Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9ACR5_LEIMA

TriTrypDb:

LmjF.14.1155 , LMJLV39_140019300 , LMJSD75_140018800

Length:

346

Annotations

LeishMANIAdb annotations

Very putatively an organellar or non-TM protein

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACR5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.506
CLV_C14_Caspase3-7	44	48	PF00656	0.711
CLV_NRD_NRD_1	102	104	PF00675	0.603
CLV_NRD_NRD_1	16	18	PF00675	0.497
CLV_NRD_NRD_1	191	193	PF00675	0.596
CLV_NRD_NRD_1	2	4	PF00675	0.566
CLV_NRD_NRD_1	63	65	PF00675	0.394
CLV_NRD_NRD_1	73	75	PF00675	0.354
CLV_PCSK_KEX2_1	102	104	PF00082	0.603
CLV_PCSK_KEX2_1	132	134	PF00082	0.751
CLV_PCSK_KEX2_1	16	18	PF00082	0.497
CLV_PCSK_KEX2_1	193	195	PF00082	0.600
CLV_PCSK_KEX2_1	2	4	PF00082	0.566
CLV_PCSK_KEX2_1	63	65	PF00082	0.385
CLV_PCSK_KEX2_1	73	75	PF00082	0.316
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.751
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.678
CLV_PCSK_PC7_1	12	18	PF00082	0.501
CLV_PCSK_PC7_1	189	195	PF00082	0.580
CLV_PCSK_SKI1_1	193	197	PF00082	0.636
CLV_PCSK_SKI1_1	30	34	PF00082	0.528
CLV_PCSK_SKI1_1	311	315	PF00082	0.693
CLV_PCSK_SKI1_1	65	69	PF00082	0.453
DEG_Nend_UBRbox_1	1	4	PF02207	0.694
DEG_SCF_FBW7_1	32	39	PF00400	0.702
DEG_SPOP_SBC_1	278	282	PF00917	0.595
DEG_SPOP_SBC_1	38	42	PF00917	0.733
DOC_CYCLIN_RxL_1	189	200	PF00134	0.444
DOC_MAPK_gen_1	189	197	PF00069	0.419
DOC_MAPK_gen_1	224	234	PF00069	0.481
DOC_MAPK_gen_1	324	334	PF00069	0.420
DOC_MAPK_gen_1	63	69	PF00069	0.635
DOC_PP1_RVXF_1	191	198	PF00149	0.443
DOC_PP1_RVXF_1	63	70	PF00149	0.658
DOC_PP2B_LxvP_1	75	78	PF13499	0.344
DOC_USP7_MATH_1	20	24	PF00917	0.784
DOC_USP7_MATH_1	243	247	PF00917	0.479
DOC_USP7_MATH_1	278	282	PF00917	0.511
DOC_USP7_MATH_1	296	300	PF00917	0.421
DOC_USP7_MATH_1	36	40	PF00917	0.772
DOC_WW_Pin1_4	117	122	PF00397	0.545
DOC_WW_Pin1_4	139	144	PF00397	0.621
DOC_WW_Pin1_4	212	217	PF00397	0.473
DOC_WW_Pin1_4	266	271	PF00397	0.543
DOC_WW_Pin1_4	297	302	PF00397	0.475
DOC_WW_Pin1_4	32	37	PF00397	0.744
LIG_14-3-3_CanoR_1	30	36	PF00244	0.756
LIG_Actin_WH2_2	81	99	PF00022	0.583
LIG_CSL_BTD_1	111	114	PF09270	0.477
LIG_deltaCOP1_diTrp_1	170	178	PF00928	0.441
LIG_EVH1_1	288	292	PF00568	0.410
LIG_FHA_1	215	221	PF00498	0.384
LIG_FHA_1	278	284	PF00498	0.535
LIG_FHA_1	314	320	PF00498	0.347
LIG_FHA_2	206	212	PF00498	0.548
LIG_LIR_Nem_3	66	72	PF02991	0.611
LIG_LIR_Nem_3	81	86	PF02991	0.378
LIG_LIR_Nem_3	92	98	PF02991	0.328
LIG_PDZ_Class_3	341	346	PF00595	0.473
