LeishMANIAdb
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ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
ANK_REP_REGION domain-containing protein
Gene product:
hypothetical protein
Species:
Leishmania major
UniProt:
E9ACP8_LEIMA
TriTrypDb:
LmjF.04.0625
Length:
338

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACP8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACP8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 126 132 PF00089 0.580
CLV_NRD_NRD_1 154 156 PF00675 0.440
CLV_NRD_NRD_1 204 206 PF00675 0.623
CLV_NRD_NRD_1 248 250 PF00675 0.528
CLV_NRD_NRD_1 330 332 PF00675 0.708
CLV_PCSK_KEX2_1 204 206 PF00082 0.623
CLV_PCSK_SKI1_1 101 105 PF00082 0.488
CLV_PCSK_SKI1_1 42 46 PF00082 0.558
CLV_Separin_Metazoa 60 64 PF03568 0.457
DEG_SPOP_SBC_1 54 58 PF00917 0.489
DOC_CKS1_1 279 284 PF01111 0.567
DOC_CYCLIN_yCln2_LP_2 124 130 PF00134 0.578
DOC_MAPK_DCC_7 55 64 PF00069 0.552
DOC_MAPK_gen_1 249 257 PF00069 0.531
DOC_MAPK_MEF2A_6 249 257 PF00069 0.531
DOC_PP2B_LxvP_1 124 127 PF13499 0.621
DOC_USP7_MATH_1 128 132 PF00917 0.651
DOC_USP7_MATH_1 145 149 PF00917 0.621
DOC_USP7_MATH_1 214 218 PF00917 0.581
DOC_USP7_MATH_1 274 278 PF00917 0.670
DOC_USP7_MATH_1 280 284 PF00917 0.733
DOC_USP7_MATH_1 54 58 PF00917 0.553
DOC_USP7_UBL2_3 310 314 PF12436 0.569
DOC_WW_Pin1_4 189 194 PF00397 0.557
DOC_WW_Pin1_4 249 254 PF00397 0.599
DOC_WW_Pin1_4 255 260 PF00397 0.584
DOC_WW_Pin1_4 267 272 PF00397 0.586
DOC_WW_Pin1_4 278 283 PF00397 0.587
DOC_WW_Pin1_4 288 293 PF00397 0.594
LIG_14-3-3_CanoR_1 129 133 PF00244 0.597
LIG_14-3-3_CanoR_1 195 203 PF00244 0.587
LIG_14-3-3_CanoR_1 232 238 PF00244 0.585
LIG_14-3-3_CanoR_1 249 253 PF00244 0.502
LIG_14-3-3_CanoR_1 305 310 PF00244 0.578
LIG_BIR_II_1 1 5 PF00653 0.485
LIG_Clathr_ClatBox_1 212 216 PF01394 0.598
LIG_deltaCOP1_diTrp_1 164 169 PF00928 0.536
LIG_DLG_GKlike_1 204 212 PF00625 0.599
LIG_FHA_1 121 127 PF00498 0.548
LIG_FHA_1 15 21 PF00498 0.389
LIG_FHA_1 304 310 PF00498 0.541
LIG_FHA_1 80 86 PF00498 0.452
LIG_FHA_2 137 143 PF00498 0.566
LIG_FHA_2 174 180 PF00498 0.476
LIG_FHA_2 195 201 PF00498 0.597
LIG_LIR_Apic_2 291 297 PF02991 0.610
LIG_PCNA_yPIPBox_3 71 83 PF02747 0.454
LIG_SH2_CRK 294 298 PF00017 0.669
LIG_SH2_NCK_1 294 298 PF00017 0.597
LIG_SH2_STAT5 302 305 PF00017 0.543
LIG_SH3_3 200 206 PF00018 0.678
LIG_SH3_3 276 282 PF00018 0.587
LIG_SH3_3 330 336 PF00018 0.719
LIG_SUMO_SIM_par_1 265 270 PF11976 0.613
LIG_SxIP_EBH_1 319 333 PF03271 0.518
MOD_CDK_SPxK_1 189 195 PF00069 0.564
MOD_CK1_1 131 137 PF00069 0.650
MOD_CK1_1 148 154 PF00069 0.630
MOD_CK1_1 217 223 PF00069 0.656
MOD_CK1_1 278 284 PF00069 0.635
MOD_CK1_1 49 55 PF00069 0.492
MOD_CK2_1 135 141 PF00069 0.658
MOD_CK2_1 173 179 PF00069 0.475
MOD_CK2_1 194 200 PF00069 0.556
MOD_CK2_1 255 261 PF00069 0.634
MOD_CK2_1 54 60 PF00069 0.556
MOD_GlcNHglycan 234 237 PF01048 0.775
MOD_GlcNHglycan 246 249 PF01048 0.589
MOD_GlcNHglycan 25 28 PF01048 0.514
MOD_GSK3_1 110 117 PF00069 0.588
MOD_GSK3_1 131 138 PF00069 0.750
MOD_GSK3_1 204 211 PF00069 0.794
MOD_GSK3_1 214 221 PF00069 0.586
MOD_GSK3_1 232 239 PF00069 0.625
MOD_GSK3_1 244 251 PF00069 0.600
MOD_GSK3_1 274 281 PF00069 0.651
MOD_GSK3_1 42 49 PF00069 0.404
MOD_LATS_1 284 290 PF00433 0.648
MOD_N-GLC_1 148 153 PF02516 0.525
MOD_N-GLC_1 218 223 PF02516 0.527
MOD_NEK2_1 119 124 PF00069 0.578
MOD_NEK2_1 15 20 PF00069 0.481
MOD_NEK2_1 173 178 PF00069 0.474
MOD_NEK2_1 183 188 PF00069 0.433
MOD_NEK2_1 208 213 PF00069 0.675
MOD_PIKK_1 131 137 PF00454 0.615
MOD_PIKK_1 184 190 PF00454 0.510
MOD_PIKK_1 194 200 PF00454 0.568
MOD_PIKK_1 214 220 PF00454 0.550
MOD_PIKK_1 296 302 PF00454 0.551
MOD_PK_1 55 61 PF00069 0.565
MOD_PKA_1 204 210 PF00069 0.619
MOD_PKA_2 128 134 PF00069 0.573
MOD_PKA_2 194 200 PF00069 0.614
MOD_PKA_2 204 210 PF00069 0.677
MOD_PKA_2 231 237 PF00069 0.633
MOD_PKA_2 248 254 PF00069 0.511
MOD_Plk_1 148 154 PF00069 0.524
MOD_Plk_1 208 214 PF00069 0.790
MOD_Plk_1 79 85 PF00069 0.411
MOD_Plk_4 208 214 PF00069 0.790
MOD_ProDKin_1 189 195 PF00069 0.564
MOD_ProDKin_1 249 255 PF00069 0.601
MOD_ProDKin_1 267 273 PF00069 0.587
MOD_ProDKin_1 278 284 PF00069 0.589
MOD_ProDKin_1 288 294 PF00069 0.593
MOD_SUMO_rev_2 109 114 PF00179 0.552
MOD_SUMO_rev_2 49 57 PF00179 0.469
TRG_DiLeu_BaLyEn_6 263 268 PF01217 0.613
TRG_ER_diArg_1 203 205 PF00400 0.600
TRG_Pf-PMV_PEXEL_1 155 160 PF00026 0.412
TRG_PTS1 335 338 PF00515 0.677

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P325 Leptomonas seymouri 29% 96%
A0A3S5H5B7 Leishmania donovani 86% 100%
A4H441 Leishmania braziliensis 54% 100%
A4HS58 Leishmania infantum 85% 100%
E9AK45 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS