Chromatin modification-related protein MEAF6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone acetyltransferase subunit NuA4, putative

Species:

Leishmania major

UniProt:

E9ACT4_LEIMA

TriTrypDb:

LmjF.26.1785 , LMJLV39_260024200 , LMJSD75_260022700

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000123	histone acetyltransferase complex	4	7
GO:0005654	nucleoplasm	2	2
GO:0031248	protein acetyltransferase complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	7
GO:1902493	acetyltransferase complex	4	7
GO:1902494	catalytic complex	2	7
GO:1990234	transferase complex	3	7

Expansion

Sequence features

E9ACT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACT4

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	7
GO:0006473	protein acetylation	6	7
GO:0006475	internal protein amino acid acetylation	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0016570	histone modification	5	7
GO:0016573	histone acetylation	6	7
GO:0018193	peptidyl-amino acid modification	5	7
GO:0018205	peptidyl-lysine modification	6	7
GO:0018393	internal peptidyl-lysine acetylation	8	7
GO:0018394	peptidyl-lysine acetylation	7	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0043543	protein acylation	5	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	80	84	PF00656	0.650
CLV_NRD_NRD_1	296	298	PF00675	0.719
CLV_NRD_NRD_1	3	5	PF00675	0.691
CLV_NRD_NRD_1	325	327	PF00675	0.709
CLV_NRD_NRD_1	40	42	PF00675	0.376
CLV_NRD_NRD_1	81	83	PF00675	0.627
CLV_PCSK_FUR_1	321	325	PF00082	0.718
CLV_PCSK_KEX2_1	261	263	PF00082	0.705
CLV_PCSK_KEX2_1	296	298	PF00082	0.714
CLV_PCSK_KEX2_1	3	5	PF00082	0.691
CLV_PCSK_KEX2_1	321	323	PF00082	0.723
CLV_PCSK_KEX2_1	324	326	PF00082	0.703
CLV_PCSK_KEX2_1	40	42	PF00082	0.376
CLV_PCSK_KEX2_1	81	83	PF00082	0.627
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.690
CLV_PCSK_PC7_1	257	263	PF00082	0.581
CLV_PCSK_PC7_1	321	327	PF00082	0.815
CLV_PCSK_SKI1_1	300	304	PF00082	0.743
DEG_SCF_FBW7_1	92	98	PF00400	0.681
DEG_SPOP_SBC_1	240	244	PF00917	0.783
DEG_SPOP_SBC_1	97	101	PF00917	0.653
DOC_CKS1_1	92	97	PF01111	0.628
DOC_MAPK_MEF2A_6	46	55	PF00069	0.619
DOC_PP1_RVXF_1	203	209	PF00149	0.627
DOC_PP4_FxxP_1	208	211	PF00568	0.608
DOC_PP4_FxxP_1	25	28	PF00568	0.670
DOC_USP7_MATH_1	165	169	PF00917	0.708
DOC_USP7_MATH_1	176	180	PF00917	0.748
DOC_USP7_MATH_1	240	244	PF00917	0.717
DOC_USP7_MATH_1	97	101	PF00917	0.618
DOC_WW_Pin1_4	119	124	PF00397	0.743
DOC_WW_Pin1_4	167	172	PF00397	0.766
DOC_WW_Pin1_4	207	212	PF00397	0.613
DOC_WW_Pin1_4	24	29	PF00397	0.563
DOC_WW_Pin1_4	91	96	PF00397	0.628
LIG_14-3-3_CanoR_1	141	147	PF00244	0.775
LIG_14-3-3_CanoR_1	214	221	PF00244	0.729
LIG_14-3-3_CanoR_1	238	246	PF00244	0.681
LIG_14-3-3_CanoR_1	262	272	PF00244	0.816
LIG_14-3-3_CterR_2	324	329	PF00244	0.714
LIG_BIR_II_1	1	5	PF00653	0.700
LIG_BRCT_BRCA1_1	143	147	PF00533	0.774
LIG_FHA_1	113	119	PF00498	0.548
LIG_FHA_1	137	143	PF00498	0.658
LIG_FHA_1	277	283	PF00498	0.740
LIG_FHA_1	58	64	PF00498	0.519
LIG_LIR_Nem_3	139	143	PF02991	0.653
LIG_LIR_Nem_3	72	77	PF02991	0.546
LIG_SH2_CRK	140	144	PF00017	0.672
LIG_SH3_3	120	126	PF00018	0.641
LIG_SH3_3	177	183	PF00018	0.744
LIG_SH3_3	89	95	PF00018	0.677
LIG_SUMO_SIM_par_1	88	94	PF11976	0.672
LIG_TRAF2_1	302	305	PF00917	0.727
MOD_CDK_SPxxK_3	207	214	PF00069	0.608
MOD_CK1_1	119	125	PF00069	0.554
MOD_CK1_1	170	176	PF00069	0.687
MOD_CK1_1	194	200	PF00069	0.679
MOD_CK1_1	217	223	PF00069	0.621
MOD_CK1_1	241	247	PF00069	0.778
MOD_CK1_1	281	287	PF00069	0.779
MOD_CK1_1	99	105	PF00069	0.640
MOD_CK2_1	207	213	PF00069	0.611
MOD_CK2_1	222	228	PF00069	0.630
MOD_CK2_1	263	269	PF00069	0.590
MOD_Cter_Amidation	259	262	PF01082	0.690
MOD_GlcNHglycan	10	13	PF01048	0.677
MOD_GlcNHglycan	118	121	PF01048	0.719
MOD_GlcNHglycan	152	155	PF01048	0.679
MOD_GlcNHglycan	216	219	PF01048	0.603
MOD_GlcNHglycan	266	269	PF01048	0.798
MOD_GlcNHglycan	283	286	PF01048	0.543
MOD_GSK3_1	112	119	PF00069	0.666
MOD_GSK3_1	122	129	PF00069	0.692
MOD_GSK3_1	165	172	PF00069	0.784
MOD_GSK3_1	191	198	PF00069	0.637
MOD_GSK3_1	230	237	PF00069	0.662
MOD_GSK3_1	238	245	PF00069	0.695
MOD_GSK3_1	276	283	PF00069	0.765
MOD_GSK3_1	65	72	PF00069	0.546
MOD_GSK3_1	91	98	PF00069	0.679
MOD_N-GLC_1	276	281	PF02516	0.662
MOD_N-GLC_1	315	320	PF02516	0.738
MOD_NEK2_1	234	239	PF00069	0.698
MOD_NEK2_1	96	101	PF00069	0.638
MOD_PK_1	40	46	PF00069	0.619
MOD_PKA_1	40	46	PF00069	0.619
MOD_PKA_2	263	269	PF00069	0.741
MOD_PKA_2	287	293	PF00069	0.698
MOD_PKA_2	40	46	PF00069	0.619
MOD_PKB_1	262	270	PF00069	0.696
MOD_Plk_2-3	315	321	PF00069	0.600
MOD_Plk_4	142	148	PF00069	0.578
MOD_Plk_4	69	75	PF00069	0.546
MOD_ProDKin_1	119	125	PF00069	0.745
MOD_ProDKin_1	167	173	PF00069	0.766
MOD_ProDKin_1	207	213	PF00069	0.611
MOD_ProDKin_1	24	30	PF00069	0.556
MOD_ProDKin_1	91	97	PF00069	0.626
MOD_SUMO_for_1	302	305	PF00179	0.727
TRG_DiLeu_BaEn_2	20	26	PF01217	0.705
TRG_ENDOCYTIC_2	140	143	PF00928	0.675
TRG_ER_diArg_1	262	265	PF00400	0.682
TRG_ER_diArg_1	321	324	PF00400	0.719
TRG_NES_CRM1_1	42	57	PF08389	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7C1	Leptomonas seymouri	54%	100%
A0A3S7WZY7	Leishmania donovani	89%	100%
A4HF24	Leishmania braziliensis	76%	100%
E9AHB5	Leishmania infantum	90%	100%
E9AYF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%