Putative vesicle-associated membrane protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vesicle-associated membrane protein 7

Species:

Leishmania major

UniProt:

E9ACV5_LEIMA

TriTrypDb:

LmjF.27.2350 , LMJLV39_270031300 , LMJSD75_270031200

Length:

220

Annotations

LeishMANIAdb annotations

Homologous to animal VAMP7 proteins. Likely involved in vesicular transport.. Localization: Vesicular (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000331	contractile vacuole	6	2
GO:0005773	vacuole	5	2
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	12
GO:0020016	ciliary pocket	2	2
GO:0020022	acidocalcisome	5	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9ACV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACV5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006950	response to stress	2	2
GO:0006970	response to osmotic stress	3	2
GO:0009628	response to abiotic stimulus	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016192	vesicle-mediated transport	4	11
GO:0033554	cellular response to stress	3	2
GO:0042221	response to chemical	2	2
GO:0050896	response to stimulus	1	2
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051716	cellular response to stimulus	2	2
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0062197	cellular response to chemical stress	4	2
GO:0070887	cellular response to chemical stimulus	3	2
GO:0071214	cellular response to abiotic stimulus	3	2
GO:0071470	cellular response to osmotic stress	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0104004	cellular response to environmental stimulus	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.388
CLV_PCSK_SKI1_1	118	122	PF00082	0.358
CLV_PCSK_SKI1_1	180	184	PF00082	0.212
CLV_PCSK_SKI1_1	72	76	PF00082	0.225
CLV_PCSK_SKI1_1	82	86	PF00082	0.225
CLV_Separin_Metazoa	166	170	PF03568	0.449
DEG_SPOP_SBC_1	2	6	PF00917	0.448
DOC_MAPK_RevD_3	203	219	PF00069	0.267
DOC_PP1_RVXF_1	70	76	PF00149	0.483
DOC_USP7_MATH_1	16	20	PF00917	0.584
DOC_USP7_MATH_1	2	6	PF00917	0.563
DOC_USP7_MATH_1	40	44	PF00917	0.505
DOC_USP7_UBL2_3	82	86	PF12436	0.478
DOC_WW_Pin1_4	100	105	PF00397	0.536
DOC_WW_Pin1_4	121	126	PF00397	0.535
DOC_WW_Pin1_4	18	23	PF00397	0.534
LIG_Clathr_ClatBox_1	7	11	PF01394	0.495
LIG_EH1_1	188	196	PF00400	0.479
LIG_FHA_1	138	144	PF00498	0.480
LIG_FHA_1	163	169	PF00498	0.391
LIG_FHA_2	158	164	PF00498	0.517
LIG_Integrin_RGD_1	154	156	PF01839	0.317
LIG_LIR_Gen_1	49	59	PF02991	0.492
LIG_LIR_Nem_3	49	54	PF02991	0.462
LIG_LIR_Nem_3	58	64	PF02991	0.392
LIG_PCNA_yPIPBox_3	71	82	PF02747	0.453
LIG_Pex14_2	85	89	PF04695	0.414
LIG_SH2_CRK	61	65	PF00017	0.402
LIG_SH2_GRB2like	69	72	PF00017	0.457
LIG_SH2_NCK_1	61	65	PF00017	0.366
LIG_SH2_STAP1	69	73	PF00017	0.534
LIG_Sin3_3	202	209	PF02671	0.182
LIG_TRAF2_1	124	127	PF00917	0.565
LIG_TYR_ITIM	59	64	PF00017	0.366
LIG_UBA3_1	78	86	PF00899	0.515
MOD_CK2_1	121	127	PF00069	0.549
MOD_CK2_1	147	153	PF00069	0.509
MOD_GlcNHglycan	137	140	PF01048	0.166
MOD_GlcNHglycan	65	68	PF01048	0.241
MOD_GSK3_1	109	116	PF00069	0.541
MOD_GSK3_1	16	23	PF00069	0.518
MOD_N-GLC_1	121	126	PF02516	0.427
MOD_NEK2_1	110	115	PF00069	0.484
MOD_NEK2_1	85	90	PF00069	0.434
MOD_Plk_1	16	22	PF00069	0.609
MOD_Plk_4	147	153	PF00069	0.490
MOD_Plk_4	3	9	PF00069	0.445
MOD_Plk_4	30	36	PF00069	0.607
MOD_ProDKin_1	100	106	PF00069	0.537
MOD_ProDKin_1	121	127	PF00069	0.542
MOD_ProDKin_1	18	24	PF00069	0.532
MOD_SUMO_rev_2	123	130	PF00179	0.555
MOD_SUMO_rev_2	33	43	PF00179	0.423
TRG_ENDOCYTIC_2	61	64	PF00928	0.388
TRG_NES_CRM1_1	45	58	PF08389	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P366	Leptomonas seymouri	24%	83%
A0A0N1I418	Leptomonas seymouri	26%	100%
A0A0N1IMB1	Leptomonas seymouri	73%	100%
A0A0S4IUW0	Bodo saltans	26%	100%
A0A0S4JCC4	Bodo saltans	49%	94%
A0A0S4JL59	Bodo saltans	21%	98%
A0A0S4JYF9	Bodo saltans	29%	100%
A0A1X0NF95	Trypanosomatidae	55%	99%
A0A1X0NQE9	Trypanosomatidae	25%	100%
A0A1X0NYJ8	Trypanosomatidae	25%	88%
A0A3S7WQ28	Leishmania donovani	28%	100%
A0A3S7X115	Leishmania donovani	93%	100%
A0A422N3E0	Trypanosoma rangeli	24%	100%
A0A422N7W7	Trypanosoma rangeli	26%	100%
A0A422NDY3	Trypanosoma rangeli	54%	99%
A4H570	Leishmania braziliensis	24%	100%
A4HG15	Leishmania braziliensis	78%	100%
A4HTF3	Leishmania infantum	28%	100%
A4I337	Leishmania infantum	93%	100%
C9ZJK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZPM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A159	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	92%
E9AM81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AZE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O23429	Arabidopsis thaliana	27%	99%
O48850	Arabidopsis thaliana	27%	77%
O49377	Arabidopsis thaliana	28%	100%
P22214	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
P47192	Arabidopsis thaliana	27%	100%
P51809	Homo sapiens	29%	100%
P70280	Mus musculus	29%	100%
Q17QI5	Bos taurus	29%	100%
Q4QIG6	Leishmania major	29%	100%
Q54NW7	Dictyostelium discoideum	24%	100%
Q5RF94	Pongo abelii	29%	100%
Q5ZL74	Gallus gallus	28%	100%
Q6C537	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	100%
Q6CJA0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	21%	100%
Q74ZD2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	21%	100%
Q86AQ7	Dictyostelium discoideum	24%	85%
Q8VY69	Arabidopsis thaliana	22%	100%
Q9FMR5	Arabidopsis thaliana	26%	100%
Q9JHW5	Rattus norvegicus	28%	100%
Q9LFP1	Arabidopsis thaliana	28%	100%
Q9M376	Arabidopsis thaliana	23%	92%
Q9MAS5	Arabidopsis thaliana	26%	100%
Q9SIQ9	Arabidopsis thaliana	29%	100%
Q9Y7L0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9ZTW3	Arabidopsis thaliana	27%	100%
V5BFM1	Trypanosoma cruzi	53%	99%