Glutaredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9ACV3_LEIMA

TriTrypDb:

LmjF.27.2337

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACV3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.577
CLV_NRD_NRD_1	101	103	PF00675	0.486
CLV_NRD_NRD_1	154	156	PF00675	0.585
CLV_NRD_NRD_1	204	206	PF00675	0.554
CLV_NRD_NRD_1	214	216	PF00675	0.461
CLV_NRD_NRD_1	253	255	PF00675	0.520
CLV_NRD_NRD_1	264	266	PF00675	0.442
CLV_NRD_NRD_1	69	71	PF00675	0.609
CLV_NRD_NRD_1	85	87	PF00675	0.429
CLV_PCSK_FUR_1	99	103	PF00082	0.609
CLV_PCSK_KEX2_1	101	103	PF00082	0.591
CLV_PCSK_KEX2_1	154	156	PF00082	0.515
CLV_PCSK_KEX2_1	204	206	PF00082	0.549
CLV_PCSK_KEX2_1	214	216	PF00082	0.459
CLV_PCSK_KEX2_1	252	254	PF00082	0.515
CLV_PCSK_KEX2_1	264	266	PF00082	0.438
CLV_PCSK_KEX2_1	69	71	PF00082	0.609
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.549
CLV_PCSK_SKI1_1	101	105	PF00082	0.615
CLV_PCSK_SKI1_1	138	142	PF00082	0.541
CLV_PCSK_SKI1_1	20	24	PF00082	0.547
CLV_PCSK_SKI1_1	245	249	PF00082	0.464
CLV_PCSK_SKI1_1	254	258	PF00082	0.455
CLV_PCSK_SKI1_1	341	345	PF00082	0.648
DEG_Nend_UBRbox_2	1	3	PF02207	0.609
DEG_SCF_FBW7_1	140	145	PF00400	0.529
DOC_CKS1_1	176	181	PF01111	0.521
DOC_CYCLIN_RxL_1	252	260	PF00134	0.508
DOC_CYCLIN_RxL_1	99	107	PF00134	0.615
DOC_MAPK_DCC_7	99	108	PF00069	0.573
DOC_MAPK_gen_1	118	128	PF00069	0.504
DOC_MAPK_gen_1	252	259	PF00069	0.510
DOC_MAPK_gen_1	99	108	PF00069	0.617
DOC_MAPK_MEF2A_6	174	183	PF00069	0.523
DOC_MAPK_MEF2A_6	99	108	PF00069	0.617
DOC_MAPK_NFAT4_5	101	109	PF00069	0.624
DOC_PP1_RVXF_1	18	25	PF00149	0.461
DOC_PP1_RVXF_1	252	259	PF00149	0.494
DOC_PP1_RVXF_1	90	96	PF00149	0.584
DOC_PP2B_LxvP_1	126	129	PF13499	0.516
DOC_PP4_FxxP_1	183	186	PF00568	0.555
DOC_SPAK_OSR1_1	112	116	PF12202	0.604
DOC_USP7_MATH_1	142	146	PF00917	0.724
DOC_USP7_MATH_1	291	295	PF00917	0.577
DOC_USP7_MATH_1	324	328	PF00917	0.600
DOC_USP7_MATH_1	60	64	PF00917	0.542
DOC_WW_Pin1_4	138	143	PF00397	0.559
DOC_WW_Pin1_4	175	180	PF00397	0.523
LIG_14-3-3_CanoR_1	264	268	PF00244	0.556
LIG_14-3-3_CanoR_1	275	279	PF00244	0.435
LIG_14-3-3_CanoR_1	299	309	PF00244	0.518
LIG_14-3-3_CanoR_1	369	373	PF00244	0.595
LIG_14-3-3_CanoR_1	43	52	PF00244	0.536
LIG_Actin_WH2_2	232	250	PF00022	0.527
LIG_AP2alpha_1	282	286	PF02296	0.549
LIG_APCC_ABBAyCdc20_2	254	260	PF00400	0.418
LIG_BRCT_BRCA1_1	26	30	PF00533	0.601
LIG_BRCT_BRCA1_1	282	286	PF00533	0.490
LIG_CaM_IQ_9	196	211	PF13499	0.494
LIG_CtBP_PxDLS_1	105	109	PF00389	0.590
LIG_deltaCOP1_diTrp_1	284	288	PF00928	0.528
LIG_FHA_1	1	7	PF00498	0.554
LIG_FHA_1	141	147	PF00498	0.552
LIG_FHA_1	176	182	PF00498	0.639
LIG_FHA_1	197	203	PF00498	0.459
LIG_FHA_1	310	316	PF00498	0.551
LIG_FHA_1	326	332	PF00498	0.562
LIG_FHA_1	47	53	PF00498	0.564
LIG_FHA_2	27	33	PF00498	0.557
LIG_FHA_2	275	281	PF00498	0.550
LIG_FHA_2	357	363	PF00498	0.578
LIG_FHA_2	66	72	PF00498	0.593
LIG_LIR_Apic_2	180	186	PF02991	0.560
LIG_LIR_Gen_1	10	19	PF02991	0.525
LIG_LIR_Gen_1	273	282	PF02991	0.486
LIG_LIR_Nem_3	10	15	PF02991	0.519
LIG_LIR_Nem_3	273	279	PF02991	0.488
LIG_LIR_Nem_3	283	289	PF02991	0.515
