Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACU1_LEIMA

TriTrypDb:

LmjF.27.2240 , LMJLV39_270029900 , LMJSD75_270029800

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000323	lytic vacuole	6	2
GO:0005768	endosome	7	2
GO:0005773	vacuole	5	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACU1

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0035493	SNARE complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.506
CLV_C14_Caspase3-7	492	496	PF00656	0.574
CLV_NRD_NRD_1	324	326	PF00675	0.590
CLV_NRD_NRD_1	376	378	PF00675	0.510
CLV_NRD_NRD_1	496	498	PF00675	0.492
CLV_NRD_NRD_1	535	537	PF00675	0.526
CLV_PCSK_FUR_1	322	326	PF00082	0.565
CLV_PCSK_FUR_1	374	378	PF00082	0.456
CLV_PCSK_KEX2_1	324	326	PF00082	0.590
CLV_PCSK_KEX2_1	376	378	PF00082	0.510
CLV_PCSK_KEX2_1	535	537	PF00082	0.526
CLV_PCSK_PC7_1	372	378	PF00082	0.463
CLV_PCSK_SKI1_1	247	251	PF00082	0.607
CLV_PCSK_SKI1_1	535	539	PF00082	0.604
DEG_APCC_DBOX_1	146	154	PF00400	0.597
DEG_APCC_DBOX_1	234	242	PF00400	0.473
DEG_Nend_UBRbox_2	1	3	PF02207	0.704
DOC_CYCLIN_RxL_1	374	386	PF00134	0.523
DOC_CYCLIN_yCln2_LP_2	462	468	PF00134	0.389
DOC_CYCLIN_yCln2_LP_2	487	493	PF00134	0.659
DOC_MAPK_gen_1	374	383	PF00069	0.523
DOC_MAPK_MEF2A_6	128	137	PF00069	0.591
DOC_MAPK_MEF2A_6	410	417	PF00069	0.583
DOC_MAPK_MEF2A_6	543	552	PF00069	0.441
DOC_PP1_RVXF_1	130	137	PF00149	0.629
DOC_PP2B_LxvP_1	487	490	PF13499	0.658
DOC_USP7_MATH_1	22	26	PF00917	0.665
DOC_USP7_MATH_1	66	70	PF00917	0.706
DOC_USP7_UBL2_3	528	532	PF12436	0.522
DOC_WW_Pin1_4	342	347	PF00397	0.615
DOC_WW_Pin1_4	475	480	PF00397	0.494
DOC_WW_Pin1_4	69	74	PF00397	0.732
DOC_WW_Pin1_4	9	14	PF00397	0.664
LIG_14-3-3_CanoR_1	138	146	PF00244	0.500
LIG_14-3-3_CanoR_1	168	173	PF00244	0.727
LIG_14-3-3_CanoR_1	219	225	PF00244	0.766
LIG_14-3-3_CanoR_1	23	28	PF00244	0.626
LIG_14-3-3_CanoR_1	295	305	PF00244	0.524
LIG_BRCT_BRCA1_1	113	117	PF00533	0.566
LIG_FHA_1	129	135	PF00498	0.646
LIG_FHA_1	138	144	PF00498	0.468
LIG_FHA_1	156	162	PF00498	0.640
LIG_FHA_1	16	22	PF00498	0.549
LIG_FHA_1	196	202	PF00498	0.570
LIG_FHA_1	307	313	PF00498	0.553
LIG_FHA_1	384	390	PF00498	0.571
LIG_FHA_1	74	80	PF00498	0.643
LIG_FHA_1	9	15	PF00498	0.505
LIG_FHA_2	175	181	PF00498	0.788
LIG_FHA_2	240	246	PF00498	0.613
LIG_FHA_2	353	359	PF00498	0.615
LIG_FHA_2	43	49	PF00498	0.538
LIG_FHA_2	431	437	PF00498	0.635
LIG_FHA_2	490	496	PF00498	0.556
LIG_LIR_Apic_2	223	229	PF02991	0.729
LIG_LIR_Gen_1	253	262	PF02991	0.530
LIG_LIR_Nem_3	253	259	PF02991	0.540
LIG_LIR_Nem_3	338	342	PF02991	0.648
LIG_LIR_Nem_3	461	467	PF02991	0.351
LIG_LYPXL_yS_3	464	467	PF13949	0.486
LIG_NRBOX	543	549	PF00104	0.478
LIG_PCNA_yPIPBox_3	91	100	PF02747	0.604
LIG_RPA_C_Fungi	285	297	PF08784	0.367
LIG_RPA_C_Fungi	360	372	PF08784	0.631
LIG_SH2_GRB2like	393	396	PF00017	0.713
LIG_SH2_NCK_1	41	45	PF00017	0.383
LIG_SH2_STAP1	17	21	PF00017	0.540
LIG_SH2_STAP1	385	389	PF00017	0.518
LIG_SH2_STAP1	393	397	PF00017	0.667
LIG_SH2_STAP1	458	462	PF00017	0.512
LIG_SH2_STAT5	139	142	PF00017	0.530
LIG_SH2_STAT5	17	20	PF00017	0.507
LIG_SH2_STAT5	342	345	PF00017	0.676
LIG_SH2_STAT5	385	388	PF00017	0.563
LIG_SH2_STAT5	491	494	PF00017	0.560
LIG_SH2_STAT5	53	56	PF00017	0.508
LIG_SH3_3	140	146	PF00018	0.435
LIG_SH3_3	7	13	PF00018	0.619
LIG_SH3_CIN85_PxpxPR_1	230	235	PF14604	0.687
LIG_Sin3_3	157	164	PF02671	0.487
LIG_SUMO_SIM_par_1	308	313	PF11976	0.501
LIG_SUMO_SIM_par_1	385	391	PF11976	0.558
LIG_SUMO_SIM_par_1	449	455	PF11976	0.429
LIG_SUMO_SIM_par_1	464	470	PF11976	0.451
LIG_TRAF2_1	211	214	PF00917	0.764
LIG_TRAF2_1	356	359	PF00917	0.521
LIG_TYR_ITIM	462	467	PF00017	0.490
LIG_Vh1_VBS_1	537	555	PF01044	0.508
MOD_CK1_1	151	157	PF00069	0.640
MOD_CK1_1	352	358	PF00069	0.568
MOD_CK1_1	470	476	PF00069	0.517
MOD_CK1_1	69	75	PF00069	0.680
MOD_CK2_1	101	107	PF00069	0.571
MOD_CK2_1	174	180	PF00069	0.788
MOD_CK2_1	305	311	PF00069	0.498
MOD_CK2_1	352	358	PF00069	0.608
MOD_CK2_1	42	48	PF00069	0.550
MOD_CK2_1	429	435	PF00069	0.603
MOD_GlcNHglycan	152	156	PF01048	0.558
MOD_GlcNHglycan	30	33	PF01048	0.606
MOD_GlcNHglycan	469	472	PF01048	0.513
MOD_GlcNHglycan	481	484	PF01048	0.588
MOD_GlcNHglycan	66	69	PF01048	0.698
MOD_GSK3_1	124	131	PF00069	0.667
MOD_GSK3_1	151	158	PF00069	0.621
MOD_GSK3_1	192	199	PF00069	0.776
MOD_GSK3_1	215	222	PF00069	0.592
MOD_GSK3_1	383	390	PF00069	0.466
MOD_GSK3_1	452	459	PF00069	0.507
MOD_GSK3_1	475	482	PF00069	0.539
MOD_GSK3_1	5	12	PF00069	0.709
MOD_GSK3_1	56	63	PF00069	0.604
MOD_GSK3_1	64	71	PF00069	0.659
MOD_N-GLC_1	479	484	PF02516	0.665
MOD_N-GLC_2	409	411	PF02516	0.587
MOD_NEK2_1	239	244	PF00069	0.738
MOD_NEK2_1	305	310	PF00069	0.546
MOD_NEK2_1	370	375	PF00069	0.563
MOD_NEK2_1	429	434	PF00069	0.652
MOD_NEK2_1	51	56	PF00069	0.521
MOD_NEK2_1	64	69	PF00069	0.675
MOD_PIKK_1	388	394	PF00454	0.546
MOD_PIKK_1	42	48	PF00454	0.568
MOD_PKA_2	137	143	PF00069	0.567
MOD_PKA_2	174	180	PF00069	0.658
MOD_PKA_2	22	28	PF00069	0.581
MOD_PKA_2	239	245	PF00069	0.720
MOD_PKA_2	352	358	PF00069	0.621
MOD_Plk_1	109	115	PF00069	0.631
MOD_Plk_4	182	188	PF00069	0.557
MOD_Plk_4	196	202	PF00069	0.649
MOD_Plk_4	452	458	PF00069	0.408
MOD_Plk_4	5	11	PF00069	0.682
MOD_Plk_4	60	66	PF00069	0.688
MOD_ProDKin_1	342	348	PF00069	0.614
MOD_ProDKin_1	475	481	PF00069	0.494
MOD_ProDKin_1	69	75	PF00069	0.734
MOD_ProDKin_1	9	15	PF00069	0.655
TRG_DiLeu_BaEn_4	439	445	PF01217	0.502
TRG_ENDOCYTIC_2	464	467	PF00928	0.486
TRG_ER_diArg_1	322	325	PF00400	0.591
TRG_ER_diArg_1	363	366	PF00400	0.615
TRG_ER_diArg_1	374	377	PF00400	0.493
TRG_ER_diArg_1	535	537	PF00400	0.542
TRG_NES_CRM1_1	380	392	PF08389	0.541
TRG_NES_CRM1_1	542	556	PF08389	0.510
TRG_Pf-PMV_PEXEL_1	324	329	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG49	Leptomonas seymouri	56%	72%
A0A3S7X103	Leishmania donovani	94%	100%
A4HG01	Leishmania braziliensis	83%	100%
A4I320	Leishmania infantum	94%	100%
C9ZJJ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	97%
E9AZD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5ANH3	Trypanosoma cruzi	26%	100%