Vitamin-K-epoxide reductase (warfarin-sensitive)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vitamin K epoxide reductase family, putative

Species:

Leishmania major

UniProt:

E9ACT6_LEIMA

TriTrypDb:

LmjF.27.2190 , LMJLV39_270029300 , LMJSD75_270029200

Length:

162

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 2
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9ACT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACT6

Function

Biological processes
Term	Name	Level	Count
GO:0006766	vitamin metabolic process	3	11
GO:0006775	fat-soluble vitamin metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0017187	peptidyl-glutamic acid carboxylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018200	peptidyl-glutamic acid modification	6	2
GO:0018214	protein carboxylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0042180	cellular ketone metabolic process	3	11
GO:0042373	vitamin K metabolic process	5	11
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	2
GO:0044281	small molecule metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901661	quinone metabolic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	11
GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	3	11
GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	4	11
GO:0016900	oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor	4	11
GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity	5	11
GO:0048038	quinone binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	141	143	PF00082	0.485
CLV_PCSK_KEX2_1	160	162	PF00082	0.611
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.537
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.506
DEG_Nend_Nbox_1	1	3	PF02207	0.535
DEG_SPOP_SBC_1	150	154	PF00917	0.399
DOC_PP4_FxxP_1	65	68	PF00568	0.242
DOC_USP7_MATH_1	149	153	PF00917	0.412
DOC_USP7_MATH_1	68	72	PF00917	0.199
DOC_USP7_UBL2_3	156	160	PF12436	0.380
DOC_USP7_UBL2_3	3	7	PF12436	0.354
LIG_APCC_ABBA_1	25	30	PF00400	0.305
LIG_BRCT_BRCA1_1	54	58	PF00533	0.273
LIG_FHA_1	102	108	PF00498	0.372
LIG_FHA_1	110	116	PF00498	0.305
LIG_FHA_1	123	129	PF00498	0.393
LIG_FHA_1	130	136	PF00498	0.241
LIG_FHA_1	89	95	PF00498	0.306
LIG_FHA_2	112	118	PF00498	0.413
LIG_GBD_Chelix_1	107	115	PF00786	0.360
LIG_IRF3_LxIS_1	90	97	PF10401	0.227
LIG_LIR_Apic_2	62	68	PF02991	0.242
LIG_LIR_Gen_1	117	126	PF02991	0.363
LIG_LIR_Gen_1	55	65	PF02991	0.320
LIG_LIR_Nem_3	117	121	PF02991	0.363
LIG_LIR_Nem_3	131	137	PF02991	0.300
LIG_LIR_Nem_3	38	42	PF02991	0.242
LIG_LIR_Nem_3	55	61	PF02991	0.142
LIG_LIR_Nem_3	62	67	PF02991	0.241
LIG_Pex14_2	54	58	PF04695	0.259
LIG_SH2_SRC	21	24	PF00017	0.323
LIG_SH2_STAP1	21	25	PF00017	0.247
LIG_SH2_STAP1	80	84	PF00017	0.291
LIG_SH2_STAT5	126	129	PF00017	0.306
LIG_SH2_STAT5	134	137	PF00017	0.306
LIG_SH2_STAT5	42	45	PF00017	0.226
LIG_SH2_STAT5	80	83	PF00017	0.241
LIG_SUMO_SIM_anti_2	91	97	PF11976	0.294
LIG_SUMO_SIM_par_1	109	114	PF11976	0.297
LIG_SUMO_SIM_par_1	91	97	PF11976	0.310
LIG_Vh1_VBS_1	67	85	PF01044	0.213
MOD_CK1_1	143	149	PF00069	0.352
MOD_CK1_1	152	158	PF00069	0.389
MOD_CK1_1	56	62	PF00069	0.342
MOD_CK1_1	97	103	PF00069	0.226
MOD_GlcNHglycan	142	145	PF01048	0.580
MOD_GlcNHglycan	96	99	PF01048	0.247
MOD_GSK3_1	151	158	PF00069	0.407
MOD_GSK3_1	17	24	PF00069	0.420
MOD_GSK3_1	48	55	PF00069	0.250
MOD_GSK3_1	97	104	PF00069	0.243
MOD_N-GLC_1	128	133	PF02516	0.379
MOD_NEK2_1	109	114	PF00069	0.326
MOD_NEK2_1	16	21	PF00069	0.267
MOD_NEK2_1	35	40	PF00069	0.260
MOD_NEK2_1	48	53	PF00069	0.183
MOD_NEK2_1	94	99	PF00069	0.290
MOD_OFUCOSY	43	50	PF10250	0.411
MOD_Plk_1	128	134	PF00069	0.379
MOD_Plk_1	56	62	PF00069	0.341
MOD_Plk_4	122	128	PF00069	0.312
MOD_Plk_4	129	135	PF00069	0.251
MOD_Plk_4	88	94	PF00069	0.251
MOD_Plk_4	97	103	PF00069	0.314
TRG_ENDOCYTIC_2	42	45	PF00928	0.212
TRG_ENDOCYTIC_2	79	82	PF00928	0.332
TRG_ER_diLys_1	157	162	PF00400	0.499
TRG_NLS_Bipartite_1	141	160	PF00514	0.324
TRG_NLS_MonoExtC_3	155	160	PF00514	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB97	Leptomonas seymouri	71%	100%
A0A0S4J6N8	Bodo saltans	51%	100%
A0A1X0NR17	Trypanosomatidae	56%	94%
A0A3R7K875	Trypanosoma rangeli	51%	100%
A0A3S7X0Y5	Leishmania donovani	98%	100%
A4HFZ6	Leishmania braziliensis	78%	100%
A4I315	Leishmania infantum	98%	100%
C9ZJI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AZC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q6B4J2	Bos taurus	36%	99%
Q6TEK3	Rattus norvegicus	31%	92%
Q6TEK4	Rattus norvegicus	33%	100%
Q6TEK5	Mus musculus	31%	92%
Q8N0U8	Homo sapiens	32%	92%
Q9BQB6	Homo sapiens	38%	99%
Q9CRC0	Mus musculus	36%	100%