Surface antigen-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen-like protein

Species:

Leishmania major

UniProt:

E9ACQ0_LEIMA

TriTrypDb:

LmjF.05.1215 , LMJLV39_050013900 , LMJSD75_050014200

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 85

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 37, no: 6
NetGPI	no	yes: 0, no: 43

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	44
GO:0042995	cell projection	2	44
GO:0043226	organelle	2	44
GO:0043227	membrane-bounded organelle	3	44
GO:0110165	cellular anatomical entity	1	44
GO:0120025	plasma membrane bounded cell projection	3	44
GO:0016020	membrane	2	10

Expansion

Sequence features

E9ACQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACQ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	96	100	PF00656	0.306
DOC_CDC14_PxL_1	43	51	PF14671	0.287
DOC_MAPK_gen_1	126	135	PF00069	0.381
DOC_USP7_MATH_1	153	157	PF00917	0.343
DOC_USP7_MATH_1	192	196	PF00917	0.414
DOC_USP7_MATH_1	21	25	PF00917	0.513
DOC_USP7_MATH_1	278	282	PF00917	0.274
DOC_USP7_MATH_1	69	73	PF00917	0.387
DOC_USP7_MATH_2	145	151	PF00917	0.281
DOC_WW_Pin1_4	254	259	PF00397	0.470
LIG_14-3-3_CanoR_1	129	135	PF00244	0.275
LIG_14-3-3_CanoR_1	244	253	PF00244	0.396
LIG_BIR_II_1	1	5	PF00653	0.705
LIG_BRCT_BRCA1_1	155	159	PF00533	0.270
LIG_BRCT_BRCA1_1	239	243	PF00533	0.333
LIG_BRCT_BRCA1_1	280	284	PF00533	0.255
LIG_BRCT_BRCA1_1	81	85	PF00533	0.485
LIG_Clathr_ClatBox_1	154	158	PF01394	0.286
LIG_FHA_1	115	121	PF00498	0.416
LIG_FHA_1	13	19	PF00498	0.508
LIG_FHA_1	26	32	PF00498	0.438
LIG_FHA_1	267	273	PF00498	0.318
LIG_FHA_1	68	74	PF00498	0.419
LIG_FHA_2	129	135	PF00498	0.445
LIG_FHA_2	88	94	PF00498	0.432
LIG_LIR_Gen_1	123	130	PF02991	0.327
LIG_LIR_Gen_1	195	204	PF02991	0.402
LIG_LIR_Gen_1	35	46	PF02991	0.424
LIG_LIR_Gen_1	4	14	PF02991	0.471
LIG_LIR_Gen_1	82	92	PF02991	0.329
LIG_LIR_Nem_3	123	127	PF02991	0.349
LIG_LIR_Nem_3	160	166	PF02991	0.459
LIG_LIR_Nem_3	195	200	PF02991	0.370
LIG_LIR_Nem_3	4	9	PF02991	0.475
LIG_LIR_Nem_3	82	88	PF02991	0.354
LIG_PDZ_Class_2	279	284	PF00595	0.443
LIG_Pex14_2	193	197	PF04695	0.294
LIG_PTB_Apo_2	158	165	PF02174	0.267
LIG_SH2_CRK	166	170	PF00017	0.282
LIG_SH2_STAT5	163	166	PF00017	0.444
LIG_SH2_STAT5	253	256	PF00017	0.320
LIG_SH3_3	17	23	PF00018	0.512
LIG_SH3_3	252	258	PF00018	0.426
LIG_SUMO_SIM_anti_2	15	21	PF11976	0.439
LIG_SUMO_SIM_par_1	275	281	PF11976	0.320
MOD_CK1_1	125	131	PF00069	0.347
MOD_CK1_1	195	201	PF00069	0.376
MOD_CK1_1	220	226	PF00069	0.413
MOD_CK1_1	245	251	PF00069	0.409
MOD_CK1_1	25	31	PF00069	0.551
MOD_CK1_1	4	10	PF00069	0.478
MOD_CK2_1	87	93	PF00069	0.447
MOD_GlcNHglycan	140	143	PF01048	0.562
MOD_GlcNHglycan	24	27	PF01048	0.718
MOD_GlcNHglycan	247	250	PF01048	0.657
MOD_GlcNHglycan	67	70	PF01048	0.566
MOD_GlcNHglycan	81	84	PF01048	0.629
