Vesicle transport protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Got1/Sft2-like family, putative

Species:

Leishmania major

UniProt:

E9ACN7_LEIMA

TriTrypDb:

LmjF.03.0920 , LMJLV39_030014600 , LMJSD75_030014700

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	23
GO:0110165	cellular anatomical entity	1	23

Expansion

Sequence features

E9ACN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACN7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	23
GO:0008104	protein localization	4	23
GO:0009987	cellular process	1	23
GO:0015031	protein transport	4	23
GO:0016192	vesicle-mediated transport	4	23
GO:0033036	macromolecule localization	2	23
GO:0045184	establishment of protein localization	3	23
GO:0051179	localization	1	23
GO:0051234	establishment of localization	2	23
GO:0051641	cellular localization	2	23
GO:0070727	cellular macromolecule localization	3	23
GO:0071702	organic substance transport	4	23
GO:0071705	nitrogen compound transport	4	23

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.622
CLV_PCSK_SKI1_1	127	131	PF00082	0.284
CLV_PCSK_SKI1_1	188	192	PF00082	0.501
DOC_CYCLIN_RxL_1	30	41	PF00134	0.575
DOC_MAPK_MEF2A_6	184	191	PF00069	0.701
DOC_USP7_MATH_1	200	204	PF00917	0.401
LIG_14-3-3_CanoR_1	184	188	PF00244	0.674
LIG_Actin_WH2_2	173	190	PF00022	0.541
LIG_BRCT_BRCA1_1	114	118	PF00533	0.304
LIG_BRCT_BRCA1_1	194	198	PF00533	0.407
LIG_eIF4E_1	32	38	PF01652	0.572
LIG_FHA_1	114	120	PF00498	0.335
LIG_FHA_1	184	190	PF00498	0.596
LIG_FHA_1	44	50	PF00498	0.768
LIG_FHA_1	69	75	PF00498	0.622
LIG_GBD_Chelix_1	145	153	PF00786	0.245
LIG_GBD_Chelix_1	169	177	PF00786	0.280
LIG_LIR_Gen_1	192	201	PF02991	0.513
LIG_LIR_Gen_1	75	86	PF02991	0.363
LIG_LIR_Nem_3	178	182	PF02991	0.357
LIG_LIR_Nem_3	195	201	PF02991	0.335
LIG_NRBOX	85	91	PF00104	0.280
LIG_PCNA_PIPBox_1	147	156	PF02747	0.266
LIG_SH2_CRK	32	36	PF00017	0.641
LIG_SH2_SRC	141	144	PF00017	0.280
LIG_SH2_STAP1	175	179	PF00017	0.310
LIG_SH2_STAP1	193	197	PF00017	0.478
LIG_SH2_STAP1	70	74	PF00017	0.625
LIG_SH2_STAT3	182	185	PF00017	0.682
LIG_SH2_STAT3	26	29	PF00017	0.665
LIG_SH2_STAT5	141	144	PF00017	0.401
LIG_SH2_STAT5	179	182	PF00017	0.366
LIG_SH2_STAT5	70	73	PF00017	0.668
LIG_SxIP_EBH_1	173	184	PF03271	0.389
LIG_UBA3_1	149	158	PF00899	0.407
MOD_CK1_1	192	198	PF00069	0.446
MOD_CK1_1	36	42	PF00069	0.699
MOD_CK1_1	63	69	PF00069	0.643
MOD_CK2_1	125	131	PF00069	0.446
MOD_GlcNHglycan	150	153	PF01048	0.375
MOD_GlcNHglycan	5	8	PF01048	0.513
MOD_GSK3_1	141	148	PF00069	0.343
MOD_GSK3_1	43	50	PF00069	0.763
MOD_GSK3_1	68	75	PF00069	0.655
MOD_GSK3_1	99	106	PF00069	0.278
MOD_NEK2_1	103	108	PF00069	0.380
MOD_NEK2_1	113	118	PF00069	0.371
MOD_NEK2_1	3	8	PF00069	0.687
MOD_NEK2_1	68	73	PF00069	0.615
MOD_NEK2_2	183	188	PF00069	0.668
MOD_NEK2_2	19	24	PF00069	0.519
MOD_PIKK_1	25	31	PF00454	0.673
MOD_PIKK_1	68	74	PF00454	0.671
MOD_PKA_1	99	105	PF00069	0.351
MOD_PKA_2	183	189	PF00069	0.661
MOD_PKA_2	72	78	PF00069	0.551
MOD_Plk_1	19	25	PF00069	0.518
MOD_Plk_1	66	72	PF00069	0.636
MOD_Plk_4	113	119	PF00069	0.370
MOD_Plk_4	145	151	PF00069	0.348
MOD_Plk_4	175	181	PF00069	0.398
MOD_Plk_4	192	198	PF00069	0.509
MOD_Plk_4	200	206	PF00069	0.357
MOD_Plk_4	33	39	PF00069	0.636
TRG_ENDOCYTIC_2	193	196	PF00928	0.520
TRG_ENDOCYTIC_2	32	35	PF00928	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5I1	Leptomonas seymouri	71%	99%
A0A0N1I3M5	Leptomonas seymouri	31%	100%
A0A0S4JF33	Bodo saltans	33%	100%
A0A1X0P315	Trypanosomatidae	31%	100%
A0A1X0P7F6	Trypanosomatidae	30%	100%
A0A1X0P987	Trypanosomatidae	44%	100%
A0A3Q8IBK0	Leishmania donovani	39%	100%
A0A3S5H567	Leishmania donovani	95%	100%
A0A3S5H5K3	Leishmania donovani	41%	100%
A0A422N175	Trypanosoma rangeli	45%	100%
A4H3Q4	Leishmania braziliensis	88%	100%
A4HDV3	Leishmania braziliensis	40%	100%
A4HRX8	Leishmania infantum	95%	100%
A4HSK3	Leishmania infantum	41%	100%
A4I148	Leishmania infantum	39%	100%
C9ZKI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	78%
E9AJX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AKI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AX82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
Q4QA90	Leishmania major	40%	100%
Q4QJC1	Leishmania major	41%	100%