FGGY_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9ACT2_LEIMA

TriTrypDb:

LmjF.26.0058 , LMJLV39_260005800 , LMJSD75_260005700

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACT2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.467
CLV_NRD_NRD_1	225	227	PF00675	0.398
CLV_PCSK_KEX2_1	227	229	PF00082	0.432
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.511
CLV_PCSK_SKI1_1	123	127	PF00082	0.461
CLV_PCSK_SKI1_1	70	74	PF00082	0.448
DEG_Nend_UBRbox_2	1	3	PF02207	0.560
DEG_ODPH_VHL_1	245	257	PF01847	0.364
DEG_SPOP_SBC_1	101	105	PF00917	0.459
DOC_CKS1_1	136	141	PF01111	0.496
DOC_MAPK_gen_1	172	181	PF00069	0.375
DOC_MAPK_MEF2A_6	14	21	PF00069	0.434
DOC_MAPK_MEF2A_6	250	257	PF00069	0.398
DOC_MAPK_NFAT4_5	250	258	PF00069	0.392
DOC_PP1_RVXF_1	175	182	PF00149	0.479
DOC_PP2B_LxvP_1	47	50	PF13499	0.597
DOC_PP4_FxxP_1	136	139	PF00568	0.490
DOC_USP7_MATH_1	197	201	PF00917	0.655
DOC_WW_Pin1_4	135	140	PF00397	0.364
DOC_WW_Pin1_4	199	204	PF00397	0.509
LIG_14-3-3_CanoR_1	14	20	PF00244	0.437
LIG_14-3-3_CanoR_1	53	57	PF00244	0.454
LIG_14-3-3_CanoR_1	70	75	PF00244	0.484
LIG_FHA_1	102	108	PF00498	0.490
LIG_FHA_1	136	142	PF00498	0.378
LIG_FHA_1	234	240	PF00498	0.374
LIG_FHA_1	247	253	PF00498	0.407
LIG_FHA_1	66	72	PF00498	0.541
LIG_FHA_1	73	79	PF00498	0.383
LIG_FHA_2	207	213	PF00498	0.511
LIG_FHA_2	41	47	PF00498	0.573
LIG_GBD_Chelix_1	253	261	PF00786	0.452
LIG_LIR_Apic_2	81	87	PF02991	0.534
LIG_LIR_Gen_1	212	223	PF02991	0.493
LIG_LIR_LC3C_4	124	128	PF02991	0.354
LIG_LIR_Nem_3	150	156	PF02991	0.591
LIG_LIR_Nem_3	168	174	PF02991	0.280
LIG_LIR_Nem_3	212	218	PF02991	0.529
LIG_NRBOX	57	63	PF00104	0.552
LIG_PDZ_Wminus1_1	267	269	PF00595	0.434
LIG_Rb_LxCxE_1	205	219	PF01857	0.455
LIG_SH2_CRK	90	94	PF00017	0.516
LIG_SH2_STAP1	90	94	PF00017	0.516
LIG_SH2_STAT5	90	93	PF00017	0.408
LIG_SH3_3	159	165	PF00018	0.641
LIG_SH3_3	241	247	PF00018	0.509
LIG_SUMO_SIM_anti_2	75	81	PF11976	0.397
LIG_SUMO_SIM_par_1	75	81	PF11976	0.429
LIG_TYR_ITIM	88	93	PF00017	0.561
MOD_CK1_1	15	21	PF00069	0.401
MOD_CK1_1	195	201	PF00069	0.610
MOD_CK2_1	144	150	PF00069	0.453
MOD_CK2_1	20	26	PF00069	0.425
MOD_CK2_1	206	212	PF00069	0.457
MOD_GlcNHglycan	123	126	PF01048	0.494
MOD_GlcNHglycan	158	161	PF01048	0.460
MOD_GlcNHglycan	199	202	PF01048	0.577
MOD_GlcNHglycan	22	25	PF01048	0.567
MOD_GlcNHglycan	257	260	PF01048	0.527
MOD_GSK3_1	101	108	PF00069	0.449
MOD_GSK3_1	144	151	PF00069	0.451
MOD_GSK3_1	15	22	PF00069	0.414
MOD_GSK3_1	195	202	PF00069	0.682
MOD_GSK3_1	257	264	PF00069	0.468
MOD_NEK2_1	156	161	PF00069	0.467
MOD_NEK2_1	255	260	PF00069	0.396
MOD_NEK2_1	64	69	PF00069	0.422
MOD_NEK2_1	80	85	PF00069	0.478
MOD_NEK2_1	88	93	PF00069	0.388
MOD_NEK2_2	65	70	PF00069	0.367
MOD_PIKK_1	105	111	PF00454	0.498
MOD_PIKK_1	72	78	PF00454	0.442
MOD_PKA_2	52	58	PF00069	0.527
MOD_Plk_4	148	154	PF00069	0.544
MOD_Plk_4	203	209	PF00069	0.570
MOD_Plk_4	233	239	PF00069	0.371
MOD_Plk_4	261	267	PF00069	0.590
MOD_Plk_4	88	94	PF00069	0.530
MOD_ProDKin_1	135	141	PF00069	0.370
MOD_ProDKin_1	199	205	PF00069	0.502
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.519
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.449
TRG_ENDOCYTIC_2	90	93	PF00928	0.398
TRG_NES_CRM1_1	229	243	PF08389	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Y9	Leptomonas seymouri	33%	95%
A0A3Q8IDH0	Leishmania donovani	91%	100%
E9AHA7	Leishmania infantum	90%	100%
E9AIR8	Leishmania braziliensis	67%	100%
E9AXZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%