EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9ACS4_LEIMA

TriTrypDb:

LmjF.23.0542 , LMJLV39_230011200 , LMJSD75_230011500

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACS4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005509	calcium ion binding	5	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	90	94	PF00656	0.608
CLV_NRD_NRD_1	125	127	PF00675	0.661
CLV_NRD_NRD_1	13	15	PF00675	0.511
CLV_NRD_NRD_1	206	208	PF00675	0.401
CLV_PCSK_KEX2_1	13	15	PF00082	0.511
CLV_PCSK_KEX2_1	206	208	PF00082	0.401
CLV_PCSK_SKI1_1	140	144	PF00082	0.671
CLV_PCSK_SKI1_1	302	306	PF00082	0.460
CLV_Separin_Metazoa	72	76	PF03568	0.509
DEG_SPOP_SBC_1	212	216	PF00917	0.539
DOC_CDC14_PxL_1	198	206	PF14671	0.465
DOC_CDC14_PxL_1	48	56	PF14671	0.444
DOC_CKS1_1	61	66	PF01111	0.496
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.571
DOC_MAPK_MEF2A_6	222	229	PF00069	0.489
DOC_PP2B_LxvP_1	171	174	PF13499	0.585
DOC_USP7_MATH_1	115	119	PF00917	0.661
DOC_USP7_MATH_1	142	146	PF00917	0.664
DOC_USP7_MATH_1	213	217	PF00917	0.622
DOC_USP7_MATH_1	220	224	PF00917	0.565
DOC_USP7_MATH_1	40	44	PF00917	0.605
DOC_USP7_UBL2_3	136	140	PF12436	0.676
DOC_WW_Pin1_4	106	111	PF00397	0.662
DOC_WW_Pin1_4	151	156	PF00397	0.520
DOC_WW_Pin1_4	166	171	PF00397	0.632
DOC_WW_Pin1_4	60	65	PF00397	0.503
DOC_WW_Pin1_4	98	103	PF00397	0.823
LIG_14-3-3_CanoR_1	14	22	PF00244	0.505
LIG_14-3-3_CanoR_1	222	226	PF00244	0.494
LIG_APCC_ABBA_1	198	203	PF00400	0.468
LIG_BIR_II_1	1	5	PF00653	0.540
LIG_BIR_III_2	37	41	PF00653	0.570
LIG_BIR_III_4	239	243	PF00653	0.472
LIG_EH1_1	67	75	PF00400	0.439
LIG_eIF4E_1	16	22	PF01652	0.479
LIG_FHA_1	16	22	PF00498	0.547
LIG_FHA_1	212	218	PF00498	0.549
LIG_FHA_2	295	301	PF00498	0.363
LIG_FHA_2	5	11	PF00498	0.458
LIG_Integrin_RGD_1	35	37	PF01839	0.520
LIG_LIR_Gen_1	190	199	PF02991	0.410
LIG_LIR_Gen_1	231	240	PF02991	0.419
LIG_LIR_Gen_1	280	288	PF02991	0.320
LIG_LIR_Gen_1	46	54	PF02991	0.499
LIG_LIR_Nem_3	190	194	PF02991	0.345
LIG_LIR_Nem_3	231	236	PF02991	0.424
LIG_LIR_Nem_3	280	284	PF02991	0.318
LIG_LIR_Nem_3	46	51	PF02991	0.511
LIG_LYPXL_S_1	200	204	PF13949	0.456
LIG_LYPXL_yS_3	201	204	PF13949	0.465
LIG_PCNA_yPIPBox_3	60	74	PF02747	0.527
LIG_SH2_STAT5	16	19	PF00017	0.484
LIG_SH2_STAT5	196	199	PF00017	0.425
LIG_SH3_3	174	180	PF00018	0.561
LIG_SH3_3	224	230	PF00018	0.509
LIG_SUMO_SIM_par_1	173	178	PF11976	0.501
LIG_SUMO_SIM_par_1	293	300	PF11976	0.511
LIG_TRAF2_1	7	10	PF00917	0.524
LIG_TYR_ITIM	199	204	PF00017	0.457
MOD_CDK_SPxxK_3	98	105	PF00069	0.702
MOD_CK1_1	165	171	PF00069	0.659
MOD_CK1_1	218	224	PF00069	0.617
MOD_CK2_1	225	231	PF00069	0.429
MOD_CK2_1	4	10	PF00069	0.492
MOD_CK2_1	40	46	PF00069	0.615
MOD_GlcNHglycan	164	167	PF01048	0.641
MOD_GlcNHglycan	181	184	PF01048	0.416
MOD_GlcNHglycan	190	194	PF01048	0.409
MOD_GlcNHglycan	208	211	PF01048	0.611
MOD_GlcNHglycan	217	220	PF01048	0.597
MOD_GlcNHglycan	78	81	PF01048	0.486
MOD_GSK3_1	111	118	PF00069	0.688
MOD_GSK3_1	130	137	PF00069	0.679
MOD_GSK3_1	158	165	PF00069	0.651
MOD_GSK3_1	175	182	PF00069	0.429
MOD_GSK3_1	202	209	PF00069	0.646
MOD_GSK3_1	211	218	PF00069	0.577
MOD_GSK3_1	221	228	PF00069	0.551
MOD_N-GLC_1	166	171	PF02516	0.576
MOD_NEK2_1	143	148	PF00069	0.600
MOD_NEK2_1	175	180	PF00069	0.514
MOD_NEK2_1	189	194	PF00069	0.501
MOD_NEK2_1	211	216	PF00069	0.556
MOD_NEK2_1	225	230	PF00069	0.328
MOD_NEK2_1	28	33	PF00069	0.543
MOD_NEK2_1	76	81	PF00069	0.458
MOD_NEK2_2	242	247	PF00069	0.399
MOD_PIKK_1	115	121	PF00454	0.692
MOD_PIKK_1	63	69	PF00454	0.520
MOD_PKA_1	206	212	PF00069	0.437
MOD_PKA_2	206	212	PF00069	0.678
MOD_PKA_2	221	227	PF00069	0.420
MOD_Plk_1	189	195	PF00069	0.374
MOD_ProDKin_1	106	112	PF00069	0.663
MOD_ProDKin_1	151	157	PF00069	0.522
MOD_ProDKin_1	166	172	PF00069	0.630
MOD_ProDKin_1	60	66	PF00069	0.499
MOD_ProDKin_1	98	104	PF00069	0.823
MOD_SUMO_for_1	85	88	PF00179	0.510
TRG_DiLeu_BaEn_1	259	264	PF01217	0.539
TRG_DiLeu_BaEn_2	71	77	PF01217	0.357
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.529
TRG_ENDOCYTIC_2	196	199	PF00928	0.425
TRG_ENDOCYTIC_2	201	204	PF00928	0.465
TRG_ER_diArg_1	13	15	PF00400	0.511
TRG_NLS_MonoCore_2	125	130	PF00514	0.627
TRG_NLS_MonoExtN_4	124	131	PF00514	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT7	Leptomonas seymouri	37%	94%
A0A3Q8IEH7	Leishmania donovani	88%	100%
A0A422N5L8	Trypanosoma rangeli	27%	76%
A4HCS0	Leishmania braziliensis	67%	100%
A4I094	Leishmania infantum	87%	100%
E9AW58	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%