Multicopper oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Multicopper oxidase

Gene product:

multicopper oxidase, putative

Species:

Leishmania major

UniProt:

E9ACP0_LEIMA

TriTrypDb:

LmjF.03.0950 , LMJLV39_030014900 , LMJSD75_030015000

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 3
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9ACP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACP0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005507	copper ion binding	6	12
GO:0016491	oxidoreductase activity	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.449
CLV_C14_Caspase3-7	303	307	PF00656	0.388
CLV_C14_Caspase3-7	56	60	PF00656	0.463
CLV_NRD_NRD_1	311	313	PF00675	0.557
CLV_NRD_NRD_1	328	330	PF00675	0.561
CLV_NRD_NRD_1	361	363	PF00675	0.654
CLV_NRD_NRD_1	437	439	PF00675	0.541
CLV_NRD_NRD_1	633	635	PF00675	0.455
CLV_PCSK_FUR_1	270	274	PF00082	0.599
CLV_PCSK_FUR_1	359	363	PF00082	0.584
CLV_PCSK_KEX2_1	272	274	PF00082	0.640
CLV_PCSK_KEX2_1	311	313	PF00082	0.557
CLV_PCSK_KEX2_1	328	330	PF00082	0.557
CLV_PCSK_KEX2_1	361	363	PF00082	0.595
CLV_PCSK_KEX2_1	437	439	PF00082	0.563
CLV_PCSK_KEX2_1	464	466	PF00082	0.498
CLV_PCSK_KEX2_1	633	635	PF00082	0.455
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.640
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.498
CLV_PCSK_SKI1_1	141	145	PF00082	0.524
CLV_PCSK_SKI1_1	520	524	PF00082	0.517
CLV_PCSK_SKI1_1	61	65	PF00082	0.576
CLV_PCSK_SKI1_1	93	97	PF00082	0.489
DEG_APCC_DBOX_1	1	9	PF00400	0.598
DEG_APCC_DBOX_1	327	335	PF00400	0.379
DEG_APCC_DBOX_1	92	100	PF00400	0.381
DEG_Nend_UBRbox_1	1	4	PF02207	0.600
DOC_MAPK_gen_1	270	279	PF00069	0.418
DOC_MAPK_gen_1	328	334	PF00069	0.379
DOC_MAPK_gen_1	35	44	PF00069	0.406
DOC_MAPK_gen_1	361	371	PF00069	0.486
DOC_MAPK_gen_1	464	471	PF00069	0.298
DOC_MAPK_gen_1	47	55	PF00069	0.260
DOC_MAPK_HePTP_8	269	281	PF00069	0.407
DOC_MAPK_MEF2A_6	2	9	PF00069	0.588
DOC_MAPK_MEF2A_6	272	281	PF00069	0.385
DOC_MAPK_MEF2A_6	37	46	PF00069	0.357
DOC_MAPK_MEF2A_6	47	55	PF00069	0.269
DOC_PP1_RVXF_1	278	284	PF00149	0.329
DOC_PP1_RVXF_1	365	372	PF00149	0.474
DOC_PP1_RVXF_1	391	398	PF00149	0.341
DOC_PP1_RVXF_1	59	66	PF00149	0.395
DOC_PP4_FxxP_1	445	448	PF00568	0.276
DOC_USP7_MATH_1	226	230	PF00917	0.429
DOC_USP7_MATH_1	233	237	PF00917	0.430
DOC_USP7_MATH_1	284	288	PF00917	0.305
DOC_USP7_MATH_1	575	579	PF00917	0.522
DOC_USP7_MATH_1	610	614	PF00917	0.725
DOC_WW_Pin1_4	193	198	PF00397	0.472
DOC_WW_Pin1_4	26	31	PF00397	0.437
DOC_WW_Pin1_4	376	381	PF00397	0.440
DOC_WW_Pin1_4	547	552	PF00397	0.410
DOC_WW_Pin1_4	605	610	PF00397	0.631
DOC_WW_Pin1_4	620	625	PF00397	0.743
LIG_14-3-3_CanoR_1	215	225	PF00244	0.391
LIG_14-3-3_CanoR_1	311	315	PF00244	0.358
LIG_14-3-3_CanoR_1	328	332	PF00244	0.393
LIG_14-3-3_CanoR_1	35	44	PF00244	0.395
LIG_14-3-3_CanoR_1	93	99	PF00244	0.310
LIG_Actin_WH2_2	298	313	PF00022	0.352
LIG_BIR_III_2	25	29	PF00653	0.295
