LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9ACR2_LEIMA
TriTrypDb:
LmjF.12.0075 , LMJLV39_120005900 , LMJSD75_120006700
Length:
90

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

E9ACR2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACR2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 31 35 PF00082 0.524
DEG_Nend_UBRbox_2 1 3 PF02207 0.760
DOC_CYCLIN_RxL_1 28 37 PF00134 0.717
DOC_MAPK_MEF2A_6 73 82 PF00069 0.515
DOC_PP4_FxxP_1 47 50 PF00568 0.705
DOC_WW_Pin1_4 16 21 PF00397 0.768
LIG_14-3-3_CanoR_1 35 42 PF00244 0.713
LIG_14-3-3_CanoR_1 73 79 PF00244 0.480
LIG_Actin_WH2_2 22 37 PF00022 0.726
LIG_FHA_1 19 25 PF00498 0.617
LIG_FHA_1 4 10 PF00498 0.689
LIG_FHA_2 17 23 PF00498 0.740
LIG_FHA_2 25 31 PF00498 0.659
LIG_NRBOX 77 83 PF00104 0.375
LIG_SH2_STAT5 25 28 PF00017 0.728
LIG_SH3_3 47 53 PF00018 0.744
LIG_SUMO_SIM_anti_2 77 82 PF11976 0.375
MOD_CK2_1 16 22 PF00069 0.718
MOD_CK2_1 24 30 PF00069 0.730
MOD_CK2_1 34 40 PF00069 0.611
MOD_GlcNHglycan 36 39 PF01048 0.506
MOD_GlcNHglycan 70 73 PF01048 0.356
MOD_NEK2_1 24 29 PF00069 0.733
MOD_NEK2_1 34 39 PF00069 0.609
MOD_NEK2_1 63 68 PF00069 0.658
MOD_PKA_2 34 40 PF00069 0.711
MOD_PKA_2 68 74 PF00069 0.546
MOD_Plk_4 74 80 PF00069 0.480
MOD_ProDKin_1 16 22 PF00069 0.767

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8I949 Leishmania donovani 88% 100%
A4H6S3 Leishmania braziliensis 69% 100%
E9AGA4 Leishmania infantum 88% 100%
E9ANT4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS