1	198	202	PF00082	0.413
CLV_PCSK_SKI1_1	33	37	PF00082	0.417
DEG_SCF_FBW7_2	91	96	PF00400	0.301
DOC_CYCLIN_RxL_1	195	202	PF00134	0.425
DOC_PP1_RVXF_1	341	347	PF00149	0.524
DOC_PP4_FxxP_1	151	154	PF00568	0.451
DOC_USP7_MATH_1	318	322	PF00917	0.520
DOC_USP7_MATH_1	349	353	PF00917	0.627
DOC_USP7_MATH_1	53	57	PF00917	0.504
DOC_USP7_UBL2_3	107	111	PF12436	0.456
DOC_USP7_UBL2_3	139	143	PF12436	0.533
DOC_USP7_UBL2_3	222	226	PF12436	0.541
DOC_WW_Pin1_4	89	94	PF00397	0.460
LIG_14-3-3_CanoR_1	330	339	PF00244	0.549
LIG_14-3-3_CanoR_1	77	87	PF00244	0.433
LIG_CaM_NSCaTE_8	14	21	PF13499	0.485
LIG_deltaCOP1_diTrp_1	95	101	PF00928	0.521
LIG_EH1_1	269	277	PF00400	0.405
LIG_FHA_1	108	114	PF00498	0.445
LIG_FHA_1	13	19	PF00498	0.462
LIG_FHA_1	154	160	PF00498	0.353
LIG_FHA_1	334	340	PF00498	0.530
LIG_FHA_1	34	40	PF00498	0.477
LIG_FHA_1	4	10	PF00498	0.531
LIG_FHA_1	64	70	PF00498	0.365
LIG_FHA_1	71	77	PF00498	0.343
LIG_FHA_1	79	85	PF00498	0.339
LIG_FHA_2	197	203	PF00498	0.405
LIG_FHA_2	256	262	PF00498	0.441
LIG_FHA_2	90	96	PF00498	0.471
LIG_LIR_Apic_2	148	154	PF02991	0.470
LIG_LIR_Gen_1	266	276	PF02991	0.345
LIG_LIR_Nem_3	211	217	PF02991	0.372
LIG_LIR_Nem_3	266	271	PF02991	0.356
LIG_NRBOX	112	118	PF00104	0.458
LIG_PAM2_1	5	17	PF00658	0.503
LIG_PCNA_yPIPBox_3	283	293	PF02747	0.431
LIG_SH2_SRC	268	271	PF00017	0.400
LIG_SH2_STAP1	268	272	PF00017	0.347
LIG_SH2_STAP1	323	327	PF00017	0.496
LIG_SH3_3	41	47	PF00018	0.534
LIG_SUMO_SIM_par_1	5	10	PF11976	0.442
LIG_TRAF2_1	192	195	PF00917	0.503
LIG_TRAF2_1	93	96	PF00917	0.318
LIG_UBA3_1	134	143	PF00899	0.392
LIG_UBA3_1	313	320	PF00899	0.381
LIG_UBA3_1	361	367	PF00899	0.501
LIG_WRC_WIRS_1	98	103	PF05994	0.506
MOD_CK1_1	145	151	PF00069	0.499
MOD_CK1_1	28	34	PF00069	0.372
MOD_CK1_1	3	9	PF00069	0.575
MOD_CK1_1	352	358	PF00069	0.657
MOD_CK1_1	40	46	PF00069	0.476
MOD_CK1_1	70	76	PF00069	0.354
MOD_CK1_1	89	95	PF00069	0.526
MOD_CK2_1	169	175	PF00069	0.494
MOD_CK2_1	189	195	PF00069	0.369
MOD_CK2_1	196	202	PF00069	0.335
MOD_CK2_1	255	261	PF00069	0.504
MOD_CK2_1	89	95	PF00069	0.449
MOD_GlcNHglycan	172	175	PF01048	0.428
MOD_GlcNHglycan	191	194	PF01048	0.210
MOD_GlcNHglycan	2	5	PF01048	0.602
MOD_GlcNHglycan	27	30	PF01048	0.362
MOD_GSK3_1	107	114	PF00069	0.511
MOD_GSK3_1	142	149	PF00069	0.386
MOD_GSK3_1	319	326	PF00069	0.488
MOD_GSK3_1	33	40	PF00069	0.420
MOD_GSK3_1	349	356	PF00069	0.633
MOD_GSK3_1	367	374	PF00069	0.510
MOD_GSK3_1	63	70	PF00069	0.274
MOD_N-GLC_1	33	38	PF02516	0.483
MOD_N-GLC_1	347	352	PF02516	0.496
MOD_NEK2_1	146	151	PF00069	0.344
MOD_NEK2_1	180	185	PF00069	0.438
MOD_NEK2_1	196	201	PF00069	0.355
MOD_NEK2_1	217	222	PF00069	0.428
MOD_NEK2_1	331	336	PF00069	0.548
MOD_NEK2_1	368	373	PF00069	0.582
MOD_NEK2_1	63	68	PF00069	0.387
MOD_NEK2_2	14	19	PF00069	0.286
MOD_PIKK_1	291	297	PF00454	0.409
MOD_PIKK_1	331	337	PF00454	0.541
MOD_PIKK_1	347	353	PF00454	0.434
MOD_PIKK_1	354	360	PF00454	0.586
MOD_PKA_1	12	18	PF00069	0.320
MOD_PKA_1	142	148	PF00069	0.480
MOD_Plk_1	33	39	PF00069	0.453
MOD_Plk_2-3	261	267	PF00069	0.282
MOD_Plk_4	142	148	PF00069	0.367
MOD_Plk_4	372	378	PF00069	0.454
MOD_Plk_4	67	73	PF00069	0.391
MOD_ProDKin_1	89	95	PF00069	0.460
MOD_SUMO_for_1	105	108	PF00179	0.519
MOD_SUMO_rev_2	220	227	PF00179	0.491
TRG_ENDOCYTIC_2	268	271	PF00928	0.330
TRG_ER_diArg_1	329	331	PF00400	0.592
TRG_NLS_MonoExtN_4	139	146	PF00514	0.293
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1A8	Leptomonas seymouri	65%	100%
A0A0S4J8X0	Bodo saltans	30%	100%
A0A1X0NG17	Trypanosomatidae	35%	99%
A0A3S7X117	Leishmania donovani	91%	100%
A0A422NDW9	Trypanosoma rangeli	36%	99%
A4HG16	Leishmania braziliensis	84%	100%
A4I338	Leishmania infantum	91%	100%
C9ZJL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	99%
E9AZE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BB08	Trypanosoma cruzi	36%	99%