Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9ACQ8_LEIMA

TriTrypDb:

LmjF.09.1315 , LMJLV39_090020500 , LMJSD75_090020100

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACQ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	305	309	PF00656	0.629
CLV_NRD_NRD_1	286	288	PF00675	0.629
CLV_NRD_NRD_1	334	336	PF00675	0.618
CLV_NRD_NRD_1	81	83	PF00675	0.557
CLV_PCSK_KEX2_1	285	287	PF00082	0.627
CLV_PCSK_KEX2_1	334	336	PF00082	0.618
CLV_PCSK_KEX2_1	81	83	PF00082	0.527
DEG_APCC_DBOX_1	93	101	PF00400	0.481
DEG_MDM2_SWIB_1	54	62	PF02201	0.426
DEG_Nend_Nbox_1	1	3	PF02207	0.579
DEG_SPOP_SBC_1	177	181	PF00917	0.586
DOC_CDC14_PxL_1	126	134	PF14671	0.529
DOC_MAPK_gen_1	334	342	PF00069	0.583
DOC_USP7_MATH_1	108	112	PF00917	0.498
DOC_USP7_MATH_1	13	17	PF00917	0.600
DOC_USP7_MATH_1	177	181	PF00917	0.630
DOC_USP7_MATH_1	266	270	PF00917	0.699
DOC_USP7_MATH_1	294	298	PF00917	0.760
DOC_USP7_MATH_1	309	313	PF00917	0.552
DOC_USP7_MATH_1	318	322	PF00917	0.554
DOC_WW_Pin1_4	192	197	PF00397	0.642
DOC_WW_Pin1_4	2	7	PF00397	0.564
DOC_WW_Pin1_4	207	212	PF00397	0.466
DOC_WW_Pin1_4	26	31	PF00397	0.566
DOC_WW_Pin1_4	34	39	PF00397	0.495
LIG_14-3-3_CanoR_1	214	220	PF00244	0.525
LIG_14-3-3_CanoR_1	255	261	PF00244	0.542
LIG_14-3-3_CanoR_1	275	283	PF00244	0.524
LIG_BIR_III_4	308	312	PF00653	0.639
LIG_FHA_1	179	185	PF00498	0.601
LIG_FHA_1	255	261	PF00498	0.640
LIG_FHA_1	294	300	PF00498	0.608
LIG_FHA_1	31	37	PF00498	0.555
LIG_FHA_2	193	199	PF00498	0.626
LIG_FHA_2	43	49	PF00498	0.417
LIG_LIR_Gen_1	136	146	PF02991	0.625
LIG_LIR_Gen_1	198	208	PF02991	0.543
LIG_LIR_Nem_3	136	141	PF02991	0.612
LIG_LIR_Nem_3	198	203	PF02991	0.552
LIG_LIR_Nem_3	269	274	PF02991	0.648
LIG_MYND_1	272	276	PF01753	0.657
LIG_PDZ_Class_3	345	350	PF00595	0.628
LIG_Pex14_2	54	58	PF04695	0.409
LIG_PTB_Apo_2	48	55	PF02174	0.426
LIG_SH2_STAT5	68	71	PF00017	0.412
LIG_SH3_3	102	108	PF00018	0.489
LIG_SH3_3	16	22	PF00018	0.626
LIG_SUMO_SIM_anti_2	16	24	PF11976	0.628
LIG_SUMO_SIM_anti_2	296	303	PF11976	0.668
LIG_SUMO_SIM_anti_2	339	349	PF11976	0.587
LIG_SUMO_SIM_par_1	16	24	PF11976	0.628
LIG_SUMO_SIM_par_1	296	303	PF11976	0.612
LIG_SUMO_SIM_par_1	339	349	PF11976	0.578
MOD_CDK_SPxK_1	34	40	PF00069	0.546
MOD_CDK_SPxxK_3	207	214	PF00069	0.587
MOD_CK1_1	178	184	PF00069	0.618
MOD_CK1_1	185	191	PF00069	0.696
MOD_CK1_1	218	224	PF00069	0.623
MOD_CK1_1	29	35	PF00069	0.570
MOD_CK2_1	134	140	PF00069	0.650
MOD_CK2_1	192	198	PF00069	0.683
MOD_CK2_1	207	213	PF00069	0.473
MOD_CK2_1	21	27	PF00069	0.546
MOD_CK2_1	89	95	PF00069	0.598
MOD_Cter_Amidation	283	286	PF01082	0.641
MOD_GlcNHglycan	222	226	PF01048	0.624
MOD_GlcNHglycan	268	271	PF01048	0.592
MOD_GlcNHglycan	296	299	PF01048	0.659
MOD_GlcNHglycan	320	323	PF01048	0.600
MOD_GlcNHglycan	74	78	PF01048	0.415
MOD_GSK3_1	169	176	PF00069	0.632
MOD_GSK3_1	178	185	PF00069	0.579
MOD_GSK3_1	214	221	PF00069	0.605
MOD_GSK3_1	26	33	PF00069	0.576
MOD_GSK3_1	89	96	PF00069	0.553
MOD_N-GLC_1	255	260	PF02516	0.508
MOD_NEK2_1	1	6	PF00069	0.548
MOD_NEK2_1	184	189	PF00069	0.601
MOD_NEK2_1	73	78	PF00069	0.440
MOD_NEK2_2	42	47	PF00069	0.501
MOD_PIKK_1	276	282	PF00454	0.555
MOD_PIKK_1	30	36	PF00454	0.567
MOD_PKA_2	254	260	PF00069	0.594
MOD_PKA_2	309	315	PF00069	0.687
MOD_PKA_2	327	333	PF00069	0.624
MOD_PKA_2	93	99	PF00069	0.489
MOD_Plk_1	255	261	PF00069	0.509
MOD_Plk_1	73	79	PF00069	0.485
MOD_ProDKin_1	192	198	PF00069	0.644
MOD_ProDKin_1	2	8	PF00069	0.565
MOD_ProDKin_1	207	213	PF00069	0.473
MOD_ProDKin_1	26	32	PF00069	0.566
MOD_ProDKin_1	34	40	PF00069	0.492
TRG_ER_diArg_1	285	287	PF00400	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4T4	Leptomonas seymouri	33%	95%
A0A3S7WQV7	Leishmania donovani	91%	100%
A4H5V9	Leishmania braziliensis	69%	100%
E9AG96	Leishmania infantum	93%	100%
E9AMY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%