LeishMANIAdb
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PCNA_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
PCNA_C domain-containing protein
Gene product:
hypothetical protein
Species:
Leishmania major
UniProt:
E9ACR6_LEIMA
TriTrypDb:
LmjF.16.1145 , LMJLV39_160017800 * , LMJSD75_160017400
Length:
117

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACR6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACR6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 111 115 PF00656 0.766
CLV_C14_Caspase3-7 36 40 PF00656 0.507
CLV_C14_Caspase3-7 87 91 PF00656 0.676
CLV_NRD_NRD_1 96 98 PF00675 0.696
CLV_PCSK_KEX2_1 98 100 PF00082 0.654
CLV_PCSK_PC1ET2_1 98 100 PF00082 0.654
CLV_PCSK_SKI1_1 17 21 PF00082 0.464
CLV_PCSK_SKI1_1 68 72 PF00082 0.504
CLV_PCSK_SKI1_1 7 11 PF00082 0.643
DOC_CYCLIN_RxL_1 4 14 PF00134 0.647
DOC_MAPK_MEF2A_6 42 49 PF00069 0.625
DOC_WW_Pin1_4 54 59 PF00397 0.629
LIG_14-3-3_CanoR_1 17 22 PF00244 0.555
LIG_AP2alpha_2 82 84 PF02296 0.499
LIG_BIR_II_1 1 5 PF00653 0.577
LIG_BRCT_BRCA1_1 105 109 PF00533 0.732
LIG_Clathr_ClatBox_1 10 14 PF01394 0.450
LIG_FHA_2 20 26 PF00498 0.515
LIG_FHA_2 85 91 PF00498 0.693
LIG_IRF3_LxIS_1 29 36 PF10401 0.481
LIG_NRBOX 28 34 PF00104 0.513
LIG_NRBOX 5 11 PF00104 0.572
LIG_PDZ_Class_1 112 117 PF00595 0.765
LIG_Pex14_1 80 84 PF04695 0.503
LIG_TRAF2_1 72 75 PF00917 0.527
LIG_UBA3_1 62 68 PF00899 0.597
MOD_CK2_1 24 30 PF00069 0.533
MOD_CK2_1 69 75 PF00069 0.522
MOD_GlcNHglycan 25 29 PF01048 0.545
MOD_GlcNHglycan 52 55 PF01048 0.662
MOD_GlcNHglycan 94 97 PF01048 0.637
MOD_GSK3_1 108 115 PF00069 0.661
MOD_GSK3_1 50 57 PF00069 0.552
MOD_N-GLC_1 50 55 PF02516 0.653
MOD_N-GLC_1 84 89 PF02516 0.554
MOD_NEK2_1 33 38 PF00069 0.600
MOD_NEK2_1 84 89 PF00069 0.578
MOD_NEK2_2 19 24 PF00069 0.539
MOD_PKA_2 33 39 PF00069 0.498
MOD_PKA_2 41 47 PF00069 0.570
MOD_PKB_1 99 107 PF00069 0.699
MOD_Plk_1 84 90 PF00069 0.464
MOD_Plk_2-3 103 109 PF00069 0.663
MOD_ProDKin_1 54 60 PF00069 0.626
TRG_DiLeu_BaEn_4 74 80 PF01217 0.609
TRG_NLS_MonoExtC_3 96 101 PF00514 0.700
TRG_NLS_MonoExtN_4 97 102 PF00514 0.707

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAA9 Leptomonas seymouri 60% 92%
A0A3S5H6Y4 Leishmania donovani 89% 100%
A4H8P1 Leishmania braziliensis 76% 98%
C9ZZZ9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 74%
E9AGP1 Leishmania infantum 89% 100%
E9AQS5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS