Putative ribosomal protein L11

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal protein L11, putative

Species:

Leishmania major

UniProt:

E9ACT9_LEIMA

TriTrypDb:

LmjF.27.2220 , LMJLV39_270029600 , LMJSD75_270029500

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0000315	organellar large ribosomal subunit	5	2
GO:0005737	cytoplasm	2	2
GO:0005762	mitochondrial large ribosomal subunit	3	2
GO:0015934	large ribosomal subunit	4	2
GO:0032991	protein-containing complex	1	13
GO:0044391	ribosomal subunit	3	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0110165	cellular anatomical entity	1	13
GO:1990904	ribonucleoprotein complex	2	13
GO:0005840	ribosome	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11

Expansion

Sequence features

E9ACT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACT9

PDB structure(s): 7aih_E , 7am2_E , 7ane_E

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	13
GO:0006518	peptide metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009059	macromolecule biosynthetic process	4	13
GO:0009987	cellular process	1	13
GO:0019538	protein metabolic process	3	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	13
GO:0043043	peptide biosynthetic process	5	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043603	amide metabolic process	3	13
GO:0043604	amide biosynthetic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044249	cellular biosynthetic process	3	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0044271	cellular nitrogen compound biosynthetic process	4	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901566	organonitrogen compound biosynthetic process	4	13
GO:1901576	organic substance biosynthetic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003735	structural constituent of ribosome	2	13
GO:0005198	structural molecule activity	1	13
GO:0005488	binding	1	2
GO:0019843	rRNA binding	5	2
GO:0070180	large ribosomal subunit rRNA binding	6	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.289
CLV_NRD_NRD_1	178	180	PF00675	0.279
CLV_NRD_NRD_1	185	187	PF00675	0.262
CLV_NRD_NRD_1	217	219	PF00675	0.496
CLV_NRD_NRD_1	289	291	PF00675	0.397
CLV_NRD_NRD_1	3	5	PF00675	0.552
CLV_PCSK_FUR_1	130	134	PF00082	0.262
CLV_PCSK_FUR_1	176	180	PF00082	0.262
CLV_PCSK_KEX2_1	132	134	PF00082	0.282
CLV_PCSK_KEX2_1	178	180	PF00082	0.279
CLV_PCSK_KEX2_1	185	187	PF00082	0.262
CLV_PCSK_KEX2_1	289	291	PF00082	0.397
CLV_PCSK_KEX2_1	3	5	PF00082	0.552
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.262
CLV_PCSK_PC7_1	285	291	PF00082	0.393
CLV_PCSK_SKI1_1	203	207	PF00082	0.422
CLV_PCSK_SKI1_1	275	279	PF00082	0.475
CLV_PCSK_SKI1_1	299	303	PF00082	0.441
CLV_PCSK_SKI1_1	307	311	PF00082	0.398
CLV_PCSK_SKI1_1	36	40	PF00082	0.349
CLV_PCSK_SKI1_1	47	51	PF00082	0.339
CLV_PCSK_SKI1_1	61	65	PF00082	0.241
CLV_PCSK_SKI1_1	8	12	PF00082	0.600
DEG_Nend_Nbox_1	1	3	PF02207	0.509
DOC_CYCLIN_RxL_1	270	282	PF00134	0.460
DOC_CYCLIN_yClb5_NLxxxL_5	259	268	PF00134	0.475
DOC_MAPK_gen_1	11	19	PF00069	0.483
DOC_MAPK_gen_1	185	191	PF00069	0.262
DOC_MAPK_MEF2A_6	167	175	PF00069	0.421
DOC_MAPK_MEF2A_6	95	104	PF00069	0.262
DOC_MAPK_NFAT4_5	95	103	PF00069	0.417
DOC_PP1_RVXF_1	305	311	PF00149	0.406
DOC_PP4_FxxP_1	26	29	PF00568	0.453
DOC_PP4_FxxP_1	39	42	PF00568	0.286
DOC_SPAK_OSR1_1	54	58	PF12202	0.262
DOC_USP7_UBL2_3	11	15	PF12436	0.575
DOC_USP7_UBL2_3	74	78	PF12436	0.262
DOC_USP7_UBL2_3	91	95	PF12436	0.262
DOC_WW_Pin1_4	197	202	PF00397	0.412
