LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9ACU4_LEIMA
TriTrypDb:
LmjF.27.2270 * , LMJLV39_270030200 * , LMJSD75_270030100 *
Length:
664

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACU4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACU4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 168 172 PF00656 0.652
CLV_C14_Caspase3-7 283 287 PF00656 0.640
CLV_C14_Caspase3-7 401 405 PF00656 0.704
CLV_C14_Caspase3-7 541 545 PF00656 0.476
CLV_NRD_NRD_1 160 162 PF00675 0.644
CLV_NRD_NRD_1 224 226 PF00675 0.657
CLV_NRD_NRD_1 274 276 PF00675 0.618
CLV_NRD_NRD_1 360 362 PF00675 0.797
CLV_NRD_NRD_1 379 381 PF00675 0.516
CLV_NRD_NRD_1 411 413 PF00675 0.671
CLV_NRD_NRD_1 418 420 PF00675 0.685
CLV_NRD_NRD_1 436 438 PF00675 0.832
CLV_PCSK_FUR_1 272 276 PF00082 0.620
CLV_PCSK_KEX2_1 160 162 PF00082 0.837
CLV_PCSK_KEX2_1 224 226 PF00082 0.657
CLV_PCSK_KEX2_1 274 276 PF00082 0.618
CLV_PCSK_KEX2_1 379 381 PF00082 0.635
CLV_PCSK_KEX2_1 411 413 PF00082 0.671
CLV_PCSK_KEX2_1 418 420 PF00082 0.685
CLV_PCSK_KEX2_1 436 438 PF00082 0.832
CLV_PCSK_KEX2_1 577 579 PF00082 0.653
CLV_PCSK_KEX2_1 74 76 PF00082 0.693
CLV_PCSK_PC1ET2_1 577 579 PF00082 0.647
CLV_PCSK_PC1ET2_1 74 76 PF00082 0.642
CLV_PCSK_SKI1_1 403 407 PF00082 0.626
CLV_PCSK_SKI1_1 457 461 PF00082 0.558
DEG_Nend_UBRbox_1 1 4 PF02207 0.625
DEG_SPOP_SBC_1 469 473 PF00917 0.665
DOC_ANK_TNKS_1 160 167 PF00023 0.591
DOC_CKS1_1 80 85 PF01111 0.722
DOC_MAPK_DCC_7 160 169 PF00069 0.661
DOC_MAPK_gen_1 361 369 PF00069 0.692
DOC_MAPK_MEF2A_6 160 169 PF00069 0.661
DOC_MAPK_MEF2A_6 361 369 PF00069 0.692
DOC_PP2B_LxvP_1 162 165 PF13499 0.661
DOC_PP2B_LxvP_1 451 454 PF13499 0.572
DOC_USP7_MATH_1 132 136 PF00917 0.733
DOC_USP7_MATH_1 257 261 PF00917 0.690
DOC_USP7_MATH_1 282 286 PF00917 0.709
DOC_USP7_MATH_1 310 314 PF00917 0.666
DOC_USP7_MATH_1 321 325 PF00917 0.656
DOC_USP7_MATH_1 365 369 PF00917 0.636
DOC_USP7_MATH_1 386 390 PF00917 0.746
DOC_USP7_MATH_1 482 486 PF00917 0.504
DOC_USP7_MATH_1 545 549 PF00917 0.454
DOC_WW_Pin1_4 153 158 PF00397 0.646
DOC_WW_Pin1_4 160 165 PF00397 0.644
DOC_WW_Pin1_4 18 23 PF00397 0.616
DOC_WW_Pin1_4 189 194 PF00397 0.638
DOC_WW_Pin1_4 238 243 PF00397 0.735
DOC_WW_Pin1_4 313 318 PF00397 0.620
DOC_WW_Pin1_4 40 45 PF00397 0.595
DOC_WW_Pin1_4 439 444 PF00397 0.723
DOC_WW_Pin1_4 449 454 PF00397 0.674
DOC_WW_Pin1_4 470 475 PF00397 0.609
DOC_WW_Pin1_4 558 563 PF00397 0.637
DOC_WW_Pin1_4 568 573 PF00397 0.674
DOC_WW_Pin1_4 613 618 PF00397 0.616
DOC_WW_Pin1_4 622 627 PF00397 0.643
DOC_WW_Pin1_4 648 653 PF00397 0.596
DOC_WW_Pin1_4 79 84 PF00397 0.656
LIG_14-3-3_CanoR_1 122 132 PF00244 0.548
LIG_14-3-3_CanoR_1 236 242 PF00244 0.671
LIG_14-3-3_CanoR_1 259 263 PF00244 0.688
LIG_14-3-3_CanoR_1 272 278 PF00244 0.623
LIG_14-3-3_CanoR_1 364 370 PF00244 0.639
