Amidohydro_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amidohydrolase family, putative

Species:

Leishmania major

UniProt:

E9ACN8_LEIMA

TriTrypDb:

LmjF.03.0930 , LMJLV39_030014700 , LMJSD75_030014800

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACN8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.522
CLV_C14_Caspase3-7	553	557	PF00656	0.485
CLV_NRD_NRD_1	11	13	PF00675	0.466
CLV_NRD_NRD_1	250	252	PF00675	0.305
CLV_NRD_NRD_1	523	525	PF00675	0.285
CLV_NRD_NRD_1	601	603	PF00675	0.395
CLV_PCSK_KEX2_1	11	13	PF00082	0.419
CLV_PCSK_KEX2_1	237	239	PF00082	0.320
CLV_PCSK_KEX2_1	250	252	PF00082	0.241
CLV_PCSK_KEX2_1	493	495	PF00082	0.370
CLV_PCSK_KEX2_1	523	525	PF00082	0.280
CLV_PCSK_KEX2_1	601	603	PF00082	0.395
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.395
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.360
CLV_PCSK_SKI1_1	111	115	PF00082	0.395
CLV_PCSK_SKI1_1	250	254	PF00082	0.312
CLV_PCSK_SKI1_1	490	494	PF00082	0.340
DEG_APCC_DBOX_1	162	170	PF00400	0.497
DEG_SPOP_SBC_1	23	27	PF00917	0.350
DOC_CDC14_PxL_1	112	120	PF14671	0.595
DOC_MAPK_gen_1	296	305	PF00069	0.507
DOC_MAPK_MEF2A_6	111	120	PF00069	0.484
DOC_MAPK_MEF2A_6	291	299	PF00069	0.540
DOC_PP1_RVXF_1	39	45	PF00149	0.471
DOC_PP2B_LxvP_1	113	116	PF13499	0.522
DOC_PP4_FxxP_1	332	335	PF00568	0.522
DOC_PP4_MxPP_1	340	343	PF00568	0.522
DOC_USP7_MATH_1	191	195	PF00917	0.595
DOC_USP7_MATH_1	22	26	PF00917	0.367
DOC_USP7_MATH_1	323	327	PF00917	0.595
DOC_USP7_MATH_1	359	363	PF00917	0.595
DOC_USP7_MATH_1	585	589	PF00917	0.560
DOC_USP7_MATH_2	609	615	PF00917	0.567
DOC_WW_Pin1_4	157	162	PF00397	0.522
DOC_WW_Pin1_4	242	247	PF00397	0.521
DOC_WW_Pin1_4	338	343	PF00397	0.595
LIG_14-3-3_CanoR_1	124	134	PF00244	0.512
LIG_14-3-3_CanoR_1	15	20	PF00244	0.540
LIG_14-3-3_CanoR_1	337	341	PF00244	0.497
LIG_14-3-3_CanoR_1	41	45	PF00244	0.464
LIG_14-3-3_CanoR_1	422	432	PF00244	0.532
LIG_14-3-3_CanoR_1	439	445	PF00244	0.439
LIG_14-3-3_CanoR_1	620	625	PF00244	0.596
LIG_14-3-3_CanoR_1	78	83	PF00244	0.562
LIG_APCC_ABBA_1	355	360	PF00400	0.595
LIG_BRCT_BRCA1_1	261	265	PF00533	0.561
LIG_BRCT_BRCA1_1	328	332	PF00533	0.595
LIG_deltaCOP1_diTrp_1	142	152	PF00928	0.485
LIG_eIF4E_1	529	535	PF01652	0.522
LIG_FHA_1	126	132	PF00498	0.519
LIG_FHA_1	187	193	PF00498	0.603
LIG_FHA_1	255	261	PF00498	0.507
LIG_FHA_1	46	52	PF00498	0.447
LIG_FHA_1	487	493	PF00498	0.540
LIG_FHA_1	636	642	PF00498	0.522
LIG_FHA_2	207	213	PF00498	0.522
LIG_FHA_2	273	279	PF00498	0.522
LIG_FHA_2	378	384	PF00498	0.494
LIG_GBD_Chelix_1	535	543	PF00786	0.395
LIG_HCF-1_HBM_1	136	139	PF13415	0.595
LIG_LIR_Apic_2	329	335	PF02991	0.525
LIG_LIR_Gen_1	125	135	PF02991	0.522
LIG_LIR_Gen_1	262	272	PF02991	0.535
LIG_LIR_Nem_3	125	130	PF02991	0.522
LIG_LIR_Nem_3	262	268	PF02991	0.595
LIG_LIR_Nem_3	313	318	PF02991	0.507
LIG_LIR_Nem_3	528	534	PF02991	0.507
LIG_LYPXL_S_1	95	99	PF13949	0.322
LIG_Pex14_2	265	269	PF04695	0.522
LIG_SH2_CRK	301	305	PF00017	0.522
LIG_SH2_CRK	498	502	PF00017	0.595
LIG_SH2_CRK	55	59	PF00017	0.501
LIG_SH2_CRK	684	688	PF00017	0.522
LIG_SH2_NCK_1	239	243	PF00017	0.497
LIG_SH2_NCK_1	644	648	PF00017	0.595
LIG_SH2_NCK_1	684	688	PF00017	0.522
LIG_SH2_SRC	239	242	PF00017	0.484
LIG_SH2_SRC	644	647	PF00017	0.595
LIG_SH2_STAP1	178	182	PF00017	0.522
