Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9ACS9_LEIMA

TriTrypDb:

LmjF.24.1435 , LMJLV39_240020900 , LMJSD75_240020300

Length:

917

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACS9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.709
CLV_C14_Caspase3-7	26	30	PF00656	0.704
CLV_C14_Caspase3-7	347	351	PF00656	0.614
CLV_C14_Caspase3-7	760	764	PF00656	0.761
CLV_MEL_PAP_1	467	473	PF00089	0.671
CLV_NRD_NRD_1	335	337	PF00675	0.680
CLV_NRD_NRD_1	383	385	PF00675	0.749
CLV_NRD_NRD_1	676	678	PF00675	0.770
CLV_NRD_NRD_1	736	738	PF00675	0.772
CLV_NRD_NRD_1	795	797	PF00675	0.600
CLV_NRD_NRD_1	908	910	PF00675	0.732
CLV_PCSK_FUR_1	677	681	PF00082	0.719
CLV_PCSK_FUR_1	906	910	PF00082	0.690
CLV_PCSK_KEX2_1	675	677	PF00082	0.767
CLV_PCSK_KEX2_1	679	681	PF00082	0.734
CLV_PCSK_KEX2_1	736	738	PF00082	0.681
CLV_PCSK_KEX2_1	795	797	PF00082	0.600
CLV_PCSK_KEX2_1	908	910	PF00082	0.732
CLV_PCSK_PC1ET2_1	675	677	PF00082	0.761
CLV_PCSK_PC1ET2_1	679	681	PF00082	0.741
CLV_PCSK_SKI1_1	384	388	PF00082	0.653
CLV_PCSK_SKI1_1	676	680	PF00082	0.775
CLV_PCSK_SKI1_1	683	687	PF00082	0.698
CLV_PCSK_SKI1_1	723	727	PF00082	0.772
CLV_PCSK_SKI1_1	801	805	PF00082	0.723
DEG_SPOP_SBC_1	253	257	PF00917	0.572
DEG_SPOP_SBC_1	342	346	PF00917	0.682
DEG_SPOP_SBC_1	546	550	PF00917	0.699
DEG_SPOP_SBC_1	59	63	PF00917	0.606
DOC_ANK_TNKS_1	188	195	PF00023	0.720
DOC_MAPK_gen_1	384	390	PF00069	0.746
DOC_MAPK_gen_1	658	666	PF00069	0.671
DOC_PP2B_LxvP_1	386	389	PF13499	0.742
DOC_PP2B_LxvP_1	484	487	PF13499	0.707
DOC_PP4_FxxP_1	819	822	PF00568	0.668
DOC_USP7_MATH_1	213	217	PF00917	0.714
DOC_USP7_MATH_1	253	257	PF00917	0.606
DOC_USP7_MATH_1	270	274	PF00917	0.663
DOC_USP7_MATH_1	278	282	PF00917	0.653
DOC_USP7_MATH_1	341	345	PF00917	0.769
DOC_USP7_MATH_1	400	404	PF00917	0.766
DOC_USP7_MATH_1	408	412	PF00917	0.666
DOC_USP7_MATH_1	419	423	PF00917	0.523
DOC_USP7_MATH_1	432	436	PF00917	0.566
DOC_USP7_MATH_1	437	441	PF00917	0.528
DOC_USP7_MATH_1	452	456	PF00917	0.658
DOC_USP7_MATH_1	509	513	PF00917	0.744
DOC_USP7_MATH_1	525	529	PF00917	0.597
DOC_USP7_MATH_1	542	546	PF00917	0.611
DOC_USP7_MATH_1	586	590	PF00917	0.727
DOC_USP7_MATH_1	592	596	PF00917	0.677
DOC_USP7_MATH_1	635	639	PF00917	0.772
DOC_USP7_MATH_1	881	885	PF00917	0.702
DOC_USP7_MATH_1	98	102	PF00917	0.597
DOC_USP7_MATH_2	797	803	PF00917	0.592
DOC_USP7_UBL2_3	675	679	PF12436	0.738
DOC_WW_Pin1_4	114	119	PF00397	0.509
DOC_WW_Pin1_4	167	172	PF00397	0.785
DOC_WW_Pin1_4	209	214	PF00397	0.745
DOC_WW_Pin1_4	279	284	PF00397	0.718
DOC_WW_Pin1_4	328	333	PF00397	0.764
DOC_WW_Pin1_4	360	365	PF00397	0.596
DOC_WW_Pin1_4	396	401	PF00397	0.715
DOC_WW_Pin1_4	454	459	PF00397	0.695
DOC_WW_Pin1_4	499	504	PF00397	0.724
DOC_WW_Pin1_4	535	540	PF00397	0.727
DOC_WW_Pin1_4	570	575	PF00397	0.610
DOC_WW_Pin1_4	587	592	PF00397	0.655
DOC_WW_Pin1_4	623	628	PF00397	0.771
DOC_WW_Pin1_4	641	646	PF00397	0.723
DOC_WW_Pin1_4	876	881	PF00397	0.617
DOC_WW_Pin1_4	94	99	PF00397	0.727
LIG_14-3-3_CanoR_1	189	193	PF00244	0.783
LIG_14-3-3_CanoR_1	269	279	PF00244	0.691
LIG_14-3-3_CanoR_1	336	341	PF00244	0.630
LIG_14-3-3_CanoR_1	343	353	PF00244	0.567
LIG_14-3-3_CanoR_1	384	389	PF00244	0.651
LIG_14-3-3_CanoR_1	585	591	PF00244	0.733
LIG_14-3-3_CanoR_1	886	892	PF00244	0.662
LIG_14-3-3_CanoR_1	94	98	PF00244	0.611
LIG_Actin_WH2_2	7	22	PF00022	0.659
LIG_APCC_ABBA_1	664	669	PF00400	0.749
LIG_BIR_II_1	1	5	PF00653	0.749
LIG_BIR_III_2	297	301	PF00653	0.763
LIG_BRCT_BRCA1_1	255	259	PF00533	0.567
LIG_BRCT_BRCA1_1	400	404	PF00533	0.588
LIG_BRCT_BRCA1_1	438	442	PF00533	0.699
LIG_BRCT_BRCA1_1	549	553	PF00533	0.651
LIG_BRCT_BRCA1_1	874	878	PF00533	0.578
LIG_DLG_GKlike_1	78	85	PF00625	0.586
LIG_eIF4E_1	813	819	PF01652	0.709
LIG_FHA_1	221	227	PF00498	0.750
LIG_FHA_1	294	300	PF00498	0.751
LIG_FHA_1	374	380	PF00498	0.744
LIG_FHA_1	381	387	PF00498	0.649
LIG_FHA_1	571	577	PF00498	0.786
LIG_FHA_1	59	65	PF00498	0.650
LIG_FHA_1	641	647	PF00498	0.706
LIG_FHA_1	687	693	PF00498	0.671
LIG_FHA_2	243	249	PF00498	0.660
LIG_FHA_2	785	791	PF00498	0.706
LIG_FHA_2	855	861	PF00498	0.764
LIG_FHA_2	862	868	PF00498	0.705
LIG_Integrin_isoDGR_2	135	137	PF01839	0.728
LIG_Integrin_RGD_1	153	155	PF01839	0.718
LIG_LIR_Gen_1	439	446	PF02991	0.696
LIG_LIR_Gen_1	465	473	PF02991	0.671
LIG_LIR_Gen_1	550	560	PF02991	0.673
LIG_LIR_Nem_3	439	445	PF02991	0.700
LIG_LIR_Nem_3	465	471	PF02991	0.674
LIG_LIR_Nem_3	550	556	PF02991	0.664
LIG_LIR_Nem_3	787	792	PF02991	0.592
LIG_REV1ctd_RIR_1	233	243	PF16727	0.725
LIG_SH2_CRK	468	472	PF00017	0.739
LIG_SH2_NCK_1	468	472	PF00017	0.739
LIG_SH2_STAP1	667	671	PF00017	0.753
LIG_SH2_STAT3	813	816	PF00017	0.707
LIG_SH2_STAT5	310	313	PF00017	0.756
LIG_SH2_STAT5	499	502	PF00017	0.595
LIG_SH2_STAT5	813	816	PF00017	0.707
LIG_SH2_STAT5	833	836	PF00017	0.689
LIG_SH2_STAT5	904	907	PF00017	0.632
LIG_SH3_1	562	568	PF00018	0.788
LIG_SH3_2	628	633	PF14604	0.691
LIG_SH3_3	277	283	PF00018	0.681
LIG_SH3_3	326	332	PF00018	0.732
LIG_SH3_3	352	358	PF00018	0.701
LIG_SH3_3	402	408	PF00018	0.712
LIG_SH3_3	484	490	PF00018	0.746
LIG_SH3_3	500	506	PF00018	0.558
LIG_SH3_3	517	523	PF00018	0.572
LIG_SH3_3	562	568	PF00018	0.753
LIG_SH3_3	624	630	PF00018	0.768
LIG_SH3_3	691	697	PF00018	0.573
LIG_SUMO_SIM_anti_2	887	896	PF11976	0.689
LIG_SUMO_SIM_par_1	203	209	PF11976	0.702
LIG_SUMO_SIM_par_1	481	488	PF11976	0.546
LIG_SUMO_SIM_par_1	575	583	PF11976	0.764
LIG_SxIP_EBH_1	427	436	PF03271	0.569
LIG_TRAF2_1	184	187	PF00917	0.786
LIG_TYR_ITIM	466	471	PF00017	0.738
LIG_WW_2	520	523	PF00397	0.561
LIG_WW_3	75	79	PF00397	0.722
MOD_CDK_SPxxK_3	626	633	PF00069	0.727
MOD_CK1_1	129	135	PF00069	0.747
MOD_CK1_1	209	215	PF00069	0.755
MOD_CK1_1	242	248	PF00069	0.659
MOD_CK1_1	255	261	PF00069	0.627
MOD_CK1_1	308	314	PF00069	0.615
MOD_CK1_1	325	331	PF00069	0.620
MOD_CK1_1	344	350	PF00069	0.596
MOD_CK1_1	363	369	PF00069	0.609
MOD_CK1_1	399	405	PF00069	0.763
MOD_CK1_1	440	446	PF00069	0.719
MOD_CK1_1	478	484	PF00069	0.635
MOD_CK1_1	545	551	PF00069	0.700
MOD_CK1_1	595	601	PF00069	0.756
MOD_CK1_1	626	632	PF00069	0.756
MOD_CK1_1	63	69	PF00069	0.704
MOD_CK1_1	81	87	PF00069	0.569
MOD_CK1_1	811	817	PF00069	0.738
MOD_CK1_1	832	838	PF00069	0.684
MOD_CK1_1	859	865	PF00069	0.637
MOD_CK1_1	884	890	PF00069	0.698
MOD_CK1_1	90	96	PF00069	0.628
MOD_CK2_1	180	186	PF00069	0.791
MOD_CK2_1	242	248	PF00069	0.659
MOD_CK2_1	25	31	PF00069	0.754
MOD_CK2_1	479	485	PF00069	0.698
MOD_CK2_1	575	581	PF00069	0.783
MOD_CK2_1	634	640	PF00069	0.710
MOD_CK2_1	80	86	PF00069	0.727
MOD_Cter_Amidation	793	796	PF01082	0.598
MOD_DYRK1A_RPxSP_1	94	98	PF00069	0.725
MOD_GlcNHglycan	1	4	PF01048	0.692
MOD_GlcNHglycan	104	107	PF01048	0.630
MOD_GlcNHglycan	128	131	PF01048	0.766
MOD_GlcNHglycan	177	180	PF01048	0.682
MOD_GlcNHglycan	182	185	PF01048	0.616
MOD_GlcNHglycan	215	218	PF01048	0.744
MOD_GlcNHglycan	229	232	PF01048	0.623
MOD_GlcNHglycan	240	244	PF01048	0.599
MOD_GlcNHglycan	259	262	PF01048	0.696
MOD_GlcNHglycan	272	275	PF01048	0.616
MOD_GlcNHglycan	314	317	PF01048	0.565
MOD_GlcNHglycan	324	327	PF01048	0.562
MOD_GlcNHglycan	370	373	PF01048	0.716
MOD_GlcNHglycan	421	424	PF01048	0.711
MOD_GlcNHglycan	439	442	PF01048	0.542
MOD_GlcNHglycan	45	48	PF01048	0.744
MOD_GlcNHglycan	450	453	PF01048	0.651
MOD_GlcNHglycan	454	457	PF01048	0.601
MOD_GlcNHglycan	471	474	PF01048	0.531
MOD_GlcNHglycan	511	514	PF01048	0.719
MOD_GlcNHglycan	515	518	PF01048	0.673
MOD_GlcNHglycan	544	547	PF01048	0.669
MOD_GlcNHglycan	594	597	PF01048	0.761
MOD_GlcNHglycan	637	640	PF01048	0.765
MOD_GlcNHglycan	649	652	PF01048	0.611
MOD_GlcNHglycan	782	785	PF01048	0.698
MOD_GlcNHglycan	799	804	PF01048	0.624
MOD_GlcNHglycan	808	811	PF01048	0.620
MOD_GlcNHglycan	834	837	PF01048	0.717
MOD_GlcNHglycan	869	872	PF01048	0.769
MOD_GlcNHglycan	874	877	PF01048	0.700
MOD_GSK3_1	102	109	PF00069	0.566
MOD_GSK3_1	126	133	PF00069	0.680
MOD_GSK3_1	205	212	PF00069	0.751
MOD_GSK3_1	251	258	PF00069	0.663
MOD_GSK3_1	270	277	PF00069	0.614
MOD_GSK3_1	298	305	PF00069	0.654
MOD_GSK3_1	308	315	PF00069	0.715
MOD_GSK3_1	318	325	PF00069	0.585
MOD_GSK3_1	341	348	PF00069	0.764
MOD_GSK3_1	360	367	PF00069	0.597
MOD_GSK3_1	375	382	PF00069	0.586
MOD_GSK3_1	384	391	PF00069	0.636
MOD_GSK3_1	395	402	PF00069	0.526
MOD_GSK3_1	409	416	PF00069	0.597
MOD_GSK3_1	43	50	PF00069	0.745
MOD_GSK3_1	432	439	PF00069	0.724
MOD_GSK3_1	448	455	PF00069	0.602
MOD_GSK3_1	475	482	PF00069	0.564
MOD_GSK3_1	497	504	PF00069	0.772
MOD_GSK3_1	509	516	PF00069	0.609
MOD_GSK3_1	541	548	PF00069	0.775
MOD_GSK3_1	587	594	PF00069	0.632
MOD_GSK3_1	59	66	PF00069	0.568
MOD_GSK3_1	596	603	PF00069	0.681
MOD_GSK3_1	619	626	PF00069	0.722
MOD_GSK3_1	641	648	PF00069	0.737
MOD_GSK3_1	692	699	PF00069	0.650
MOD_GSK3_1	762	769	PF00069	0.778
MOD_GSK3_1	780	787	PF00069	0.513
MOD_GSK3_1	799	806	PF00069	0.526
MOD_GSK3_1	86	93	PF00069	0.720
MOD_GSK3_1	867	874	PF00069	0.759
MOD_GSK3_1	94	101	PF00069	0.648
MOD_N-GLC_1	766	771	PF02516	0.757
MOD_N-GLC_2	903	905	PF02516	0.564
MOD_NEK2_1	107	112	PF00069	0.556
MOD_NEK2_1	128	133	PF00069	0.733
MOD_NEK2_1	165	170	PF00069	0.685
MOD_NEK2_1	175	180	PF00069	0.714
MOD_NEK2_1	252	257	PF00069	0.633
