Class I SAM-dependent methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania major

UniProt:

E9ACR1_LEIMA

TriTrypDb:

LmjF.10.1228 , LMJLV39_100020300 , LMJSD75_100020300

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACR1

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	243	245	PF00675	0.415
CLV_NRD_NRD_1	95	97	PF00675	0.392
CLV_PCSK_KEX2_1	186	188	PF00082	0.411
CLV_PCSK_KEX2_1	243	245	PF00082	0.388
CLV_PCSK_KEX2_1	95	97	PF00082	0.441
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.411
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.388
CLV_PCSK_SKI1_1	49	53	PF00082	0.571
DEG_MDM2_SWIB_1	167	174	PF02201	0.445
DEG_Nend_UBRbox_2	1	3	PF02207	0.638
DOC_CYCLIN_yCln2_LP_2	160	166	PF00134	0.411
DOC_MAPK_MEF2A_6	17	26	PF00069	0.514
DOC_MAPK_MEF2A_6	175	184	PF00069	0.399
DOC_USP7_MATH_1	20	24	PF00917	0.530
DOC_WD40_RPTOR_TOS_1	125	131	PF00400	0.314
DOC_WW_Pin1_4	18	23	PF00397	0.538
DOC_WW_Pin1_4	94	99	PF00397	0.467
LIG_14-3-3_CanoR_1	232	241	PF00244	0.548
LIG_BRCT_BRCA1_1	41	45	PF00533	0.460
LIG_FHA_1	152	158	PF00498	0.411
LIG_FHA_1	183	189	PF00498	0.411
LIG_FHA_1	229	235	PF00498	0.518
LIG_FHA_2	150	156	PF00498	0.411
LIG_LIR_Apic_2	131	136	PF02991	0.405
LIG_LIR_Gen_1	146	156	PF02991	0.514
LIG_LIR_Gen_1	169	176	PF02991	0.357
LIG_LIR_Gen_1	212	223	PF02991	0.410
LIG_LIR_Gen_1	70	81	PF02991	0.354
LIG_LIR_Nem_3	128	133	PF02991	0.411
LIG_LIR_Nem_3	146	151	PF02991	0.411
LIG_LIR_Nem_3	165	170	PF02991	0.426
LIG_LIR_Nem_3	212	218	PF02991	0.410
LIG_LIR_Nem_3	70	76	PF02991	0.354
LIG_Pex14_2	167	171	PF04695	0.483
LIG_PTB_Apo_2	194	201	PF02174	0.411
LIG_PTB_Phospho_1	194	200	PF10480	0.411
LIG_SH2_CRK	148	152	PF00017	0.411
LIG_SH2_STAP1	73	77	PF00017	0.411
LIG_SH2_STAT3	99	102	PF00017	0.314
LIG_SH2_STAT5	134	137	PF00017	0.352
LIG_SH2_STAT5	140	143	PF00017	0.352
LIG_SH2_STAT5	200	203	PF00017	0.411
LIG_SH2_STAT5	87	90	PF00017	0.393
LIG_SH3_1	95	101	PF00018	0.380
LIG_SH3_3	41	47	PF00018	0.427
LIG_SH3_3	95	101	PF00018	0.504
LIG_SH3_5	83	87	PF00018	0.445
LIG_SUMO_SIM_anti_2	237	242	PF11976	0.432
LIG_SUMO_SIM_par_1	179	185	PF11976	0.399
LIG_TRAF2_1	54	57	PF00917	0.528
MOD_CK1_1	221	227	PF00069	0.528
MOD_CK1_1	3	9	PF00069	0.617
MOD_CK1_1	94	100	PF00069	0.294
MOD_CK2_1	149	155	PF00069	0.371
MOD_CK2_1	221	227	PF00069	0.444
MOD_CK2_1	50	56	PF00069	0.517
MOD_GlcNHglycan	118	121	PF01048	0.393
MOD_GlcNHglycan	234	237	PF01048	0.546
MOD_GlcNHglycan	53	56	PF01048	0.468
MOD_GlcNHglycan	88	91	PF01048	0.358
MOD_GSK3_1	162	169	PF00069	0.415
MOD_GSK3_1	18	25	PF00069	0.512
MOD_GSK3_1	198	205	PF00069	0.501
MOD_GSK3_1	221	228	PF00069	0.528
MOD_N-GLC_1	123	128	PF02516	0.423
MOD_N-GLC_1	91	96	PF02516	0.314
MOD_N-GLC_2	14	16	PF02516	0.475
MOD_NEK2_1	1	6	PF00069	0.630
MOD_NEK2_1	170	175	PF00069	0.347
MOD_NEK2_1	209	214	PF00069	0.445
MOD_NEK2_1	218	223	PF00069	0.364
MOD_NEK2_1	50	55	PF00069	0.483
MOD_NEK2_2	22	27	PF00069	0.524
MOD_Plk_1	1	7	PF00069	0.636
MOD_Plk_1	123	129	PF00069	0.522
MOD_Plk_4	162	168	PF00069	0.445
MOD_Plk_4	22	28	PF00069	0.577
MOD_Plk_4	39	45	PF00069	0.259
MOD_ProDKin_1	18	24	PF00069	0.535
MOD_ProDKin_1	94	100	PF00069	0.467
MOD_SUMO_rev_2	53	60	PF00179	0.495
TRG_DiLeu_BaEn_2	145	151	PF01217	0.405
TRG_ENDOCYTIC_2	148	151	PF00928	0.515
TRG_ENDOCYTIC_2	73	76	PF00928	0.411
TRG_ER_diLys_1	243	248	PF00400	0.479
TRG_ER_FFAT_2	146	155	PF00635	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF1	Leptomonas seymouri	59%	100%
A0A3S7WRE9	Leishmania donovani	89%	80%
A4H6B4	Leishmania braziliensis	72%	100%
A4HUN7	Leishmania infantum	91%	100%
E9AND6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%