LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein
Species:
Leishmania major
UniProt:
E9ACS3_LEIMA
TriTrypDb:
LmjF.23.0355 , LMJLV39_230008900 * , LMJSD75_230009100
Length:
358

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACS3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACS3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 217 221 PF00656 0.465
CLV_C14_Caspase3-7 224 228 PF00656 0.480
CLV_NRD_NRD_1 60 62 PF00675 0.607
CLV_NRD_NRD_1 73 75 PF00675 0.344
CLV_PCSK_KEX2_1 60 62 PF00082 0.596
CLV_PCSK_KEX2_1 73 75 PF00082 0.356
DEG_SPOP_SBC_1 138 142 PF00917 0.578
DEG_SPOP_SBC_1 319 323 PF00917 0.531
DEG_SPOP_SBC_1 94 98 PF00917 0.522
DOC_CKS1_1 272 277 PF01111 0.528
DOC_MAPK_DCC_7 279 289 PF00069 0.493
DOC_MAPK_gen_1 60 67 PF00069 0.549
DOC_MAPK_MEF2A_6 8 17 PF00069 0.431
DOC_PP4_FxxP_1 272 275 PF00568 0.505
DOC_USP7_MATH_1 137 141 PF00917 0.612
DOC_USP7_MATH_1 180 184 PF00917 0.612
DOC_USP7_MATH_1 312 316 PF00917 0.606
DOC_USP7_MATH_1 319 323 PF00917 0.582
DOC_USP7_MATH_1 347 351 PF00917 0.662
DOC_USP7_MATH_1 59 63 PF00917 0.440
DOC_USP7_MATH_1 94 98 PF00917 0.543
DOC_WW_Pin1_4 139 144 PF00397 0.636
DOC_WW_Pin1_4 255 260 PF00397 0.387
DOC_WW_Pin1_4 271 276 PF00397 0.502
DOC_WW_Pin1_4 28 33 PF00397 0.486
DOC_WW_Pin1_4 282 287 PF00397 0.464
LIG_14-3-3_CanoR_1 152 156 PF00244 0.457
LIG_14-3-3_CanoR_1 179 188 PF00244 0.574
LIG_14-3-3_CanoR_1 222 232 PF00244 0.504
LIG_14-3-3_CterR_2 355 358 PF00244 0.455
LIG_Actin_WH2_2 9 25 PF00022 0.438
LIG_BIR_II_1 1 5 PF00653 0.589
LIG_BIR_III_4 311 315 PF00653 0.564
LIG_FHA_1 209 215 PF00498 0.506
LIG_FHA_1 23 29 PF00498 0.339
LIG_FHA_1 321 327 PF00498 0.588
LIG_FHA_1 337 343 PF00498 0.589
LIG_FHA_2 222 228 PF00498 0.472
LIG_FHA_2 346 352 PF00498 0.394
LIG_GBD_Chelix_1 16 24 PF00786 0.394
LIG_LIR_Gen_1 102 111 PF02991 0.350
LIG_LIR_Gen_1 153 164 PF02991 0.423
LIG_LIR_Gen_1 350 357 PF02991 0.452
LIG_LIR_Nem_3 102 107 PF02991 0.397
LIG_LIR_Nem_3 153 159 PF02991 0.413
LIG_LIR_Nem_3 350 356 PF02991 0.446
LIG_RPA_C_Fungi 69 81 PF08784 0.328
LIG_SH2_CRK 104 108 PF00017 0.396
LIG_SH2_CRK 35 39 PF00017 0.455
LIG_SH2_CRK 45 49 PF00017 0.357
LIG_SH2_NCK_1 309 313 PF00017 0.552
LIG_SH2_SRC 309 312 PF00017 0.537
LIG_SH2_STAP1 45 49 PF00017 0.450
LIG_SH2_STAT5 171 174 PF00017 0.417
LIG_SH3_3 108 114 PF00018 0.397
LIG_SUMO_SIM_anti_2 12 17 PF11976 0.492
LIG_TYR_ITIM 43 48 PF00017 0.375
MOD_CDK_SPK_2 28 33 PF00069 0.486
MOD_CK1_1 142 148 PF00069 0.624
MOD_CK1_1 151 157 PF00069 0.466
MOD_CK1_1 187 193 PF00069 0.428
MOD_CK1_1 221 227 PF00069 0.545
MOD_CK1_1 285 291 PF00069 0.420
MOD_CK1_1 99 105 PF00069 0.437
MOD_CK2_1 319 325 PF00069 0.633
MOD_CK2_1 51 57 PF00069 0.497
MOD_CMANNOS 247 250 PF00535 0.341
MOD_GlcNHglycan 134 137 PF01048 0.606
MOD_GlcNHglycan 160 163 PF01048 0.528
MOD_GlcNHglycan 182 185 PF01048 0.513
MOD_GlcNHglycan 227 231 PF01048 0.624
MOD_GlcNHglycan 236 239 PF01048 0.460
MOD_GlcNHglycan 316 319 PF01048 0.610
MOD_GlcNHglycan 98 101 PF01048 0.514
MOD_GSK3_1 138 145 PF00069 0.594
MOD_GSK3_1 150 157 PF00069 0.511
MOD_GSK3_1 180 187 PF00069 0.466
MOD_GSK3_1 194 201 PF00069 0.507
MOD_GSK3_1 218 225 PF00069 0.473
MOD_GSK3_1 234 241 PF00069 0.371
MOD_GSK3_1 314 321 PF00069 0.557
MOD_GSK3_1 89 96 PF00069 0.525
MOD_NEK2_1 194 199 PF00069 0.347
MOD_NEK2_1 22 27 PF00069 0.389
MOD_NEK2_1 51 56 PF00069 0.405
MOD_PIKK_1 3 9 PF00454 0.555
MOD_PIKK_1 51 57 PF00454 0.422
MOD_PKA_2 151 157 PF00069 0.469
MOD_PKA_2 178 184 PF00069 0.561
MOD_PKA_2 208 214 PF00069 0.393
MOD_PKA_2 22 28 PF00069 0.374
MOD_PKA_2 221 227 PF00069 0.527
MOD_PKA_2 331 337 PF00069 0.604
MOD_PKA_2 59 65 PF00069 0.437
MOD_Plk_2-3 345 351 PF00069 0.411
MOD_Plk_4 151 157 PF00069 0.542
MOD_Plk_4 194 200 PF00069 0.439
MOD_Plk_4 238 244 PF00069 0.381
MOD_Plk_4 99 105 PF00069 0.457
MOD_ProDKin_1 139 145 PF00069 0.635
MOD_ProDKin_1 255 261 PF00069 0.379
MOD_ProDKin_1 271 277 PF00069 0.509
MOD_ProDKin_1 28 34 PF00069 0.483
MOD_ProDKin_1 282 288 PF00069 0.451
TRG_DiLeu_BaEn_1 12 17 PF01217 0.490
TRG_ENDOCYTIC_2 104 107 PF00928 0.397
TRG_ENDOCYTIC_2 35 38 PF00928 0.449
TRG_ENDOCYTIC_2 45 48 PF00928 0.349
TRG_ER_diArg_1 72 74 PF00400 0.390
TRG_Pf-PMV_PEXEL_1 295 299 PF00026 0.452
TRG_Pf-PMV_PEXEL_1 8 12 PF00026 0.443

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5J7 Leptomonas seymouri 40% 92%
A0A3Q8IFQ9 Leishmania donovani 85% 98%
E9AH10 Leishmania infantum 86% 98%
E9AIQ8 Leishmania braziliensis 68% 100%
E9AW39 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS