Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9ACQ2_LEIMA

TriTrypDb:

LmjF.07.0715 , LMJLV39_070013600 , LMJSD75_070013700

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACQ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.739
CLV_C14_Caspase3-7	384	388	PF00656	0.520
CLV_C14_Caspase3-7	407	411	PF00656	0.594
CLV_NRD_NRD_1	13	15	PF00675	0.690
CLV_NRD_NRD_1	369	371	PF00675	0.636
CLV_NRD_NRD_1	396	398	PF00675	0.675
CLV_NRD_NRD_1	428	430	PF00675	0.639
CLV_NRD_NRD_1	449	451	PF00675	0.693
CLV_NRD_NRD_1	500	502	PF00675	0.620
CLV_NRD_NRD_1	570	572	PF00675	0.705
CLV_PCSK_KEX2_1	13	15	PF00082	0.690
CLV_PCSK_KEX2_1	369	371	PF00082	0.636
CLV_PCSK_KEX2_1	396	398	PF00082	0.671
CLV_PCSK_KEX2_1	428	430	PF00082	0.653
CLV_PCSK_KEX2_1	432	434	PF00082	0.651
CLV_PCSK_KEX2_1	449	451	PF00082	0.573
CLV_PCSK_KEX2_1	500	502	PF00082	0.620
CLV_PCSK_KEX2_1	570	572	PF00082	0.705
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.675
CLV_PCSK_PC7_1	428	434	PF00082	0.649
CLV_PCSK_PC7_1	9	15	PF00082	0.695
CLV_PCSK_SKI1_1	266	270	PF00082	0.746
CLV_PCSK_SKI1_1	31	35	PF00082	0.594
CLV_PCSK_SKI1_1	335	339	PF00082	0.686
CLV_PCSK_SKI1_1	359	363	PF00082	0.696
CLV_PCSK_SKI1_1	369	373	PF00082	0.465
DEG_APCC_DBOX_1	126	134	PF00400	0.721
DEG_APCC_DBOX_1	368	376	PF00400	0.569
DEG_Nend_UBRbox_2	1	3	PF02207	0.787
DEG_SCF_FBW7_1	35	41	PF00400	0.745
DOC_CKS1_1	35	40	PF01111	0.746
DOC_CYCLIN_yClb5_NLxxxL_5	397	405	PF00134	0.531
DOC_MAPK_gen_1	150	160	PF00069	0.580
DOC_MAPK_gen_1	369	377	PF00069	0.623
DOC_MAPK_gen_1	431	440	PF00069	0.664
DOC_PP1_RVXF_1	19	25	PF00149	0.709
DOC_PP2B_LxvP_1	184	187	PF13499	0.558
DOC_PP2B_LxvP_1	308	311	PF13499	0.786
DOC_PP2B_LxvP_1	352	355	PF13499	0.659
DOC_PP2B_LxvP_1	416	419	PF13499	0.673
DOC_PP4_MxPP_1	113	116	PF00568	0.536
DOC_USP7_MATH_1	144	148	PF00917	0.608
DOC_USP7_MATH_1	177	181	PF00917	0.787
DOC_USP7_MATH_1	185	189	PF00917	0.654
DOC_USP7_MATH_1	249	253	PF00917	0.673
DOC_USP7_MATH_1	268	272	PF00917	0.637
DOC_USP7_MATH_1	275	279	PF00917	0.601
DOC_USP7_MATH_1	346	350	PF00917	0.742
DOC_USP7_MATH_1	38	42	PF00917	0.797
DOC_USP7_MATH_1	381	385	PF00917	0.495
DOC_USP7_MATH_1	417	421	PF00917	0.643
DOC_USP7_MATH_1	43	47	PF00917	0.757
DOC_USP7_MATH_1	581	585	PF00917	0.508
DOC_WW_Pin1_4	111	116	PF00397	0.657
DOC_WW_Pin1_4	260	265	PF00397	0.783
DOC_WW_Pin1_4	266	271	PF00397	0.814
DOC_WW_Pin1_4	34	39	PF00397	0.765
DOC_WW_Pin1_4	354	359	PF00397	0.658
DOC_WW_Pin1_4	461	466	PF00397	0.850
DOC_WW_Pin1_4	49	54	PF00397	0.620
DOC_WW_Pin1_4	537	542	PF00397	0.761
DOC_WW_Pin1_4	74	79	PF00397	0.739
LIG_14-3-3_CanoR_1	302	311	PF00244	0.720
LIG_14-3-3_CanoR_1	314	319	PF00244	0.671
LIG_14-3-3_CanoR_1	449	458	PF00244	0.831
LIG_14-3-3_CanoR_1	586	590	PF00244	0.518
LIG_Actin_WH2_2	8	23	PF00022	0.560
LIG_APCC_ABBA_1	547	552	PF00400	0.764
LIG_APCC_ABBAyCdc20_2	335	341	PF00400	0.585
LIG_BIR_III_2	248	252	PF00653	0.610
LIG_BRCT_BRCA1_1	513	517	PF00533	0.668
LIG_EVH1_1	352	356	PF00568	0.583
LIG_FHA_1	252	258	PF00498	0.639
LIG_FHA_1	303	309	PF00498	0.813
LIG_FHA_1	310	316	PF00498	0.672
LIG_FHA_1	393	399	PF00498	0.607
LIG_FHA_1	487	493	PF00498	0.736
LIG_FHA_1	577	583	PF00498	0.502
LIG_FHA_2	267	273	PF00498	0.595
LIG_FHA_2	327	333	PF00498	0.727
LIG_FHA_2	405	411	PF00498	0.602
LIG_FHA_2	518	524	PF00498	0.708
LIG_GSK3_LRP6_1	354	359	PF00069	0.573
LIG_LIR_Gen_1	156	161	PF02991	0.791
LIG_LIR_Gen_1	336	346	PF02991	0.593
LIG_LIR_Nem_3	156	160	PF02991	0.795
LIG_LIR_Nem_3	336	342	PF02991	0.589
LIG_MYND_1	535	539	PF01753	0.698
LIG_SH2_SRC	339	342	PF00017	0.597
LIG_SH2_STAT5	550	553	PF00017	0.751
LIG_SH3_2	458	463	PF14604	0.631
LIG_SH3_3	254	260	PF00018	0.835
LIG_SH3_3	350	356	PF00018	0.725
LIG_SH3_3	42	48	PF00018	0.813
LIG_SH3_3	455	461	PF00018	0.846
LIG_SH3_3	502	508	PF00018	0.737
LIG_SH3_3	527	533	PF00018	0.777
LIG_SH3_3	535	541	PF00018	0.716
LIG_SH3_3	72	78	PF00018	0.737
LIG_SH3_CIN85_PxpxPR_1	354	359	PF14604	0.678
LIG_SUMO_SIM_par_1	414	420	PF11976	0.636
MOD_CDC14_SPxK_1	263	266	PF00782	0.612
MOD_CDC14_SPxK_1	464	467	PF00782	0.719
MOD_CDC14_SPxK_1	77	80	PF00782	0.741
MOD_CDK_SPK_2	354	359	PF00069	0.608
MOD_CDK_SPxK_1	260	266	PF00069	0.608
MOD_CDK_SPxK_1	461	467	PF00069	0.722
MOD_CDK_SPxK_1	74	80	PF00069	0.743
MOD_CK1_1	180	186	PF00069	0.707
MOD_CK1_1	271	277	PF00069	0.723
MOD_CK1_1	325	331	PF00069	0.743
MOD_CK1_1	386	392	PF00069	0.559
MOD_CK1_1	420	426	PF00069	0.700
MOD_CK1_1	451	457	PF00069	0.816
MOD_CK1_1	459	465	PF00069	0.749
MOD_CK1_1	486	492	PF00069	0.744
MOD_CK1_1	510	516	PF00069	0.776
MOD_CK2_1	100	106	PF00069	0.556
MOD_DYRK1A_RPxSP_1	266	270	PF00069	0.816
MOD_GlcNHglycan	102	105	PF01048	0.560
MOD_GlcNHglycan	139	142	PF01048	0.674
MOD_GlcNHglycan	167	170	PF01048	0.695
MOD_GlcNHglycan	187	190	PF01048	0.481
MOD_GlcNHglycan	2	5	PF01048	0.683
MOD_GlcNHglycan	231	234	PF01048	0.718
MOD_GlcNHglycan	272	276	PF01048	0.705
MOD_GlcNHglycan	344	347	PF01048	0.740
MOD_GlcNHglycan	389	392	PF01048	0.722
