Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACU9_LEIMA

TriTrypDb:

LmjF.27.2310 , LMJLV39_270030700 , LMJSD75_270030600

Length:

247

Annotations

LeishMANIAdb annotations

A conserved but unique protein in Kinetoplastids (can also be organellar)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9ACU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACU9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.703
CLV_NRD_NRD_1	15	17	PF00675	0.548
CLV_NRD_NRD_1	66	68	PF00675	0.489
CLV_NRD_NRD_1	76	78	PF00675	0.444
CLV_PCSK_KEX2_1	17	19	PF00082	0.543
CLV_PCSK_KEX2_1	187	189	PF00082	0.392
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.543
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.451
CLV_PCSK_SKI1_1	77	81	PF00082	0.505
DEG_Nend_UBRbox_2	1	3	PF02207	0.749
DOC_CYCLIN_yCln2_LP_2	131	137	PF00134	0.724
DOC_MAPK_gen_1	118	127	PF00069	0.712
DOC_MAPK_gen_1	187	195	PF00069	0.543
DOC_MAPK_gen_1	234	243	PF00069	0.676
DOC_MAPK_gen_1	77	84	PF00069	0.709
DOC_MAPK_HePTP_8	184	201	PF00069	0.380
DOC_MAPK_MEF2A_6	188	197	PF00069	0.548
DOC_MAPK_RevD_3	174	188	PF00069	0.348
DOC_PP1_RVXF_1	78	85	PF00149	0.681
DOC_PP2B_LxvP_1	131	134	PF13499	0.699
DOC_PP4_FxxP_1	139	142	PF00568	0.401
DOC_PP4_FxxP_1	209	212	PF00568	0.524
DOC_PP4_FxxP_1	84	87	PF00568	0.682
DOC_USP7_MATH_1	212	216	PF00917	0.401
DOC_WW_Pin1_4	158	163	PF00397	0.398
LIG_14-3-3_CanoR_1	188	194	PF00244	0.475
LIG_14-3-3_CanoR_1	234	243	PF00244	0.623
LIG_BIR_III_4	91	95	PF00653	0.594
LIG_BRCT_BRCA1_1	142	146	PF00533	0.408
LIG_Clathr_ClatBox_1	100	104	PF01394	0.771
LIG_CtBP_PxDLS_1	73	77	PF00389	0.695
LIG_deltaCOP1_diTrp_1	8	15	PF00928	0.740
LIG_FHA_1	192	198	PF00498	0.444
LIG_FHA_1	224	230	PF00498	0.432
LIG_FHA_1	27	33	PF00498	0.734
LIG_LIR_Apic_2	83	87	PF02991	0.682
LIG_LIR_Gen_1	238	246	PF02991	0.661
LIG_LIR_Gen_1	7	15	PF02991	0.687
LIG_LIR_Nem_3	238	243	PF02991	0.632
LIG_LIR_Nem_3	7	12	PF02991	0.667
LIG_Pex14_2	209	213	PF04695	0.365
LIG_SH2_STAP1	191	195	PF00017	0.429
LIG_SH2_STAT5	160	163	PF00017	0.335
LIG_SH2_STAT5	231	234	PF00017	0.548
LIG_SH3_3	100	106	PF00018	0.667
LIG_SH3_3	83	89	PF00018	0.742
LIG_SUMO_SIM_anti_2	149	154	PF11976	0.444
LIG_SUMO_SIM_anti_2	215	220	PF11976	0.380
LIG_SUMO_SIM_anti_2	225	231	PF11976	0.294
LIG_SUMO_SIM_par_1	123	129	PF11976	0.693
LIG_SUMO_SIM_par_1	151	156	PF11976	0.380
LIG_SUMO_SIM_par_1	171	178	PF11976	0.229
LIG_SUMO_SIM_par_1	41	49	PF11976	0.689
LIG_UBA3_1	182	187	PF00899	0.485
LIG_WRC_WIRS_1	12	17	PF05994	0.746
LIG_WRC_WIRS_1	240	245	PF05994	0.669
LIG_WRC_WIRS_1	81	86	PF05994	0.681
LIG_WW_3	85	89	PF00397	0.730
MOD_CAAXbox	244	247	PF01239	0.714
MOD_CDK_SPxK_1	158	164	PF00069	0.458
MOD_CK1_1	110	116	PF00069	0.768
MOD_CK1_1	156	162	PF00069	0.444
MOD_CK1_1	30	36	PF00069	0.723
MOD_GlcNHglycan	142	145	PF01048	0.408
MOD_GSK3_1	235	242	PF00069	0.604
MOD_GSK3_1	26	33	PF00069	0.772
MOD_GSK3_1	34	41	PF00069	0.741
MOD_NEK2_1	153	158	PF00069	0.527
MOD_NEK2_1	222	227	PF00069	0.366
MOD_PKA_2	235	241	PF00069	0.616
MOD_PKB_1	234	242	PF00069	0.585
MOD_Plk_4	126	132	PF00069	0.666
MOD_Plk_4	212	218	PF00069	0.401
MOD_Plk_4	223	229	PF00069	0.372
MOD_Plk_4	236	242	PF00069	0.560
MOD_ProDKin_1	158	164	PF00069	0.399
TRG_DiLeu_BaEn_3	97	103	PF01217	0.604
TRG_ENDOCYTIC_2	240	243	PF00928	0.666
TRG_ER_diArg_1	15	18	PF00400	0.748
TRG_ER_diArg_1	233	236	PF00400	0.625
TRG_NLS_Bipartite_1	67	81	PF00514	0.722
TRG_NLS_MonoExtN_4	74	81	PF00514	0.703

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI2	Leptomonas seymouri	65%	100%
A0A1X0NSH8	Trypanosomatidae	37%	100%
A0A3Q8IAR5	Leishmania donovani	95%	100%
A0A3R7NGU7	Trypanosoma rangeli	32%	100%
A4HG09	Leishmania braziliensis	82%	100%
A4I328	Leishmania infantum	96%	100%
E9AZD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5B3U0	Trypanosoma cruzi	34%	100%