LIG_14-3-3_CanoR_1 418 425 PF00244 0.648
LIG_BIR_III_2 144 148 PF00653 0.658
LIG_BIR_III_2 550 554 PF00653 0.602
LIG_BIR_III_4 404 408 PF00653 0.636
LIG_Clathr_ClatBox_1 65 69 PF01394 0.581
LIG_FHA_1 103 109 PF00498 0.598
LIG_FHA_1 153 159 PF00498 0.568
LIG_FHA_1 296 302 PF00498 0.716
LIG_FHA_1 35 41 PF00498 0.665
LIG_FHA_1 418 424 PF00498 0.700
LIG_FHA_1 470 476 PF00498 0.656
LIG_FHA_1 535 541 PF00498 0.457
LIG_FHA_1 641 647 PF00498 0.654
LIG_FHA_1 79 85 PF00498 0.585
LIG_FHA_2 207 213 PF00498 0.651
LIG_FHA_2 238 244 PF00498 0.632
LIG_FHA_2 493 499 PF00498 0.473
LIG_FHA_2 591 597 PF00498 0.674
LIG_FHA_2 80 86 PF00498 0.681
LIG_NRBOX 507 513 PF00104 0.451
LIG_PTB_Apo_2 60 67 PF02174 0.583
LIG_RPA_C_Fungi 220 232 PF08784 0.560
LIG_SH3_3 236 242 PF00018 0.744
LIG_SH3_3 364 370 PF00018 0.614
LIG_SH3_3 38 44 PF00018 0.597
LIG_SH3_3 444 450 PF00018 0.670
LIG_SH3_3 616 622 PF00018 0.634
LIG_SH3_3 643 649 PF00018 0.653
LIG_SUMO_SIM_anti_2 596 603 PF11976 0.596
LIG_SUMO_SIM_anti_2 81 88 PF11976 0.577
LIG_SUMO_SIM_par_1 600 605 PF11976 0.629
LIG_SUMO_SIM_par_1 81 88 PF11976 0.653
LIG_TRAF2_1 594 597 PF00917 0.627
LIG_TRFH_1 449 453 PF08558 0.530
LIG_WRC_WIRS_1 302 307 PF05994 0.634
MOD_CDK_SPxK_1 624 630 PF00069 0.647
MOD_CDK_SPxxK_3 153 160 PF00069 0.637
MOD_CDK_SPxxK_3 238 245 PF00069 0.640
MOD_CDK_SPxxK_3 470 477 PF00069 0.606
MOD_CK1_1 135 141 PF00069 0.708
MOD_CK1_1 194 200 PF00069 0.662
MOD_CK1_1 237 243 PF00069 0.634
MOD_CK1_1 268 274 PF00069 0.617
MOD_CK1_1 313 319 PF00069 0.626
MOD_CK1_1 34 40 PF00069 0.603
MOD_CK1_1 452 458 PF00069 0.560
MOD_CK1_1 567 573 PF00069 0.683
MOD_CK1_1 612 618 PF00069 0.661
MOD_CK1_1 88 94 PF00069 0.625
MOD_CK2_1 206 212 PF00069 0.690
MOD_CK2_1 492 498 PF00069 0.476
MOD_CK2_1 532 538 PF00069 0.574
MOD_CK2_1 590 596 PF00069 0.676
MOD_Cter_Amidation 222 225 PF01082 0.635
MOD_Cter_Amidation 272 275 PF01082 0.620
MOD_DYRK1A_RPxSP_1 238 242 PF00069 0.676
MOD_GlcNHglycan 133 137 PF01048 0.641
MOD_GlcNHglycan 196 199 PF01048 0.700
MOD_GlcNHglycan 267 270 PF01048 0.633
MOD_GlcNHglycan 277 280 PF01048 0.657
MOD_GlcNHglycan 325 328 PF01048 0.789
MOD_GlcNHglycan 376 379 PF01048 0.677
MOD_GlcNHglycan 387 391 PF01048 0.602
MOD_GlcNHglycan 454 457 PF01048 0.576
MOD_GlcNHglycan 51 55 PF01048 0.669
MOD_GlcNHglycan 540 543 PF01048 0.515
MOD_GlcNHglycan 607 610 PF01048 0.678
MOD_GlcNHglycan 611 614 PF01048 0.621
MOD_GlcNHglycan 75 78 PF01048 0.570
MOD_GlcNHglycan 95 98 PF01048 0.549
MOD_GSK3_1 10 17 PF00069 0.725
MOD_GSK3_1 170 177 PF00069 0.685
MOD_GSK3_1 181 188 PF00069 0.536
MOD_GSK3_1 194 201 PF00069 0.677
MOD_GSK3_1 202 209 PF00069 0.817
MOD_GSK3_1 234 241 PF00069 0.669
MOD_GSK3_1 323 330 PF00069 0.627
MOD_GSK3_1 365 372 PF00069 0.641
MOD_GSK3_1 417 424 PF00069 0.726
MOD_GSK3_1 439 446 PF00069 0.781
