Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACP7_LEIMA

TriTrypDb:

LmjF.04.0127 , LMJLV39_040006500 , LMJSD75_040006500

Length:

434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACP7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.707
CLV_NRD_NRD_1	241	243	PF00675	0.726
CLV_NRD_NRD_1	267	269	PF00675	0.495
CLV_NRD_NRD_1	28	30	PF00675	0.609
CLV_NRD_NRD_1	420	422	PF00675	0.456
CLV_NRD_NRD_1	429	431	PF00675	0.551
CLV_PCSK_FUR_1	149	153	PF00082	0.647
CLV_PCSK_KEX2_1	151	153	PF00082	0.707
CLV_PCSK_KEX2_1	182	184	PF00082	0.733
CLV_PCSK_KEX2_1	267	269	PF00082	0.495
CLV_PCSK_KEX2_1	28	30	PF00082	0.609
CLV_PCSK_KEX2_1	420	422	PF00082	0.456
CLV_PCSK_KEX2_1	429	431	PF00082	0.551
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.599
CLV_PCSK_PC7_1	178	184	PF00082	0.597
CLV_PCSK_SKI1_1	226	230	PF00082	0.649
CLV_PCSK_SKI1_1	267	271	PF00082	0.693
CLV_PCSK_SKI1_1	28	32	PF00082	0.728
DEG_APCC_DBOX_1	266	274	PF00400	0.551
DEG_APCC_KENBOX_2	66	70	PF00400	0.506
DEG_Nend_Nbox_1	1	3	PF02207	0.615
DEG_SCF_FBW7_1	188	193	PF00400	0.621
DEG_SPOP_SBC_1	386	390	PF00917	0.461
DOC_CKS1_1	354	359	PF01111	0.545
DOC_MAPK_gen_1	314	323	PF00069	0.482
DOC_MAPK_gen_1	404	414	PF00069	0.490
DOC_MAPK_MEF2A_6	197	205	PF00069	0.622
DOC_PP2B_PxIxI_1	200	206	PF00149	0.618
DOC_USP7_MATH_1	159	163	PF00917	0.611
DOC_USP7_MATH_1	176	180	PF00917	0.749
DOC_USP7_MATH_1	277	281	PF00917	0.532
DOC_USP7_MATH_1	310	314	PF00917	0.508
DOC_USP7_UBL2_3	67	71	PF12436	0.502
DOC_WW_Pin1_4	16	21	PF00397	0.587
DOC_WW_Pin1_4	186	191	PF00397	0.684
DOC_WW_Pin1_4	257	262	PF00397	0.547
DOC_WW_Pin1_4	353	358	PF00397	0.548
LIG_14-3-3_CanoR_1	353	357	PF00244	0.636
LIG_14-3-3_CanoR_1	93	99	PF00244	0.518
LIG_Actin_WH2_2	213	228	PF00022	0.618
LIG_Actin_WH2_2	389	406	PF00022	0.493
LIG_BIR_III_2	21	25	PF00653	0.593
LIG_eIF4E_1	115	121	PF01652	0.539
LIG_FHA_1	13	19	PF00498	0.572
LIG_FHA_1	276	282	PF00498	0.574
LIG_FHA_1	354	360	PF00498	0.586
LIG_FHA_1	388	394	PF00498	0.465
LIG_FHA_1	398	404	PF00498	0.428
LIG_FHA_2	100	106	PF00498	0.503
LIG_FHA_2	187	193	PF00498	0.665
LIG_FHA_2	52	58	PF00498	0.579
LIG_GBD_Chelix_1	281	289	PF00786	0.449
LIG_LIR_Gen_1	110	121	PF02991	0.657
LIG_LIR_Nem_3	110	116	PF02991	0.495
LIG_LIR_Nem_3	367	372	PF02991	0.650
LIG_PCNA_yPIPBox_3	322	331	PF02747	0.384
LIG_SH2_CRK	185	189	PF00017	0.535
LIG_SH2_CRK	328	332	PF00017	0.370
LIG_SH2_CRK	83	87	PF00017	0.501
LIG_SH2_STAT5	115	118	PF00017	0.503
LIG_SH2_STAT5	215	218	PF00017	0.617
LIG_SH2_STAT5	417	420	PF00017	0.401
LIG_SH2_STAT5	427	430	PF00017	0.546
LIG_SH3_3	329	335	PF00018	0.456
LIG_SH3_3	354	360	PF00018	0.630
LIG_SH3_3	381	387	PF00018	0.543
LIG_SUMO_SIM_par_1	13	19	PF11976	0.575
LIG_TYR_ITIM	81	86	PF00017	0.471
MOD_CDK_SPK_2	353	358	PF00069	0.550
MOD_CK1_1	169	175	PF00069	0.629
MOD_CK1_1	204	210	PF00069	0.632
MOD_CK1_1	302	308	PF00069	0.547
MOD_CK2_1	126	132	PF00069	0.585
MOD_CK2_1	186	192	PF00069	0.644
MOD_CK2_1	252	258	PF00069	0.616
MOD_CK2_1	51	57	PF00069	0.571
MOD_GlcNHglycan	161	164	PF01048	0.754
MOD_GlcNHglycan	226	229	PF01048	0.688
MOD_GlcNHglycan	34	37	PF01048	0.635
MOD_GlcNHglycan	350	353	PF01048	0.668
MOD_GlcNHglycan	360	363	PF01048	0.571
MOD_GlcNHglycan	372	375	PF01048	0.551
MOD_GSK3_1	12	19	PF00069	0.595
MOD_GSK3_1	134	141	PF00069	0.654
MOD_GSK3_1	174	181	PF00069	0.621
MOD_GSK3_1	186	193	PF00069	0.727
MOD_GSK3_1	20	27	PF00069	0.583
MOD_GSK3_1	234	241	PF00069	0.658
MOD_GSK3_1	28	35	PF00069	0.598
MOD_GSK3_1	348	355	PF00069	0.613
MOD_GSK3_1	385	392	PF00069	0.643
MOD_GSK3_1	421	428	PF00069	0.415
MOD_N-GLC_1	24	29	PF02516	0.583
MOD_N-GLC_1	348	353	PF02516	0.575
MOD_NEK2_1	232	237	PF00069	0.656
MOD_NEK2_1	370	375	PF00069	0.597
MOD_NEK2_1	85	90	PF00069	0.466
MOD_NEK2_2	108	113	PF00069	0.381
MOD_NEK2_2	51	56	PF00069	0.419
MOD_PIKK_1	85	91	PF00454	0.511
MOD_PIKK_1	92	98	PF00454	0.510
MOD_PKA_1	28	34	PF00069	0.566
MOD_PKA_2	137	143	PF00069	0.599
MOD_PKA_2	150	156	PF00069	0.636
MOD_PKA_2	275	281	PF00069	0.630
MOD_PKA_2	28	34	PF00069	0.566
MOD_PKA_2	302	308	PF00069	0.574
MOD_PKA_2	352	358	PF00069	0.623
MOD_PKA_2	428	434	PF00069	0.613
MOD_PKA_2	49	55	PF00069	0.595
MOD_PKA_2	92	98	PF00069	0.518
MOD_PKA_2	99	105	PF00069	0.566
MOD_PKB_1	59	67	PF00069	0.529
MOD_Plk_1	108	114	PF00069	0.579
MOD_Plk_4	108	114	PF00069	0.422
MOD_Plk_4	12	18	PF00069	0.572
MOD_Plk_4	190	196	PF00069	0.538
MOD_Plk_4	277	283	PF00069	0.474
MOD_Plk_4	285	291	PF00069	0.391
MOD_Plk_4	389	395	PF00069	0.514
MOD_ProDKin_1	16	22	PF00069	0.586
MOD_ProDKin_1	186	192	PF00069	0.688
MOD_ProDKin_1	257	263	PF00069	0.537
MOD_ProDKin_1	353	359	PF00069	0.545
TRG_DiLeu_BaEn_3	245	251	PF01217	0.549
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.499
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.545
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.433
TRG_ENDOCYTIC_2	185	188	PF00928	0.534
TRG_ENDOCYTIC_2	328	331	PF00928	0.367
TRG_ENDOCYTIC_2	83	86	PF00928	0.503
TRG_ER_diArg_1	143	146	PF00400	0.672
TRG_ER_diArg_1	149	152	PF00400	0.721
TRG_ER_diArg_1	267	269	PF00400	0.486
TRG_ER_diArg_1	420	422	PF00400	0.451
TRG_ER_diArg_1	429	432	PF00400	0.543
TRG_Pf-PMV_PEXEL_1	9	13	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVL6	Leptomonas seymouri	35%	100%
A0A3S5H580	Leishmania donovani	89%	100%
A4H3T5	Leishmania braziliensis	61%	93%
A4HS10	Leishmania infantum	89%	100%
E9AJZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%