Sucrose-6-phosphate hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sucrose hydrolase-like protein

Species:

Leishmania major

UniProt:

E9ACV4_LEIMA

TriTrypDb:

LmjF.27.2340 , LMJLV39_270031200 , LMJSD75_270031100

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E9ACV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACV4

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	20
GO:0008152	metabolic process	1	20
GO:0044238	primary metabolic process	2	20
GO:0071704	organic substance metabolic process	2	20

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	20
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	20
GO:0004564	beta-fructofuranosidase activity	5	18
GO:0016787	hydrolase activity	2	20
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.334
CLV_NRD_NRD_1	291	293	PF00675	0.312
CLV_PCSK_KEX2_1	146	148	PF00082	0.240
CLV_PCSK_KEX2_1	291	293	PF00082	0.312
CLV_PCSK_KEX2_1	402	404	PF00082	0.316
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.240
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.316
CLV_PCSK_SKI1_1	291	295	PF00082	0.277
CLV_PCSK_SKI1_1	320	324	PF00082	0.240
DOC_CKS1_1	331	336	PF01111	0.306
DOC_CYCLIN_RxL_1	268	278	PF00134	0.227
DOC_CYCLIN_RxL_1	317	326	PF00134	0.289
DOC_MAPK_gen_1	179	189	PF00069	0.240
DOC_MAPK_gen_1	246	255	PF00069	0.195
DOC_MAPK_MEF2A_6	248	257	PF00069	0.197
DOC_MAPK_MEF2A_6	355	364	PF00069	0.227
DOC_PP2B_LxvP_1	316	319	PF13499	0.319
DOC_PP4_FxxP_1	160	163	PF00568	0.319
DOC_USP7_MATH_1	124	128	PF00917	0.329
DOC_USP7_UBL2_3	19	23	PF12436	0.324
DOC_WW_Pin1_4	231	236	PF00397	0.289
DOC_WW_Pin1_4	330	335	PF00397	0.316
LIG_14-3-3_CanoR_1	18	22	PF00244	0.338
LIG_14-3-3_CanoR_1	351	355	PF00244	0.258
LIG_14-3-3_CanoR_1	36	41	PF00244	0.176
LIG_14-3-3_CanoR_1	462	467	PF00244	0.376
LIG_APCC_ABBA_1	393	398	PF00400	0.240
LIG_BIR_II_1	1	5	PF00653	0.387
LIG_Clathr_ClatBox_1	374	378	PF01394	0.240
LIG_deltaCOP1_diTrp_1	196	203	PF00928	0.257
LIG_deltaCOP1_diTrp_1	91	99	PF00928	0.240
LIG_eIF4E_1	249	255	PF01652	0.240
LIG_eIF4E_1	369	375	PF01652	0.234
LIG_EVH1_2	153	157	PF00568	0.240
LIG_FHA_1	190	196	PF00498	0.282
LIG_FHA_1	200	206	PF00498	0.319
LIG_FHA_1	249	255	PF00498	0.264
LIG_FHA_1	311	317	PF00498	0.417
LIG_FHA_1	331	337	PF00498	0.398
LIG_FHA_1	470	476	PF00498	0.243
LIG_FHA_2	365	371	PF00498	0.299
LIG_FHA_2	474	480	PF00498	0.237
LIG_FHA_2	71	77	PF00498	0.305
LIG_HP1_1	319	323	PF01393	0.240
LIG_Integrin_RGD_1	477	479	PF01839	0.227
LIG_IRF3_LxIS_1	132	138	PF10401	0.257
LIG_KLC1_Yacidic_2	394	398	PF13176	0.417
LIG_LIR_Apic_2	158	163	PF02991	0.227
LIG_LIR_Apic_2	420	424	PF02991	0.240
LIG_LIR_Gen_1	162	169	PF02991	0.240
LIG_LIR_Gen_1	200	210	PF02991	0.319
LIG_LIR_LC3C_4	401	406	PF02991	0.257
LIG_LIR_Nem_3	108	114	PF02991	0.279
LIG_LIR_Nem_3	162	167	PF02991	0.297
LIG_LIR_Nem_3	169	175	PF02991	0.346
LIG_LIR_Nem_3	200	206	PF02991	0.319
LIG_LIR_Nem_3	24	29	PF02991	0.322
LIG_LIR_Nem_3	267	273	PF02991	0.317
LIG_LIR_Nem_3	416	421	PF02991	0.240
LIG_PTB_Apo_2	404	411	PF02174	0.316
LIG_PTB_Phospho_1	404	410	PF10480	0.316
LIG_Rb_pABgroove_1	358	366	PF01858	0.439
LIG_Rb_pABgroove_1	369	377	PF01858	0.202
LIG_SH2_CRK	421	425	PF00017	0.240
LIG_SH2_NCK_1	421	425	PF00017	0.227
LIG_SH2_STAP1	106	110	PF00017	0.253
LIG_SH2_STAP1	369	373	PF00017	0.312
LIG_SH2_STAT3	130	133	PF00017	0.299
LIG_SH2_STAT3	280	283	PF00017	0.319
LIG_SH2_STAT3	55	58	PF00017	0.237
LIG_SH2_STAT5	111	114	PF00017	0.319
LIG_SH2_STAT5	164	167	PF00017	0.297
LIG_SH2_STAT5	348	351	PF00017	0.227
LIG_SH2_STAT5	396	399	PF00017	0.417
LIG_SH2_STAT5	434	437	PF00017	0.250
LIG_SH2_STAT5	46	49	PF00017	0.252
LIG_SH3_3	147	153	PF00018	0.319
LIG_SUMO_SIM_par_1	320	326	PF11976	0.240
LIG_UBA3_1	253	259	PF00899	0.207
MOD_CDK_SPxxK_3	330	337	PF00069	0.304
MOD_CK1_1	100	106	PF00069	0.274
MOD_CK1_1	265	271	PF00069	0.270
MOD_CK2_1	204	210	PF00069	0.237
MOD_CK2_1	364	370	PF00069	0.316
MOD_CK2_1	377	383	PF00069	0.317
MOD_CK2_1	435	441	PF00069	0.316
MOD_CK2_1	69	75	PF00069	0.227
MOD_Cter_Amidation	289	292	PF01082	0.279
MOD_GlcNHglycan	325	330	PF01048	0.261
MOD_GlcNHglycan	38	41	PF01048	0.247
MOD_GlcNHglycan	415	418	PF01048	0.316
MOD_GlcNHglycan	99	102	PF01048	0.309
MOD_GSK3_1	262	269	PF00069	0.277
MOD_GSK3_1	310	317	PF00069	0.327
MOD_GSK3_1	413	420	PF00069	0.316
MOD_GSK3_1	469	476	PF00069	0.315
MOD_N-GLC_1	355	360	PF02516	0.252
MOD_N-GLC_1	469	474	PF02516	0.372
MOD_N-GLC_1	483	488	PF02516	0.302
MOD_NEK2_1	204	209	PF00069	0.264
MOD_NEK2_1	264	269	PF00069	0.289
MOD_NEK2_1	34	39	PF00069	0.202
MOD_NEK2_1	364	369	PF00069	0.304
MOD_NEK2_1	377	382	PF00069	0.388
MOD_NEK2_1	435	440	PF00069	0.247
MOD_NEK2_1	483	488	PF00069	0.452
MOD_NEK2_1	99	104	PF00069	0.319
MOD_NEK2_2	350	355	PF00069	0.227
MOD_PIKK_1	124	130	PF00454	0.257
MOD_PIKK_1	355	361	PF00454	0.234
MOD_PKA_2	17	23	PF00069	0.318
MOD_PKA_2	178	184	PF00069	0.240
MOD_PKA_2	350	356	PF00069	0.254
MOD_PKB_1	246	254	PF00069	0.289
MOD_Plk_1	124	130	PF00069	0.257
MOD_Plk_1	198	204	PF00069	0.240
MOD_Plk_1	355	361	PF00069	0.281
MOD_Plk_1	364	370	PF00069	0.342
MOD_Plk_1	435	441	PF00069	0.320
MOD_Plk_1	483	489	PF00069	0.346
MOD_Plk_2-3	365	371	PF00069	0.247
MOD_Plk_2-3	436	442	PF00069	0.316
MOD_Plk_4	100	106	PF00069	0.214
MOD_Plk_4	199	205	PF00069	0.240
MOD_Plk_4	281	287	PF00069	0.372
MOD_Plk_4	462	468	PF00069	0.249
MOD_Plk_4	483	489	PF00069	0.408
MOD_ProDKin_1	231	237	PF00069	0.289
MOD_ProDKin_1	330	336	PF00069	0.313
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.266
TRG_ENDOCYTIC_2	164	167	PF00928	0.297
TRG_ENDOCYTIC_2	434	437	PF00928	0.257
TRG_ENDOCYTIC_2	51	54	PF00928	0.319
TRG_ER_diArg_1	245	248	PF00400	0.319
TRG_ER_diArg_1	291	293	PF00400	0.312
TRG_NES_CRM1_1	128	139	PF08389	0.240
TRG_NES_CRM1_1	426	441	PF08389	0.365
TRG_Pf-PMV_PEXEL_1	320	325	PF00026	0.289

