Multicopper oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Multicopper oxidase

Gene product:

multicopper oxidase, putative

Species:

Leishmania major

UniProt:

E9ACP0_LEIMA

TriTrypDb:

LmjF.03.0950 , LMJLV39_030014900 , LMJSD75_030015000

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 3
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

E9ACP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACP0

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005507	copper ion binding	6	12
GO:0016491	oxidoreductase activity	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.449
CLV_C14_Caspase3-7	303	307	PF00656	0.388
CLV_C14_Caspase3-7	56	60	PF00656	0.463
CLV_NRD_NRD_1	311	313	PF00675	0.557
CLV_NRD_NRD_1	328	330	PF00675	0.561
CLV_NRD_NRD_1	361	363	PF00675	0.654
CLV_NRD_NRD_1	437	439	PF00675	0.541
CLV_NRD_NRD_1	633	635	PF00675	0.455
CLV_PCSK_FUR_1	270	274	PF00082	0.599
CLV_PCSK_FUR_1	359	363	PF00082	0.584

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAX0	Leptomonas seymouri	63%	100%
A0A0S4JGF1	Bodo saltans	26%	73%
A0A1X0P996	Trypanosomatidae	48%	98%
A0A3R7JTK5	Trypanosoma rangeli	52%	100%
A0A3S5H569	Leishmania donovani	94%	100%
A4H3Q7	Leishmania braziliensis	78%	100%
A4HRY1	Leishmania infantum	94%	100%
C9ZKJ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	98%
E9AJX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BXB2	Trypanosoma cruzi	49%	100%

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