DOC_WW_Pin1_4	299	304	PF00397	0.433
DOC_WW_Pin1_4	341	346	PF00397	0.712
LIG_14-3-3_CanoR_1	13	18	PF00244	0.442
LIG_14-3-3_CanoR_1	3	10	PF00244	0.527
LIG_APCC_ABBA_1	104	109	PF00400	0.262
LIG_APCC_ABBAyCdc20_2	103	109	PF00400	0.262
LIG_BRCT_BRCA1_1	110	114	PF00533	0.335
LIG_BRCT_BRCA1_1	22	26	PF00533	0.544
LIG_CtBP_PxDLS_1	303	307	PF00389	0.404
LIG_FHA_1	134	140	PF00498	0.281
LIG_FHA_1	14	20	PF00498	0.456
LIG_FHA_2	251	257	PF00498	0.419
LIG_FHA_2	300	306	PF00498	0.375
LIG_LIR_Apic_2	23	29	PF02991	0.463
LIG_LIR_Apic_2	37	42	PF02991	0.281
LIG_LIR_Gen_1	71	80	PF02991	0.262
LIG_LIR_Nem_3	121	126	PF02991	0.262
LIG_LIR_Nem_3	164	168	PF02991	0.304
LIG_LIR_Nem_3	169	173	PF02991	0.266
LIG_LIR_Nem_3	71	75	PF02991	0.262
LIG_LYPXL_yS_3	170	173	PF13949	0.275
LIG_Pex14_2	82	86	PF04695	0.262
LIG_PTB_Apo_2	49	56	PF02174	0.333
LIG_REV1ctd_RIR_1	53	62	PF16727	0.262
LIG_SH2_CRK	313	317	PF00017	0.462
LIG_SH2_GRB2like	291	294	PF00017	0.389
LIG_SH2_SRC	155	158	PF00017	0.274
LIG_SH2_STAT5	107	110	PF00017	0.271
LIG_SH2_STAT5	112	115	PF00017	0.320
LIG_SH2_STAT5	145	148	PF00017	0.324
LIG_SH2_STAT5	210	213	PF00017	0.499
LIG_SH2_STAT5	291	294	PF00017	0.389
LIG_SH2_STAT5	9	12	PF00017	0.567
LIG_SH3_2	42	47	PF14604	0.357
LIG_SH3_3	165	171	PF00018	0.275
LIG_SH3_3	39	45	PF00018	0.352
LIG_SH3_4	91	98	PF00018	0.262
LIG_SUMO_SIM_anti_2	96	102	PF11976	0.275
LIG_TRAF2_1	302	305	PF00917	0.410
LIG_TRAF2_1	316	319	PF00917	0.428
LIG_TYR_ITIM	168	173	PF00017	0.417
LIG_TYR_ITIM	223	228	PF00017	0.388
LIG_UBA3_1	125	132	PF00899	0.275
LIG_UBA3_1	264	270	PF00899	0.460
MOD_CDC14_SPxK_1	200	203	PF00782	0.402
MOD_CDK_SPxK_1	197	203	PF00069	0.402
MOD_CK1_1	276	282	PF00069	0.360
MOD_CK2_1	250	256	PF00069	0.416
MOD_CK2_1	299	305	PF00069	0.395
MOD_GlcNHglycan	234	237	PF01048	0.500
MOD_GlcNHglycan	4	7	PF01048	0.636
MOD_GSK3_1	193	200	PF00069	0.392
MOD_GSK3_1	269	276	PF00069	0.417
MOD_N-GLC_1	325	330	PF02516	0.499
MOD_N-GLC_2	144	146	PF02516	0.327
MOD_NEK2_1	108	113	PF00069	0.262
MOD_NEK2_1	2	7	PF00069	0.601
MOD_NEK2_1	250	255	PF00069	0.540
MOD_NEK2_1	268	273	PF00069	0.340
MOD_NEK2_1	325	330	PF00069	0.412
MOD_NEK2_2	193	198	PF00069	0.381
MOD_PIKK_1	250	256	PF00454	0.618
MOD_PIKK_1	276	282	PF00454	0.586
MOD_PIKK_1	331	337	PF00454	0.532
MOD_PKA_2	2	8	PF00069	0.589
MOD_Plk_1	108	114	PF00069	0.262
MOD_Plk_4	108	114	PF00069	0.269
MOD_Plk_4	273	279	PF00069	0.481
MOD_ProDKin_1	197	203	PF00069	0.417
MOD_ProDKin_1	299	305	PF00069	0.431
MOD_SUMO_for_1	316	319	PF00179	0.325
MOD_SUMO_rev_2	28	35	PF00179	0.536
TRG_DiLeu_LyEn_5	234	239	PF01217	0.446
TRG_ENDOCYTIC_2	148	151	PF00928	0.314
TRG_ENDOCYTIC_2	170	173	PF00928	0.275
TRG_ENDOCYTIC_2	225	228	PF00928	0.388
TRG_ER_diArg_1	175	178	PF00400	0.288
TRG_ER_diArg_1	185	187	PF00400	0.256
TRG_ER_diArg_1	2	4	PF00400	0.538
TRG_ER_diArg_1	289	291	PF00400	0.416
TRG_NLS_MonoCore_2	129	134	PF00514	0.262
TRG_NLS_MonoExtC_3	129	135	PF00514	0.262
TRG_NLS_MonoExtN_4	127	134	PF00514	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMB3	Leptomonas seymouri	84%	100%
A0A0S4IQP6	Bodo saltans	64%	100%
A0A1X0NR49	Trypanosomatidae	72%	100%
A0A3R7NDU6	Trypanosoma rangeli	73%	100%
A0A3S7X0Z8	Leishmania donovani	97%	100%
A4HFZ9	Leishmania braziliensis	93%	100%
A4I318	Leishmania infantum	97%	100%
C9ZJH2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
C9ZJI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AZC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5AS82	Trypanosoma cruzi	73%	100%