Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACQ6_LEIMA

TriTrypDb:

LmjF.08.1265 , LMJLV39_080016500 , LMJSD75_080016900

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	346	350	PF00656	0.729
CLV_NRD_NRD_1	337	339	PF00675	0.719
CLV_NRD_NRD_1	87	89	PF00675	0.655
CLV_PCSK_KEX2_1	337	339	PF00082	0.719
CLV_PCSK_KEX2_1	87	89	PF00082	0.657
CLV_PCSK_SKI1_1	234	238	PF00082	0.669
CLV_PCSK_SKI1_1	87	91	PF00082	0.641
DEG_COP1_1	306	317	PF00400	0.535
DEG_SPOP_SBC_1	19	23	PF00917	0.716
DEG_SPOP_SBC_1	30	34	PF00917	0.618
DOC_MAPK_gen_1	87	95	PF00069	0.640
DOC_MAPK_MEF2A_6	129	136	PF00069	0.492
DOC_MAPK_MEF2A_6	257	265	PF00069	0.571
DOC_MAPK_NFAT4_5	129	137	PF00069	0.490
DOC_PP2B_LxvP_1	297	300	PF13499	0.544
DOC_PP4_FxxP_1	295	298	PF00568	0.546
DOC_USP7_MATH_1	241	245	PF00917	0.646
DOC_USP7_MATH_1	29	33	PF00917	0.762
DOC_USP7_MATH_1	298	302	PF00917	0.611
DOC_USP7_MATH_1	305	309	PF00917	0.651
DOC_USP7_MATH_1	4	8	PF00917	0.732
DOC_USP7_MATH_1	429	433	PF00917	0.651
DOC_USP7_MATH_1	57	61	PF00917	0.718
DOC_USP7_MATH_1	63	67	PF00917	0.680
DOC_USP7_MATH_1	9	13	PF00917	0.662
DOC_WW_Pin1_4	11	16	PF00397	0.696
DOC_WW_Pin1_4	140	145	PF00397	0.644
DOC_WW_Pin1_4	183	188	PF00397	0.553
DOC_WW_Pin1_4	256	261	PF00397	0.665
DOC_WW_Pin1_4	276	281	PF00397	0.369
DOC_WW_Pin1_4	308	313	PF00397	0.728
DOC_WW_Pin1_4	336	341	PF00397	0.622
DOC_WW_Pin1_4	420	425	PF00397	0.723
DOC_WW_Pin1_4	95	100	PF00397	0.690
LIG_14-3-3_CanoR_1	10	18	PF00244	0.566
LIG_14-3-3_CanoR_1	129	133	PF00244	0.496
LIG_14-3-3_CanoR_1	304	314	PF00244	0.660
LIG_14-3-3_CanoR_1	329	335	PF00244	0.652
LIG_APCC_ABBA_1	390	395	PF00400	0.648
LIG_BIR_III_2	349	353	PF00653	0.665
LIG_CSL_BTD_1	424	427	PF09270	0.657
LIG_FHA_1	122	128	PF00498	0.683
LIG_FHA_1	129	135	PF00498	0.602
LIG_FHA_1	154	160	PF00498	0.622
LIG_FHA_1	192	198	PF00498	0.578
LIG_FHA_1	294	300	PF00498	0.450
LIG_FHA_1	337	343	PF00498	0.633
LIG_FHA_1	413	419	PF00498	0.627
LIG_FHA_1	53	59	PF00498	0.729
LIG_FHA_2	412	418	PF00498	0.625
LIG_GBD_Chelix_1	261	269	PF00786	0.608
LIG_LIR_Apic_2	376	382	PF02991	0.614
LIG_LIR_Gen_1	37	44	PF02991	0.631
LIG_LIR_Gen_1	384	392	PF02991	0.728
LIG_LIR_Nem_3	143	149	PF02991	0.628
LIG_LIR_Nem_3	37	42	PF02991	0.638
LIG_LIR_Nem_3	384	390	PF02991	0.730
LIG_PCNA_yPIPBox_3	243	257	PF02747	0.623
LIG_PDZ_Class_2	430	435	PF00595	0.701
LIG_PDZ_Wminus1_1	433	435	PF00595	0.706
LIG_SH2_CRK	387	391	PF00017	0.731
LIG_SH2_PTP2	148	151	PF00017	0.588
LIG_SH2_PTP2	379	382	PF00017	0.626
LIG_SH2_PTP2	39	42	PF00017	0.621
LIG_SH2_SRC	379	382	PF00017	0.626
LIG_SH2_SRC	39	42	PF00017	0.621
LIG_SH2_STAP1	318	322	PF00017	0.710
LIG_SH2_STAP1	52	56	PF00017	0.717
LIG_SH2_STAT5	148	151	PF00017	0.588
