WW domain binding protein 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACS7_LEIMA

TriTrypDb:

LmjF.24.0552 , LMJLV39_240011100 , LMJSD75_240010700

Length:

130

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9ACS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACS7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.527
CLV_NRD_NRD_1	73	75	PF00675	0.508
CLV_NRD_NRD_1	91	93	PF00675	0.460
CLV_NRD_NRD_1	94	96	PF00675	0.487
CLV_PCSK_FUR_1	71	75	PF00082	0.504
CLV_PCSK_FUR_1	92	96	PF00082	0.550
CLV_PCSK_KEX2_1	73	75	PF00082	0.508
CLV_PCSK_KEX2_1	90	92	PF00082	0.455
CLV_PCSK_KEX2_1	94	96	PF00082	0.484
CLV_PCSK_PC7_1	90	96	PF00082	0.446
DOC_PP2B_LxvP_1	115	118	PF13499	0.754
DOC_USP7_MATH_1	107	111	PF00917	0.759
DOC_USP7_MATH_1	21	25	PF00917	0.457
DOC_WW_Pin1_4	32	37	PF00397	0.509
LIG_14-3-3_CanoR_1	14	21	PF00244	0.452
LIG_14-3-3_CanoR_1	73	77	PF00244	0.575
LIG_14-3-3_CanoR_1	92	102	PF00244	0.670
LIG_APCC_ABBA_1	67	72	PF00400	0.612
LIG_BIR_II_1	1	5	PF00653	0.507
LIG_FHA_1	64	70	PF00498	0.479
LIG_FHA_2	1	7	PF00498	0.579
LIG_FHA_2	14	20	PF00498	0.535
LIG_LIR_Nem_3	40	45	PF02991	0.491
LIG_LIR_Nem_3	66	70	PF02991	0.344
LIG_MYND_1	124	128	PF01753	0.670
LIG_SH2_CRK	42	46	PF00017	0.530
LIG_SH2_CRK	79	83	PF00017	0.643
LIG_SH2_STAP1	37	41	PF00017	0.552
LIG_SH2_STAT5	15	18	PF00017	0.465
LIG_SH2_STAT5	42	45	PF00017	0.455
LIG_SH2_STAT5	79	82	PF00017	0.674
LIG_SH3_3	101	107	PF00018	0.805
LIG_SUMO_SIM_par_1	60	66	PF11976	0.359
LIG_WRC_WIRS_1	64	69	PF05994	0.280
MOD_CK1_1	122	128	PF00069	0.726
MOD_CK2_1	107	113	PF00069	0.728
MOD_GlcNHglycan	109	112	PF01048	0.566
MOD_GSK3_1	21	28	PF00069	0.521
MOD_N-GLC_2	29	31	PF02516	0.657
MOD_NEK2_1	63	68	PF00069	0.280
MOD_NEK2_2	13	18	PF00069	0.472
MOD_PIKK_1	117	123	PF00454	0.756
MOD_PKA_2	122	128	PF00069	0.754
MOD_PKA_2	13	19	PF00069	0.471
MOD_PKA_2	21	27	PF00069	0.456
MOD_PKA_2	72	78	PF00069	0.545
MOD_PKA_2	93	99	PF00069	0.682
MOD_Plk_4	77	83	PF00069	0.734
MOD_ProDKin_1	32	38	PF00069	0.511
MOD_SUMO_for_1	82	85	PF00179	0.679
TRG_ENDOCYTIC_2	42	45	PF00928	0.539
TRG_ENDOCYTIC_2	79	82	PF00928	0.656
TRG_ER_diArg_1	90	92	PF00400	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9I9	Leptomonas seymouri	48%	100%
A0A3S7WY70	Leishmania donovani	93%	100%
A4HDB4	Leishmania braziliensis	70%	100%
E9AH55	Leishmania infantum	94%	100%
E9AWP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%