RNB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACN9_LEIMA

TriTrypDb:

LmjF.03.0940 , LMJLV39_030014800 , LMJSD75_030014900

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACN9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.760
CLV_C14_Caspase3-7	235	239	PF00656	0.396
CLV_NRD_NRD_1	111	113	PF00675	0.694
CLV_NRD_NRD_1	12	14	PF00675	0.534
CLV_NRD_NRD_1	16	18	PF00675	0.518
CLV_NRD_NRD_1	187	189	PF00675	0.707
CLV_NRD_NRD_1	227	229	PF00675	0.442
CLV_NRD_NRD_1	26	28	PF00675	0.549
CLV_NRD_NRD_1	269	271	PF00675	0.482
CLV_NRD_NRD_1	314	316	PF00675	0.663
CLV_NRD_NRD_1	64	66	PF00675	0.636
CLV_NRD_NRD_1	99	101	PF00675	0.677
CLV_PCSK_FUR_1	62	66	PF00082	0.711
CLV_PCSK_KEX2_1	110	112	PF00082	0.703
CLV_PCSK_KEX2_1	12	14	PF00082	0.518
CLV_PCSK_KEX2_1	16	18	PF00082	0.507
CLV_PCSK_KEX2_1	187	189	PF00082	0.707
CLV_PCSK_KEX2_1	26	28	PF00082	0.544
CLV_PCSK_KEX2_1	269	271	PF00082	0.460
CLV_PCSK_KEX2_1	49	51	PF00082	0.669
CLV_PCSK_KEX2_1	64	66	PF00082	0.543
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.723
CLV_PCSK_PC7_1	12	18	PF00082	0.619
CLV_PCSK_SKI1_1	157	161	PF00082	0.528
CLV_PCSK_SKI1_1	17	21	PF00082	0.529
CLV_PCSK_SKI1_1	3	7	PF00082	0.574
DEG_Nend_Nbox_1	1	3	PF02207	0.616
DEG_SPOP_SBC_1	129	133	PF00917	0.703
DOC_CYCLIN_yCln2_LP_2	164	170	PF00134	0.335
DOC_MAPK_DCC_7	161	170	PF00069	0.529
DOC_MAPK_MEF2A_6	161	170	PF00069	0.529
DOC_MAPK_NFAT4_5	161	169	PF00069	0.330
DOC_PP2B_LxvP_1	164	167	PF13499	0.327
DOC_USP7_MATH_1	129	133	PF00917	0.692
DOC_USP7_MATH_1	190	194	PF00917	0.718
DOC_USP7_MATH_1	205	209	PF00917	0.592
DOC_USP7_MATH_1	296	300	PF00917	0.489
DOC_USP7_MATH_1	63	67	PF00917	0.792
DOC_USP7_MATH_1	71	75	PF00917	0.765
LIG_14-3-3_CanoR_1	16	22	PF00244	0.514
LIG_14-3-3_CanoR_1	187	194	PF00244	0.570
LIG_14-3-3_CanoR_1	322	326	PF00244	0.691
LIG_Actin_WH2_2	147	163	PF00022	0.426
LIG_Actin_WH2_2	261	279	PF00022	0.508
LIG_Actin_WH2_2	301	317	PF00022	0.692
LIG_FHA_1	271	277	PF00498	0.554
LIG_FHA_1	39	45	PF00498	0.510
LIG_FHA_1	67	73	PF00498	0.741
LIG_FHA_2	34	40	PF00498	0.596
LIG_GBD_Chelix_1	216	224	PF00786	0.551
LIG_LIR_Gen_1	132	140	PF02991	0.631
LIG_LIR_Gen_1	149	159	PF02991	0.450
LIG_LIR_Gen_1	222	227	PF02991	0.341
LIG_LIR_Nem_3	132	138	PF02991	0.650
LIG_LIR_Nem_3	149	154	PF02991	0.407
LIG_LIR_Nem_3	222	226	PF02991	0.335
LIG_LIR_Nem_3	324	328	PF02991	0.707
LIG_Pex14_1	321	325	PF04695	0.572
LIG_PTB_Apo_2	248	255	PF02174	0.401
LIG_PTB_Phospho_1	248	254	PF10480	0.405
LIG_SH2_CRK	135	139	PF00017	0.701
LIG_SH2_CRK	162	166	PF00017	0.435
LIG_SH2_NCK_1	135	139	PF00017	0.533
LIG_SH2_NCK_1	213	217	PF00017	0.454
LIG_SH2_SRC	213	216	PF00017	0.456
LIG_SH2_STAP1	213	217	PF00017	0.579
LIG_SH2_STAP1	323	327	PF00017	0.696
LIG_SH2_STAT5	254	257	PF00017	0.403
LIG_SH2_STAT5	323	326	PF00017	0.696
LIG_Sin3_3	151	158	PF02671	0.485
LIG_TRAF2_1	146	149	PF00917	0.606
LIG_TRAF2_1	87	90	PF00917	0.621
LIG_TYR_ITIM	211	216	PF00017	0.515
LIG_UBA3_1	43	49	PF00899	0.684
MOD_CK1_1	178	184	PF00069	0.585
MOD_CK1_1	33	39	PF00069	0.643
MOD_CK1_1	66	72	PF00069	0.742
MOD_CK1_1	74	80	PF00069	0.653
MOD_CK2_1	33	39	PF00069	0.646
MOD_Cter_Amidation	10	13	PF01082	0.574
MOD_GlcNHglycan	125	128	PF01048	0.697
MOD_GlcNHglycan	144	147	PF01048	0.314
MOD_GlcNHglycan	177	180	PF01048	0.565
MOD_GlcNHglycan	183	186	PF01048	0.634
MOD_GlcNHglycan	188	191	PF01048	0.648
MOD_GlcNHglycan	206	211	PF01048	0.648
MOD_GlcNHglycan	23	26	PF01048	0.663
MOD_GlcNHglycan	277	280	PF01048	0.732
MOD_GlcNHglycan	65	68	PF01048	0.708
MOD_GSK3_1	119	126	PF00069	0.731
MOD_GSK3_1	17	24	PF00069	0.553
MOD_GSK3_1	186	193	PF00069	0.628
MOD_GSK3_1	33	40	PF00069	0.440
MOD_GSK3_1	72	79	PF00069	0.648
MOD_N-GLC_1	72	77	PF02516	0.693
MOD_N-GLC_2	251	253	PF02516	0.558
MOD_NEK2_1	38	43	PF00069	0.620
MOD_NEK2_2	232	237	PF00069	0.479
MOD_PIKK_1	307	313	PF00454	0.680
MOD_PKA_2	186	192	PF00069	0.607
MOD_PKA_2	321	327	PF00069	0.692
MOD_PKA_2	33	39	PF00069	0.570
MOD_PKA_2	63	69	PF00069	0.722
MOD_Plk_1	206	212	PF00069	0.614
MOD_Plk_1	38	44	PF00069	0.634
MOD_Plk_4	222	228	PF00069	0.471
MOD_Plk_4	243	249	PF00069	0.501
MOD_Plk_4	33	39	PF00069	0.643
MOD_SUMO_rev_2	193	200	PF00179	0.580
TRG_DiLeu_BaEn_1	39	44	PF01217	0.582
TRG_DiLeu_LyEn_5	39	44	PF01217	0.582
TRG_ENDOCYTIC_2	135	138	PF00928	0.561
TRG_ENDOCYTIC_2	213	216	PF00928	0.456
TRG_ENDOCYTIC_2	264	267	PF00928	0.440
TRG_ENDOCYTIC_2	325	328	PF00928	0.615
TRG_ER_diArg_1	109	112	PF00400	0.705
TRG_ER_diArg_1	16	18	PF00400	0.535
TRG_ER_diArg_1	268	270	PF00400	0.459
TRG_ER_diArg_1	62	65	PF00400	0.722
TRG_Pf-PMV_PEXEL_1	269	274	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	306	311	PF00026	0.717

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I474	Leptomonas seymouri	52%	100%
A0A1X0P9T2	Trypanosomatidae	33%	98%
A0A3R7JZ70	Trypanosoma rangeli	36%	100%
A0A3S5H568	Leishmania donovani	93%	100%
A4H3Q6	Leishmania braziliensis	78%	100%
A4HRY0	Leishmania infantum	93%	100%
C9ZKI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AJX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BC75	Trypanosoma cruzi	36%	100%