LIG_LIR_Nem_3	333	339	PF02991	0.614
LIG_LIR_Nem_3	35	40	PF02991	0.427
LIG_MAD2	121	129	PF02301	0.510
LIG_NRBOX	78	84	PF00104	0.529
LIG_Pex14_2	282	286	PF04695	0.549
LIG_Pex14_2	37	41	PF04695	0.546
LIG_REV1ctd_RIR_1	284	292	PF16727	0.613
LIG_SH2_CRK	336	340	PF00017	0.618
LIG_SH2_NCK_1	61	65	PF00017	0.515
LIG_SH2_STAP1	166	170	PF00017	0.634
LIG_SH2_STAP1	398	402	PF00017	0.550
LIG_SH3_3	336	342	PF00018	0.663
LIG_SUMO_SIM_par_1	2	11	PF11976	0.584
LIG_TRAF2_1	269	272	PF00917	0.402
LIG_TYR_ITIM	59	64	PF00017	0.534
LIG_UBA3_1	52	57	PF00899	0.592
LIG_UBA3_1	78	87	PF00899	0.527
LIG_WRC_WIRS_1	34	39	PF05994	0.585
LIG_WRC_WIRS_1	9	14	PF05994	0.511
MOD_CK1_1	124	130	PF00069	0.677
MOD_CK1_1	144	150	PF00069	0.609
MOD_CK1_1	270	276	PF00069	0.568
MOD_CK1_1	294	300	PF00069	0.569
MOD_CK1_1	327	333	PF00069	0.658
MOD_CK1_1	401	407	PF00069	0.492
MOD_CK1_1	46	52	PF00069	0.492
MOD_CK2_1	274	280	PF00069	0.553
MOD_CK2_1	41	47	PF00069	0.595
MOD_CK2_1	65	71	PF00069	0.519
MOD_CMANNOS	298	301	PF00535	0.610
MOD_Cter_Amidation	262	265	PF01082	0.526
MOD_GlcNHglycan	166	169	PF01048	0.588
MOD_GlcNHglycan	231	234	PF01048	0.517
MOD_GSK3_1	117	124	PF00069	0.654
MOD_GSK3_1	138	145	PF00069	0.632
MOD_GSK3_1	22	29	PF00069	0.703
MOD_GSK3_1	263	270	PF00069	0.551
MOD_GSK3_1	327	334	PF00069	0.627
MOD_GSK3_1	397	404	PF00069	0.611
MOD_N-GLC_1	280	285	PF02516	0.494
MOD_N-GLC_1	318	323	PF02516	0.474
MOD_NEK2_1	146	151	PF00069	0.688
MOD_NEK2_1	229	234	PF00069	0.511
MOD_NEK2_1	24	29	PF00069	0.438
MOD_NEK2_1	247	252	PF00069	0.360
MOD_NEK2_1	274	279	PF00069	0.548
MOD_NEK2_1	309	314	PF00069	0.514
MOD_NEK2_1	368	373	PF00069	0.550
MOD_NEK2_1	5	10	PF00069	0.582
MOD_NEK2_1	73	78	PF00069	0.547
MOD_NEK2_2	398	403	PF00069	0.552
MOD_PIKK_1	196	202	PF00454	0.486
MOD_PIKK_1	291	297	PF00454	0.571
MOD_PIKK_1	302	308	PF00454	0.535
MOD_PKA_2	117	123	PF00069	0.655
MOD_PKA_2	263	269	PF00069	0.555
MOD_PKA_2	274	280	PF00069	0.440
MOD_PKA_2	324	330	PF00069	0.668
MOD_PKA_2	368	374	PF00069	0.552
MOD_PKB_1	316	324	PF00069	0.511
MOD_Plk_1	270	276	PF00069	0.568
MOD_Plk_1	398	404	PF00069	0.551
MOD_Plk_2-3	26	32	PF00069	0.579
MOD_Plk_4	33	39	PF00069	0.544
MOD_Plk_4	368	374	PF00069	0.552
MOD_Plk_4	48	54	PF00069	0.479
MOD_Plk_4	73	79	PF00069	0.527
MOD_ProDKin_1	138	144	PF00069	0.558
MOD_ProDKin_1	175	181	PF00069	0.522
MOD_SUMO_rev_2	116	123	PF00179	0.495
MOD_SUMO_rev_2	187	194	PF00179	0.599
MOD_SUMO_rev_2	81	88	PF00179	0.503
TRG_DiLeu_BaEn_2	25	31	PF01217	0.552
TRG_ENDOCYTIC_2	336	339	PF00928	0.618
TRG_ENDOCYTIC_2	61	64	PF00928	0.545
TRG_ER_diArg_1	14	17	PF00400	0.511
TRG_ER_diArg_1	153	155	PF00400	0.657
TRG_ER_diArg_1	213	215	PF00400	0.541
TRG_ER_diArg_1	251	254	PF00400	0.494
TRG_ER_diArg_1	315	318	PF00400	0.578
TRG_ER_diArg_1	99	102	PF00400	0.579
TRG_NES_CRM1_1	72	85	PF08389	0.569
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T5	Leptomonas seymouri	27%	99%
A0A3Q8IEE0	Leishmania donovani	89%	100%
A4HG13	Leishmania braziliensis	64%	100%
E9AHG2	Leishmania infantum	88%	100%
E9AZE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%