MOD_GSK3_1	116	123	PF00069	0.370
MOD_GSK3_1	153	160	PF00069	0.359
MOD_GSK3_1	192	199	PF00069	0.362
MOD_GSK3_1	21	28	PF00069	0.559
MOD_GSK3_1	216	223	PF00069	0.359
MOD_GSK3_1	245	252	PF00069	0.404
MOD_GSK3_1	65	72	PF00069	0.387
MOD_N-GLC_1	171	176	PF02516	0.528
MOD_N-GLC_2	57	59	PF02516	0.483
MOD_NEK2_1	1	6	PF00069	0.770
MOD_NEK2_1	103	108	PF00069	0.413
MOD_NEK2_1	116	121	PF00069	0.405
MOD_NEK2_1	133	138	PF00069	0.335
MOD_NEK2_1	159	164	PF00069	0.382
MOD_NEK2_1	193	198	PF00069	0.365
MOD_NEK2_1	206	211	PF00069	0.292
MOD_NEK2_1	87	92	PF00069	0.391
MOD_PIKK_1	177	183	PF00454	0.379
MOD_PIKK_1	32	38	PF00454	0.394
MOD_PKA_2	114	120	PF00069	0.353
MOD_PKA_2	125	131	PF00069	0.299
MOD_PKA_2	138	144	PF00069	0.317
MOD_Plk_1	171	177	PF00069	0.301
MOD_Plk_1	94	100	PF00069	0.304
MOD_Plk_4	1	7	PF00069	0.575
MOD_Plk_4	12	18	PF00069	0.623
MOD_Plk_4	159	165	PF00069	0.281
MOD_Plk_4	278	284	PF00069	0.322
MOD_ProDKin_1	254	260	PF00069	0.477
MOD_SUMO_rev_2	219	225	PF00179	0.335
TRG_ER_diArg_1	137	140	PF00400	0.303
TRG_NES_CRM1_1	146	158	PF08389	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E6	Leptomonas seymouri	28%	100%
A0A0N0P2L4	Leptomonas seymouri	26%	96%
A0A0N0P4M2	Leptomonas seymouri	31%	100%
A0A0S4IVH1	Bodo saltans	28%	100%
A0A1X0NKN8	Trypanosomatidae	38%	99%
A0A3Q8I9A6	Leishmania donovani	29%	74%
A0A3Q8I9D0	Leishmania donovani	29%	100%
A0A3Q8IIJ9	Leishmania donovani	25%	94%
A0A3S5H6D6	Leishmania donovani	29%	100%
A0A3S7WP69	Leishmania donovani	31%	99%
A0A3S7WPB2	Leishmania donovani	94%	100%
A0A3S7X4J4	Leishmania donovani	25%	94%
A4H4D2	Leishmania braziliensis	27%	98%
A4H4G6	Leishmania braziliensis	79%	100%
A4H5P0	Leishmania braziliensis	31%	99%
A4HSL2	Leishmania infantum	31%	99%
A4HTX9	Leishmania infantum	28%	100%
A4HVB0	Leishmania infantum	24%	70%
A4I6S4	Leishmania infantum	25%	94%
E8NHP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	94%
E9AG65	Leishmania infantum	94%	100%
E9AGG5	Leishmania infantum	24%	68%
E9AGH0	Leishmania infantum	27%	75%
E9AKJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	99%
E9AKM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AMQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	84%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	73%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	77%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	68%
E9B1U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	83%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	68%
E9B1U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	94%
Q25331	Leishmania major	30%	74%
Q4Q6B6	Leishmania major	26%	94%
Q4Q6B7	Leishmania major	26%	94%
Q4QGJ4	Leishmania major	30%	74%
Q4QGJ7	Leishmania major	30%	76%
Q4QGK6	Leishmania major	30%	74%
Q4QGL4	Leishmania major	28%	72%
Q4QHW6	Leishmania major	28%	100%
Q4QJB2	Leishmania major	29%	99%