MOD_GlcNHglycan	485	488	PF01048	0.809
MOD_GlcNHglycan	544	547	PF01048	0.794
MOD_GlcNHglycan	58	61	PF01048	0.758
MOD_GlcNHglycan	88	91	PF01048	0.749
MOD_GSK3_1	111	118	PF00069	0.635
MOD_GSK3_1	144	151	PF00069	0.656
MOD_GSK3_1	225	232	PF00069	0.779
MOD_GSK3_1	271	278	PF00069	0.793
MOD_GSK3_1	298	305	PF00069	0.766
MOD_GSK3_1	310	317	PF00069	0.604
MOD_GSK3_1	322	329	PF00069	0.609
MOD_GSK3_1	34	41	PF00069	0.777
MOD_GSK3_1	342	349	PF00069	0.554
MOD_GSK3_1	382	389	PF00069	0.740
MOD_GSK3_1	404	411	PF00069	0.574
MOD_GSK3_1	43	50	PF00069	0.673
MOD_GSK3_1	448	455	PF00069	0.820
MOD_GSK3_1	507	514	PF00069	0.790
MOD_GSK3_1	537	544	PF00069	0.739
MOD_GSK3_1	56	63	PF00069	0.529
MOD_GSK3_1	581	588	PF00069	0.508
MOD_GSK3_1	74	81	PF00069	0.673
MOD_N-GLC_1	100	105	PF02516	0.556
MOD_N-GLC_1	137	142	PF02516	0.590
MOD_NEK2_1	283	288	PF00069	0.738
MOD_NEK2_1	362	367	PF00069	0.637
MOD_NEK2_1	408	413	PF00069	0.617
MOD_NEK2_1	448	453	PF00069	0.814
MOD_NEK2_1	517	522	PF00069	0.738
MOD_NEK2_1	582	587	PF00069	0.507
MOD_PIKK_1	283	289	PF00454	0.741
MOD_PIKK_1	362	368	PF00454	0.526
MOD_PIKK_1	550	556	PF00454	0.672
MOD_PKA_1	449	455	PF00069	0.758
MOD_PKA_2	149	155	PF00069	0.647
MOD_PKA_2	165	171	PF00069	0.732
MOD_PKA_2	298	304	PF00069	0.761
MOD_PKA_2	420	426	PF00069	0.695
MOD_PKA_2	448	454	PF00069	0.846
MOD_PKA_2	459	465	PF00069	0.697
MOD_PKA_2	585	591	PF00069	0.523
MOD_Plk_1	510	516	PF00069	0.702
MOD_Plk_4	153	159	PF00069	0.754
MOD_Plk_4	276	282	PF00069	0.717
MOD_Plk_4	314	320	PF00069	0.773
MOD_ProDKin_1	111	117	PF00069	0.660
MOD_ProDKin_1	260	266	PF00069	0.786
MOD_ProDKin_1	34	40	PF00069	0.765
MOD_ProDKin_1	354	360	PF00069	0.658
MOD_ProDKin_1	461	467	PF00069	0.850
MOD_ProDKin_1	49	55	PF00069	0.616
MOD_ProDKin_1	537	543	PF00069	0.763
MOD_ProDKin_1	74	80	PF00069	0.743
TRG_ENDOCYTIC_2	339	342	PF00928	0.597
TRG_ER_diArg_1	12	14	PF00400	0.689
TRG_ER_diArg_1	369	371	PF00400	0.577
TRG_ER_diArg_1	396	398	PF00400	0.671
TRG_ER_diArg_1	427	429	PF00400	0.634
TRG_ER_diArg_1	430	433	PF00400	0.636
TRG_ER_diArg_1	448	450	PF00400	0.566
TRG_ER_diArg_1	499	501	PF00400	0.609
TRG_ER_diArg_1	570	572	PF00400	0.649
TRG_NES_CRM1_1	366	379	PF08389	0.464
TRG_NLS_MonoExtN_4	428	435	PF00514	0.648
TRG_Pf-PMV_PEXEL_1	570	575	PF00026	0.705

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPX7	Leishmania donovani	84%	100%
A4H523	Leishmania braziliensis	57%	100%
A4HT96	Leishmania infantum	84%	100%
E9AL85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%