FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania major

UniProt:

E9ACT5_LEIMA

TriTrypDb:

LmjF.27.2180 , LMJLV39_270029200 , LMJSD75_270029100

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	10
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9ACT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACT5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004721	phosphoprotein phosphatase activity	3	4
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	4
GO:0016791	phosphatase activity	5	4
GO:0042578	phosphoric ester hydrolase activity	4	4
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.311
CLV_NRD_NRD_1	70	72	PF00675	0.522
CLV_PCSK_KEX2_1	173	175	PF00082	0.292
CLV_PCSK_KEX2_1	21	23	PF00082	0.393
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.292
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.399
CLV_PCSK_SKI1_1	135	139	PF00082	0.292
CLV_PCSK_SKI1_1	167	171	PF00082	0.287
CLV_PCSK_SKI1_1	222	226	PF00082	0.315
CLV_PCSK_SKI1_1	250	254	PF00082	0.428
CLV_PCSK_SKI1_1	270	274	PF00082	0.235
DEG_APCC_DBOX_1	105	113	PF00400	0.255
DEG_APCC_DBOX_1	134	142	PF00400	0.336
DEG_APCC_DBOX_1	75	83	PF00400	0.311
DEG_APCC_KENBOX_2	4	8	PF00400	0.498
DEG_COP1_1	232	241	PF00400	0.363
DEG_MDM2_SWIB_1	23	31	PF02201	0.522
DEG_Nend_Nbox_1	1	3	PF02207	0.494
DOC_MAPK_gen_1	132	140	PF00069	0.319
DOC_MAPK_gen_1	71	83	PF00069	0.325
DOC_MAPK_MEF2A_6	76	85	PF00069	0.277
DOC_MAPK_NFAT4_5	78	86	PF00069	0.404
DOC_PP1_RVXF_1	165	172	PF00149	0.311
DOC_USP7_UBL2_3	279	283	PF12436	0.422
LIG_14-3-3_CanoR_1	185	190	PF00244	0.316
LIG_EH1_1	40	48	PF00400	0.345
LIG_FHA_1	177	183	PF00498	0.251
LIG_FHA_1	40	46	PF00498	0.397
LIG_FHA_1	49	55	PF00498	0.484
LIG_FHA_1	78	84	PF00498	0.290
LIG_FHA_2	115	121	PF00498	0.352
LIG_FHA_2	208	214	PF00498	0.336
LIG_LIR_Gen_1	25	32	PF02991	0.518
LIG_LIR_Nem_3	6	12	PF02991	0.480
LIG_NRBOX	108	114	PF00104	0.255
LIG_Pex14_2	23	27	PF04695	0.526
LIG_SH2_STAP1	165	169	PF00017	0.265
LIG_SH2_STAT3	133	136	PF00017	0.292
LIG_SH2_STAT5	108	111	PF00017	0.258
LIG_SH2_STAT5	115	118	PF00017	0.246
LIG_SH2_STAT5	12	15	PF00017	0.446
LIG_SH2_STAT5	151	154	PF00017	0.323
LIG_SH2_STAT5	241	244	PF00017	0.345
LIG_SH2_STAT5	274	277	PF00017	0.336
LIG_SH3_3	101	107	PF00018	0.383
LIG_SUMO_SIM_anti_2	42	48	PF11976	0.415
LIG_SUMO_SIM_anti_2	77	84	PF11976	0.281
LIG_SUMO_SIM_par_1	177	183	PF11976	0.335
LIG_SUMO_SIM_par_1	79	84	PF11976	0.322
LIG_UBA3_1	169	173	PF00899	0.336
MOD_CK1_1	127	133	PF00069	0.311
MOD_CK1_1	234	240	PF00069	0.514
MOD_CK1_1	77	83	PF00069	0.290
MOD_CK2_1	234	240	PF00069	0.456
MOD_GlcNHglycan	126	129	PF01048	0.307
MOD_GlcNHglycan	232	236	PF01048	0.358
MOD_GSK3_1	146	153	PF00069	0.375
MOD_GSK3_1	230	237	PF00069	0.334
MOD_NEK2_1	176	181	PF00069	0.275
MOD_NEK2_1	231	236	PF00069	0.406
MOD_NEK2_1	48	53	PF00069	0.436
MOD_NEK2_2	220	225	PF00069	0.294
MOD_PIKK_1	146	152	PF00454	0.311
MOD_PK_1	185	191	PF00069	0.311
MOD_PKA_2	146	152	PF00069	0.268
MOD_PKA_2	77	83	PF00069	0.253
MOD_Plk_1	176	182	PF00069	0.268
MOD_Plk_1	85	91	PF00069	0.315
MOD_Plk_2-3	10	16	PF00069	0.524
MOD_Plk_4	176	182	PF00069	0.289
MOD_Plk_4	223	229	PF00069	0.412
MOD_Plk_4	77	83	PF00069	0.302
MOD_Plk_4	85	91	PF00069	0.334
TRG_DiLeu_BaEn_1	63	68	PF01217	0.379
TRG_DiLeu_BaEn_4	63	69	PF01217	0.375
TRG_ENDOCYTIC_2	38	41	PF00928	0.381
TRG_ER_diArg_1	247	250	PF00400	0.463
TRG_ER_diArg_1	75	78	PF00400	0.351
TRG_NLS_MonoExtN_4	70	75	PF00514	0.416
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9I9	Leptomonas seymouri	83%	72%
A0A0S4IUQ9	Bodo saltans	28%	79%
A0A0S4J5Z2	Bodo saltans	65%	90%
A0A1X0NLU1	Trypanosomatidae	31%	100%
A0A1X0NR11	Trypanosomatidae	77%	84%
A0A1X0PA23	Trypanosomatidae	29%	81%
A0A3Q8IHT4	Leishmania donovani	99%	100%
A0A3S7X8P8	Leishmania donovani	31%	100%
A4HFZ5	Leishmania braziliensis	94%	100%
A4HM58	Leishmania braziliensis	31%	100%
A4I314	Leishmania infantum	99%	100%
A4IAS0	Leishmania infantum	31%	100%
C9ZJI3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	85%
C9ZZ90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A3Q0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AEA2	Leishmania major	28%	100%
E9AEJ6	Leishmania major	31%	100%
E9AZC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B5Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
V5AYU0	Trypanosoma cruzi	76%	83%