MOD_GSK3_1 464 471 PF00069 0.566
MOD_GSK3_1 478 485 PF00069 0.569
MOD_GSK3_1 534 541 PF00069 0.460
MOD_GSK3_1 554 561 PF00069 0.640
MOD_GSK3_1 563 570 PF00069 0.752
MOD_GSK3_1 605 612 PF00069 0.665
MOD_GSK3_1 85 92 PF00069 0.660
MOD_GSK3_1 98 105 PF00069 0.550
MOD_N-GLC_1 605 610 PF02516 0.678
MOD_NEK2_1 185 190 PF00069 0.697
MOD_NEK2_1 196 201 PF00069 0.599
MOD_NEK2_1 251 256 PF00069 0.684
MOD_NEK2_1 258 263 PF00069 0.615
MOD_NEK2_1 68 73 PF00069 0.697
MOD_NEK2_1 87 92 PF00069 0.525
MOD_NEK2_2 198 203 PF00069 0.654
MOD_PIKK_1 482 488 PF00454 0.511
MOD_PIKK_1 492 498 PF00454 0.554
MOD_PK_1 329 335 PF00069 0.685
MOD_PK_1 532 538 PF00069 0.534
MOD_PK_1 89 95 PF00069 0.647
MOD_PKA_2 10 16 PF00069 0.579
MOD_PKA_2 123 129 PF00069 0.533
MOD_PKA_2 152 158 PF00069 0.690
MOD_PKA_2 175 181 PF00069 0.641
MOD_PKA_2 237 243 PF00069 0.611
MOD_PKA_2 258 264 PF00069 0.596
MOD_PKA_2 265 271 PF00069 0.598
MOD_PKA_2 273 279 PF00069 0.625
MOD_PKA_2 417 423 PF00069 0.644
MOD_PKA_2 492 498 PF00069 0.462
MOD_PKB_1 189 197 PF00069 0.644
MOD_Plk_1 545 551 PF00069 0.502
MOD_Plk_1 554 560 PF00069 0.591
MOD_Plk_1 68 74 PF00069 0.528
MOD_Plk_4 191 197 PF00069 0.800
MOD_Plk_4 301 307 PF00069 0.774
MOD_Plk_4 89 95 PF00069 0.670
MOD_ProDKin_1 153 159 PF00069 0.645
MOD_ProDKin_1 160 166 PF00069 0.642
MOD_ProDKin_1 18 24 PF00069 0.614
MOD_ProDKin_1 189 195 PF00069 0.638
MOD_ProDKin_1 238 244 PF00069 0.734
MOD_ProDKin_1 313 319 PF00069 0.619
MOD_ProDKin_1 40 46 PF00069 0.597
MOD_ProDKin_1 439 445 PF00069 0.722
MOD_ProDKin_1 449 455 PF00069 0.665
MOD_ProDKin_1 470 476 PF00069 0.604
MOD_ProDKin_1 558 564 PF00069 0.639
MOD_ProDKin_1 568 574 PF00069 0.676
MOD_ProDKin_1 613 619 PF00069 0.616
MOD_ProDKin_1 622 628 PF00069 0.643
MOD_ProDKin_1 648 654 PF00069 0.599
MOD_ProDKin_1 79 85 PF00069 0.656
MOD_SUMO_for_1 427 430 PF00179 0.683
MOD_SUMO_rev_2 52 61 PF00179 0.763
TRG_DiLeu_BaEn_3 596 602 PF01217 0.619
TRG_DiLeu_BaLyEn_6 650 655 PF01217 0.678
TRG_ENDOCYTIC_2 62 65 PF00928 0.535
TRG_ER_diArg_1 1 4 PF00400 0.548
TRG_ER_diArg_1 122 125 PF00400 0.447
TRG_ER_diArg_1 150 153 PF00400 0.680
TRG_ER_diArg_1 159 161 PF00400 0.613
TRG_ER_diArg_1 187 190 PF00400 0.601
TRG_ER_diArg_1 224 227 PF00400 0.676
TRG_ER_diArg_1 236 239 PF00400 0.580
TRG_ER_diArg_1 272 275 PF00400 0.623
TRG_ER_diArg_1 417 419 PF00400 0.694
TRG_ER_diArg_1 435 437 PF00400 0.792
TRG_NLS_MonoExtC_3 360 365 PF00514 0.611
TRG_NLS_MonoExtN_4 359 365 PF00514 0.608
TRG_Pf-PMV_PEXEL_1 275 280 PF00026 0.704
TRG_Pf-PMV_PEXEL_1 457 461 PF00026 0.563

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I823 Leptomonas seymouri 42% 94%
A0A3S7X108 Leishmania donovani 90% 100%
A4HG04 Leishmania braziliensis 71% 99%
A4I323 Leishmania infantum 90% 100%
E9AZD3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS