Transcription elongation regulator-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription elongation regulator-like protein

Species:

Leishmania major

UniProt:

E9ACU7_LEIMA

TriTrypDb:

LmjF.27.2300 , LMJLV39_270030500 , LMJSD75_270030400

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0008023	transcription elongation factor complex	3	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032044	DSIF complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	12
GO:0140513	nuclear protein-containing complex	2	2
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10

Expansion

Sequence features

E9ACU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACU7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006354	DNA-templated transcription elongation	6	2
GO:0006355	regulation of DNA-templated transcription	6	12
GO:0006357	regulation of transcription by RNA polymerase II	7	12
GO:0006368	transcription elongation by RNA polymerase II	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009889	regulation of biosynthetic process	4	12
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0016070	RNA metabolic process	5	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	12
GO:0019222	regulation of metabolic process	3	12
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0032774	RNA biosynthetic process	5	2
GO:0032784	regulation of DNA-templated transcription elongation	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051252	regulation of RNA metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	12
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1903506	regulation of nucleic acid-templated transcription	7	12
GO:2001141	regulation of RNA biosynthetic process	6	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	408	412	PF00656	0.547
CLV_C14_Caspase3-7	81	85	PF00656	0.692
CLV_NRD_NRD_1	159	161	PF00675	0.621
CLV_NRD_NRD_1	205	207	PF00675	0.301
CLV_NRD_NRD_1	231	233	PF00675	0.321
CLV_NRD_NRD_1	37	39	PF00675	0.643
CLV_NRD_NRD_1	43	45	PF00675	0.611
CLV_NRD_NRD_1	46	48	PF00675	0.598
CLV_NRD_NRD_1	646	648	PF00675	0.661
CLV_NRD_NRD_1	651	653	PF00675	0.726
CLV_PCSK_KEX2_1	159	161	PF00082	0.588
CLV_PCSK_KEX2_1	233	235	PF00082	0.426
CLV_PCSK_KEX2_1	322	324	PF00082	0.527
CLV_PCSK_KEX2_1	50	52	PF00082	0.671
CLV_PCSK_KEX2_1	54	56	PF00082	0.703
CLV_PCSK_KEX2_1	651	653	PF00082	0.726
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.426
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.527
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.692
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.710
CLV_PCSK_PC7_1	647	653	PF00082	0.703
CLV_PCSK_SKI1_1	114	118	PF00082	0.644
CLV_PCSK_SKI1_1	257	261	PF00082	0.426
CLV_PCSK_SKI1_1	327	331	PF00082	0.541
