TMhelix containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9ACT1_LEIMA

TriTrypDb:

LmjF.25.2375 , LMJLV39_250031600 , LMJSD75_250031900

Length:

Annotations

LeishMANIAdb annotations

The TM segment is conserved among Kinetoplastids. Unknown function.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9ACT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACT1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_1	1	4	PF02207	0.710
DOC_CYCLIN_RxL_1	59	68	PF00134	0.434
LIG_14-3-3_CanoR_1	36	44	PF00244	0.490
LIG_BRCT_BRCA1_1	49	53	PF00533	0.333
LIG_FHA_1	32	38	PF00498	0.579
LIG_LIR_Nem_3	50	55	PF02991	0.328
LIG_MLH1_MIPbox_1	49	53	PF16413	0.333
LIG_SH2_STAT5	52	55	PF00017	0.341
LIG_SH2_STAT5	58	61	PF00017	0.445
LIG_SH3_3	6	12	PF00018	0.661
LIG_TYR_ITIM	59	64	PF00017	0.425
MOD_CK1_1	30	36	PF00069	0.668
MOD_GSK3_1	27	34	PF00069	0.600
MOD_GSK3_1	47	54	PF00069	0.338
MOD_NEK2_1	47	52	PF00069	0.333
MOD_PKA_2	35	41	PF00069	0.568
TRG_ENDOCYTIC_2	52	55	PF00928	0.325
TRG_ENDOCYTIC_2	61	64	PF00928	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M8	Leptomonas seymouri	64%	100%
A0A3Q8IBY2	Leishmania donovani	93%	100%
A4HEE1	Leishmania braziliensis	69%	100%
E9AH99	Leishmania infantum	93%	100%
E9AXX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%