G_PROTEIN_RECEP_F1_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACR4_LEIMA

TriTrypDb:

LmjF.14.1045 , LMJLV39_140017300 , LMJSD75_140016700

Length:

207

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9ACR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.443
CLV_NRD_NRD_1	203	205	PF00675	0.497
DEG_Nend_UBRbox_2	1	3	PF02207	0.673
DOC_CKS1_1	53	58	PF01111	0.249
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.620
DOC_MAPK_DCC_7	98	106	PF00069	0.622
DOC_PP1_RVXF_1	155	162	PF00149	0.338
DOC_PP4_FxxP_1	16	19	PF00568	0.591
DOC_PP4_FxxP_1	21	24	PF00568	0.332
DOC_SPAK_OSR1_1	166	170	PF12202	0.249
DOC_USP7_MATH_1	184	188	PF00917	0.615
DOC_WW_Pin1_4	52	57	PF00397	0.341
DOC_WW_Pin1_4	86	91	PF00397	0.572
LIG_BRCT_BRCA1_1	12	16	PF00533	0.581
LIG_BRCT_BRCA1_1	122	126	PF00533	0.353
LIG_BRCT_BRCA1_1	70	74	PF00533	0.355
LIG_BRCT_BRCA1_2	70	76	PF00533	0.249
LIG_FHA_1	127	133	PF00498	0.442
LIG_FHA_1	174	180	PF00498	0.429
LIG_FHA_1	18	24	PF00498	0.498
LIG_FHA_1	183	189	PF00498	0.639
LIG_FHA_1	53	59	PF00498	0.357
LIG_FHA_1	64	70	PF00498	0.300
LIG_FHA_1	79	85	PF00498	0.597
LIG_LIR_Apic_2	13	19	PF02991	0.547
LIG_LIR_Apic_2	193	199	PF02991	0.699
LIG_LIR_Apic_2	20	24	PF02991	0.252
LIG_LIR_Gen_1	64	72	PF02991	0.437
LIG_LIR_Gen_1	9	19	PF02991	0.599
LIG_LIR_LC3C_4	129	132	PF02991	0.442
LIG_LIR_Nem_3	162	168	PF02991	0.320
LIG_LIR_Nem_3	64	68	PF02991	0.437
LIG_LIR_Nem_3	9	15	PF02991	0.554
LIG_PCNA_PIPBox_1	152	161	PF02747	0.409
LIG_PCNA_yPIPBox_3	152	166	PF02747	0.362
LIG_Pex14_2	12	16	PF04695	0.573
LIG_Pex14_2	21	25	PF04695	0.325
LIG_SH2_CRK	122	126	PF00017	0.409
LIG_SH2_CRK	196	200	PF00017	0.682
LIG_SH2_NCK_1	122	126	PF00017	0.393
LIG_SH2_STAP1	122	126	PF00017	0.389
LIG_SH2_STAT5	158	161	PF00017	0.383
LIG_SH2_STAT5	178	181	PF00017	0.197
LIG_SH2_STAT5	37	40	PF00017	0.355
LIG_SH3_3	185	191	PF00018	0.636
LIG_SUMO_SIM_anti_2	29	35	PF11976	0.302
LIG_SUMO_SIM_par_1	128	134	PF11976	0.397
LIG_TYR_ITIM	120	125	PF00017	0.409
LIG_WRC_WIRS_1	62	67	PF05994	0.374
MOD_CDK_SPxxK_3	86	93	PF00069	0.585
MOD_CK1_1	192	198	PF00069	0.721
MOD_CK1_1	26	32	PF00069	0.442
MOD_CK1_1	75	81	PF00069	0.653
MOD_CK2_1	39	45	PF00069	0.396
MOD_Cter_Amidation	202	205	PF01082	0.496
MOD_GlcNHglycan	47	50	PF01048	0.672
MOD_GSK3_1	168	175	PF00069	0.320
MOD_GSK3_1	23	30	PF00069	0.247
MOD_GSK3_1	40	47	PF00069	0.385
MOD_GSK3_1	6	13	PF00069	0.653
MOD_GSK3_1	68	75	PF00069	0.366
MOD_N-GLC_1	45	50	PF02516	0.661
MOD_NEK2_1	159	164	PF00069	0.385
MOD_NEK2_1	39	44	PF00069	0.369
MOD_NEK2_1	63	68	PF00069	0.376
MOD_NEK2_1	74	79	PF00069	0.657
MOD_PIKK_1	10	16	PF00454	0.581
MOD_PIKK_1	182	188	PF00454	0.561
MOD_PIKK_1	75	81	PF00454	0.637
MOD_PKA_2	17	23	PF00069	0.538
MOD_Plk_1	39	45	PF00069	0.382
MOD_Plk_2-3	40	46	PF00069	0.397
MOD_Plk_4	102	108	PF00069	0.569
MOD_Plk_4	120	126	PF00069	0.249
MOD_Plk_4	160	166	PF00069	0.309
MOD_Plk_4	184	190	PF00069	0.612
MOD_Plk_4	29	35	PF00069	0.337
MOD_ProDKin_1	52	58	PF00069	0.341
MOD_ProDKin_1	86	92	PF00069	0.567
TRG_ENDOCYTIC_2	122	125	PF00928	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I195	Leptomonas seymouri	64%	100%
A0A0S4IKP2	Bodo saltans	29%	96%
A0A0S4JKJ4	Bodo saltans	26%	90%
A0A3Q8I8V9	Leishmania donovani	93%	100%
A4H7Q8	Leishmania braziliensis	81%	100%
E9AGL4	Leishmania infantum	93%	100%
E9APV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%