CLV_PCSK_SKI1_1	393	397	PF00082	0.557
CLV_PCSK_SKI1_1	618	622	PF00082	0.406
CLV_PCSK_SKI1_1	74	78	PF00082	0.731
DEG_APCC_DBOX_1	285	293	PF00400	0.404
DOC_CKS1_1	328	333	PF01111	0.563
DOC_CKS1_1	599	604	PF01111	0.498
DOC_CYCLIN_RxL_1	111	121	PF00134	0.608
DOC_MAPK_gen_1	180	188	PF00069	0.321
DOC_MAPK_gen_1	206	213	PF00069	0.306
DOC_MAPK_gen_1	271	280	PF00069	0.417
DOC_MAPK_gen_1	546	554	PF00069	0.411
DOC_MAPK_MEF2A_6	206	213	PF00069	0.318
DOC_MAPK_MEF2A_6	446	454	PF00069	0.439
DOC_MAPK_MEF2A_6	485	494	PF00069	0.510
DOC_PP2B_PxIxI_1	404	410	PF00149	0.517
DOC_PP4_FxxP_1	328	331	PF00568	0.415
DOC_SPAK_OSR1_1	248	252	PF12202	0.426
DOC_USP7_MATH_1	181	185	PF00917	0.426
DOC_USP7_MATH_1	19	23	PF00917	0.679
DOC_USP7_MATH_1	477	481	PF00917	0.435
DOC_USP7_MATH_1	63	67	PF00917	0.722
DOC_USP7_MATH_1	677	681	PF00917	0.684
DOC_USP7_MATH_1	79	83	PF00917	0.508
DOC_USP7_UBL2_3	315	319	PF12436	0.448
DOC_USP7_UBL2_3	41	45	PF12436	0.641
DOC_USP7_UBL2_3	50	54	PF12436	0.575
DOC_WW_Pin1_4	327	332	PF00397	0.565
DOC_WW_Pin1_4	598	603	PF00397	0.477
DOC_WW_Pin1_4	624	629	PF00397	0.507
LIG_14-3-3_CanoR_1	159	167	PF00244	0.486
LIG_14-3-3_CanoR_1	266	274	PF00244	0.568
LIG_14-3-3_CanoR_1	414	420	PF00244	0.521
LIG_14-3-3_CanoR_1	562	567	PF00244	0.468
LIG_14-3-3_CanoR_1	647	655	PF00244	0.647
LIG_Actin_WH2_2	406	423	PF00022	0.499
LIG_APCC_ABBA_1	491	496	PF00400	0.395
LIG_APCC_ABBAyCdc20_2	223	229	PF00400	0.306
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_CSL_BTD_1	599	602	PF09270	0.598
LIG_eIF4E_1	111	117	PF01652	0.465
LIG_FHA_1	187	193	PF00498	0.426
LIG_FHA_1	267	273	PF00498	0.618
LIG_FHA_1	301	307	PF00498	0.367
LIG_FHA_1	319	325	PF00498	0.371
LIG_FHA_1	361	367	PF00498	0.476
LIG_FHA_1	375	381	PF00498	0.522
LIG_FHA_1	415	421	PF00498	0.464
LIG_FHA_1	434	440	PF00498	0.434
LIG_FHA_1	607	613	PF00498	0.402
LIG_FHA_1	617	623	PF00498	0.380
LIG_FHA_1	92	98	PF00498	0.647
LIG_FHA_2	123	129	PF00498	0.511
LIG_FHA_2	150	156	PF00498	0.665
LIG_Integrin_RGD_1	286	288	PF01839	0.514
LIG_KLC1_Yacidic_2	224	229	PF13176	0.306
LIG_LIR_Apic_2	325	331	PF02991	0.562
LIG_LIR_Gen_1	224	230	PF02991	0.307
LIG_LIR_Gen_1	276	285	PF02991	0.376
LIG_LIR_Gen_1	4	15	PF02991	0.697
LIG_LIR_Gen_1	563	572	PF02991	0.540
LIG_LIR_Nem_3	224	228	PF02991	0.307
LIG_LIR_Nem_3	276	280	PF02991	0.358
LIG_LIR_Nem_3	343	349	PF02991	0.462
LIG_LIR_Nem_3	4	10	PF02991	0.692
LIG_LIR_Nem_3	486	490	PF02991	0.518
LIG_LIR_Nem_3	563	569	PF02991	0.535
LIG_NRBOX	9	15	PF00104	0.596
LIG_PTB_Apo_2	190	197	PF02174	0.306
LIG_PTB_Phospho_1	190	196	PF10480	0.306
LIG_SH2_CRK	566	570	PF00017	0.547
LIG_SH2_NCK_1	133	137	PF00017	0.611
LIG_SH2_NCK_1	566	570	PF00017	0.573
LIG_SH2_NCK_1	668	672	PF00017	0.737
LIG_SH2_PTP2	225	228	PF00017	0.306
LIG_SH2_PTP2	277	280	PF00017	0.494
LIG_SH2_SRC	133	136	PF00017	0.609
LIG_SH2_SRC	225	228	PF00017	0.306
LIG_SH2_STAP1	196	200	PF00017	0.321
LIG_SH2_STAP1	668	672	PF00017	0.737
LIG_SH2_STAP1	7	11	PF00017	0.693
LIG_SH2_STAT3	384	387	PF00017	0.587
LIG_SH2_STAT5	115	118	PF00017	0.591
LIG_SH2_STAT5	225	228	PF00017	0.306
LIG_SH2_STAT5	277	280	PF00017	0.494
LIG_SH2_STAT5	344	347	PF00017	0.412
LIG_SH2_STAT5	356	359	PF00017	0.194
LIG_SH2_STAT5	75	78	PF00017	0.626
LIG_SH3_3	250	256	PF00018	0.426
LIG_SH3_3	310	316	PF00018	0.482
LIG_SH3_3	596	602	PF00018	0.482
LIG_SH3_4	315	322	PF00018	0.507
LIG_SUMO_SIM_anti_2	489	494	PF11976	0.495
LIG_SUMO_SIM_anti_2	551	557	PF11976	0.457
LIG_SUMO_SIM_anti_2	639	645	PF11976	0.450
LIG_SUMO_SIM_par_1	531	537	PF11976	0.404
LIG_TRAF2_1	125	128	PF00917	0.495
LIG_TRAF2_1	376	379	PF00917	0.439
LIG_TRAF2_1	655	658	PF00917	0.768
LIG_TYR_ITIM	5	10	PF00017	0.684
LIG_TYR_ITIM	564	569	PF00017	0.536
MOD_CDK_SPK_2	327	332	PF00069	0.565
MOD_CK1_1	154	160	PF00069	0.686
MOD_CK1_1	457	463	PF00069	0.517
MOD_CK1_1	486	492	PF00069	0.505
MOD_CK1_1	520	526	PF00069	0.548
MOD_CK1_1	680	686	PF00069	0.727
MOD_CK1_1	82	88	PF00069	0.628
MOD_CK2_1	122	128	PF00069	0.509
MOD_CK2_1	373	379	PF00069	0.437
MOD_CK2_1	531	537	PF00069	0.489
MOD_CK2_1	63	69	PF00069	0.783
MOD_CK2_1	82	88	PF00069	0.533
MOD_Cter_Amidation	645	648	PF01082	0.647
MOD_GlcNHglycan	367	370	PF01048	0.472
MOD_GlcNHglycan	455	459	PF01048	0.546
MOD_GlcNHglycan	479	482	PF01048	0.441
MOD_GlcNHglycan	663	666	PF01048	0.716
MOD_GlcNHglycan	675	678	PF01048	0.721
MOD_GlcNHglycan	696	699	PF01048	0.591
MOD_GlcNHglycan	81	84	PF01048	0.628
MOD_GSK3_1	151	158	PF00069	0.680
MOD_GSK3_1	262	269	PF00069	0.633
MOD_GSK3_1	405	412	PF00069	0.525
MOD_GSK3_1	429	436	PF00069	0.455
MOD_GSK3_1	457	464	PF00069	0.465
MOD_GSK3_1	479	486	PF00069	0.462
MOD_GSK3_1	511	518	PF00069	0.552
MOD_GSK3_1	573	580	PF00069	0.568
MOD_GSK3_1	673	680	PF00069	0.708
MOD_N-GLC_1	694	699	PF02516	0.689
MOD_N-GLC_2	193	195	PF02516	0.306
MOD_N-GLC_2	509	511	PF02516	0.498
MOD_NEK2_1	340	345	PF00069	0.514
MOD_NEK2_1	357	362	PF00069	0.376
MOD_NEK2_1	365	370	PF00069	0.442
MOD_NEK2_1	420	425	PF00069	0.429
MOD_NEK2_1	431	436	PF00069	0.434
MOD_NEK2_1	439	444	PF00069	0.399
MOD_NEK2_1	616	621	PF00069	0.378
MOD_NEK2_2	212	217	PF00069	0.306
MOD_NEK2_2	517	522	PF00069	0.665
MOD_PIKK_1	160	166	PF00454	0.638
MOD_PIKK_1	266	272	PF00454	0.629
MOD_PIKK_1	653	659	PF00454	0.686
MOD_PK_1	515	521	PF00069	0.646
MOD_PKA_1	647	653	PF00069	0.730
MOD_PKA_2	181	187	PF00069	0.426
MOD_PKA_2	265	271	PF00069	0.582
MOD_PKA_2	413	419	PF00069	0.482
MOD_PKA_2	420	426	PF00069	0.404
MOD_PKA_2	573	579	PF00069	0.498
MOD_PKA_2	646	652	PF00069	0.601
MOD_PKA_2	673	679	PF00069	0.680
MOD_PKA_2	680	686	PF00069	0.632
MOD_Plk_1	340	346	PF00069	0.482
MOD_Plk_1	583	589	PF00069	0.569
MOD_Plk_1	686	692	PF00069	0.690
MOD_Plk_1	694	700	PF00069	0.688
MOD_Plk_2-3	122	128	PF00069	0.623
MOD_Plk_2-3	531	537	PF00069	0.516
MOD_Plk_2-3	687	693	PF00069	0.718
MOD_Plk_2-3	84	90	PF00069	0.668
MOD_Plk_4	340	346	PF00069	0.514
MOD_Plk_4	479	485	PF00069	0.411
MOD_Plk_4	486	492	PF00069	0.385
MOD_Plk_4	687	693	PF00069	0.718
MOD_ProDKin_1	327	333	PF00069	0.566
MOD_ProDKin_1	598	604	PF00069	0.480
MOD_ProDKin_1	624	630	PF00069	0.505
MOD_SUMO_for_1	504	507	PF00179	0.526
MOD_SUMO_for_1	636	639	PF00179	0.512
MOD_SUMO_rev_2	119	126	PF00179	0.659
MOD_SUMO_rev_2	169	175	PF00179	0.453
TRG_DiLeu_BaEn_1	639	644	PF01217	0.459
TRG_DiLeu_BaEn_1	9	14	PF01217	0.597
TRG_ENDOCYTIC_2	225	228	PF00928	0.306
TRG_ENDOCYTIC_2	277	280	PF00928	0.494
TRG_ENDOCYTIC_2	566	569	PF00928	0.543
TRG_ENDOCYTIC_2	7	10	PF00928	0.690
TRG_ER_diArg_1	159	161	PF00400	0.645
TRG_ER_diArg_1	180	183	PF00400	0.321
TRG_ER_diArg_1	232	235	PF00400	0.426
TRG_ER_diArg_1	278	281	PF00400	0.369
TRG_ER_diArg_1	622	625	PF00400	0.376
TRG_NES_CRM1_1	210	220	PF08389	0.321
TRG_NLS_Bipartite_1	38	58	PF00514	0.713
TRG_NLS_MonoCore_2	53	58	PF00514	0.723
TRG_NLS_MonoExtC_3	231	237	PF00514	0.426
TRG_NLS_MonoExtC_3	37	42	PF00514	0.659
TRG_NLS_MonoExtC_3	43	48	PF00514	0.627
TRG_NLS_MonoExtC_3	53	59	PF00514	0.507
TRG_NLS_MonoExtN_4	36	42	PF00514	0.660
TRG_NLS_MonoExtN_4	44	51	PF00514	0.610
TRG_NLS_MonoExtN_4	53	58	PF00514	0.453
TRG_Pf-PMV_PEXEL_1	114	119	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9I1	Leptomonas seymouri	81%	100%
A0A0S4IUW1	Bodo saltans	42%	95%
A0A1X0NRB9	Trypanosomatidae	51%	96%
A0A3Q8IDN1	Leishmania donovani	97%	100%
A0A422NAL6	Trypanosoma rangeli	52%	99%
A4HG07	Leishmania braziliensis	91%	100%
A4I326	Leishmania infantum	97%	100%
C9ZJK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	98%
E9AZD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O13936	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	71%
O80770	Arabidopsis thaliana	25%	71%
Q4I5I4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	26%	67%
Q4PIC4	Ustilago maydis (strain 521 / FGSC 9021)	23%	73%
Q4WP96	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	66%
Q5ALX3	Candida albicans (strain SC5314 / ATCC MYA-2876)	27%	73%
Q5BCN2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	69%
Q6BZG0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	27%	72%
Q6CC84	Yarrowia lipolytica (strain CLIB 122 / E 150)	28%	71%
Q6CWW9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	68%
Q6FRZ5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	27%	69%
Q7S3C4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	66%
Q9STN3	Arabidopsis thaliana	25%	67%
V5D465	Trypanosoma cruzi	49%	97%