Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACP5_LEIMA

TriTrypDb:

LmjF.04.0045 , LMJLV39_040005500 , LMJSD75_040005500

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACP5

PDB structure(s): 7aih_BA , 7am2_BA , 7ane_BA

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.466
CLV_NRD_NRD_1	77	79	PF00675	0.497
CLV_PCSK_KEX2_1	131	133	PF00082	0.466
CLV_PCSK_KEX2_1	17	19	PF00082	0.498
CLV_PCSK_KEX2_1	77	79	PF00082	0.506
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.498
CLV_PCSK_SKI1_1	53	57	PF00082	0.593
CLV_PCSK_SKI1_1	80	84	PF00082	0.606
DEG_SPOP_SBC_1	159	163	PF00917	0.620
DOC_CYCLIN_RxL_1	51	61	PF00134	0.613
DOC_CYCLIN_RxL_1	77	84	PF00134	0.565
DOC_CYCLIN_yCln2_LP_2	82	88	PF00134	0.516
DOC_MAPK_gen_1	108	115	PF00069	0.542
DOC_MAPK_gen_1	53	59	PF00069	0.542
DOC_USP7_MATH_1	159	163	PF00917	0.634
DOC_USP7_MATH_1	33	37	PF00917	0.601
DOC_USP7_MATH_1	39	43	PF00917	0.566
DOC_USP7_UBL2_3	7	11	PF12436	0.469
DOC_WW_Pin1_4	81	86	PF00397	0.529
LIG_14-3-3_CanoR_1	137	143	PF00244	0.495
LIG_14-3-3_CanoR_1	34	38	PF00244	0.615
LIG_BIR_II_1	1	5	PF00653	0.482
LIG_Clathr_ClatBox_1	56	60	PF01394	0.560
LIG_FHA_2	46	52	PF00498	0.575
LIG_LIR_Gen_1	38	47	PF02991	0.556
LIG_LIR_Nem_3	38	43	PF02991	0.602
LIG_MYND_1	81	85	PF01753	0.498
LIG_SH2_CRK	19	23	PF00017	0.562
LIG_SH2_STAT5	23	26	PF00017	0.563
LIG_SH3_3	150	156	PF00018	0.534
LIG_SH3_3	99	105	PF00018	0.432
LIG_SUMO_SIM_par_1	55	64	PF11976	0.558
LIG_SUMO_SIM_par_1	67	74	PF11976	0.349
LIG_WRC_WIRS_1	40	45	PF05994	0.572
MOD_CK1_1	136	142	PF00069	0.571
MOD_CK1_1	58	64	PF00069	0.607
MOD_CK2_1	103	109	PF00069	0.517
MOD_CK2_1	70	76	PF00069	0.510
MOD_GlcNHglycan	48	51	PF01048	0.552
MOD_GlcNHglycan	63	66	PF01048	0.420
MOD_GlcNHglycan	96	99	PF01048	0.433
MOD_GSK3_1	158	165	PF00069	0.701
MOD_GSK3_1	39	46	PF00069	0.638
MOD_GSK3_1	55	62	PF00069	0.514
MOD_N-GLC_2	125	127	PF02516	0.463
MOD_NEK2_1	43	48	PF00069	0.572
MOD_PKA_2	136	142	PF00069	0.368
MOD_PKA_2	33	39	PF00069	0.592
MOD_Plk_2-3	70	76	PF00069	0.533
MOD_ProDKin_1	81	87	PF00069	0.522
MOD_SUMO_rev_2	49	55	PF00179	0.522
TRG_DiLeu_BaLyEn_6	78	83	PF01217	0.495
TRG_ENDOCYTIC_2	28	31	PF00928	0.614
TRG_ENDOCYTIC_2	40	43	PF00928	0.454
TRG_ER_diArg_1	130	132	PF00400	0.452
TRG_ER_diArg_1	77	80	PF00400	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ09	Leptomonas seymouri	68%	97%
A0A1X0NLF4	Trypanosomatidae	51%	100%
A0A3R7KUB4	Trypanosoma rangeli	46%	99%
A0A451EJV1	Leishmania donovani	95%	100%
A4H3S5	Leishmania braziliensis	78%	100%
A4HS00	Leishmania infantum	95%	100%
C9ZXZ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AJY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%