LIG_Pex14_2	109	113	PF04695	0.405
LIG_SH2_STAP1	249	253	PF00017	0.493
LIG_SH2_STAT5	98	101	PF00017	0.383
LIG_SH3_3	115	121	PF00018	0.472
LIG_SH3_3	199	205	PF00018	0.541
LIG_SH3_3	258	264	PF00018	0.468
LIG_SH3_3	283	289	PF00018	0.556
LIG_SH3_3	295	301	PF00018	0.502
LIG_SUMO_SIM_par_1	114	120	PF11976	0.560
LIG_TRFH_1	86	90	PF08558	0.569
LIG_WW_2	289	292	PF00397	0.408
MOD_CK1_1	141	147	PF00069	0.606
MOD_CK1_1	269	275	PF00069	0.543
MOD_CK1_1	31	37	PF00069	0.736
MOD_CK1_1	39	45	PF00069	0.750
MOD_CK2_1	117	123	PF00069	0.540
MOD_CK2_1	181	187	PF00069	0.481
MOD_CK2_1	205	211	PF00069	0.503
MOD_CK2_1	212	218	PF00069	0.460
MOD_CK2_1	238	244	PF00069	0.475
MOD_GlcNHglycan	22	25	PF01048	0.578
MOD_GlcNHglycan	43	46	PF01048	0.540
MOD_GlcNHglycan	6	9	PF01048	0.556
MOD_GSK3_1	119	126	PF00069	0.559
MOD_GSK3_1	133	140	PF00069	0.460
MOD_GSK3_1	160	167	PF00069	0.524
MOD_GSK3_1	205	212	PF00069	0.516
MOD_GSK3_1	26	33	PF00069	0.750
MOD_GSK3_1	309	316	PF00069	0.489
MOD_GSK3_1	34	41	PF00069	0.723
MOD_GSK3_1	4	11	PF00069	0.760
MOD_N-GLC_1	138	143	PF02516	0.662
MOD_NEK2_1	105	110	PF00069	0.397
MOD_NEK2_1	313	318	PF00069	0.362
MOD_NEK2_1	4	9	PF00069	0.738
MOD_NEK2_2	78	83	PF00069	0.485
MOD_PKA_1	181	187	PF00069	0.511
MOD_PKA_2	4	10	PF00069	0.760
MOD_PKA_2	88	94	PF00069	0.468
MOD_Plk_1	105	111	PF00069	0.402
MOD_Plk_1	205	211	PF00069	0.546
MOD_Plk_1	309	315	PF00069	0.493
MOD_Plk_4	160	166	PF00069	0.482
MOD_Plk_4	205	211	PF00069	0.523
MOD_ProDKin_1	117	123	PF00069	0.548
MOD_ProDKin_1	139	145	PF00069	0.621
MOD_ProDKin_1	212	218	PF00069	0.471
MOD_ProDKin_1	266	272	PF00069	0.543
MOD_ProDKin_1	297	303	PF00069	0.471
MOD_ProDKin_1	32	38	PF00069	0.745
TRG_DiLeu_BaEn_4	221	227	PF01217	0.530
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.419
TRG_ENDOCYTIC_2	83	86	PF00928	0.401
TRG_ER_diArg_1	1	3	PF00400	0.792
TRG_ER_diArg_1	192	195	PF00400	0.422
TRG_ER_diArg_1	62	64	PF00400	0.597
TRG_ER_diArg_1	72	74	PF00400	0.364
TRG_NLS_Bipartite_1	181	196	PF00514	0.457
TRG_NLS_MonoExtN_4	189	196	PF00514	0.473
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.735

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P306	Leptomonas seymouri	47%	98%
A0A1X0NQ49	Trypanosomatidae	35%	100%
A0A3R7M3H5	Trypanosoma rangeli	34%	100%
A0A3S5H6S8	Leishmania donovani	91%	99%
A4H7R9	Leishmania braziliensis	69%	100%
C9ZSW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AGL5	Leishmania infantum	92%	100%
E9APW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%