LIG_SH2_STAT5	294	297	PF00017	0.595
LIG_SH2_STAT5	379	382	PF00017	0.626
LIG_SH2_STAT5	39	42	PF00017	0.636
LIG_SH2_STAT5	409	412	PF00017	0.706
LIG_SH3_3	148	154	PF00018	0.593
LIG_SH3_3	309	315	PF00018	0.728
LIG_SH3_3	421	427	PF00018	0.654
LIG_SUMO_SIM_par_1	92	98	PF11976	0.695
LIG_WRC_WIRS_1	331	336	PF05994	0.611
LIG_WW_1	144	147	PF00397	0.627
MOD_CK1_1	180	186	PF00069	0.654
MOD_CK1_1	21	27	PF00069	0.743
MOD_CK1_1	279	285	PF00069	0.679
MOD_CK1_1	308	314	PF00069	0.728
MOD_CK1_1	333	339	PF00069	0.628
MOD_CK1_1	362	368	PF00069	0.507
MOD_CK1_1	61	67	PF00069	0.718
MOD_CK1_1	69	75	PF00069	0.661
MOD_CK2_1	411	417	PF00069	0.626
MOD_GlcNHglycan	11	14	PF01048	0.535
MOD_GlcNHglycan	239	242	PF01048	0.643
MOD_GlcNHglycan	307	310	PF01048	0.684
MOD_GlcNHglycan	320	323	PF01048	0.503
MOD_GlcNHglycan	33	36	PF01048	0.705
MOD_GlcNHglycan	365	368	PF01048	0.568
MOD_GlcNHglycan	60	63	PF01048	0.714
MOD_GlcNHglycan	68	71	PF01048	0.662
MOD_GSK3_1	112	119	PF00069	0.686
MOD_GSK3_1	19	26	PF00069	0.700
MOD_GSK3_1	191	198	PF00069	0.649
MOD_GSK3_1	237	244	PF00069	0.648
MOD_GSK3_1	276	283	PF00069	0.646
MOD_GSK3_1	304	311	PF00069	0.660
MOD_GSK3_1	358	365	PF00069	0.509
MOD_GSK3_1	57	64	PF00069	0.741
MOD_GSK3_1	95	102	PF00069	0.630
MOD_NEK2_1	128	133	PF00069	0.707
MOD_NEK2_1	168	173	PF00069	0.619
MOD_NEK2_1	237	242	PF00069	0.681
MOD_NEK2_1	287	292	PF00069	0.624
MOD_NEK2_1	303	308	PF00069	0.505
MOD_NEK2_1	330	335	PF00069	0.610
MOD_NEK2_1	342	347	PF00069	0.563
MOD_NEK2_1	358	363	PF00069	0.557
MOD_OFUCOSY	111	116	PF10250	0.647
MOD_OFUCOSY	359	364	PF10250	0.510
MOD_PIKK_1	118	124	PF00454	0.498
MOD_PIKK_1	205	211	PF00454	0.654
MOD_PKA_2	128	134	PF00069	0.576
MOD_PKA_2	191	197	PF00069	0.550
MOD_PKA_2	303	309	PF00069	0.658
MOD_PKA_2	395	401	PF00069	0.666
MOD_PKA_2	9	15	PF00069	0.556
MOD_Plk_4	168	174	PF00069	0.619
MOD_Plk_4	264	270	PF00069	0.604
MOD_Plk_4	313	319	PF00069	0.661
MOD_ProDKin_1	11	17	PF00069	0.698
MOD_ProDKin_1	140	146	PF00069	0.639
MOD_ProDKin_1	183	189	PF00069	0.544
MOD_ProDKin_1	256	262	PF00069	0.657
MOD_ProDKin_1	276	282	PF00069	0.369
MOD_ProDKin_1	308	314	PF00069	0.728
MOD_ProDKin_1	336	342	PF00069	0.626
MOD_ProDKin_1	420	426	PF00069	0.723
MOD_ProDKin_1	95	101	PF00069	0.695
TRG_DiLeu_BaEn_1	326	331	PF01217	0.680
TRG_DiLeu_LyEn_5	326	331	PF01217	0.680
TRG_ENDOCYTIC_2	146	149	PF00928	0.600
TRG_ENDOCYTIC_2	294	297	PF00928	0.595
TRG_ENDOCYTIC_2	387	390	PF00928	0.733
TRG_ENDOCYTIC_2	39	42	PF00928	0.636
TRG_ER_diArg_1	86	88	PF00400	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H698	Leishmania donovani	94%	100%
A4HC45	Leishmania braziliensis	72%	100%
E9AG91	Leishmania infantum	94%	100%
E9AMJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	80%