PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Meiotic cell cortex C-terminal pleckstrin homology, putative

Species:

Leishmania major

UniProt:

E9ACU5_LEIMA

TriTrypDb:

LmjF.27.2280 , LMJLV39_270030300 , LMJSD75_270030200

Length:

130

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	5
GO:0005938	cell cortex	3	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9ACU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACU5

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	5
GO:0032065	maintenance of protein location in cell cortex	4	5
GO:0032507	maintenance of protein location in cell	3	5
GO:0045185	maintenance of protein location	3	5
GO:0051179	localization	1	5
GO:0051235	maintenance of location	2	5
GO:0051651	maintenance of location in cell	2	5

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0005543	phospholipid binding	3	5
GO:0008289	lipid binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.316
CLV_NRD_NRD_1	28	30	PF00675	0.366
CLV_NRD_NRD_1	88	90	PF00675	0.366
CLV_PCSK_KEX2_1	28	30	PF00082	0.366
CLV_PCSK_KEX2_1	90	92	PF00082	0.366
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.366
CLV_PCSK_SKI1_1	124	128	PF00082	0.567
CLV_PCSK_SKI1_1	67	71	PF00082	0.233
CLV_PCSK_SKI1_1	90	94	PF00082	0.366
DEG_Nend_UBRbox_2	1	3	PF02207	0.418
DOC_CYCLIN_RxL_1	88	98	PF00134	0.364
DOC_MAPK_gen_1	89	95	PF00069	0.361
DOC_USP7_UBL2_3	18	22	PF12436	0.366
DOC_WW_Pin1_4	46	51	PF00397	0.283
LIG_14-3-3_CanoR_1	4	8	PF00244	0.428
LIG_BRCT_BRCA1_1	48	52	PF00533	0.283
LIG_Clathr_ClatBox_1	69	73	PF01394	0.233
LIG_deltaCOP1_diTrp_1	14	19	PF00928	0.366
LIG_FHA_1	78	84	PF00498	0.366
LIG_FHA_2	103	109	PF00498	0.316
LIG_FHA_2	63	69	PF00498	0.441
LIG_LIR_Gen_1	104	114	PF02991	0.366
LIG_LIR_Gen_1	35	45	PF02991	0.366
LIG_LIR_Gen_1	80	86	PF02991	0.366
LIG_LIR_Nem_3	104	110	PF02991	0.366
LIG_LIR_Nem_3	35	41	PF02991	0.366
LIG_LIR_Nem_3	43	48	PF02991	0.299
LIG_LIR_Nem_3	80	85	PF02991	0.366
LIG_PALB2_WD40_1	102	110	PF16756	0.366
LIG_SH2_PTP2	82	85	PF00017	0.332
LIG_SH2_STAT5	38	41	PF00017	0.366
LIG_SH2_STAT5	82	85	PF00017	0.332
LIG_SUMO_SIM_par_1	82	88	PF11976	0.402
MOD_CK1_1	6	12	PF00069	0.366
MOD_CK2_1	102	108	PF00069	0.391
MOD_CK2_1	40	46	PF00069	0.383
MOD_CK2_1	68	74	PF00069	0.408
MOD_GSK3_1	18	25	PF00069	0.259
MOD_GSK3_1	40	47	PF00069	0.499
MOD_NEK2_1	40	45	PF00069	0.366
MOD_NEK2_1	52	57	PF00069	0.224
MOD_NEK2_1	85	90	PF00069	0.366
MOD_PK_1	22	28	PF00069	0.366
MOD_PKA_2	3	9	PF00069	0.426
MOD_Plk_2-3	68	74	PF00069	0.366
MOD_Plk_4	102	108	PF00069	0.316
MOD_Plk_4	34	40	PF00069	0.316
MOD_Plk_4	77	83	PF00069	0.332
MOD_ProDKin_1	46	52	PF00069	0.283
TRG_ENDOCYTIC_2	38	41	PF00928	0.366
TRG_ENDOCYTIC_2	81	84	PF00928	0.366
TRG_ER_diArg_1	28	30	PF00400	0.366
TRG_ER_diArg_1	89	92	PF00400	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HG05	Leishmania braziliensis	86%	100%
A4I324	Leishmania infantum	96%	100%
E9AZD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	69%