LIG_SH2_STAT3	579	582	PF00017	0.540
LIG_SH2_STAT5	349	352	PF00017	0.522
LIG_SH2_STAT5	515	518	PF00017	0.522
LIG_SH2_STAT5	622	625	PF00017	0.522
LIG_SH2_STAT5	635	638	PF00017	0.522
LIG_SH2_STAT5	684	687	PF00017	0.522
LIG_SH3_3	16	22	PF00018	0.440
LIG_SH3_3	545	551	PF00018	0.522
LIG_SUMO_SIM_anti_2	2	9	PF11976	0.433
LIG_SUMO_SIM_par_1	214	220	PF11976	0.567
LIG_TRAF2_1	573	576	PF00917	0.484
LIG_TYR_ITIM	682	687	PF00017	0.388
MOD_CDC14_SPxK_1	160	163	PF00782	0.352
MOD_CDK_SPxK_1	157	163	PF00069	0.352
MOD_CK1_1	267	273	PF00069	0.388
MOD_CK1_1	326	332	PF00069	0.489
MOD_CK1_1	362	368	PF00069	0.400
MOD_CK1_1	486	492	PF00069	0.412
MOD_CK2_1	206	212	PF00069	0.489
MOD_CK2_1	303	309	PF00069	0.334
MOD_CK2_1	410	416	PF00069	0.373
MOD_CK2_1	44	50	PF00069	0.445
MOD_CK2_1	474	480	PF00069	0.388
MOD_GlcNHglycan	183	186	PF01048	0.388
MOD_GlcNHglycan	224	227	PF01048	0.256
MOD_GlcNHglycan	325	328	PF01048	0.454
MOD_GlcNHglycan	393	396	PF01048	0.486
MOD_GlcNHglycan	399	403	PF01048	0.337
MOD_GlcNHglycan	450	453	PF01048	0.357
MOD_GlcNHglycan	587	590	PF01048	0.373
MOD_GSK3_1	259	266	PF00069	0.405
MOD_GSK3_1	267	274	PF00069	0.364
MOD_GSK3_1	326	333	PF00069	0.457
MOD_GSK3_1	40	47	PF00069	0.307
MOD_GSK3_1	585	592	PF00069	0.482
MOD_N-GLC_1	278	283	PF02516	0.352
MOD_N-GLC_1	376	381	PF02516	0.412
MOD_NEK2_1	120	125	PF00069	0.334
MOD_NEK2_1	263	268	PF00069	0.350
MOD_NEK2_1	271	276	PF00069	0.316
MOD_NEK2_1	410	415	PF00069	0.373
MOD_NEK2_1	44	49	PF00069	0.465
MOD_NEK2_1	530	535	PF00069	0.388
MOD_NEK2_1	99	104	PF00069	0.388
MOD_NEK2_2	191	196	PF00069	0.436
MOD_NEK2_2	264	269	PF00069	0.489
MOD_PIKK_1	122	128	PF00454	0.489
MOD_PIKK_1	578	584	PF00454	0.389
MOD_PK_1	15	21	PF00069	0.317
MOD_PKA_1	524	530	PF00069	0.388
MOD_PKA_2	336	342	PF00069	0.388
MOD_PKA_2	40	46	PF00069	0.461
MOD_PKB_1	78	86	PF00069	0.539
MOD_Plk_1	330	336	PF00069	0.373
MOD_Plk_1	525	531	PF00069	0.373
MOD_Plk_1	645	651	PF00069	0.436
MOD_Plk_2-3	383	389	PF00069	0.343
MOD_Plk_2-3	611	617	PF00069	0.388
MOD_Plk_4	15	21	PF00069	0.461
MOD_Plk_4	264	270	PF00069	0.489
MOD_Plk_4	272	278	PF00069	0.357
MOD_Plk_4	515	521	PF00069	0.400
MOD_Plk_4	525	531	PF00069	0.369
MOD_Plk_4	682	688	PF00069	0.388
MOD_ProDKin_1	157	163	PF00069	0.388
MOD_ProDKin_1	242	248	PF00069	0.386
MOD_ProDKin_1	338	344	PF00069	0.489
MOD_SUMO_rev_2	486	495	PF00179	0.373
TRG_DiLeu_BaEn_1	31	36	PF01217	0.542
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.489
TRG_ENDOCYTIC_2	316	319	PF00928	0.357
TRG_ENDOCYTIC_2	349	352	PF00928	0.388
TRG_ENDOCYTIC_2	498	501	PF00928	0.489
TRG_ENDOCYTIC_2	55	58	PF00928	0.578
TRG_ENDOCYTIC_2	644	647	PF00928	0.475
TRG_ENDOCYTIC_2	684	687	PF00928	0.388
TRG_ENDOCYTIC_2	96	99	PF00928	0.368
TRG_ER_diArg_1	11	13	PF00400	0.466
TRG_ER_diArg_1	295	298	PF00400	0.388
TRG_ER_diArg_1	475	478	PF00400	0.483
TRG_ER_diArg_1	600	602	PF00400	0.489
TRG_ER_diArg_1	675	678	PF00400	0.256

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P539	Leptomonas seymouri	70%	99%
A0A1I9LN01	Arabidopsis thaliana	26%	100%
A0A451EJU1	Leishmania donovani	95%	100%
A4H3Q5	Leishmania braziliensis	89%	100%
A4HRX9	Leishmania infantum	95%	100%
E9AJX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O34355	Bacillus subtilis (strain 168)	24%	100%
Q68AP4	Arthrobacter pascens	24%	100%