Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9ACS1_LEIMA

TriTrypDb:

LmjF.06.1290 , LMJLV39_220005000 , LMJSD75_220005100

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9ACS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACS1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0020037	heme binding	4	4
GO:0046906	tetrapyrrole binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_3	1	3	PF02207	0.559
DOC_MAPK_gen_1	15	25	PF00069	0.331
DOC_MAPK_MEF2A_6	18	25	PF00069	0.331
DOC_USP7_MATH_1	31	35	PF00917	0.306
DOC_USP7_MATH_1	5	9	PF00917	0.516
DOC_USP7_MATH_1	75	79	PF00917	0.571
DOC_USP7_UBL2_3	47	51	PF12436	0.331
LIG_deltaCOP1_diTrp_1	64	72	PF00928	0.453
LIG_LIR_Gen_1	46	56	PF02991	0.306
LIG_SH2_CRK	19	23	PF00017	0.348
LIG_SH2_STAT5	3	6	PF00017	0.526
LIG_SH3_3	1	7	PF00018	0.489
MOD_CK1_1	78	84	PF00069	0.629
MOD_GlcNHglycan	77	80	PF01048	0.647
MOD_N-GLC_1	52	57	PF02516	0.339
MOD_NEK2_1	77	82	PF00069	0.476
MOD_Plk_1	52	58	PF00069	0.518
MOD_Plk_4	32	38	PF00069	0.371
MOD_SUMO_rev_2	64	72	PF00179	0.391
TRG_NES_CRM1_1	50	64	PF08389	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JJZ5	Bodo saltans	40%	69%
A0A3Q8ICI2	Leishmania donovani	38%	85%
A0A3Q8ILC3	Leishmania donovani	88%	77%
A0A3S7WPP2	Leishmania donovani	87%	77%
A0A3S7X4C9	Leishmania donovani	36%	79%
A4H4U1	Leishmania braziliensis	77%	78%
A4HJ97	Leishmania braziliensis	35%	100%
A4HT20	Leishmania infantum	88%	77%
A4I6P2	Leishmania infantum	36%	79%
A4I6P3	Leishmania infantum	38%	85%
E9AGY1	Leishmania infantum	88%	77%
E9AL09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	77%
E9AVI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	77%
E9B1R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	85%
Q4Q6E6	Leishmania major	37%	85%
Q4QIU6	Leishmania major	95%	77%