MOD_NEK2_1	322	327	PF00069	0.582
MOD_NEK2_1	379	384	PF00069	0.602
MOD_NEK2_1	547	552	PF00069	0.686
MOD_NEK2_1	647	652	PF00069	0.675
MOD_NEK2_1	773	778	PF00069	0.610
MOD_NEK2_1	87	92	PF00069	0.724
MOD_NEK2_2	10	15	PF00069	0.621
MOD_NEK2_2	803	808	PF00069	0.713
MOD_PIKK_1	156	162	PF00454	0.618
MOD_PIKK_1	547	553	PF00454	0.690
MOD_PIKK_1	645	651	PF00454	0.555
MOD_PKA_1	336	342	PF00069	0.585
MOD_PKA_1	384	390	PF00069	0.651
MOD_PKA_2	136	142	PF00069	0.715
MOD_PKA_2	165	171	PF00069	0.599
MOD_PKA_2	188	194	PF00069	0.782
MOD_PKA_2	342	348	PF00069	0.587
MOD_PKA_2	413	419	PF00069	0.667
MOD_PKA_2	448	454	PF00069	0.697
MOD_PKA_2	469	475	PF00069	0.735
MOD_PKA_2	53	59	PF00069	0.723
MOD_PKA_2	542	548	PF00069	0.719
MOD_PKA_2	586	592	PF00069	0.734
MOD_PKA_2	93	99	PF00069	0.726
MOD_Plk_1	205	211	PF00069	0.575
MOD_Plk_1	302	308	PF00069	0.572
MOD_Plk_1	893	899	PF00069	0.676
MOD_Plk_4	305	311	PF00069	0.594
MOD_Plk_4	462	468	PF00069	0.680
MOD_Plk_4	479	485	PF00069	0.554
MOD_Plk_4	575	581	PF00069	0.783
MOD_Plk_4	619	625	PF00069	0.601
MOD_Plk_4	829	835	PF00069	0.703
MOD_Plk_4	887	893	PF00069	0.630
MOD_ProDKin_1	114	120	PF00069	0.504
MOD_ProDKin_1	167	173	PF00069	0.782
MOD_ProDKin_1	209	215	PF00069	0.744
MOD_ProDKin_1	279	285	PF00069	0.714
MOD_ProDKin_1	328	334	PF00069	0.765
MOD_ProDKin_1	360	366	PF00069	0.597
MOD_ProDKin_1	396	402	PF00069	0.717
MOD_ProDKin_1	454	460	PF00069	0.694
MOD_ProDKin_1	499	505	PF00069	0.718
MOD_ProDKin_1	535	541	PF00069	0.729
MOD_ProDKin_1	570	576	PF00069	0.609
MOD_ProDKin_1	587	593	PF00069	0.657
MOD_ProDKin_1	623	629	PF00069	0.770
MOD_ProDKin_1	641	647	PF00069	0.721
MOD_ProDKin_1	876	882	PF00069	0.617
MOD_ProDKin_1	94	100	PF00069	0.729
TRG_DiLeu_BaLyEn_6	642	647	PF01217	0.703
TRG_ENDOCYTIC_2	468	471	PF00928	0.742
TRG_ER_diArg_1	17	20	PF00400	0.751
TRG_ER_diArg_1	735	737	PF00400	0.679
TRG_ER_diArg_1	770	773	PF00400	0.722
TRG_ER_diArg_1	795	797	PF00400	0.600
TRG_ER_diArg_1	906	909	PF00400	0.678
TRG_NLS_MonoExtC_3	674	679	PF00514	0.734
TRG_NLS_MonoExtN_4	672	679	PF00514	0.728

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID28	Leishmania donovani	84%	100%
A4HDJ8	Leishmania braziliensis	55%	100%
A4I0Y3	Leishmania infantum	84%	100%
E9AWY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%