Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania major

UniProt:

E9ACT7_LEIMA

TriTrypDb:

LmjF.27.2200 , LMJLV39_270029400 , LMJSD75_270029300

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9ACT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACT7

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	3
GO:0006996	organelle organization	4	3
GO:0007010	cytoskeleton organization	5	3
GO:0007017	microtubule-based process	2	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0071840	cellular component organization or biogenesis	2	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.396
CLV_NRD_NRD_1	49	51	PF00675	0.574
CLV_NRD_NRD_1	94	96	PF00675	0.469
CLV_PCSK_KEX2_1	158	160	PF00082	0.396
CLV_PCSK_KEX2_1	49	51	PF00082	0.570
CLV_PCSK_KEX2_1	94	96	PF00082	0.496
CLV_PCSK_SKI1_1	165	169	PF00082	0.305
CLV_PCSK_SKI1_1	171	175	PF00082	0.272
CLV_PCSK_SKI1_1	50	54	PF00082	0.684
DEG_APCC_DBOX_1	94	102	PF00400	0.587
DEG_Nend_Nbox_1	1	3	PF02207	0.583
DOC_MAPK_gen_1	226	235	PF00069	0.466
DOC_MAPK_MEF2A_6	165	172	PF00069	0.362
DOC_PP1_RVXF_1	204	211	PF00149	0.435
DOC_USP7_UBL2_3	70	74	PF12436	0.578
DOC_WW_Pin1_4	177	182	PF00397	0.309
LIG_14-3-3_CanoR_1	158	167	PF00244	0.347
LIG_14-3-3_CanoR_1	186	196	PF00244	0.359
LIG_FHA_1	150	156	PF00498	0.315
LIG_FHA_1	22	28	PF00498	0.481
LIG_FHA_1	39	45	PF00498	0.572
LIG_FHA_1	51	57	PF00498	0.635
LIG_LIR_Gen_1	125	132	PF02991	0.350
LIG_LIR_Nem_3	118	122	PF02991	0.420
LIG_LIR_Nem_3	125	131	PF02991	0.339
LIG_SH2_NCK_1	64	68	PF00017	0.492
LIG_SH2_SRC	64	67	PF00017	0.529
LIG_SH3_3	60	66	PF00018	0.490
LIG_TRAF2_1	103	106	PF00917	0.580
MOD_CK1_1	161	167	PF00069	0.486
MOD_CK1_1	4	10	PF00069	0.567
MOD_GlcNHglycan	3	6	PF01048	0.571
MOD_GlcNHglycan	7	10	PF01048	0.565
MOD_GSK3_1	1	8	PF00069	0.576
MOD_GSK3_1	212	219	PF00069	0.437
MOD_LATS_1	48	54	PF00433	0.551
MOD_N-GLC_1	21	26	PF02516	0.478
MOD_NEK2_1	1	6	PF00069	0.571
MOD_NEK2_1	163	168	PF00069	0.355
MOD_NEK2_1	187	192	PF00069	0.435
MOD_PIKK_1	120	126	PF00454	0.328
MOD_PKA_1	158	164	PF00069	0.391
MOD_PKA_2	158	164	PF00069	0.356
MOD_PKA_2	187	193	PF00069	0.285
MOD_PKA_2	38	44	PF00069	0.701
MOD_PKB_1	186	194	PF00069	0.365
MOD_Plk_2-3	216	222	PF00069	0.397
MOD_ProDKin_1	177	183	PF00069	0.309
TRG_DiLeu_BaEn_2	177	183	PF01217	0.293
TRG_ENDOCYTIC_2	119	122	PF00928	0.430
TRG_ER_diArg_1	158	160	PF00400	0.424
TRG_ER_diArg_1	186	189	PF00400	0.363
TRG_ER_diArg_1	49	51	PF00400	0.690
TRG_ER_diArg_1	93	95	PF00400	0.437
TRG_NES_CRM1_1	88	99	PF08389	0.592
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI4	Leptomonas seymouri	78%	99%
A0A0S4J4Q7	Bodo saltans	61%	97%
A0A1X0NR32	Trypanosomatidae	67%	98%
A0A3R7KUG1	Trypanosoma rangeli	65%	97%
A0A3S7X0Z3	Leishmania donovani	95%	100%
A0A3S7X612	Leishmania donovani	35%	100%
A0A422NZU0	Trypanosoma rangeli	34%	100%
A4HFZ7	Leishmania braziliensis	89%	99%
A4HKU1	Leishmania braziliensis	34%	100%
A4I316	Leishmania infantum	95%	100%
A4I8C0	Leishmania infantum	35%	100%
C9ZJI5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	95%
E9AZC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B379	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
Q9U1D8	Leishmania major	35%	100%
V5DF31	Trypanosoma cruzi	68%	98%