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8F7	Leptomonas seymouri	81%	100%
A0A1X0NFY9	Trypanosomatidae	24%	100%
A0A1X0NTL0	Trypanosomatidae	24%	77%
A0A1X0NTM3	Trypanosomatidae	22%	77%
A0A1X0NY19	Trypanosomatidae	25%	77%
A0A1X0P322	Trypanosomatidae	24%	77%
A0A1X0P5Y7	Trypanosomatidae	25%	76%
A0A3Q8IB13	Leishmania donovani	49%	89%
A0A3Q8IFU7	Leishmania donovani	52%	93%
A0A3S5H595	Leishmania donovani	23%	76%
A0A3S5H7I4	Leishmania donovani	95%	100%
A0A3S7WXQ4	Leishmania donovani	52%	95%
A0A3S7WXS2	Leishmania donovani	52%	93%
A1STJ9	Psychromonas ingrahamii (strain 37)	33%	90%
A2R0E0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	26%	91%
A2X5P7	Oryza sativa subsp. indica	25%	85%
A2YZ01	Oryza sativa subsp. indica	23%	82%
A4H3V1	Leishmania braziliensis	25%	76%
A4HCV9	Leishmania braziliensis	50%	90%
A4HCW0	Leishmania braziliensis	51%	100%
A4HG14	Leishmania braziliensis	85%	100%
A4HS26	Leishmania infantum	23%	76%
A4I0D9	Leishmania infantum	50%	89%
A4I0E0	Leishmania infantum	51%	95%
A4I336	Leishmania infantum	95%	100%
A4IAW1	Leishmania infantum	26%	70%
A5ABL2	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	26%	95%
A5DHM6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	23%	95%
A5EZZ8	Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)	30%	90%
A8W7I5	Meyerozyma guilliermondii	23%	95%
B6DXP5	Leymus chinensis	25%	82%
B6DZC8	Triticum aestivum	25%	82%
B6DZD0	Triticum urartu	24%	82%
B6DZD1	Aegilops speltoides	24%	82%
B6DZD2	Aegilops tauschii	25%	82%
D2IGW7	Bromus pictus	24%	81%
E1ABX2	Aspergillus ficuum	26%	91%
E8NHF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	93%
E8NHF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9AK13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	77%
E9AWA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9AZE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
F8DVG5	Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 / NCIMB 8938 / NRRL B-806 / ZM1)	37%	96%
H2DF87	Rosa hybrid cultivar	25%	83%
H2DF88	Rosa hybrid cultivar	24%	76%
K0E681	Aspergillus rugulosus	24%	96%
O07003	Bacillus subtilis (strain 168)	26%	95%
O24509	Phaseolus vulgaris	27%	75%
O33833	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	32%	100%
O42878	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	96%
O59852	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	84%
O74641	Aspergillus niger	26%	95%
O74642	Aspergillus niger	26%	95%
O94220	Aspergillus ficuum	27%	95%
P05656	Bacillus subtilis (strain 168)	29%	72%
P07819	Bacillus subtilis (strain 168)	35%	100%
P0DJA7	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	37%	96%
P10594	Saccharomyces cerevisiae	22%	92%
P10596	Saccharomyces cerevisiae	25%	92%
P13394	Vibrio alginolyticus	28%	100%
P13522	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	27%	100%
P16553	Escherichia coli	48%	100%
P24133	Schwanniomyces occidentalis	27%	92%
P26792	Daucus carota	25%	83%
P27217	Klebsiella pneumoniae	32%	100%
P29000	Solanum lycopersicum	24%	77%
P29001	Vigna radiata var. radiata	26%	75%
P37075	Salmonella typhimurium	32%	100%
P40714	Escherichia coli	46%	100%
P40912	Wickerhamomyces anomalus	25%	89%
P43471	Pediococcus pentosaceus	25%	98%
P49174	Zea mays	27%	83%
P49175	Zea mays	25%	73%
P80065	Daucus carota	24%	74%
P92916	Allium cepa	26%	80%
P93761	Capsicum annuum	25%	76%
P94469	Geobacillus stearothermophilus	26%	100%
Q01IS7	Oryza sativa subsp. indica	26%	82%
Q01IS8	Oryza sativa subsp. indica	23%	83%
Q04937	Lactococcus lactis subsp. lactis	26%	100%
Q05936	Staphylococcus xylosus	30%	99%
Q0E0P0	Oryza sativa subsp. japonica	25%	85%
Q0J360	Oryza sativa subsp. japonica	26%	82%
Q0JDC5	Oryza sativa subsp. japonica	26%	82%
Q0JDC6	Oryza sativa subsp. japonica	23%	83%
Q1PEF8	Arabidopsis thaliana	24%	83%
Q2UXF7	Triticum aestivum	26%	82%
Q39041	Arabidopsis thaliana	27%	74%
Q39692	Daucus carota	27%	83%
Q39693	Daucus carota	25%	84%
Q43089	Pisum sativum	24%	88%
Q43348	Arabidopsis thaliana	26%	75%
Q43857	Vicia faba	23%	76%
Q43866	Arabidopsis thaliana	24%	84%
Q4QB75	Leishmania major	52%	95%
Q4QB76	Leishmania major	50%	89%
Q56660	Vibrio cholerae	30%	90%
Q56UD0	Oryza sativa subsp. japonica	27%	82%
Q56UD1	Oryza sativa subsp. japonica	24%	90%
Q5FC15	Asparagus officinalis	24%	80%
Q5JJV0	Oryza sativa subsp. japonica	23%	83%
Q67XZ3	Arabidopsis thaliana	27%	82%
Q6BJW6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	24%	92%
Q70AT7	Hordeum vulgare	24%	82%
Q70XE6	Beta vulgaris	27%	81%
Q76HP6	Aspergillus niger	26%	91%
Q84LA1	Triticum aestivum	24%	82%
Q84PN8	Triticum aestivum	24%	82%
Q8W413	Arabidopsis thaliana	27%	83%
Q8W4S6	Arabidopsis thaliana	27%	89%
Q96TU3	Aspergillus awamori	25%	91%
Q9FSV7	Festuca arundinacea	26%	75%
Q9KLT6	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	30%	89%
Q9LIB9	Arabidopsis thaliana	28%	85%
Q9XTP3	Leishmania major	23%	76%