LIG_BIR_III_4	336	340	PF00653	0.292
LIG_BRCT_BRCA1_1	500	504	PF00533	0.325
LIG_BRCT_BRCA1_1	581	585	PF00533	0.360
LIG_Clathr_ClatBox_1	237	241	PF01394	0.395
LIG_deltaCOP1_diTrp_1	318	323	PF00928	0.353
LIG_deltaCOP1_diTrp_1	56	64	PF00928	0.434
LIG_EH_1	137	141	PF12763	0.353
LIG_FHA_1	266	272	PF00498	0.350
LIG_FHA_1	311	317	PF00498	0.372
LIG_FHA_1	338	344	PF00498	0.369
LIG_FHA_1	41	47	PF00498	0.358
LIG_FHA_1	444	450	PF00498	0.344
LIG_FHA_1	452	458	PF00498	0.298
LIG_FHA_1	505	511	PF00498	0.271
LIG_FHA_1	83	89	PF00498	0.337
LIG_FHA_1	9	15	PF00498	0.615
LIG_FHA_2	301	307	PF00498	0.408
LIG_FHA_2	621	627	PF00498	0.742
LIG_GBD_Chelix_1	94	102	PF00786	0.492
LIG_LIR_Apic_2	251	255	PF02991	0.437
LIG_LIR_Gen_1	287	295	PF02991	0.360
LIG_LIR_Gen_1	318	326	PF02991	0.328
LIG_LIR_Gen_1	425	435	PF02991	0.347
LIG_LIR_Gen_1	578	589	PF02991	0.338
LIG_LIR_LC3C_4	330	333	PF02991	0.314
LIG_LIR_Nem_3	318	323	PF02991	0.336
LIG_LIR_Nem_3	379	385	PF02991	0.376
LIG_LIR_Nem_3	390	395	PF02991	0.405
LIG_LIR_Nem_3	405	411	PF02991	0.405
LIG_LIR_Nem_3	425	431	PF02991	0.321
LIG_LIR_Nem_3	440	445	PF02991	0.225
LIG_LIR_Nem_3	545	549	PF02991	0.278
LIG_LIR_Nem_3	578	584	PF02991	0.332
LIG_LIR_Nem_3	68	74	PF02991	0.350
LIG_PCNA_PIPBox_1	207	216	PF02747	0.383
LIG_PCNA_yPIPBox_3	207	221	PF02747	0.420
LIG_Pex14_2	570	574	PF04695	0.576
LIG_PTB_Apo_2	121	128	PF02174	0.362
LIG_SH2_CRK	581	585	PF00017	0.398
LIG_SH2_GRB2like	289	292	PF00017	0.388
LIG_SH2_NCK_1	252	256	PF00017	0.431
LIG_SH2_STAP1	581	585	PF00017	0.460
LIG_SH2_STAT5	289	292	PF00017	0.388
LIG_SH2_STAT5	322	325	PF00017	0.302
LIG_SH2_STAT5	355	358	PF00017	0.347
LIG_SH2_STAT5	382	385	PF00017	0.335
LIG_SH2_STAT5	409	412	PF00017	0.363
LIG_SH2_STAT5	45	48	PF00017	0.347
LIG_SH2_STAT5	524	527	PF00017	0.324
LIG_SH2_STAT5	546	549	PF00017	0.276
LIG_SH2_STAT5	599	602	PF00017	0.681
LIG_SH2_STAT5	67	70	PF00017	0.299
LIG_SH3_3	139	145	PF00018	0.342
LIG_SH3_3	194	200	PF00018	0.469
LIG_SH3_3	236	242	PF00018	0.418
LIG_SH3_3	28	34	PF00018	0.431
LIG_SH3_3	366	372	PF00018	0.447
LIG_SH3_3	48	54	PF00018	0.307
LIG_SH3_3	545	551	PF00018	0.337
LIG_SH3_3	76	82	PF00018	0.382
LIG_SUMO_SIM_anti_2	313	318	PF11976	0.382
LIG_SUMO_SIM_anti_2	330	336	PF11976	0.371
LIG_SUMO_SIM_par_1	312	318	PF11976	0.438
LIG_SUMO_SIM_par_1	330	336	PF11976	0.373
LIG_SUMO_SIM_par_1	6	11	PF11976	0.626
LIG_TYR_ITAM	389	411	PF00017	0.471
LIG_TYR_ITSM	388	395	PF00017	0.458
LIG_UBA3_1	353	357	PF00899	0.406
LIG_WRC_WIRS_1	478	483	PF05994	0.306
MOD_CDK_SPK_2	193	198	PF00069	0.388
MOD_CDK_SPK_2	547	552	PF00069	0.436
MOD_CDK_SPxxK_3	547	554	PF00069	0.419
MOD_CK1_1	550	556	PF00069	0.497
MOD_CK2_1	620	626	PF00069	0.738
MOD_Cter_Amidation	359	362	PF01082	0.513
MOD_Cter_Amidation	435	438	PF01082	0.519
MOD_GlcNHglycan	111	114	PF01048	0.414
MOD_GlcNHglycan	500	503	PF01048	0.524
MOD_GlcNHglycan	571	574	PF01048	0.631
MOD_GlcNHglycan	590	593	PF01048	0.490
MOD_GlcNHglycan	612	615	PF01048	0.476
MOD_GlcNHglycan	76	79	PF01048	0.625
MOD_GSK3_1	109	116	PF00069	0.214
MOD_GSK3_1	337	344	PF00069	0.391
MOD_GSK3_1	416	423	PF00069	0.313
MOD_GSK3_1	45	52	PF00069	0.354
MOD_GSK3_1	575	582	PF00069	0.540
MOD_GSK3_1	616	623	PF00069	0.755
MOD_N-GLC_1	108	113	PF02516	0.554
MOD_N-GLC_1	120	125	PF02516	0.476
MOD_N-GLC_1	216	221	PF02516	0.591
MOD_N-GLC_1	290	295	PF02516	0.508
MOD_N-GLC_1	421	426	PF02516	0.522
MOD_N-GLC_1	490	495	PF02516	0.484
MOD_NEK2_1	300	305	PF00069	0.333
MOD_NEK2_1	321	326	PF00069	0.316
MOD_NEK2_1	420	425	PF00069	0.317
MOD_NEK2_1	504	509	PF00069	0.337
MOD_NEK2_1	542	547	PF00069	0.276
MOD_NEK2_1	588	593	PF00069	0.370
MOD_NEK2_1	65	70	PF00069	0.312
MOD_NEK2_1	8	13	PF00069	0.545
MOD_NEK2_2	113	118	PF00069	0.242
MOD_NEK2_2	284	289	PF00069	0.306
MOD_NEK2_2	387	392	PF00069	0.392
MOD_NEK2_2	513	518	PF00069	0.344
MOD_PIKK_1	203	209	PF00454	0.403
MOD_PIKK_1	395	401	PF00454	0.358
MOD_PIKK_1	562	568	PF00454	0.499
MOD_PKA_2	265	271	PF00069	0.410
MOD_PKA_2	310	316	PF00069	0.352
MOD_PKA_2	327	333	PF00069	0.393
MOD_PKA_2	49	55	PF00069	0.340
MOD_PKA_2	504	510	PF00069	0.276
MOD_PKB_1	35	43	PF00069	0.383
MOD_Plk_1	290	296	PF00069	0.329
MOD_Plk_1	393	399	PF00069	0.353
MOD_Plk_1	490	496	PF00069	0.285
MOD_Plk_4	145	151	PF00069	0.366
MOD_Plk_4	233	239	PF00069	0.441
MOD_Plk_4	387	393	PF00069	0.461
MOD_Plk_4	40	46	PF00069	0.348
MOD_Plk_4	520	526	PF00069	0.285
MOD_Plk_4	542	548	PF00069	0.276
MOD_Plk_4	579	585	PF00069	0.342
MOD_Plk_4	8	14	PF00069	0.692
MOD_Plk_4	94	100	PF00069	0.278
MOD_ProDKin_1	193	199	PF00069	0.466
MOD_ProDKin_1	26	32	PF00069	0.434
MOD_ProDKin_1	376	382	PF00069	0.434
MOD_ProDKin_1	547	553	PF00069	0.418
MOD_ProDKin_1	605	611	PF00069	0.632
MOD_ProDKin_1	620	626	PF00069	0.744
MOD_SUMO_rev_2	132	136	PF00179	0.357
MOD_SUMO_rev_2	38	43	PF00179	0.394
MOD_SUMO_rev_2	550	559	PF00179	0.471
MOD_SUMO_rev_2	56	63	PF00179	0.330
TRG_DiLeu_LyEn_5	626	631	PF01217	0.754
TRG_ENDOCYTIC_2	175	178	PF00928	0.301
TRG_ENDOCYTIC_2	289	292	PF00928	0.382
TRG_ENDOCYTIC_2	382	385	PF00928	0.391
TRG_ENDOCYTIC_2	392	395	PF00928	0.448
TRG_ENDOCYTIC_2	408	411	PF00928	0.232
TRG_ENDOCYTIC_2	428	431	PF00928	0.313
TRG_ENDOCYTIC_2	442	445	PF00928	0.220
TRG_ENDOCYTIC_2	581	584	PF00928	0.475
TRG_ER_diArg_1	310	312	PF00400	0.366
TRG_ER_diArg_1	34	37	PF00400	0.470
TRG_ER_diArg_1	359	362	PF00400	0.438
TRG_ER_diArg_1	437	439	PF00400	0.353
TRG_ER_diArg_1	600	603	PF00400	0.728

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAX0	Leptomonas seymouri	63%	100%
A0A0S4JGF1	Bodo saltans	26%	73%
A0A1X0P996	Trypanosomatidae	48%	98%
A0A3R7JTK5	Trypanosoma rangeli	52%	100%
A0A3S5H569	Leishmania donovani	94%	100%
A4H3Q7	Leishmania braziliensis	78%	100%
A4HRY1	Leishmania infantum	94%	100%
C9ZKJ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	98%
E9AJX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BXB2	Trypanosoma cruzi	49%	100%