Obg-like ATPase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Obg-like ATPase 1

Gene product:

GTP binding protein, putative

Species:

Leishmania major

UniProt:

E9ACV1_LEIMA

TriTrypDb:

LmjF.27.2330 , LMJLV39_270030900 , LMJSD75_270030800

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9ACV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACV1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043021	ribonucleoprotein complex binding	3	12
GO:0043022	ribosome binding	4	12
GO:0043023	ribosomal large subunit binding	4	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0044877	protein-containing complex binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	373	377	PF00656	0.318
CLV_PCSK_SKI1_1	12	16	PF00082	0.491
CLV_PCSK_SKI1_1	190	194	PF00082	0.456
CLV_PCSK_SKI1_1	240	244	PF00082	0.488
CLV_PCSK_SKI1_1	291	295	PF00082	0.365
DOC_MAPK_HePTP_8	15	27	PF00069	0.397
DOC_MAPK_MEF2A_6	18	27	PF00069	0.407
DOC_PP1_RVXF_1	205	212	PF00149	0.399
DOC_USP7_UBL2_3	240	244	PF12436	0.390
DOC_USP7_UBL2_3	388	392	PF12436	0.520
DOC_USP7_UBL2_3	4	8	PF12436	0.631
DOC_WW_Pin1_4	165	170	PF00397	0.418
DOC_WW_Pin1_4	269	274	PF00397	0.449
LIG_APCC_ABBA_1	124	129	PF00400	0.461
LIG_BRCT_BRCA1_1	35	39	PF00533	0.449
LIG_deltaCOP1_diTrp_1	346	350	PF00928	0.422
LIG_FHA_1	11	17	PF00498	0.484
LIG_FHA_1	166	172	PF00498	0.386
LIG_FHA_1	212	218	PF00498	0.345
LIG_FHA_1	264	270	PF00498	0.491
LIG_FHA_1	59	65	PF00498	0.449
LIG_FHA_2	131	137	PF00498	0.449
LIG_FHA_2	331	337	PF00498	0.359
LIG_FXI_DFP_1	347	351	PF00024	0.369
LIG_LIR_Gen_1	265	276	PF02991	0.431
LIG_LIR_Gen_1	295	305	PF02991	0.326
LIG_LIR_Gen_1	346	353	PF02991	0.310
LIG_LIR_Gen_1	36	47	PF02991	0.449
LIG_LIR_Gen_1	68	77	PF02991	0.449
LIG_LIR_Nem_3	295	300	PF02991	0.338
LIG_LIR_Nem_3	346	350	PF02991	0.310
LIG_LIR_Nem_3	36	42	PF02991	0.449
LIG_LIR_Nem_3	378	384	PF02991	0.318
LIG_LIR_Nem_3	68	74	PF02991	0.449
LIG_MLH1_MIPbox_1	35	39	PF16413	0.422
LIG_Pex14_2	302	306	PF04695	0.215
LIG_REV1ctd_RIR_1	379	387	PF16727	0.318
LIG_SH2_CRK	297	301	PF00017	0.341
LIG_SH2_NCK_1	297	301	PF00017	0.450
LIG_SH2_STAT3	234	237	PF00017	0.500
LIG_SH2_STAT3	372	375	PF00017	0.318
LIG_SH2_STAT5	234	237	PF00017	0.446
LIG_SH2_STAT5	279	282	PF00017	0.469
LIG_SH2_STAT5	305	308	PF00017	0.318
LIG_SH3_3	25	31	PF00018	0.449
LIG_SH3_3	253	259	PF00018	0.439
LIG_SUMO_SIM_anti_2	144	151	PF11976	0.354
LIG_TYR_ITSM	293	300	PF00017	0.374
LIG_UBA3_1	148	155	PF00899	0.350
MOD_CK1_1	112	118	PF00069	0.510
MOD_CK2_1	130	136	PF00069	0.449
MOD_CK2_1	269	275	PF00069	0.447
MOD_CK2_1	330	336	PF00069	0.302
MOD_CK2_1	98	104	PF00069	0.449
MOD_Cter_Amidation	389	392	PF01082	0.511
MOD_GlcNHglycan	260	263	PF01048	0.355
MOD_GSK3_1	109	116	PF00069	0.554
MOD_N-GLC_1	227	232	PF02516	0.358
MOD_NEK2_1	175	180	PF00069	0.468
MOD_NEK2_1	211	216	PF00069	0.390
MOD_NEK2_2	34	39	PF00069	0.458
MOD_PIKK_1	284	290	PF00454	0.389
MOD_PK_1	79	85	PF00069	0.461
MOD_PKA_2	319	325	PF00069	0.302
MOD_Plk_1	130	136	PF00069	0.449
MOD_Plk_4	10	16	PF00069	0.551
MOD_Plk_4	159	165	PF00069	0.382
MOD_Plk_4	295	301	PF00069	0.407
MOD_Plk_4	34	40	PF00069	0.449
MOD_Plk_4	79	85	PF00069	0.461
MOD_ProDKin_1	165	171	PF00069	0.416
MOD_ProDKin_1	269	275	PF00069	0.450
MOD_SUMO_rev_2	194	199	PF00179	0.514
MOD_SUMO_rev_2	275	285	PF00179	0.504
MOD_SUMO_rev_2	7	14	PF00179	0.696
TRG_ENDOCYTIC_2	297	300	PF00928	0.338
TRG_ER_diArg_1	235	238	PF00400	0.419
TRG_NES_CRM1_1	138	151	PF08389	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD45	Leptomonas seymouri	32%	100%
A0A0N1PG70	Leptomonas seymouri	90%	100%
A0A0S4JQA1	Bodo saltans	79%	100%
A0A0S4JQX4	Bodo saltans	32%	100%
A0A1X0NR20	Trypanosomatidae	81%	99%
A0A1X0NSW3	Trypanosomatidae	34%	100%
A0A3R7MAR4	Trypanosoma rangeli	80%	99%
A0A3R7MNI8	Trypanosoma rangeli	33%	100%
A0A3S7X0V3	Leishmania donovani	35%	100%
A0A3S7X112	Leishmania donovani	97%	100%
A0JPJ7	Rattus norvegicus	55%	99%
A4HFV7	Leishmania braziliensis	34%	100%
A4HG11	Leishmania braziliensis	95%	100%
A4I2Y9	Leishmania infantum	35%	100%
A4I330	Leishmania infantum	97%	100%
B8BBN7	Oryza sativa subsp. indica	56%	99%
C9ZJD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZJK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	99%
E9ADG1	Leishmania major	34%	100%
E9AZ85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AZE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O13998	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	100%
O14078	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	96%
P0ABU2	Escherichia coli (strain K12)	41%	100%
P0ABU3	Escherichia coli O157:H7	41%	100%
P0ABU4	Shigella flexneri	41%	100%
P37518	Bacillus subtilis (strain 168)	40%	100%
P38219	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	99%
P38746	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	97%
P44681	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	41%	100%
P47270	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	38%	100%
P57288	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	38%	100%
P75088	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	38%	100%
P91917	Caenorhabditis elegans	57%	99%
Q2HJ33	Bos taurus	55%	99%
Q58728	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	27%	100%
Q5R821	Pongo abelii	54%	99%
Q5ZM25	Gallus gallus	55%	99%
Q66JG0	Xenopus tropicalis	54%	99%
Q6Z1J6	Oryza sativa subsp. japonica	56%	99%
Q7VMI2	Haemophilus ducreyi (strain 35000HP / ATCC 700724)	41%	100%
Q7ZU42	Danio rerio	56%	99%
Q7ZWM6	Xenopus laevis	54%	99%
Q89AR6	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	36%	100%
Q8K9V2	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	38%	100%
Q8SWU7	Drosophila melanogaster	54%	99%
Q9CP90	Pasteurella multocida (strain Pm70)	41%	100%
Q9CZ30	Mus musculus	54%	99%
Q9NTK5	Homo sapiens	55%	99%
Q9SA73	Arabidopsis thaliana	55%	99%
V5AYP1	Trypanosoma cruzi	34%	91%
V5B8C6	Trypanosoma cruzi	81%	99%