LeishMANIAdb
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Protein phosphatase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein phosphatase-like protein
Gene product:
protein phosphatase 2C, putative
Species:
Leishmania major
UniProt:
E9ACV0_LEIMA
TriTrypDb:
LmjF.27.2320 , LMJLV39_270030800 , LMJSD75_270030700
Length:
314

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0031974 membrane-enclosed lumen 2 2
GO:0031981 nuclear lumen 5 2
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 2
GO:0043233 organelle lumen 3 2
GO:0070013 intracellular organelle lumen 4 2
GO:0097014 ciliary plasm 5 2
GO:0099568 cytoplasmic region 3 2
GO:0110165 cellular anatomical entity 1 4
GO:0016020 membrane 2 2

Expansion

Sequence features

E9ACV0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACV0

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 14
GO:0006793 phosphorus metabolic process 3 14
GO:0006796 phosphate-containing compound metabolic process 4 14
GO:0006807 nitrogen compound metabolic process 2 14
GO:0008152 metabolic process 1 14
GO:0009987 cellular process 1 14
GO:0016311 dephosphorylation 5 14
GO:0019538 protein metabolic process 3 14
GO:0036211 protein modification process 4 14
GO:0043170 macromolecule metabolic process 3 14
GO:0043412 macromolecule modification 4 14
GO:0044237 cellular metabolic process 2 14
GO:0044238 primary metabolic process 2 14
GO:0071704 organic substance metabolic process 2 14
GO:1901564 organonitrogen compound metabolic process 3 14
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 14
GO:0004721 phosphoprotein phosphatase activity 3 14
GO:0004722 protein serine/threonine phosphatase activity 4 14
GO:0016787 hydrolase activity 2 14
GO:0016788 hydrolase activity, acting on ester bonds 3 14
GO:0016791 phosphatase activity 5 14
GO:0042578 phosphoric ester hydrolase activity 4 14
GO:0140096 catalytic activity, acting on a protein 2 14
GO:0017018 myosin phosphatase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 97 101 PF00656 0.397
CLV_PCSK_SKI1_1 109 113 PF00082 0.334
CLV_PCSK_SKI1_1 154 158 PF00082 0.259
CLV_PCSK_SKI1_1 180 184 PF00082 0.305
CLV_PCSK_SKI1_1 300 304 PF00082 0.393
DEG_SCF_FBW7_2 231 236 PF00400 0.282
DOC_CYCLIN_RxL_1 297 308 PF00134 0.474
DOC_MAPK_MEF2A_6 214 222 PF00069 0.397
DOC_MAPK_RevD_3 292 306 PF00069 0.448
DOC_PP1_RVXF_1 251 258 PF00149 0.352
DOC_PP2B_LxvP_1 56 59 PF13499 0.259
DOC_USP7_MATH_1 36 40 PF00917 0.448
DOC_USP7_UBL2_3 306 310 PF12436 0.455
DOC_WW_Pin1_4 16 21 PF00397 0.377
DOC_WW_Pin1_4 220 225 PF00397 0.301
DOC_WW_Pin1_4 229 234 PF00397 0.232
DOC_WW_Pin1_4 280 285 PF00397 0.419
LIG_14-3-3_CanoR_1 35 44 PF00244 0.280
LIG_14-3-3_CanoR_1 45 49 PF00244 0.226
LIG_Actin_WH2_2 289 307 PF00022 0.339
LIG_APCC_ABBA_1 231 236 PF00400 0.256
LIG_BRCT_BRCA1_1 199 203 PF00533 0.345
LIG_deltaCOP1_diTrp_1 94 102 PF00928 0.294
LIG_FHA_1 11 17 PF00498 0.549
LIG_FHA_1 115 121 PF00498 0.424
LIG_FHA_1 221 227 PF00498 0.412
LIG_FHA_1 291 297 PF00498 0.286
LIG_FHA_2 230 236 PF00498 0.275
LIG_FHA_2 45 51 PF00498 0.259
LIG_FHA_2 95 101 PF00498 0.294
LIG_LIR_Gen_1 23 29 PF02991 0.413
LIG_LIR_Gen_1 235 245 PF02991 0.243
LIG_LIR_Nem_3 200 206 PF02991 0.319
LIG_LIR_Nem_3 23 28 PF02991 0.438
LIG_LIR_Nem_3 235 240 PF02991 0.243
LIG_Pex14_2 299 303 PF04695 0.342
LIG_PTB_Apo_2 140 147 PF02174 0.275
LIG_PTB_Phospho_1 140 146 PF10480 0.275
LIG_SH2_CRK 25 29 PF00017 0.391
LIG_SH2_STAP1 25 29 PF00017 0.370
LIG_SH2_STAT5 115 118 PF00017 0.400
LIG_SH2_STAT5 146 149 PF00017 0.250
LIG_SH2_STAT5 55 58 PF00017 0.352
LIG_SH3_3 169 175 PF00018 0.259
LIG_SH3_3 56 62 PF00018 0.262
LIG_SUMO_SIM_anti_2 293 298 PF11976 0.249
LIG_SUMO_SIM_par_1 13 19 PF11976 0.440
LIG_SUMO_SIM_par_1 195 200 PF11976 0.246
LIG_UBA3_1 294 300 PF00899 0.277
MOD_CDC14_SPxK_1 19 22 PF00782 0.346
MOD_CDK_SPxK_1 16 22 PF00069 0.432
MOD_CK1_1 131 137 PF00069 0.261
MOD_CK1_1 282 288 PF00069 0.473
MOD_CK2_1 43 49 PF00069 0.275
MOD_GlcNHglycan 129 133 PF01048 0.250
MOD_GlcNHglycan 311 314 PF01048 0.676
MOD_GSK3_1 12 19 PF00069 0.442
MOD_GSK3_1 279 286 PF00069 0.405
MOD_N-GLC_1 290 295 PF02516 0.252
MOD_N-GLC_2 277 279 PF02516 0.397
MOD_NEK2_1 197 202 PF00069 0.235
MOD_NEK2_1 218 223 PF00069 0.377
MOD_NEK2_1 84 89 PF00069 0.324
MOD_PIKK_1 10 16 PF00454 0.507
MOD_PKA_2 44 50 PF00069 0.235
MOD_Plk_1 209 215 PF00069 0.362
MOD_Plk_1 266 272 PF00069 0.275
MOD_Plk_1 290 296 PF00069 0.251
MOD_Plk_4 12 18 PF00069 0.465
MOD_Plk_4 23 29 PF00069 0.392
MOD_Plk_4 290 296 PF00069 0.258
MOD_Plk_4 298 304 PF00069 0.294
MOD_ProDKin_1 16 22 PF00069 0.379
MOD_ProDKin_1 220 226 PF00069 0.301
MOD_ProDKin_1 229 235 PF00069 0.232
MOD_ProDKin_1 280 286 PF00069 0.419
MOD_SUMO_rev_2 167 173 PF00179 0.236
MOD_SUMO_rev_2 26 34 PF00179 0.351
TRG_ENDOCYTIC_2 25 28 PF00928 0.429
TRG_ENDOCYTIC_2 55 58 PF00928 0.347

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5C7 Leptomonas seymouri 39% 79%
A0A0N0P8F8 Leptomonas seymouri 87% 100%
A0A0N1I0H9 Leptomonas seymouri 41% 100%
A0A0N1I8W9 Leptomonas seymouri 30% 72%
A0A0N1IHU6 Leptomonas seymouri 30% 77%
A0A0N1PAL8 Leptomonas seymouri 32% 82%
A0A0N1PEL9 Leptomonas seymouri 32% 84%
A0A0S4IY95 Bodo saltans 52% 87%
A0A0S4J0A6 Bodo saltans 30% 77%
A0A0S4JHB4 Bodo saltans 28% 82%
A0A0S4JPC3 Bodo saltans 42% 100%
A0A0S4JPM8 Bodo saltans 40% 83%
A0A0S4KIS4 Bodo saltans 41% 69%
A0A0S4KJV9 Bodo saltans 46% 73%
A0A1X0NRG3 Trypanosomatidae 68% 99%
A0A1X0NVC4 Trypanosomatidae 40% 76%
A0A1X0P2A0 Trypanosomatidae 33% 82%
A0A1X0P568 Trypanosomatidae 32% 77%
A0A1X0P991 Trypanosomatidae 44% 100%
A0A1X0PAN4 Trypanosomatidae 30% 98%
A0A3Q8IEK6 Leishmania donovani 99% 100%
A0A3Q8IFG7 Leishmania donovani 34% 82%
A0A3Q8IK65 Leishmania donovani 42% 100%
A0A3Q8IL63 Leishmania donovani 29% 80%
A0A3S7WTA2 Leishmania donovani 41% 78%
A0A3S7WZ14 Leishmania donovani 30% 77%
A0A3S7X808 Leishmania donovani 32% 70%
A0A422N8D7 Trypanosoma rangeli 32% 99%
A0A422NAJ1 Trypanosoma rangeli 68% 99%
A0A422NBV9 Trypanosoma rangeli 30% 77%
A0A422NL94 Trypanosoma rangeli 45% 72%
A0A422NML6 Trypanosoma rangeli 33% 82%
A0A422NS77 Trypanosoma rangeli 38% 76%
A0A422P293 Trypanosoma rangeli 42% 100%
A0BLX0 Paramecium tetraurelia 40% 100%
A0BQL0 Paramecium tetraurelia 41% 100%
A0CUB5 Paramecium tetraurelia 37% 100%
A0DSB3 Paramecium tetraurelia 38% 100%
A0DTY1 Paramecium tetraurelia 37% 100%
A3A8W2 Oryza sativa subsp. japonica 35% 92%
A4H7Y6 Leishmania braziliensis 39% 78%
A4HAW5 Leishmania braziliensis 27% 79%
A4HAW6 Leishmania braziliensis 32% 70%
A4HE10 Leishmania braziliensis 28% 77%
A4HG10 Leishmania braziliensis 94% 100%
A4HHY5 Leishmania braziliensis 34% 82%
A4HNR1 Leishmania braziliensis 41% 100%
A4HWB4 Leishmania infantum 42% 78%
A4I1B7 Leishmania infantum 30% 77%
A4I329 Leishmania infantum 99% 100%
A4I565 Leishmania infantum 34% 82%
A4IA25 Leishmania infantum 29% 80%
A4IA26 Leishmania infantum 32% 70%
A4ICT4 Leishmania infantum 42% 100%
A5PJZ2 Bos taurus 31% 87%
C9ZJK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 98%
C9ZMJ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZNW4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 74%
C9ZQJ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 82%
D0A2L9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
D0A5L0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 77%
D0AA51 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 73%
E9AQ14 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 78%
E9ASH0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9AXF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 77%
E9AZD9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
E9B0G2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 82%
E9B540 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 80%
E9B541 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
O04719 Arabidopsis thaliana 30% 74%
O14189 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 71%
O62829 Bos taurus 36% 82%
O64583 Arabidopsis thaliana 29% 93%
O80492 Arabidopsis thaliana 28% 73%
O80871 Arabidopsis thaliana 30% 79%
O81716 Arabidopsis thaliana 38% 88%
O81760 Arabidopsis thaliana 27% 83%
O82637 Arabidopsis thaliana 28% 96%
P20650 Rattus norvegicus 36% 82%
P34221 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 67%
P35182 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 100%
P35813 Homo sapiens 36% 82%
P35814 Oryctolagus cuniculus 36% 82%
P35815 Rattus norvegicus 37% 81%
P36982 Leishmania chagasi 30% 77%
P36993 Mus musculus 35% 81%
P38089 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 80%
P39966 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 41% 68%
P40371 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 90%
P49443 Mus musculus 36% 82%
P49444 Paramecium tetraurelia 40% 100%
P49593 Homo sapiens 31% 69%
P49594 Caenorhabditis elegans 28% 70%
P49596 Caenorhabditis elegans 43% 88%
P49597 Arabidopsis thaliana 33% 72%
P49598 Arabidopsis thaliana 34% 79%
P49599 Arabidopsis thaliana 31% 81%
P93006 Arabidopsis thaliana 34% 83%
Q09172 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 45% 85%
Q09173 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 44% 76%
Q0D673 Oryza sativa subsp. japonica 30% 100%
Q0DBU3 Oryza sativa subsp. japonica 32% 89%
Q0IIF0 Bos taurus 33% 85%
Q0J2L7 Oryza sativa subsp. japonica 31% 88%
Q0J2R1 Oryza sativa subsp. japonica 34% 86%
Q0JAA0 Oryza sativa subsp. japonica 32% 98%
Q0JL75 Oryza sativa subsp. japonica 33% 83%
Q0JLP9 Oryza sativa subsp. japonica 29% 67%
Q0V7V2 Arabidopsis thaliana 29% 82%
Q10MN6 Oryza sativa subsp. japonica 27% 73%
Q10MX1 Oryza sativa subsp. japonica 32% 80%
Q10S32 Oryza sativa subsp. japonica 27% 79%
Q19775 Caenorhabditis elegans 36% 67%
Q2PC20 Bos taurus 31% 84%
Q2QN36 Oryza sativa subsp. japonica 28% 80%
Q2QWE3 Oryza sativa subsp. japonica 28% 75%
Q2RBJ6 Oryza sativa subsp. japonica 27% 75%
Q3EAF9 Arabidopsis thaliana 33% 82%
Q4PSE8 Arabidopsis thaliana 34% 70%
Q4Q225 Leishmania major 41% 100%
Q4Q2U5 Leishmania major 32% 70%
Q4Q2U6 Leishmania major 28% 80%
Q4Q7S1 Leishmania major 31% 82%
Q4QA19 Leishmania major 30% 100%
Q4QFG7 Leishmania major 41% 78%
Q501F9 Arabidopsis thaliana 29% 85%
Q5JKN1 Oryza sativa subsp. japonica 30% 81%
Q5MFV5 Oryza sativa subsp. indica 25% 83%
Q5N9N2 Oryza sativa subsp. japonica 32% 76%
Q5PNS9 Arabidopsis thaliana 27% 78%
Q5SGD2 Homo sapiens 31% 87%
Q5SMK6 Oryza sativa subsp. japonica 32% 87%
Q5SN75 Oryza sativa subsp. japonica 28% 78%
Q5Z6F5 Oryza sativa subsp. japonica 34% 96%
Q5Z8P0 Oryza sativa subsp. japonica 26% 80%
Q652Z7 Oryza sativa subsp. japonica 33% 83%
Q653S3 Oryza sativa subsp. japonica 36% 87%
Q65XG6 Oryza sativa subsp. japonica 33% 75%
Q65XK7 Oryza sativa subsp. japonica 33% 82%
Q67J17 Oryza sativa subsp. japonica 27% 74%
Q67UP9 Oryza sativa subsp. japonica 37% 85%
Q67UX7 Oryza sativa subsp. japonica 33% 90%
Q69QZ0 Oryza sativa subsp. japonica 34% 89%
Q69VD9 Oryza sativa subsp. japonica 34% 86%
Q6AUQ4 Oryza sativa subsp. japonica 33% 81%
Q6EN45 Oryza sativa subsp. japonica 35% 87%
Q6ETK3 Oryza sativa subsp. japonica 36% 87%
Q6ING9 Xenopus laevis 28% 84%
Q6L4R7 Oryza sativa subsp. japonica 31% 71%
Q6L5H6 Oryza sativa subsp. japonica 28% 81%
Q6NKS1 Arabidopsis thaliana 29% 82%
Q6YTI2 Oryza sativa subsp. japonica 29% 71%
Q6ZHC8 Oryza sativa subsp. japonica 26% 81%
Q7XCJ7 Oryza sativa subsp. japonica 25% 80%
Q7XHN8 Oryza sativa subsp. japonica 26% 83%
Q7XQU7 Oryza sativa subsp. japonica 30% 100%
Q7XR06 Oryza sativa subsp. japonica 34% 100%
Q7XU84 Oryza sativa subsp. japonica 35% 89%
Q7XUC5 Oryza sativa subsp. japonica 27% 81%
Q7Y138 Oryza sativa subsp. japonica 27% 81%
Q84JD5 Arabidopsis thaliana 27% 80%
Q84JI0 Oryza sativa subsp. japonica 34% 78%
Q8BGL1 Mus musculus 35% 78%
Q8BHN0 Mus musculus 31% 87%
Q8BXN7 Mus musculus 30% 84%
Q8CGA0 Mus musculus 30% 69%
Q8GY60 Arabidopsis thaliana 27% 67%
Q8H063 Oryza sativa subsp. japonica 26% 80%
Q8H4S6 Oryza sativa subsp. japonica 31% 74%
Q8L7I4 Arabidopsis thaliana 32% 100%
Q8LAY8 Arabidopsis thaliana 35% 89%
Q8N3J5 Homo sapiens 31% 84%
Q8N819 Homo sapiens 36% 73%
Q8R0F6 Mus musculus 33% 80%
Q8RX37 Arabidopsis thaliana 31% 83%
Q8RXV3 Arabidopsis thaliana 34% 100%
Q8VZN9 Arabidopsis thaliana 35% 85%
Q93YW5 Arabidopsis thaliana 31% 100%
Q94AT1 Arabidopsis thaliana 32% 75%
Q94CL8 Arabidopsis thaliana 26% 82%
Q94H98 Oryza sativa subsp. japonica 25% 83%
Q9FG61 Arabidopsis thaliana 30% 70%
Q9FIF5 Arabidopsis thaliana 34% 76%
Q9FKX4 Arabidopsis thaliana 27% 82%
Q9FLI3 Arabidopsis thaliana 30% 75%
Q9FXE4 Arabidopsis thaliana 35% 71%
Q9FYN7 Oryza sativa subsp. japonica 35% 83%
Q9H0C8 Homo sapiens 34% 80%
Q9LDA7 Arabidopsis thaliana 32% 100%
Q9LHJ9 Arabidopsis thaliana 26% 82%
Q9LME4 Arabidopsis thaliana 34% 100%
Q9LMT1 Arabidopsis thaliana 32% 89%
Q9LNF4 Arabidopsis thaliana 34% 82%
Q9LNW3 Arabidopsis thaliana 33% 71%
Q9LUU7 Arabidopsis thaliana 33% 74%
Q9M1V8 Arabidopsis thaliana 24% 74%
Q9M9C6 Arabidopsis thaliana 29% 72%
Q9S9Z7 Arabidopsis thaliana 31% 100%
Q9SD02 Arabidopsis thaliana 35% 87%
Q9SD12 Arabidopsis thaliana 27% 83%
Q9SLA1 Arabidopsis thaliana 34% 80%
Q9SZ53 Arabidopsis thaliana 36% 88%
Q9WVR7 Rattus norvegicus 33% 70%
Q9XEE8 Arabidopsis thaliana 31% 81%
Q9XGZ9 Arabidopsis thaliana 29% 95%
Q9Z1Z6 Rattus norvegicus 33% 80%
Q9ZW21 Arabidopsis thaliana 29% 87%
V5AZJ4 Trypanosoma cruzi 44% 79%
V5BA03 Trypanosoma cruzi 42% 100%
V5BCX6 Trypanosoma cruzi 67% 100%
V5BH00 Trypanosoma cruzi 31% 89%
V5BSS7 Trypanosoma cruzi 31% 77%
V5DCR6 Trypanosoma cruzi 40% 76%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS