Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACQ3_LEIMA

TriTrypDb:

LmjF.07.1035 , LMJLV39_070017700 , LMJSD75_070018000

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACQ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.567
CLV_NRD_NRD_1	178	180	PF00675	0.559
CLV_PCSK_FUR_1	156	160	PF00082	0.564
CLV_PCSK_FUR_1	176	180	PF00082	0.448
CLV_PCSK_KEX2_1	158	160	PF00082	0.567
CLV_PCSK_KEX2_1	178	180	PF00082	0.559
CLV_PCSK_SKI1_1	2	6	PF00082	0.652
CLV_PCSK_SKI1_1	9	13	PF00082	0.594
DEG_Nend_UBRbox_1	1	4	PF02207	0.644
DOC_CKS1_1	84	89	PF01111	0.546
DOC_CYCLIN_RxL_1	6	16	PF00134	0.614
DOC_MAPK_gen_1	144	152	PF00069	0.528
DOC_MAPK_gen_1	156	166	PF00069	0.543
DOC_MAPK_gen_1	176	186	PF00069	0.491
DOC_MAPK_MEF2A_6	144	152	PF00069	0.568
DOC_PP2B_LxvP_1	167	170	PF13499	0.588
DOC_USP7_MATH_1	93	97	PF00917	0.595
DOC_WW_Pin1_4	18	23	PF00397	0.587
DOC_WW_Pin1_4	83	88	PF00397	0.606
LIG_14-3-3_CanoR_1	151	155	PF00244	0.620
LIG_14-3-3_CanoR_1	156	166	PF00244	0.571
LIG_14-3-3_CanoR_1	6	12	PF00244	0.674
LIG_BRCT_BRCA1_1	58	62	PF00533	0.645
LIG_FHA_1	147	153	PF00498	0.579
LIG_FHA_1	24	30	PF00498	0.604
LIG_FHA_1	40	46	PF00498	0.496
LIG_FHA_1	84	90	PF00498	0.591
LIG_LIR_Gen_1	153	161	PF02991	0.657
LIG_LIR_Nem_3	153	157	PF02991	0.654
LIG_LIR_Nem_3	58	64	PF02991	0.652
LIG_MLH1_MIPbox_1	58	62	PF16413	0.645
LIG_SH2_CRK	154	158	PF00017	0.642
LIG_SH2_CRK	181	185	PF00017	0.582
LIG_SH2_STAT5	102	105	PF00017	0.600
LIG_SH3_3	103	109	PF00018	0.499
LIG_SH3_3	69	75	PF00018	0.700
LIG_SH3_3	87	93	PF00018	0.721
LIG_SUMO_SIM_par_1	41	46	PF11976	0.584
LIG_TYR_ITIM	152	157	PF00017	0.642
MOD_CK1_1	57	63	PF00069	0.767
MOD_GlcNHglycan	141	144	PF01048	0.716
MOD_GlcNHglycan	48	51	PF01048	0.723
MOD_GSK3_1	146	153	PF00069	0.600
MOD_GSK3_1	39	46	PF00069	0.572
MOD_GSK3_1	52	59	PF00069	0.670
MOD_GSK3_1	93	100	PF00069	0.630
MOD_NEK2_1	185	190	PF00069	0.597
MOD_NEK2_1	43	48	PF00069	0.558
MOD_NEK2_1	52	57	PF00069	0.565
MOD_PKA_2	150	156	PF00069	0.709
MOD_PKA_2	157	163	PF00069	0.605
MOD_PKA_2	16	22	PF00069	0.625
MOD_PKA_2	5	11	PF00069	0.664
MOD_Plk_1	160	166	PF00069	0.633
MOD_Plk_1	170	176	PF00069	0.538
MOD_Plk_2-3	118	124	PF00069	0.433
MOD_Plk_4	24	30	PF00069	0.604
MOD_Plk_4	57	63	PF00069	0.648
MOD_Plk_4	97	103	PF00069	0.725
MOD_ProDKin_1	18	24	PF00069	0.588
MOD_ProDKin_1	83	89	PF00069	0.607
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.665
TRG_ENDOCYTIC_2	154	157	PF00928	0.663
TRG_ENDOCYTIC_2	181	184	PF00928	0.534
TRG_ER_diArg_1	156	159	PF00400	0.568
TRG_ER_diArg_1	176	179	PF00400	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSB8	Leptomonas seymouri	37%	100%
A0A3S5H613	Leishmania donovani	89%	94%
A4H552	Leishmania braziliensis	68%	100%
E9AG77	Leishmania infantum	89%	94%
E9ALC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%