MORN repeat family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MORN repeat, putative

Species:

Leishmania major

UniProt:

E9ACP2_LEIMA

TriTrypDb:

LmjF.03.0970 , LMJLV39_030015100 , LMJSD75_030015200

Length:

354

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACP2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.454
CLV_NRD_NRD_1	26	28	PF00675	0.603
CLV_NRD_NRD_1	329	331	PF00675	0.361
CLV_NRD_NRD_1	4	6	PF00675	0.629
CLV_PCSK_FUR_1	213	217	PF00082	0.312
CLV_PCSK_KEX2_1	215	217	PF00082	0.312
CLV_PCSK_KEX2_1	238	240	PF00082	0.292
CLV_PCSK_KEX2_1	26	28	PF00082	0.603
CLV_PCSK_KEX2_1	329	331	PF00082	0.460
CLV_PCSK_KEX2_1	4	6	PF00082	0.629
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.312
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.292
CLV_PCSK_SKI1_1	175	179	PF00082	0.563
CLV_PCSK_SKI1_1	4	8	PF00082	0.527
DOC_ANK_TNKS_1	191	198	PF00023	0.472
DOC_MAPK_gen_1	142	152	PF00069	0.431
DOC_MAPK_gen_1	53	59	PF00069	0.457
DOC_USP7_MATH_1	271	275	PF00917	0.347
DOC_USP7_UBL2_3	258	262	PF12436	0.335
DOC_USP7_UBL2_3	301	305	PF12436	0.473
LIG_14-3-3_CanoR_1	26	31	PF00244	0.585
LIG_deltaCOP1_diTrp_1	279	285	PF00928	0.446
LIG_deltaCOP1_diTrp_1	79	85	PF00928	0.383
LIG_EH1_1	192	200	PF00400	0.481
LIG_FHA_1	104	110	PF00498	0.388
LIG_FHA_1	334	340	PF00498	0.507
LIG_FHA_2	74	80	PF00498	0.514
LIG_LIR_Nem_3	18	24	PF02991	0.438
LIG_LIR_Nem_3	263	268	PF02991	0.335
LIG_LIR_Nem_3	314	320	PF02991	0.465
LIG_LYPXL_yS_3	317	320	PF13949	0.489
LIG_Pex14_1	81	85	PF04695	0.374
LIG_Pex14_2	8	12	PF04695	0.433
LIG_Pex14_2	96	100	PF04695	0.496
LIG_REV1ctd_RIR_1	136	147	PF16727	0.310
LIG_SH2_CRK	110	114	PF00017	0.391
LIG_SH2_GRB2like	247	250	PF00017	0.292
LIG_SH2_NCK_1	63	67	PF00017	0.488
LIG_SH2_PTP2	149	152	PF00017	0.298
LIG_SH2_SRC	247	250	PF00017	0.339
LIG_SH2_STAP1	63	67	PF00017	0.436
LIG_SH2_STAT5	149	152	PF00017	0.343
LIG_SH2_STAT5	211	214	PF00017	0.351
LIG_SH2_STAT5	247	250	PF00017	0.339
LIG_SH2_STAT5	58	61	PF00017	0.373
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.493
LIG_TYR_ITIM	315	320	PF00017	0.397
MOD_CK1_1	103	109	PF00069	0.428
MOD_CK1_1	130	136	PF00069	0.455
MOD_CK1_1	17	23	PF00069	0.444
MOD_CK1_1	89	95	PF00069	0.381
MOD_CK2_1	29	35	PF00069	0.435
MOD_CK2_1	293	299	PF00069	0.397
MOD_CK2_1	73	79	PF00069	0.595
MOD_Cter_Amidation	140	143	PF01082	0.298
MOD_Cter_Amidation	213	216	PF01082	0.312
MOD_GlcNHglycan	120	123	PF01048	0.349
MOD_GlcNHglycan	129	132	PF01048	0.324
MOD_GlcNHglycan	171	174	PF01048	0.504
MOD_GlcNHglycan	253	256	PF01048	0.307
MOD_GlcNHglycan	336	339	PF01048	0.423
MOD_GlcNHglycan	90	94	PF01048	0.537
MOD_GSK3_1	150	157	PF00069	0.286
MOD_GSK3_1	179	186	PF00069	0.506
MOD_GSK3_1	25	32	PF00069	0.434
MOD_NEK2_1	100	105	PF00069	0.322
MOD_NEK2_1	169	174	PF00069	0.341
MOD_NEK2_1	322	327	PF00069	0.423
MOD_PKA_1	26	32	PF00069	0.435
MOD_PKA_2	25	31	PF00069	0.433
MOD_Plk_1	17	23	PF00069	0.444
MOD_Plk_2-3	73	79	PF00069	0.542
MOD_Plk_4	225	231	PF00069	0.292
MOD_Plk_4	293	299	PF00069	0.445
MOD_SUMO_rev_2	172	180	PF00179	0.322
MOD_SUMO_rev_2	296	302	PF00179	0.445
MOD_SUMO_rev_2	32	38	PF00179	0.657
TRG_ENDOCYTIC_2	149	152	PF00928	0.287
TRG_ENDOCYTIC_2	245	248	PF00928	0.295
TRG_ENDOCYTIC_2	317	320	PF00928	0.488
TRG_ER_diArg_1	25	27	PF00400	0.441
TRG_ER_diArg_1	3	5	PF00400	0.645
TRG_ER_diArg_1	328	330	PF00400	0.343
TRG_ER_diArg_1	8	11	PF00400	0.561
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVW7	Leptomonas seymouri	81%	100%
A0A0S4IT41	Bodo saltans	54%	100%
A0A1X0P8X9	Trypanosomatidae	60%	100%
A0A451EJU5	Leishmania donovani	97%	100%
A4H3Q9	Leishmania braziliensis	86%	100%
A4HPP6	Leishmania braziliensis	23%	100%
A4HRY3	Leishmania infantum	98%	100%
A4ID18	Leishmania infantum	24%	100%
C9ZKJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AJY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5DTY1	Trypanosoma cruzi	63%	100%