RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania major

UniProt:

E9ACQ5_LEIMA

TriTrypDb:

LmjF.08.1101

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACQ5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004842	ubiquitin-protein transferase activity	4	10
GO:0005488	binding	1	9
GO:0016740	transferase activity	2	10
GO:0019787	ubiquitin-like protein transferase activity	3	10
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0061630	ubiquitin protein ligase activity	5	10
GO:0061659	ubiquitin-like protein ligase activity	4	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:0008270	zinc ion binding	6	4
GO:0046914	transition metal ion binding	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	336	340	PF00656	0.620
CLV_NRD_NRD_1	10	12	PF00675	0.580
CLV_NRD_NRD_1	185	187	PF00675	0.499
CLV_NRD_NRD_1	242	244	PF00675	0.528
CLV_NRD_NRD_1	263	265	PF00675	0.617
CLV_NRD_NRD_1	274	276	PF00675	0.471
CLV_NRD_NRD_1	311	313	PF00675	0.449
CLV_PCSK_KEX2_1	12	14	PF00082	0.452
CLV_PCSK_KEX2_1	185	187	PF00082	0.517
CLV_PCSK_KEX2_1	242	244	PF00082	0.559
CLV_PCSK_KEX2_1	274	276	PF00082	0.477
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.457
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.600
CLV_PCSK_SKI1_1	103	107	PF00082	0.482
DEG_Nend_Nbox_1	1	3	PF02207	0.642
DOC_PP2B_LxvP_1	343	346	PF13499	0.629
DOC_SPAK_OSR1_1	32	36	PF12202	0.397
DOC_USP7_MATH_1	132	136	PF00917	0.480
DOC_USP7_MATH_1	17	21	PF00917	0.479
DOC_USP7_MATH_1	193	197	PF00917	0.406
DOC_USP7_MATH_1	207	211	PF00917	0.602
DOC_USP7_MATH_1	215	219	PF00917	0.625
DOC_USP7_UBL2_3	294	298	PF12436	0.316
LIG_14-3-3_CanoR_1	185	191	PF00244	0.510
LIG_BRCT_BRCA1_1	195	199	PF00533	0.514
LIG_Clathr_ClatBox_1	235	239	PF01394	0.445
LIG_FHA_1	109	115	PF00498	0.553
LIG_FHA_1	209	215	PF00498	0.620
LIG_FHA_1	340	346	PF00498	0.700
LIG_FHA_1	62	68	PF00498	0.368
LIG_FHA_2	24	30	PF00498	0.316
LIG_FHA_2	323	329	PF00498	0.648
LIG_LIR_Gen_1	170	181	PF02991	0.451
LIG_LIR_Gen_1	230	238	PF02991	0.413
LIG_LIR_Gen_1	301	309	PF02991	0.303
LIG_LIR_Nem_3	170	176	PF02991	0.431
LIG_LIR_Nem_3	221	227	PF02991	0.494
LIG_LIR_Nem_3	230	235	PF02991	0.392
LIG_LIR_Nem_3	255	261	PF02991	0.460
LIG_LIR_Nem_3	301	306	PF02991	0.303
LIG_NRBOX	64	70	PF00104	0.377
LIG_Pex14_1	299	303	PF04695	0.375
LIG_Rb_LxCxE_1	100	118	PF01857	0.310
LIG_REV1ctd_RIR_1	69	77	PF16727	0.471
LIG_SH2_CRK	173	177	PF00017	0.397
LIG_SH2_CRK	232	236	PF00017	0.511
LIG_SH2_GRB2like	85	88	PF00017	0.442
LIG_SH2_STAP1	173	177	PF00017	0.491
LIG_SH2_STAP1	232	236	PF00017	0.456
LIG_SH2_STAT5	173	176	PF00017	0.441
LIG_SH2_STAT5	181	184	PF00017	0.374
LIG_SH2_STAT5	188	191	PF00017	0.419
LIG_SH2_STAT5	258	261	PF00017	0.516
LIG_SH2_STAT5	85	88	PF00017	0.442
LIG_SH3_1	192	198	PF00018	0.448
LIG_SH3_3	192	198	PF00018	0.587
LIG_SH3_3	349	355	PF00018	0.556
LIG_SUMO_SIM_anti_2	64	69	PF11976	0.368
LIG_SUMO_SIM_par_1	233	239	PF11976	0.548
LIG_TYR_ITIM	222	227	PF00017	0.488
LIG_TYR_ITIM	256	261	PF00017	0.402
LIG_UBA3_1	235	242	PF00899	0.578
MOD_CK1_1	110	116	PF00069	0.434
MOD_CK1_1	15	21	PF00069	0.427
MOD_CK1_1	162	168	PF00069	0.581
MOD_CK1_1	210	216	PF00069	0.575
MOD_CK1_1	252	258	PF00069	0.530
MOD_CK1_1	301	307	PF00069	0.394
MOD_CK1_1	347	353	PF00069	0.583
MOD_CK2_1	148	154	PF00069	0.488
MOD_CK2_1	322	328	PF00069	0.676
MOD_GlcNHglycan	134	137	PF01048	0.509
MOD_GlcNHglycan	14	17	PF01048	0.450
MOD_GSK3_1	148	155	PF00069	0.498
MOD_GSK3_1	167	174	PF00069	0.561
MOD_GSK3_1	193	200	PF00069	0.432
MOD_GSK3_1	329	336	PF00069	0.662
MOD_GSK3_1	344	351	PF00069	0.580
MOD_GSK3_1	51	58	PF00069	0.403
MOD_N-GLC_1	162	167	PF02516	0.532
MOD_N-GLC_1	171	176	PF02516	0.460
MOD_N-GLC_1	252	257	PF02516	0.531
MOD_N-GLC_1	265	270	PF02516	0.413
MOD_N-GLC_1	43	48	PF02516	0.349
MOD_N-GLC_2	141	143	PF02516	0.579
MOD_N-GLC_2	280	282	PF02516	0.372
MOD_NEK2_1	199	204	PF00069	0.597
MOD_NEK2_1	276	281	PF00069	0.302
MOD_NEK2_1	333	338	PF00069	0.588
MOD_OFUCOSY	168	175	PF10250	0.400
MOD_OFUCOSY	262	269	PF10250	0.424
MOD_PIKK_1	317	323	PF00454	0.539
MOD_PIKK_1	55	61	PF00454	0.464
MOD_PK_1	348	354	PF00069	0.574
MOD_PKA_1	12	18	PF00069	0.479
MOD_PKA_2	107	113	PF00069	0.347
MOD_PKA_2	12	18	PF00069	0.450
MOD_Plk_1	162	168	PF00069	0.597
MOD_Plk_1	171	177	PF00069	0.376
MOD_Plk_1	252	258	PF00069	0.436
MOD_Plk_1	43	49	PF00069	0.453
MOD_Plk_2-3	322	328	PF00069	0.494
MOD_Plk_4	63	69	PF00069	0.435
MOD_SUMO_rev_2	151	157	PF00179	0.508
MOD_SUMO_rev_2	322	332	PF00179	0.584
MOD_SUMO_rev_2	96	105	PF00179	0.522
TRG_DiLeu_BaEn_1	90	95	PF01217	0.420
TRG_DiLeu_BaEn_4	249	255	PF01217	0.559
TRG_ENDOCYTIC_2	173	176	PF00928	0.386
TRG_ENDOCYTIC_2	224	227	PF00928	0.469
TRG_ENDOCYTIC_2	232	235	PF00928	0.430
TRG_ENDOCYTIC_2	258	261	PF00928	0.408
TRG_ER_diArg_1	10	13	PF00400	0.494
TRG_ER_diArg_1	273	275	PF00400	0.394
TRG_NLS_MonoExtN_4	9	15	PF00514	0.380
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H3	Leptomonas seymouri	43%	96%
A0A0S4KHN3	Bodo saltans	27%	67%
A0A1X0NP60	Trypanosomatidae	30%	79%
A0A3S7WQF3	Leishmania donovani	93%	100%
A4H5E8	Leishmania braziliensis	70%	99%
C9ZPE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	79%
E9AG87	Leishmania infantum	93%	100%
E9AMH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%